Histopathologic studies of aqueous extracts of five selected local edible vegetables in isoproterenol-induced myocardial infarction in male Wistar albino rats

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
TF Salisu ◽  
B Ottu ◽  
J Okpuzor
Keyword(s):  
Myocardial Infarction ◽  
Albino Rats ◽  
Aqueous Extracts ◽  
Wistar Albino Rats

scholarly journals Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat

2018 ◽  
Vol 16 (1) ◽  
pp. 20
Author(s):  
Neng Fisheri Kurniati ◽  
Elin Yulinah Sukandar ◽  
Rian Pardilah ◽  
Nova Suliska ◽  
Dhyan Kusuma Ayuningtyas
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Ethanol Extract ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
Wistar Albino Rats ◽  
Sonchus Arvensis

Sonchus arvensis L. leaves have been used traditionally to treat various disease conditions. This study is designed to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar albino rats were divided into three main groups: negative control (saline only), positive control (isoproterenol only), and S. arvensis extract treated groups. S. arvensis extract was administered in three doses; 50, 100, and 200 mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was given intraperitoneally to positive control and extract treated groups. The parameters studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Creatine Kinase-MB (CK-MB), Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could significantly (P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in myocardial infarcted rats compared to positive control. The increase of the dose of S. arvensis extract was not followed by an increase of its cardioprotective activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg b.w. has potential to be developed as cardioprotective drug.

scholarly journals PHARMACOLOGICAL ACTIVITY OF ULVA LACTUCA POLYPHENOLS FRACTION: CARDIOPROTECTIVE AND ANTIOXIDANT ACTIVITIES AGAINST ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN RATS

2019 ◽  
pp. 133-136
Author(s):  
RAVINDRAN NT ◽  
MOHAMED SADIQ A
Keyword(s):  
Myocardial Infarction ◽  
Antioxidant Activities ◽  
Reduced Glutathione ◽  
Serum Markers ◽  
Ulva Lactuca ◽  
Albino Rats ◽  
High Dose ◽  
Dependent Manner ◽  
Wistar Albino Rats ◽  
Antioxidant Markers

Objective: The objective of this study is to assess the activity of Ulva lactuca polyphenols fraction in protecting the myocardial infarction induced by a high dose of isoproterenol. Methods: This study was carried out using Wistar albino rats divided into six groups. Group 1 was the normal group. Groups 2, 3, 4, 5, and 6 received isoproterenol (85 mg/kg) i.p. twice at an interval of 24 h on the 14th and 15th day. In addition to isoproterenol, Group 3 received verapamil (5 μmol/kg) as a single dose intravenously on the 14th day 10 min before isoproterenol and Groups 4, 5, and 6 received U. lactuca polyphenols fraction at the doses of 50, 100, and 200 mg/kg, respectively, for 14 days. On the 16th day, serum and heart samples were harvested from the animals and the cardioprotective and antioxidant activities were assessed by studying the levels of cardiac functional heart marker enzymes, lipid profile, reduced glutathione, and antioxidant enzymes. Results: U. lactuca polyphenols fraction, at the tested doses, restored the levels of all serum markers and enzymes (aspartate aminotransferase, alanine aminotransferase, creatine phosphokinase, lactate dehydrogenase, cholesterol, triglycerides, and reduced glutathione) and heart homogenate antioxidant markers (reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase) significantly, in dose-dependent manner. Conclusion: This study suggests that U. lactuca polyphenols fraction has a cardioprotective effect against isoproterenol-induced myocardial infarction and possess antioxidant activities.

scholarly journals Effect of Curcuma longa (Turmeric) on serum creatine kinase-MB and troponin I in isoproterenol induced myocardial infarction in wistar albino rats

2018 ◽  
Vol 13 (2) ◽  
pp. 47-53
Author(s):  
Sharmin Nahar ◽  
Qazi Shamima Akhter
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Troponin I ◽  
Curcuma Longa ◽  
Heart Weight ◽  
Control Group ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
The Mean ◽  
Wistar Albino Rats

Background: The prevalence of myocardial infarction (MI) is increasing day by day in Bangladesh due to socioeconomic transition. Spices and herbs are important source of remedy for various diseases in human. Curcuma longa suggested to be used as an indigenous medicine for the prevention and treatment of cardiovascular disease. Objective: To observe the effect of Curcuma longa in isoproterenol induced myocardial infarction in Wistar albino rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Twenty one Wistar albino male rats, weighing 100 to 150 g (initial body weight); aged 85 to 100 days were selected for the study. After acclimatization for 14 days, the rats were divided into BC (Baseline control group), ISP-TC (Isoproterenol treated control group) and CLP-ISPT (Curcuma longa pretreated and isoproterenol treated group). Each group consisted of 7 rats. After experiment, on the 10th day, final body weight was taken, rats were sacrificed and blood samples were collected from the heart. The heart was removed and weighed. Serum creatine kinase-MB (CK-MB) level was estimated by ELISA method and Troponin I (cTnI) level by AxSYM method. The statistical analysis was done by one way ANOVA and Bonferroni test as applicable. Results: In this study, the mean percent (%) change of body weight (p<0.01), mean serum CK-MB (p<0.001) and cTnI (p<0.001) levels were significantly higher but mean heart weight was non significantly higher in ISP-TC in comparison to those of BC. Again, the mean percent (%) change of body weight (p<0.01), mean heart weight (p<0.01), mean serum CK-MB (p<0.01) and cTnI (p<0.001) levels were significantly lower in CLP-ISPT than those of ISP-TC group. Conclusion: From the results, it can be concluded that Curcuma longa may have cardioprotective effect. J Bangladesh Soc Physiol. 2018, December; 13(2): 47-53

Effects of aqueous extracts ofAcacia albidastem bark on Wistar albino rats infected withTrypanosoma evansi

2014 ◽  
Vol 29 (12) ◽  
pp. 1153-1156 ◽  
Author(s):  
Uche Samuel Ndidi ◽  
Ismaila Alhaji Umar ◽  
Aminu Mohammed ◽  
Cosmas Samuel ◽  
Amos Oladiran Oladeru ◽  
...  
Keyword(s):  
Albino Rats ◽  
Aqueous Extracts ◽  
Wistar Albino Rats

scholarly journals Efficacy of Zanthoxylum armatum fruit on isoproterenol induced myocardial infarction in rats

2019 ◽  
Vol 8 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Malathi Mangalanathan ◽  
Tamiloli Devendhiran ◽  
Saraswathi Uthamaramasamy ◽  
Keerthika Kumarasamy ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Lipid Profile ◽  
Troponin T ◽  
Serum Markers ◽  
Albino Rats ◽  
Zanthoxylum Armatum ◽  
Creatine Kinase Mb ◽  
Enzymic Antioxidants ◽  
Wistar Albino Rats

The present study was elucidating the cardioprotective activity of hydroethanoic extract of Zanthoxylum armatum (Z. armatum) fruit on serum cardiac markers, lipid profile and the level of antioxidants in experimentally induced myocardial infarction (MI). The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400 mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, isoproterenol (ISO) (8.5mg/100g body weight) wasadministered to induce MI. Animals were sacrificed; blood and heart tissues were removed and the biochemical parameters were carried out. Serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and troponin –T were significantly (p<0.05) increased after ISO treatment. Altered lipid profile and significant changes in enzymic and non- enzymic antioxidants were also observed in MI. The altered levels were brought back to near normal by the administration of hydroethanoic extract of Z. armatum fruit which might be due to the active phytoconstituents present in it.

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