scholarly journals Embolization of Hemorrhoidal Arteries: A Novel Endovascular Therapy Option for the Treatment of Hemorrhoidal Disease

Author(s):  
Ludger Feyen ◽  
Patrick Freyhardt ◽  
Peter Schott ◽  
Christoph Wullstein ◽  
Alexandra Dimitriou-Zarra ◽  
...  

Background Hemorrhoids are a widespread disease. Treatment options range from dietary measures to open surgery. A novel treatment approach is the embolization of the hemorrhoidal arteries. Method A review was performed based on a selective literature search in PubMed representing the current state of research. The keywords “hemorrhoid” and “embolization” and “emborrhoid” were used. In addition, technical details of the hemorrhoidal embolization procedure are explained. Results and Conclusion Embolization of hemorrhoidal arteries is a safe treatment, which allows efficient symptom control even in patients with contraindications for open surgery. Key Points:  Citation Format

2019 ◽  
Vol 4 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Rita Grazina ◽  
Sérgio Teixeira ◽  
Renato Ramos ◽  
Henrique Sousa ◽  
Andreia Ferreira ◽  
...  

Dupuytren’s disease is a fibroproliferative disease that involves collagen deposition, leading to hand contractures that ultimately affect hand mobility and grip strength. It is a benign disorder but can cause high morbidity by limiting daily activities. Many factors have been proposed for its aetiology: namely genetics, smoking, alcohol intake and diabetes. However, there is still controversy as to the main aetiological cause of the disease. Treatment is not yet uniform around the world and still varies with the surgeon’s experience and preference. In this review, the authors review the pathogenesis and treatment options for Dupuytren’s disease in an attempt to summarize the current state of the art. Cite this article: EFORT Open Rev 2019;4:63-69. DOI: 10.1302/2058-5241.4.180021.


2020 ◽  
Vol 37 (08) ◽  
pp. 792-799 ◽  
Author(s):  
Devin D. Smith ◽  
Jessica L. Pippen ◽  
Adebayo A. Adesomo ◽  
Kara M. Rood ◽  
Mark B. Landon ◽  
...  

Objective Pregnant women have been historically excluded from clinical trials for nonobstetric conditions, even during prior epidemics. The objective of this review is to describe the current state of research for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Study Design We conducted a search of international trial registries for trials relating to the novel coronavirus. The eligibility criteria for each trial were reviewed for inclusion/exclusion of pregnant women. Relevant data were extracted and descriptive statistics were calculated for individual and combined data. The total number of trials from each registry were compared, as well as the proportions of pregnancy-related trials within each. Results Among 621,370 trials in the World Health Organization International Clinical Trials Registry, 927 (0.15%) were COVID-19 related. Of those, the majority (52%) explicitly excluded pregnancy or failed to address pregnancy at all (46%) and only 16 (1.7%) were pregnancy specific. When categorized by region, 688 (74.2%) of COVID-19 trials were in Asia, followed by 128 (13.8%) in Europe, and 66 (7.2%) in North America. Of the COVID-19 trials which included pregnant women, only three were randomized-controlled drug trials. Conclusion Approximately 1.7% of current COVID-19 research is pregnancy related and the majority of trials either explicitly exclude or fail to address pregnancy. Only three interventional trials worldwide involved pregnant women. The knowledge gap concerning the safety and efficacy of interventions for COVID-19 created by the exclusion of pregnant women may ultimately harm them. While “ethical” concerns about fetal exposure are often cited, it is in fact unethical to habitually exclude pregnant women from research. Key Points


Author(s):  
Felix Brandl ◽  
Chun Meng ◽  
Claus Zimmer ◽  
Christian Sorg

Background About two-thirds of all patients with major depressive disorder (MDD) suffer from depressive relapse, the mechanisms of which are still poorly understood. In recent years, analyses of the brain’s connectome have increasingly been employed to identify potential biomarkers of depressive relapse. The term “connectome” refers to the map of all structural or functional connections in the brain. It can be investigated by structural or functional magnetic resonance imaging followed by graph theory-based analysis to characterize network topology on the global and regional level. Methods This review is based on a selective literature search in PubMed representing the current state of research, as well as on an already published study which was awarded the Promotionspreis of the Deutsche Röntgengesellschaft. Results and Conclusion Numerous studies point to altered network topology, e. g., of default-mode network and striatum, as being crucial for the pathophysiology of MDD. Our group was able to show that striatal centrality (or hubness) is associated with the number of depressive episodes, which is one of the best predictors for depressive relapse. These data suggest aberrant striatal network topology as a potential biomarker for depressive relapse risk. The translation of these promising findings into clinical routine diagnostics is promoted by several methodological advantages, while some unresolved issues still hinder this process. Key points  Citation Format


Vox Patrum ◽  
2019 ◽  
Vol 72 ◽  
pp. 149-170
Author(s):  
Marcela Andokova ◽  
Robert Horka

In the year 2002 Milewski published an article devoted to the current state of research concerning Augustine’s Commentary on the Gospel of John where, among other topics, he reports on the state of research in the chronology of this work by Augustine, and after a brief summary of the latest solutions proposed by prominent Augustinian scholars he concludes that the history of the Tractates’ composition calls for a careful appreciation of their development and appearance over the course of Augustine’s busy episcopate and in relation to his other pastoral endeavours. This study therefore serves as the point of departure for our present article in which we would like to contribute to the recently proposed solution to certain questions related to the chronology of the two series of Augustine’s homilies, i.e. Tractatus in Iohannis Evangelium 1-16 and Enarrationes in Psalmos 119-133, especially in those points where the present solutions appear to be rather vague. Hence, our analysis concerns primarily the division of Tractates 1-12 and 13-16 made by Le Landais, and consequently accepted by all later scholars. Moreover, it focuses on some key points of the chronology: the dating of Tractate 7 at a pagan festival, the so-called dies sanguinis, proposed by La Bonnardière, then the synchronization of Tractates 1-16 with the parallel series of Enarrationes in Psalmos 119-133, and, finally, the re-evaluation of the year of the delivery of both series of homilies, dated between the years 406/407 or 407/408. Our argumentation is based, first and foremost, on the principle similar topic means similar liturgical time thanks to which we can place Tractates 10-12 of the Commentary on John’s Gospel right before the beginning of the Lenten season. Consequently, it enables us to include Tractates 13-16 in Augustine’s preaching activity during the Lenten season until as late as the beginning of the Easter Octave. In addition, if we admit that Tractate 7 was not delivered on the so-called dies sanguinis feast related to the rites of Cybele and Attis but on the occassion of another unknown local festival of an aitiological myth in Hippo Regius, we do not need to place it on the 24th of March as La Bonnardière did. Finally, these findings help us outline the new synchronized chronology of the two series of Augustine’s exegetical homilies for both the years 406/407 and 407/408.


2020 ◽  
Vol 2 ◽  
pp. 145-158
Author(s):  
Kenta Nagasawa

Purpose: This paper is a thematic literature review to examine the current state of research about Culturally Responsive Pedagogy in mathematics. The main themes are students’ perception, teacher education for pre-service teacher and professional development for teachers. Research methods/ approach: Literature was collected from Eric, which is a research engine of the education field. Also, Google Scholar is used to find articles of major scholars introduced by Dr. Rich Milner, who is the instructor of this course. Findings: Students faced microaggressions in mathematics class, which discouraged them to learn mathematics. The effect of teacher education was inconsistent in terms of the awareness of culturally responsive pedagogy and lesson plans. Research of professional development mentioned that mathematics was cultural. Implications for research and practice: It is more interesting to conduct long term or follow-up research to find the teacher’s practice after a taking professional development program. Also, it is critical to expand research scope besides African American and Latino students. Finally, evidence-based research is needed to change the political situation. Keywords: culturally responsive teaching, mathematics, teacher education, professional development, student’s perception


2013 ◽  
Vol 1 (2) ◽  
pp. 1-3
Author(s):  
João José Pinto Ferreira ◽  
Anne-Laure Mention ◽  
Marko Torkkeli

The expansion of human knowledge in all areas is largely the outcome of the activity of academic institutions and the result of their mission to contribute to the cultural, intellectual and economic development of the society, involving education, research and university extension activities. For many years, the academic community has been organizing itself in all different ways to respond to current and future needs, ensuring research integrity and recognition, and building on successive generations of peers to validate and support the launching and development of novel research streams. We owe the current state of research and development of our society to generations of scholars and scientists that have brought all of us here.(...)


2020 ◽  
Author(s):  
Mariya Andriyanova ◽  
Aslanli Aslanli ◽  
Nataliya Basova ◽  
Viktor Bykov ◽  
Sergey Varfolomeev ◽  
...  

The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.


i-Perception ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 204166952110203
Author(s):  
Jonas K. Olofsson ◽  
Ingrid Ekström ◽  
Maria Larsson ◽  
Steven Nordin

Olfaction, the sense of smell, is characterized by a notable age-dependency such that aging individuals are more likely to have poor olfactory abilities. These impairments are considered to be mostly irreversible and as having potentially profound effects on quality of life and food behavior, as well as constituting warning signs of mortality, cognitive dysfunction, and dementia. Here, we review the current state of research on aging and olfaction, focusing on five topics which we regard to be of particular relevance for the field: nutrition and health, cognition and dementia, mortality, environment and genetics, and training-based enhancement. Under each of these headlines, we provide a state-of-the-art overview and discuss gaps in our knowledge which might be filled by further research. Understanding how olfactory abilities are diminished in aging, and how they may be alleviated or recovered, involves a set of challenging tasks for researchers in the years to come.


2021 ◽  
pp. 004728162110315
Author(s):  
Mason Pellegrini

Fierce competition has made innovation increasingly necessary for business success, and this has increased the importance of user-based innovation strategies like design thinking (DT). While many studies in technical and professional communication (TPC) have explored how DT can be used pedagogically, no studies have done this through investigating how DT is used as a workplace composing process. This study does exactly that. First, it presents the current state of research on pedagogical uses of DT in TPC, and then it builds upon those suggestions with an empirical study that chronicles on how two web design firms use DT to make websites. My main suggestion is to teach DT as a recursive process that allows students transcend potentially incorrect assumptions built into design tasks through gathering data not only from users, but from clients as well.


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