scholarly journals The effect of various hormonal preparations and calcium supplementation on bone mass in early menopause. Is there a predictive value for the initial bone density and body weight?

1999 ◽  
Vol 246 (4) ◽  
pp. 357-361 ◽  
Author(s):  
A. Pines ◽  
H. Katchman ◽  
Y. Villa ◽  
V. Mijatovic ◽  
I. Dotan ◽  
...  
Keyword(s):  
Body Weight ◽  
Bone Density ◽  
Bone Mass ◽  
Predictive Value ◽  
Calcium Supplementation ◽  
Early Menopause

Messages About Calcium and Weight In Canadian Women's Magazines

2007 ◽  
Vol 68 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Talia Hassan ◽  
Gail Marchessault ◽  
Marian Campbell ◽  
Bruce Huhmann
Keyword(s):  
Body Weight ◽  
Bone Density ◽  
Bone Mass ◽  
Calcium Intake ◽  
Women's Magazines ◽  
Nutrition Information ◽  
Younger Women ◽  
Signed Rank ◽  
Nutrition Messages ◽  
Information Gaps

Purpose: Osteoporosis affects 1.4 million Canadians. Maximizing bone mass by age 30 may reduce this risk. Because calcium intake and body weight are both associated with bone mass, and many Canadian women report that they obtain nutrition information from magazines, we compared the frequency of calcium and body weight messages in Chatelaine and Flare, Canadian magazines for mature versus younger women, respectively. Methods: Using keywords, we identified relevant advertisements and articles in all issues of Chatelaine and Flare for 2000 to 2001. Data were analyzed using paired t-tests and Wilcoxon signed-rank sum tests. Results: Chatelaine had more calcium and weight messages per 100 pages than did Flare (significant only for calcium, p ≤0.0001). Within Chatelaine, there were no significant differences between the frequency of calcium and weight messages; however, almost 90% of Flare's messages focused on weight (p ≤0.0001), with only eight messages in two years addressing calcium. Conclusions: Magazines with limited calcium and many weight messages inadvertently promote a lifestyle that may increase the risk for osteoporosis. The opportunity exists to provide improved calcium and osteoporosis coverage for women at the prime age for maximizing bone density. Awareness of information gaps may help dietitians strategize in promoting nutrition messages to women.

Genetic loci determining bone density in mice with diet-induced atherosclerosis

2001 ◽  
Vol 5 (4) ◽  
pp. 205-215 ◽  
Author(s):  
THOMAS A. DRAKE ◽  
ERIC SCHADT ◽  
KAMBIZ HANNANI ◽  
J. MICHAEL KABO ◽  
KELLY KRASS ◽  
...  
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Bone Density ◽  
Bone Mass ◽  
Plasma Lipids ◽  
Statistical Tests ◽  
Genetic Relationships ◽  
Bone Mass Density ◽  
Tissue Mass ◽  
Adipose Tissue Mass

This study investigates the phenotypic and genetic relationships among bone-density-related traits and those of adipose tissue and plasma lipids in mice with diet-induced atherosclerosis. Sixteen-month-old female F2 progeny of a C57BL/6J and DBA/2J intercross, which had received an atherogenic diet for 4 mo, were examined for multiple measures of femoral bone mass, density, and biomechanical properties using both computerized tomographic and radiographic methods. In addition, body weight and length, adipose tissue mass, plasma lipids and insulin, and aortic fatty lesions were assessed. Bone mass was inversely correlated with extent of atherosclerosis and with a prooxidant lipid profile and directly correlated with body weight, length, and, most strongly, adipose tissue mass. Quantitative trait locus (QTL) analysis, using composite interval mapping (CIM) and multi-trait analysis, identified six loci with multi-trait CIM LOD scores > 5. Three of these coincided with loci linked with adipose tissue and plasma high-density lipoprotein. Application of statistical tests for distinguishing close linkage vs. pleiotropy supported the presence of a potential pleiotropic effect of two of the loci on these traits. This study shows that bone mass in older female mice with atherosclerosis has multiple genetic determinants and provides phenotypic and genetic evidence linking the regulation of bone density with adipose tissue and plasma lipids.

Body weight versus body fat distribution, adiposity, and frame size as predictors of bone density.

1995 ◽  
Vol 80 (4) ◽  
pp. 1118-1123 ◽  
Author(s):  
H S Glauber ◽  
W M Vollmer ◽  
M C Nevitt ◽  
K E Ensrud ◽  
E S Orwoll
Keyword(s):  
Body Weight ◽  
Bone Density ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Frame Size

Aging, body weight and menopause: Influence on bone mass

1996 ◽  
Vol 6 (S1) ◽  
pp. 185-185
Author(s):  
F. Bruschi ◽  
M. Meschia ◽  
D. Perotti ◽  
E. Bologna ◽  
M. Curtarelli ◽  
...  
Keyword(s):  
Body Weight ◽  
Bone Mass ◽  
Aging Body

scholarly journals Effects of Eggshell Calcium Supplementation on Bone Mass in Postmenopausal Vietnamese Women

2017 ◽  
Vol 63 (2) ◽  
pp. 120-124 ◽  
Author(s):  
Seigo SAKAI ◽  
Vu Thi Thu HIEN ◽  
Le Danh TUYEN ◽  
Ha Anh DUC ◽  
Yasunobu MASUDA ◽  
...  
Keyword(s):  
Bone Mass ◽  
Calcium Supplementation ◽  
Vietnamese Women

scholarly journals Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss

2015 ◽  
Vol 227 (3) ◽  
pp. 129-141 ◽  
Author(s):  
Russell T Turner ◽  
Michael Dube ◽  
Adam J Branscum ◽  
Carmen P Wong ◽  
Dawn A Olson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Body Weight ◽  
Bone Loss ◽  
Bone Mass ◽  
Bone Turnover ◽  
Cancellous Bone ◽  
Mass Density ◽  
Female Rats ◽  
Bone Mass Density ◽  
Age Related

Excessive weight gain in adults is associated with a variety of negative health outcomes. Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effects, including accelerating age-related cancellous bone loss. We investigated the efficacy of using hypothalamic leptin gene therapy as an alternative method for reducing weight in skeletally-mature (9 months old) female rats and determined the impact of leptin-induced weight loss on bone mass, density, and microarchitecture, and serum biomarkers of bone turnover (CTx and osteocalcin). Rats were implanted with cannulae in the 3rd ventricle of the hypothalamus and injected with either recombinant adeno-associated virus encoding the gene for rat leptin (rAAV-Leptin,n=7) or a control vector encoding green fluorescent protein (rAAV-GFP,n=10) and sacrificed 18 weeks later. A baseline control group (n=7) was sacrificed at vector administration. rAAV-Leptin-treated rats lost weight (−4±2%) while rAAV-GFP-treated rats gained weight (14±2%) during the study. At study termination, rAAV-Leptin-treated rats weighed 17% less than rAAV-GFP-treated rats and had lower abdominal white adipose tissue weight (−80%), serum leptin (−77%), and serum IGF1 (−34%). Cancellous bone volume fraction in distal femur metaphysis and epiphysis, and in lumbar vertebra tended to be lower (P<0.1) in rAAV-GFP-treated rats (13.5 months old) compared to baseline control rats (9 months old). Significant differences in cancellous bone or biomarkers of bone turnover were not detected between rAAV-Leptin and rAAV-GFP rats. In summary, rAAV-Leptin-treated rats maintained a lower body weight compared to baseline and rAAV-GFP-treated rats with minimal effects on bone mass, density, microarchitecture, or biochemical markers of bone turnover.

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P &lt; .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

scholarly journals Calcium Supplementation Enhanced Adipogenesis and Improved Glucose Homeostasis Through Activation of Camkii and PI3K/Akt Signaling Pathway in Porcine Bone Marrow Mesenchymal Stem Cells (pBMSCs) and Mice Fed High Fat Diet (HFD)

2018 ◽  
Vol 51 (1) ◽  
pp. 154-172 ◽  
Author(s):  
Fenglin Zhang ◽  
Jingjing Ye ◽  
Yingying Meng ◽  
Wei Ai ◽  
Han Su ◽  
...  
Keyword(s):  
Body Weight ◽  
Glucose Uptake ◽  
Glucose Homeostasis ◽  
High Fat Diet ◽  
Calcium Supplementation ◽  
Akt Signaling Pathway ◽  
Glut4 Expression ◽  
Marrow Mesenchymal Stem Cells

Background/Aims: It has been implicated that calcium supplementation is involved in reducing body weight/fat and improving glucose homeostasis. However, the underlying mechanisms are still not fully understood. Here, we investigated the effects of calcium supplementation on adipogenesis and glucose homeostasis in porcine bone marrow mesenchymal stem cells (pBMSCs) and high fat diet (HFD)-fed mice and explored the involved signaling pathways. Methods: In vitro, pBMSCs were treated with 4 mM extracellular calcium ([Ca2+]o) and/or 1 μM nifedipine, 0.1 μM BAPTA-AM, 1 μM KN-93, 50 nM wortmannin for 10 days. The intracellular calcium ([Ca2+]i) levels were measured using Fluo 3-AM by flow cytometry. The adipogenic differentiation of pBMSCs was determined by Oil Red-O staining and triglyceride assay. The expression of marker genes involved in adipogenesis (peroxisome proliferator activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα)) and glucose uptake (glucose transporter 4 (GLUT4)), as well as the activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and PI3K/Akt-FoxO1/AS160 signaling pathways were determined by Western blotting. Glucose uptake and utilization were examined using 2-NBDG assay and glucose content assay, respectively. In vivo, C57BL/6J male mice were fed a HFD (containing 1.2% calcium) without or with 0.6% (w/w) calcium chloride in drinking water for 13 weeks. The adipogenesis, glucose homeostasis and the involvement of CaMKII and PI3K/Akt signaling pathway were also assessed. Results: In vitro, [Ca2+]o stimulated pBMSCs adipogenesis by increasing [Ca2+]i level and activating CaMKII and PI3K/Akt-FoxO1 pathways. In addition, [Ca2+]o promoted glucose uptake/utilization by enhancing AS160 phosphorylation, GLUT4 expression and translocation. However, the stimulating effects of [Ca2+]o on pBMSCs adipogenesis and glucose uptake/utilization were abolished by L-VGCC blocker Nifedipine, [Ca2+]i chelator BAPTA-AM, CaMKII inhibitor KN-93, or PI3K inhibitor Wortmannin. In vivo, calcium supplementation decreased body weight and fat content, increased adipocyte number, and improved glucose homeostasis, with elevated PPARγ and GLUT4 expression and PI3K/Akt activation in iWAT. Conclusion: calcium supplementation enhanced adipogenesis and glucose uptake in pBMSCs, which was coincident with the increased adipocyte number and improved glucose homeostasis in HFD-fed mice, and was associated with activation of CaMKII and PI3K/Akt-FoxO1/AS160 pathways. These data provided a broader understanding of the mechanisms underlying calcium-induced body weight/fat loss and glycemic control.

scholarly journals Relationship Parity and Contraception with Mild Preeclampsia at Puskesmas Jagir

2016 ◽  
Vol 4 (1) ◽  
pp. 100
Author(s):  
Rizky Pradana Setiawan
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Family History ◽  
Pregnant Women ◽  
Calcium Supplementation ◽  
Chronic Hypertension ◽  
Family History Of Diabetes ◽  
Maternal Characteristics ◽  
History Of ◽  
Mild Preeclampsia

Mild preeclampsia is the frequent disease experienced by pregnant women in Puskesmas Jagir in 2011-2014. The number of mild preeclampsia in Puskesmas Jagir keep increase significantly. The purpose of this study is to analyze the association between the characteristics, family history and calcium supplementation in pregnant women with mild preeclampsia at Puskesmas Jagir Surabaya. The type of research is non-reactive research with case control design. Subjects was taken from the population using simple random sampling. The variables studied were age, body weight changes, parity, family history of preeclampsia, contraception, family history of diabetes mellitus, family history of chronic hypertension, and calcium supplementation. The statistical test was Chi-square test with α = 0.05, odds Ratio is calculated by value with 95% confidence interval (CI 95%). Variables associated with mild preeclampsia is a maternal characteristics such as parity (p = 0.001, OR 0.17) and contraception (p = 0.019, OR = 5.636). Variables that are not associated with mild preeclampsia is a maternal characteristics such as the form of changes in body weight during pregnancy, age, and family history of diabetes mellitus in the form of family history and family history of hypertension and calcium supplementation. There is a association between parity and contraception with mild preeclampsia.Keywords: mild preeclampsia, parity, contraception 

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