scholarly journals Whole genome survey and microsatellite motif identification ofArtemia franciscana

2021 ◽  
Vol 41 (3) ◽  
Author(s):  
Euna Jo ◽  
Seung Jae Lee ◽  
Eunkyung Choi ◽  
Jinmu Kim ◽  
Sung Gu Lee ◽  
...  
Keyword(s):  
Native Species ◽  
Genetic Research ◽  
Model Organism ◽  
Genomic Research ◽  
Toxicity Tests ◽  
Marker Development ◽  
Microsatellite Motif ◽  
Genome Survey ◽  
Ssr Loci ◽  
Molecular Marker Development

AbstractArtemia is an industrially important genus used in aquaculture as a nutritious diet for fish and as an aquatic model organism for toxicity tests. However, despite the significance of Artemia, genomic research remains incomplete and knowledge on its genomic characteristics is insufficient. In particular, Artemia franciscana of North America has been widely used in fisheries of other continents, resulting in invasion of native species. Therefore, studies on population genetics and molecular marker development as well as morphological analyses are required to investigate its population structure and to discriminate closely related species. Here, we used the Illumina Hi-Seq platform to estimate the genomic characteristics of A. franciscana through genome survey sequencing (GSS). Further, simple sequence repeat (SSR) loci were identified for microsatellite marker development. The predicted genome size was ∼867 Mb using K-mer (a sequence of k characters in a string) analysis (K = 17), and heterozygosity and duplication rates were 0.655 and 0.809%, respectively. A total of 421467 SSRs were identified from the genome survey assembly, most of which were dinucleotide motifs with a frequency of 77.22%. The present study will be a useful basis in genomic and genetic research for A. franciscana.

scholarly journals State Control of the Interpretation of Genomic Studies and Medical Applications in the United States of America

2018 ◽  
Vol 22 (3) ◽  
pp. 328-344
Author(s):  
Anzhelika R Sakhipgareeva
Keyword(s):  
United States ◽  
United States Of America ◽  
Genetic Research ◽  
The United States ◽  
Legal Aspects ◽  
The State ◽  
Genomic Research ◽  
Medical Applications ◽  
State Control ◽  
Genomic Studies

This Article is devoted to the theoretical ideas about the features of state control in genomic research and medical applications in the United States of America. The purpose of this study is to examine the legal aspects of the interpretation of genomic research and medical applications in the United States of America, to study the features of the state control of medical applications, as well as companies providing services in the field of genomic research. As a result of the review, the author provides with the information about several features of the state control of the US Food and drug administration (FDA), degree of regulatory intervention in the activities of genetic research companies, identify classification of medical applications apps.

The Pathway to Bacterial Genetics

2021 ◽  
pp. 15-30
Author(s):  
Thomas E. Schindler
Keyword(s):  
Graduate School ◽  
Research Laboratory ◽  
Genetic Research ◽  
Model Organism ◽  
Biochemical Genetics ◽  
Research Experience ◽  
Induced Mutations ◽  
New Paradigm ◽  
Career Pathway ◽  
Early Training

This chapter reviews Esther Zimmer’s early training, as she set out on a parallel career pathway, from Neurospora to bacteria, to her future husband Joshua Lederberg. While still a junior at Hunter College, Zimmer found the best possible mentor in Bernard Ogilvie Dodge, the foremost expert in Neurospora, the new model organism of genetic research. After graduation, Dodge helped her gain further research experience at the Industrial Hygiene Research Laboratory in Bethesda, Maryland, where she worked with Alexander Hollaender, an expert in radiation biology. After two years of training in the procedures for developing X-ray and UV induced mutations, Zimmer acquired her bona fides for graduate school. She was accepted to graduate school at Stanford University because of Dodge’s association with George Beadle, who, with Edward Tatum, had developed a new paradigm for biochemical genetics: “one gene: one enzyme.” In 1946, their similar experiences in Neurospora research brought Joshua and Esther together.

scholarly journals The preferences of potential stakeholders in psychiatric genomic research regarding consent procedures and information delivery

2019 ◽  
Vol 55 ◽  
pp. 29-35 ◽  
Author(s):  
Anna Sundby ◽  
Merete Watt Boolsen ◽  
Kristoffer Sølvsten Burgdorf ◽  
Henrik Ullum ◽  
Thomas Folkmann Hansen ◽  
...  
Keyword(s):  
Informed Consent ◽  
Incidental Findings ◽  
Genetic Research ◽  
Genomic Research ◽  
Research Subjects ◽  
Cross Sectional ◽  
Telephone Consultation ◽  
Active Involvement ◽  
Consent Procedure ◽  
To Receive

AbstractBackground:Genomic sequencing plays an increasing role in genetic research, also in psychiatry. This raises challenges concerning the validity and type of the informed consent and the return of incidental findings. However, no solution currently exists on the best way to obtain the informed consent and deliver findings to research subjects.Aims:This study aims to explore the attitudes among potential stakeholders in psychiatric genomic research toward the consenting procedure and the delivery of incidental findings.Methods:We developed a cross-sectional web-based survey among five groups of stakeholders. A total of 2637 stakeholders responded: 241 persons with a mental disorder, 671 relatives, 1623 blood donors, 74 psychiatrists, and 28 clinical geneticists.Results:The stakeholders wanted active involvement as 92.7% preferred a specific consent and 85.1% wanted to receive information through a dynamic consent procedure. The majority of stakeholders preferred to receive genomic information related to serious or life-threatening health conditions through direct contact (69.5%) with a health professional, i.e. face-to-face consultation or telephone consultation (82.4%). Persons with mental disorders and relatives did not differ in their attitudes from the other stakeholder groups.Conclusion:The findings illustrate that the stakeholders want to be more actively involved and consider consent as a reciprocal transaction between the involved subjects and the researchers in the project. The results highlight the importance of collaboration between researchers and clinical geneticists as the latter are trained, through their education and clinical experience, to return and explain genomic data to patients, relatives, and research subjects.

scholarly journals Identifiability, Genomics and UK Data Protection Law

2010 ◽  
Vol 17 (4) ◽  
pp. 329-344 ◽  
Author(s):  
Liam Curren ◽  
Jane Kaye ◽  
Paula Boddington ◽  
Karen Melham ◽  
Naomi Hawkins ◽  
...  
Keyword(s):  
Data Protection ◽  
Genetic Research ◽  
Research Data ◽  
Genomic Research ◽  
Research Use ◽  
Next Generation Dna Sequencing ◽  
Ethical Concerns ◽  
Whole Genomes ◽  
Protection Legislation ◽  
Data Protection Law

AbstractAnalyses of individuals’ genomes — their entire DNA sequence — have increased knowledge about the links between genetics and disease. Anticipated advances in ‘next generation’ DNA-sequencing techniques will see the routine research use of whole genomes, rather than distinct parts, within the next few years. The scientific benefits of genomic research are, however, accompanied by legal and ethical concerns. Despite the assumption that genetic research data can and will be rendered anonymous, participants’ identities can sometimes be elucidated, which could cause data protection legislation to apply. We undertake a timely reappraisal of these laws — particularly new penalties — and identifiability in genomic research.

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