scholarly journals Adverse effects of medicinal plants used by cancer patients in Beni Mellal and the communication of this use

2021 ◽  
Vol 319 ◽  
pp. 01107
Author(s):  
Mohamed Aboufaras ◽  
Karima Selmaoui ◽  
Nadia Ouzennou
Keyword(s):  
Medicinal Plants ◽  
Adverse Effects ◽  
Cancer Patients ◽  
Relative Frequency ◽  
Botanical Survey ◽  
Traditional Herbal Medicine ◽  
Juniperus Oxycedrus ◽  
Marrubium Vulgare ◽  
Beni Mellal ◽  
Oncology Center

Moroccan cancer patients use traditional herbal medicine and no ethno botanical study has targeted them in the Béni Mellal Khénifra region. We had the objective to measure the frequency use of medicinal plants by cancer patients in the region of Béni Mellal Khénifra as well as the communication around this use and to inventory the plants used added to their adverse effects. We used an ethno botanical survey was conducted among 314 patients at the regional oncology center of Béni Mellal. The prevalence of use and the relative frequency of citation (RFC), the proportion of patients reporting this use and its adverse effects were measured. the prevalence of medicinal herbs use was 37.3% (n = 117). The citation relative frequency of plants ranged from 0.005 to 0.16. We found, also, 32 species belonging to 19 botanical families. Almost 90% (n = 102) of patients do not communicate this use and the most used plants are: Marrubium vulgare (16%), Ephedra alata (13%) and Juniperus oxycedrus (12%) Some plants seem toxic, in particular Juniperus oxycedrus used in a form of tar. The drug-plant interaction requires monitoring due to the lack of communication.

scholarly journals Ethno-botanical Survey on Medicinal plants used by Tribes of Karanja (Ghadge) Tahsil of Wardha District, Maharashtra, India

2021 ◽  
Vol 12 (1) ◽  
pp. 43-52
Author(s):  
Bharat Jagdishji Rathi ◽  
Pramod Khobragade ◽  
Renu Rathi ◽  
Rajkumar Gupta
Keyword(s):  
Medicinal Plants ◽  
Relative Frequency ◽  
Rank Order ◽  
Digital Data ◽  
Use Value ◽  
Botanical Survey ◽  
Fidelity Level ◽  
Medicinal Uses ◽  
Field Surveys ◽  
Informant Consensus

Introduction: Tribals or forest dwellers have much knowledge of the drugs growing around them. Most of this treasure of knowledge has been passed orally without any written documents. It is therefore very important to preserve and protect the traditional knowledge and also to prepare a digital data base of traditional medicine. Aim & Objectives: Ethno-botanical survey on medicinal Plants used by the Tribes of Karanja (Ghadge) Tahsil of Wardha District, Maharashtra, India and to prepare the ethno-botanical database of study area. Material & Methods: Ethno-botanical study was conducted through field surveys. Data was collected using questionnaire, interviews and discussions. The collected data was investigated using specific quantitative parameters including Informant Consensus Factor (ICF), Relative popularity level (RPL), Use value (UV), Fidelity level (FL), Relative frequency citation (RFC) and Rank order priority (ROP). Observations & results: Total 7 local informants were interviewed for Ethno-botanical data. Total 65 plants associated to 46 families were verified, authenticated and then recognized with ethno medicinal uses. Informants used 10 types of parts of plant from 6 kind of habitat and do the management of the patients with 6 type of medicinal preparations through 5 routes of administrations. Values obtained by calculating ICF, UV, RFC, FL, RPL and ROP were suggestive of informant’s knowledge regarding particular plant species in treating the particular ailment. Conclusion: The present work would be useful in identification of newer species and their therapeutic applications.

scholarly journals Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuichi Michikawa ◽  
Tomo Suga ◽  
Atsuko Ishikawa ◽  
Hideki Hayashi ◽  
Akira Oka ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Microsatellite Markers ◽  
Cancer Patients ◽  
Genome Wide

Trastuzumab-Associated Cardiac Adverse Effects in the Herceptin Adjuvant Trial

2007 ◽  
Vol 25 (25) ◽  
pp. 3859-3865 ◽  
Author(s):  
Thomas M. Suter ◽  
Marion Procter ◽  
Dirk J. van Veldhuisen ◽  
Michael Muscholl ◽  
Jonas Bergh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Adverse Effects ◽  
Cancer Patients ◽  
Cardiac Dysfunction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Breast Cancer Patients ◽  
Ventricular Ejection Fraction ◽  
Neo Adjuvant Chemotherapy

Purpose The purpose of this analysis was to investigate trastuzumab-associated cardiac adverse effects in breast cancer patients after completion of (neo)adjuvant chemotherapy with or without radiotherapy. Patients and Methods The Herceptin Adjuvant (HERA) trial is a three-group, multicenter, open-label randomized trial that compared 1 or 2 years of trastuzumab given once every 3 weeks with observation in patients with HER-2–positive breast cancer. Only patients who after completion of (neo)adjuvant chemotherapy with or without radiotherapy had normal left ventricular ejection fraction (LVEF ≥ 55%) were eligible. A repeat LVEF assessment was performed in case of cardiac dysfunction. Results Data were available for 1,693 patients randomly assigned to 1 year trastuzumab and 1,693 patients randomly assigned to observation. The incidence of trastuzumab discontinuation due to cardiac disorders was low (4.3%). The incidence of cardiac end points was higher in the trastuzumab group compared with observation (severe congestive heart failure [CHF], 0.60% v 0.00%; symptomatic CHF, 2.15% v 0.12%; confirmed significant LVEF drops, 3.04% v 0.53%). Most patients with cardiac dysfunction recovered in fewer than 6 months. Patients with trastuzumab-associated cardiac dysfunction were treated with higher cumulative doses of doxorubicin (287 mg/m2 v 257 mg/m2) or epirubicin (480 mg/m2 v 422 mg/m2) and had a lower screening LVEF and a higher body mass index. Conclusion Given the clear benefit in disease-free survival, the low incidence of cardiac adverse events, and the suggestion that cardiac dysfunction might be reversible, adjuvant trastuzumab should be considered for treatment of breast cancer patients who fulfill the HERA trial eligibility criteria.

Highlights on Important Medicinal Plants for the Menopause Syndrome

2021 ◽  
Vol 17 ◽  
Author(s):  
Rafaele de A. Rodrigues ◽  
Aline de S. Ramos ◽  
José Luiz P. Ferreira ◽  
Jefferson Rocha de A. Silva ◽  
Ana Clara B. Maria ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Medicinal Plants ◽  
Adverse Effects ◽  
Replacement Therapy ◽  
Trifolium Pratense ◽  
Hormone Replacement ◽  
Signs And Symptoms ◽  
Sufficient Information ◽  
Hormonal Changes ◽  
Artery Disease

Background: A reduction in ovarian hormones, which is distinctive of menopause, often involves signs and symptoms that compromise the quality of life and health of women. The transient manifestations are changes in the menstrual cycle, vasomotor symptoms, neuropsychological symptoms, and genitourinary changes. In some cases, the hormonal changes can evolve to non-transitory manifestations, which include urinary incontinence, changes in metabolism, osteoporosis and cardiovascular diseases. Hormone replacement therapy is the treatment of choice to alleviate transient symptoms of menopause; however, there are many limitations, contraindications and situations in which the risks of adverse effects are high, such as coronary artery disease, stroke, venous thromboembolism, dementia, type 2 diabetes, and the increased incidence of breast cancer. Objective: This work aims to highlight important medicinal plants for the treatment of the transient symptoms of menopause, with less side effects than traditional hormone replacement therapy. Results: There is sufficient information regarding the efficacy and safety in the use of the following plant species in the treatment of transient symptoms of menopause: Actaea racemosa, Glycine max, Trifolium pratense, Salvia officinalis, Humulus lupulus, Panax ginseng, Vitex agnus-castus, and Trigonella foenum-graecum. Additionally, the search indicated the chemical classes related to the benefits of the selected species, adverse effects, and interactions with other drugs.

scholarly journals Chemical Composition, in vitro Cytotoxic, and Antibacterial Activities of Moroccan Medicinal Plants Euphorbia resinifera and Marrubium vulgare

2020 ◽  
Vol 10 (6) ◽  
pp. 7343-7355
Keyword(s):  
Medicinal Plants ◽  
Solid Medium ◽  
Chemical Compounds ◽  
Antibacterial Activities ◽  
Antibacterial Effects ◽  
Animal Cells ◽  
Aerial Parts ◽  
Marrubium Vulgare ◽  
Major Chemical

The purpose of our study was to bring elements of knowledge on the anticancer and antibacterial effects of two plants, widely used in Moroccan traditional pharmacopeia. These plants are: Marrubium vulgare and Euphorbia resinifera. The aerial parts of each plant were extracted successively with Hexane, Dichloromethane, and finally with methanol. The MTT-based method was applied to evaluate the cytotoxicity of the cancer cells: animal cells BSR and Vero and human cell RD. We evidenced an anticancer activity of the extract of the Marrubium vulgare and the dichloromethane extract of Euphorbia resinifera against the studied cells. The antibacterial activity was evaluated for three species of Rhodococcus: Rhodococcus equi, and strains GK1, GK3, grown in a liquid medium, or this medium solidified with agar. In the last test, the method is based on substance diffusion from well throughout the solid medium. The obtained profiles showed that the growth of bacteria is strongly inhibited by the extracts of Marrubium vulgare. However, the extracts of Euphorbia resinifera had no significant effect on bacterial growth. The chemical analysis of the raw extracts of Marrubium vulgare and Euphorbia resinifera by GC-MS analysis showed the presence of several major chemical compounds, mainly: octadecane, 2,6,10,15-tetramethylheptadecane, 2,6,10-trimethyltetradecane, linoleic acid, and deisopropylatrazine. Our observations an encouraging for deepening the studies of the extracts, in order to target better the active molecules, isolate them and to determine their mechanisms of action. The suggested studies would result in the much better valorization of these two medicinal plants.

Medicinal Plants

2020 ◽  
pp. 67-90
Author(s):  
Aashaq Hussain Bhat ◽  
Himani Sharma
Keyword(s):  
Adverse Effect ◽  
Free Radicals ◽  
Medicinal Plants ◽  
Adverse Effects ◽  
Natural Resource ◽  
Medicinal Herbs ◽  
The Body ◽  
Natural Source ◽  
Plant Origin ◽  
Novel Drugs

Medicines of plant origin have been used for treating humans and animals without any adverse effects. New medicinal plants are searched to develop more effective and cheaper drugs in place of synthetics drugs. Plants represent a large natural source of compounds that might serve for the development of novel drugs. Currently medicinal herbs are researched for diuretic properties, and several medicinal herbs are used as diuretics. Currently various synthetic medicines are available for this purpose; however, natural resource medicines are still an important choice because of their higher efficiency and better safety. Further, some herbs are also important sources of antioxidants, which protect the body from the effects of free radicals produced in the body. Antioxidants are required by our body due to increase in the likely exposure of the body to harmful pollutants, radiation, UV lights, etc. These have the ability to delay the oxidation, and plant-derived products are of great interest due to the adverse effect of antibiotics.

scholarly journals Ethnopharmacological Survey of Herbal Remedies Used for the Treatment of Cancer in the Greater Casablanca-Morocco

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Mohammed Bourhia ◽  
Abdelaaty Abdelaziz Shahat ◽  
Omer Mohammed Almarfadi ◽  
Fahd Ali Naser ◽  
Wael Mostafa Abdelmageed ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Cancer Treatment ◽  
Traditional Medicine ◽  
Local Population ◽  
Traditional Healers ◽  
Herbal Remedies ◽  
Traditional Herbal Medicine ◽  
Ethnobotanical Survey ◽  
Scientific Validity

Medicinal plants played an important role in traditional medicine for the treatment of diseases since antiquities. The aim of the study is to carry out an ethnobotanical survey on medicinal plants used traditionally in cancer treatment in the region of Greater Casablanca-Morocco, and to enhance the traditional herbal medicine knowledge. 110 traditional healers in the study area were interviewed face to face to response a survey questionnaire including the names of plants used in cancer treatment, used parts, methods of preparation, and route of administration. Indices of Fidelity Level (FL), Use Value (UV), and Relative Frequency of Citation (RFC) were calculated to identify the most effective plants used for cancer treatment. Eight species were specified including Aristolochia baetica, Aristolochia paucinervis, Bryonia dioica, Aquilaria malaccensis, Marrubium vulgare, Lavandula maroccana, Ephedra alata, and Euphorbia resinifera belonging to 7 families. Aristolochiaceae, Aquilariaceae, and Cucurbitaceae were the most useful families in cancer treatment with high significant indices of UV, FL, and RFC with values of 1, 100%, and 1, respectively. Roots and leaves were the most commonly used plant parts. Decoction and powder mixed with honey were the frequently used method for remedies preparation. The present study showed that the people living in Morocco’s economic capital are still highly dependent on traditional herbal medicine for the treatment of cancer. Therefore, it seems that herbal medicine still plays a crucial role in the primary healthcare system for the local population. During this survey, it was reported that even some plant families are highly toxic for humans like Aristolochiaceae that are frequently used in cancer treatment in the study area. As many people still rely on natural traditional medicine considering (it is safe with no side effects), so combined effort between all social categories including scientists and traditional healers should be established for involving the scientific validity of the used plants in the treatment of diseases.

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