scholarly journals The role of acute respiratory infections in the pathogenesis of distal limb infections in cattle

2021 ◽  
Vol 282 ◽  
pp. 03015
Author(s):  
A.D. Alekseev ◽  
O.G. Petrova ◽  
M.I. Barashkin ◽  
I.M. Milstein ◽  
N.M. Kolobkova
Keyword(s):  
Respiratory Infections ◽  
Economic Damage ◽  
Pathogenetic Factor ◽  
Respiratory Pathology ◽  
Acute Respiratory Diseases ◽  
The Russian Federation ◽  
Type 3 ◽  
Infectious Etiology

Acute respiratory diseases of infectious etiology of cattle occupy the second place in the nosological picture after diseases of the digestive system and cause huge economic damage, which in the Russian Federation is estimated at several billion rubles annually. Very often, respiratory pathology in highly productive cows is associated with infections of the distal extremities, primarily with necrobacteriosis, streptococcosis and staphylococcosis, which cause significant economic damage by reducing the productivity of animals. An important pathogenetic factor affecting the development of diseases of the distal extremities in cattle (cattle) are infections of the respiratory tract. According to our long-term observations, all farms in which outbreaks of necrobacteriosis were recorded were unfavorable for respiratory infections of cattle, such as infectious rhinotracheitis (IRT), viral diarrhea (VD), parainfluenza type 3 (PG-3), respiratory syncytial infection (RSI), pasteurellosis, chlamydia, salmonellosis and others.

scholarly journals CYSTIC FIBROSIS: A BREAKTHROUGH IN 21ST-CENTURY THERAPY

2020 ◽  
Vol 23 (1) ◽  
pp. 35-41
Author(s):  
Olga I. Simonova ◽  
Yulia V. Gorinova ◽  
Vera P. Chernevich
Keyword(s):  
Cystic Fibrosis ◽  
Web Of Science ◽  
New Drugs ◽  
Cystic Fibrosis Gene ◽  
Multicenter Studies ◽  
Antibacterial Compounds ◽  
The Russian Federation ◽  
Mucolytic Agents

The review presents new data on the latest advances in the treatment of cystic fibrosis, a rare genetic disease. The methods used were literature search in the Scopus, Web of Science, and EMBASE databases. The importance of a number of drugs prescribed for anti-inflammatory purposes (ibuprofen, azithromycin) is discussed, data from multicenter studies of new drugs are presented. The role of mucolytic agents and the need to develop new antibacterial compounds are shown. Particular attention in the review is given to the development of new targeted therapies for cystic fibrosis. The data of studies of ivacaftor, lumacactor, tezacactor in this category of patients are presented, as well as a spectrum of mutations of the cystic fibrosis gene in which these molecules can be prescribed. The experience of the use of correctors in adult patients with cystic fibrosis in the Russian Federation is described, the effectiveness and safety of the long-term use of these drugs are described.

scholarly journals INTERWENCJA FEDERACJI ROSYJSKIEJ W SYRII – STUDIUM PRZYPADKU ROSYJSKIEJ POLITYKI NA BLISKIM WSCHODZIE

2019 ◽  
pp. 51-64
Author(s):  
Dariusz Brążkiewicz
Keyword(s):  
Middle East ◽  
Russian Federation ◽  
Dominant Role ◽  
The West ◽  
International Environment ◽  
The World ◽  
The Usa ◽  
The Russian Federation

Abstrakt: Współczesna polityka Federacji Rosyjskiej na Bliskim Wschodzie jest elementem szerokiej strategii ukierunkowanej na cele w środowisku międzynarodowym oraz na cele wewnątrzpaństwowe. Polityka ta jest konfrontacyjna na płaszczyźnie Rosja – Zachód i stanowi koło zamachowe w dążeniu kraju do odzyskania dominującej roli w świecie. Zaangażowanie Federacji Rosyjskiej w konflikt w Syrii jest konsekwencją jej mocarstwowej polityki w zmieniającym się środowisku międzynarodowym. Głównym celem było wyeliminowanie rozwiązań USA i innych państw Zachodu w zakresie interwencji humanitarnej w Syrii. Poza tym utrzymując reżim Baszara al-Asada Federacja Rosyjska podjęła realizację własnego ładu na Bliskim Wschodzie, gdzie chce odgrywać kluczową rolę. Pomagają jej w tym Iran – wieloletni oponent USA oraz Turcja – nowy koalicjant, które mają też swoje partykularne cele w regionie. W przypadku polityki wewnętrznej, rosyjskie elity polityczne chcą utrwalić władzę populistyczną, oferując narodowi drogę dokonań państwa, szczególnie w wymiarze międzynarodowym – wskazując siłę militarną i wyższość polityczną, jako podstawowe elementy odbudowy mocarstwowej roli Federacji Rosyjskiej w świecie. Te kierunki polityki zewnętrznej i wewnętrznej dają obraz konsekwentnych, a jednocześnie zaskakujących działań Federacji Rosyjskiej na Bliskim Wschodzie. Abstract: Contemporary policy of the Russian Federation in the Middle East is an element of a broad strategy focused on international and internal purposes. This policy is confrontational at the level of Russia - the West and constitutes a flywheel in the pursuit of the country to regain its dominant role in the world. The involvement of the Russian Federation in the conflict in Syria is a consequence of its superpower policy in the changing international environment. The main goal was to eliminate the solutions of the USA and other Western countries in the field of humanitarian intervention in Syria. What is more, maintaining the regime of Bashar al-Assad, the Russian Federation has embarked on the implementation of its own order in the Middle East, where it wants to play a key role. Iran, a long-term opponent of the USA, and Turkey, a new coalition partner that also has its particular goals in the region, are the countries which help Russia in this area. In the case of domestic policy, Russia’s power elites want to consolidate populist power by presenting the nation country’s accomplishments, especially in the international dimension, indicating military strength and political superiority as the basic elements of rebuilding the superpower role of the Russian Federation in the world. These external and internal policies give a picture of the consistent and also surprising actions of the Russian Federation in the Middle East

scholarly journals Current trends in paediatric infections in the Russian Federation

2020 ◽  
Vol 27 (4) ◽  
pp. 119-133
Author(s):  
Yu. V. Lobzin ◽  
S. V. Rychkova ◽  
A. N. Uskov ◽  
N. V. Skripchenko ◽  
V. V. Fedorov
Keyword(s):  
Infectious Diseases ◽  
Russian Federation ◽  
Herd Immunity ◽  
Human Microbiome ◽  
Economic Damage ◽  
Comparative Dynamics ◽  
Treatment And Prevention ◽  
Intestinal Infections ◽  
Acute Respiratory Diseases ◽  
The Russian Federation

The onset of 2020 clearly demonstrated that infection agents pose a major threat to mankind. Current infectiology is shaped by resurrection of “old” seemingly forgotten infections, emergence of “new” infection agents, unusual combinations of known agents, evolving resistance of microorganisms to antibacterial drugs, transformation of human microbiome leading to distortions in herd immunity and, ultimately, emergence of healthcare-related infectious diseases, not letting alone threats of bioterror. Infection agents evolve together with mankind. Novel facets emerge in infectiology, alongside with trends in diagnosis, treatment and prevention of infectious diseases that become more diverse as the list of pathogens grows. Human and infection agent links extend beyond antagonistic relations towards symbiosis. Microorganisms adapt quickly in the new technogenic environment giving rise to novel pathogens and making it unlikely for the mankind to get free from infections any time soon.The total economic damage from infectious diseases increases by year, despite continuous improvement in therapy. Infectious mortality in children aged 0 to 14 years is the top fourth among other causes of death. The work assesses comparative dynamics of “common” childhood infections in the Russian Federation during 2018–2020. We analyse official statistics on paediatric infectious morbidity, comparative dynamics of main infectious diseases (acute respiratory diseases, intestinal infections of bacterial and viral nature, neuroinfections, anthropozoonotic infections, viral hepatitises), assess trends in morbidity of vaccine-preventable infections in children and adults in the Russian Federation, with greater detail towards selected regions, from January 2018 to April 2020.

Causes and prerequisites of the occupation of Luhansk and Donetsk regions: empirical analysis of territories (on the basis of indicators of the democratization index “Freedom in the World 2020”)

2021 ◽  
pp. 43-48
Author(s):  
M. Vehesh ◽  
R. Kopolovets
Keyword(s):  
Armed Forces ◽  
Political Regime ◽  
Military Conflict ◽  
Democratic Development ◽  
Occupied Territories ◽  
The Russian Federation ◽  
Hybrid War ◽  
First Time

Summary. The article examines the main reasons and preconditions for the occupation of certain regions in eastern Ukraine. The influence and role of Russia in this military conflict are analyzed, and for the first time an empirical (applied) analysis of the democratization index in the temporarily occupied territories is carried out. Russia’s aggressive policy in eastern Ukraine is part of a “hybrid” war against Ukraine that began in early 2014 with the occupation of the Autonomous Republic of Crimea. With the support of Russia, the so-called “Donetsk and Luhansk” people’s republics were created in eastern Ukraine. In essence, these are occupation military administrations that number more than 30,000 people, including regular troops and instructors of the armed forces of the Russian Federation. These are well-armed military formations, the number and combat capabilities of which are not inferior to the armies of individual European countries. In the temporarily occupied territories there is a total political and ideological “Russification”, the purpose of which is the alienation and further isolation of these territories from official Kyiv. It should be noted that the hostilities, which have been going on for the sixth year, pose serious economic, political, legal, and geopolitical problems on Ukraine’s path to consolidating the democratic regime and integrating with the European community. The change of political regime in 2013 in Ukraine opened up prospects for the consolidation of national identity and the restoration of the course of Euro-Atlantic integration, which was usually not accepted by official Moscow and personally by President Putin. It should be clearly understood that the war in Donbass, provoked by Russia, is the result of a systematic and long-term policy of Russia towards Ukraine as a country with a favorable geopolitical location and a kind of bridge between Europe and Russia. The article pays special attention to the theoretical and applied analysis of democratic development in Donbass. It should be noted that from 2020 “Freedom House” will start monitoring the territory and accordingly provide quantitative data on the democratization index with the appropriate analytical base and forecasts.

Role of Chronic, Long Term Intravenous Lidocaine in the Clinical Management of Patients with Malignant Type 3 Long QT Syndrome

Heart Rhythm ◽  
2021 ◽  
Author(s):  
Sahej Bains ◽  
Adi Lador ◽  
Raquel Neves ◽  
J. Martijn Bos ◽  
John R. Giudicessi ◽  
...  
Keyword(s):  
Long Qt Syndrome ◽  
Clinical Management ◽  
Intravenous Lidocaine ◽  
Long Qt ◽  
Qt Syndrome ◽  
Type 3

scholarly journals Municipal Toponymic Policy as a Tool for Translation of Regional Identity: a Case of Modern Kazan (Russia)

2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Marina Golomidova
Keyword(s):  
Russian Federation ◽  
Regional Identity ◽  
Regulatory Documents ◽  
The Russian Federation ◽  
The Republic ◽  
The City

Currently, the Russian cities are involved in the marketing of territories and competition for various types of resources. This aspect determines the relevance of issues related to building a strong image of the city, including its toponymic component. The category of regional identity is one of the significant tools for managing the image of a city. According to the author, it can be used in municipal toponymic policy to build a long-term strategy for toponymic designation. The author analyzes the current toponymic policy in the city of Kazan, the capital of the Republic of Tatarstan of the Russian Federation, in terms of the manifestation of regional identity. The directions for the correction of the urban toponymicon in the post-Soviet era are considered. The dominant components of regional identity, explicated in the modern toponymy of Kazan, are revealed. The role of regulatory documents in the implementation of the municipal toponymic policy of the contemporary period is characterized.

scholarly journals POLYCOMPONENT VACCINE IMMUNOVAC-VP-4 AND IMMUNOTHERAPEUTIC CONCEPT OF ITS USE FOR THE PREVENTION AND TREATMENT OF DISEASES CAUSED BY OPPORTUNISTIC MICROORGANISMS

2019 ◽  
Vol 1 (1) ◽  
pp. 43-49 ◽  
Author(s):  
N. B. Egorova ◽  
E. A. Kurbatova ◽  
N. K. Akhmatova ◽  
I. M. Gruber
Keyword(s):  
Dendritic Cells ◽  
Clinical Effect ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Interspecific Cross ◽  
Allergic Diseases ◽  
Immunological Parameters ◽  
Treatment And Prevention ◽  
Acute Respiratory Diseases

Aim. Analysis of experimental data and results of long-term clinical studies of immunotherapeutic and prophylactic effectiveness of a polycomponent vaccine, Immunovac-VP-4. Materials and methods. Immunogenic strains of Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, which antigens possessed broad intra — and interspecific cross-protective activity were selected to obtain the vaccine. Immunological parameters were determined using flow cytometry with the use of diagnostic monoclonal antibodies to cytokines, Toll-like receptors, surface molecules of dendritic cells and lymphocytes. The clinical effect of Immunovac-VP-4 was evaluated in chronic inflammatory and allergic diseases, as well as in the prevention of acute respiratory diseases (ARI) in children’s organized groups. Results. Immunovac-VP-4, protected the mice from infection caused by etiologically significant strains of bacteria and viruses, increased TLR-2, 4, 9-expressing cells; maturing the dendritic cells; the synthesis of cytokines IL1β, IL-6, IL-10, IL-12, IFNγ,; proliferation and increased cytotoxicity of NK cells. Significant clinical effect (69.2 — 100)% of Immunovac-VP-4 on the background of the basic therapy was obtained in patients with chronic inflammatory and allergic diseases. The therapeutic effect was accompanied by a positive dynamics of immunological parameters, in particular, an increase in IFNγ and a decrease in IL-4. Immunotherapy and immunoprophylaxis using Immunovac-VP-4 led to a decrease in the number of episodes of acute respiratory infections and their bacterial complications, including children in organized groups. Conclusion. Immunological feasibility of using Immunovac-VP-4 in complex treatment and prevention of bacterial and viral infections, caused by opportunistic microorganisms, as well as in allergic diseases was proved. 

scholarly journals Selective approaches to regulation of long-term migration in the Russian Federation

2021 ◽  
Vol 2021 (4) ◽  
pp. 188-197
Author(s):  
Svetlana Lampadova
Keyword(s):  
Work Experience ◽  
Professional Competence ◽  
Migration Policy ◽  
Negative Consequences ◽  
Effective System ◽  
The Russian Federation ◽  
Economic Needs ◽  
Different Levels

The number of foreign citizens that a country can admit without negative consequences for its economy in general and its labor market in particular, as well as for the socio-political situation, is limited and individual for each country. In this regard, states legislations in addition to the existing conditions set quotas. The purpose of the quota is to quantitatively limit the influx of foreign nationals into a country based on its socio-economic needs and capabilities in a given period. The quota is spent in order of priority without any differentiation and is a restrictive rather than a selection mechanism for ensuring a state’s migration policy. Most often, the selection approach is mentioned in the legislations regulating labor and, in the first place, skilled migration. Only in the context of this subspecies of migration, it is possible to talk of the inequality of candidates based on the different levels of their professional competence and capacity for adaptation to the host country social environment. In the context of skilled labor migration, the role of education, work experience and the ability to communicate freely in the host state language increase significantly. This type of migration is voluntary and aims at mutual satisfaction of the needs of a state in strengthening its economy with highly professional labor force and the needs of foreign citizens in getting the best conditions for realizing their potential. The laws of the market economy shape it. A state possessing the «demand» must, in order to best ensure its own socio-economic needs, build an effective system of evaluation of the «supply» by foreign citizens.

scholarly journals COMPOSITION OF INVESTMENT IN INNOVATION PROCESSES

2020 ◽  
pp. 43-49
Author(s):  
E. N. Kononova ◽  
A. N. Kazakova
Keyword(s):  
Russian Federation ◽  
Russian Economy ◽  
Innovative Products ◽  
Long Term Trends ◽  
The Russian Federation ◽  
Innovation Processes

The article analyzes long-term trends in innovation processes in the Russian economy. The dynamics of the share of innovation-active organizations, the share of innovative products, and costs for innovation in 2010-2019 was considered. The role of investment as a factor in the intensity of innovation processes was shown. Ranking of roadblocks against innovations was carried out based on the analysis of sociological surveys. The composition of investment in innovations by sources of financing and problems of their attraction in the economy of the Russian federation were revealed.

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