An Investigation of Hearing (250–20,000 Hz) in Children with Endocrine Diseases and Evaluation of Tinnitus and Vertigo Symptoms

Abstract Introduction Despite much advancement in medicine, endocrine and metabolic diseases remain an important cause of morbidity and even mortality in children. Objective The present study was planned to investigate the evaluation of hearing that also includes high frequencies, and the presence and degree of vertigo and tinnitus symptoms in pediatric patients diagnosed with endocrine diseases such as type 1 diabetes mellitus (DM), growth hormone deficiency (GHD), obesity, idiopathic short stature, and precocious puberty Methods The present study included a patient group of 207 children patients diagnosed with endocrine disease (95 males, 112 females; mean age 9.71 years old [range 6–16 years old]) and a control group including 55 healthy children who do not have any kind of chronic disease (26 males, 29 females; mean age 9.33 years old [range 6–16 years old]). The subjects underwent a hearing test with frequencies between 250 and 20,000 Hz. The vestibular and tinnitus symptoms were evaluated with the Pediatric Vestibular Symptom Questionnaire. Results Out of 207 patients in the patient group, 5 (2.4%) had hearing loss in pure tones, 10 (4.8%) had it in high frequencies, 40 (19.3%) had tinnitus symptoms, and 18 (8.7%) had vertigo symptoms. A total of 4 out of 207 patients in the study group (1.9%), 2 out of 59 with type 1 DM patients (3.4%), 1 out of 46 with GHD (2.2%), and 1 out of 43 obesity patients (2.3%) had hearing loss, vertigo, and tinnitus symptoms. Conclusions Our results suggest that some childhood endocrine diseases can cause some changes in the inner ear, although the exact cause is unknown. Perhaps, a detailed hearing and balance examination should be a routine in a child diagnosed with an endocrine disease. We think it is necessary to work on more comprehensive patient groups and tests in the future.

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Investigation of TAGAP gene polymorphism (rs1738074) in Turkish pediatric celiac patients

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0419 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Melek Pehlivan ◽

Tülay K. Ayna ◽

Maşallah Baran ◽

Mustafa Soyöz ◽

Aslı Ö. Koçyiğit ◽

...

Keyword(s):

Pediatric Patients ◽

Disease Risk ◽

Polymerase Chain Reaction Method ◽

Control Group ◽

Healthy Children ◽

Single Nucleotide ◽

Significant Difference ◽

Allele Specific ◽

And Control

Abstract Objectives There are several hypotheses on the effects of the rs1738074 T/C single nucleotide polymorphism in the TAGAP gene; however, there has been no study on Turkish pediatric patients. We aimed to investigate the association of celiac disease (CD) and type 1 diabetes mellitus (T1DM) comorbidity with the polymorphism in the TAGAP gene of Turkish pediatric patients. Methods Totally, 127 pediatric CD patients and 100 healthy children were included. We determined the polymorphism by the allele-specific polymerase chain reaction method. We used IBM SPSS Statistics version 25.0 and Arlequin 3.5.2 for the statistical analyses. The authors have no conflict of interest. Results It was determined that 72% (n=154) of only CD patients had C allele, whereas 28% (n=60) had T allele. Of the patients with celiac and T1DM, 42.5% (n=17) and 57.5% (n=23) had T and C alleles, respectively. Of the individuals in control group, 67% (n=134) had C allele, whereas 33% (n=66) had T allele. Conclusions There was no significant difference in the genotype and allele frequencies between the patient and control groups (p>0.05). There was no significant association between the disease risk and the polymorphism in our study group.

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Approach to the Patient with Endocrine Disorders

10.2310/im.1264 ◽

2016 ◽

Author(s):

Graham T McMahon ◽

Robert G. Dluhy

Keyword(s):

Chronic Care ◽

Adrenal Incidentaloma ◽

Hormone Deficiency ◽

Patient Specific ◽

Endocrine Disorders ◽

Endocrine Disease ◽

Endocrine Diseases ◽

Characteristic Sets ◽

Patients Experience

The distribution of hormones throughout the human body results in presentations of endocrine disease that are diffuse and variable. Although some endocrine syndromes result in characteristic sets of symptoms and features, most patients experience a limited number of components of the syndrome and may note symptoms that are not typically syndromic. This review discusses presentations of endocrine diseases and the endocrine patient. Specific attention is given to endocrine testing, which can be achieved by measuring the hormone itself, stimulating or suppressing a hormone feedback loop, or measuring peripheral hormone receptor function. The chronic care relationship is explored as many patients with endocrine diseases require extended chronic care to achieve control of abnormal hormonal systems. The dependency on chronic care necessitates that endocrinologists develop particular expertise in managing illnesses over the long term. Tables list hormones and their associated syndromes, clusters of contrasting symptoms and signs of over- and underactivity of the thyroid and adrenal glands, approaches to endocrine testing and treatment, and variability in selected hormone concentrations over time. Figures show diagnostic criteria related to hypercalcemia, growth hormone deficiency, acromegaly, and adrenal incidentaloma. The chronic care model is also represented. This review contains 4 highly rendered figures, 4 tables, and 12 references.

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Effect of treatment on cognitive and attention problems in children with narcolepsy type 1

SLEEP ◽

10.1093/sleep/zsaa114 ◽

2020 ◽

Vol 43 (12) ◽

Cited By ~ 1

Author(s):

Karin A M Janssens ◽

Laury Quaedackers ◽

Gert Jan Lammers ◽

Pauline Amesz ◽

Petra van Mierlo ◽

...

Keyword(s):

Processing Speed ◽

Attention Problems ◽

Control Group ◽

Healthy Children ◽

Regular Treatment ◽

Verbal Scale ◽

Treatment Naïve ◽

Healthy Control ◽

And Gender

Abstract Study Objectives To ascertain the presence of cognitive and attention problems in treatment naïve children with narcolepsy type 1 (NT1) and to explore whether children recently diagnosed with NT1 improve with respect to cognition and attention problems 1 year after regular treatment for NT1. Methods A total of 15 treatment naïve children (7–15 years) with recently diagnosed NT1 were recruited from three sleep medicine centers in the Netherlands. The control group consisted of 15 healthy children, being frequency matched on age and gender. Both groups were investigated at baseline to examine intelligence profile (Wechsler Intelligence Scale for Children [WISC] III), attention problems, and processing speed (Bourdon Vos and sustained attention to respond task [SART]). These tests were repeated in children with NT1 1 year after regular (behavioral and medication) treatment for NT1. Results Children with NT1 scored significantly lower on the verbal scale and processing speed subscale of the WISC III, showed more fluctuations in reaction time of the Bourdon Vos and made more mistakes during the SART than the healthy control group at baseline. Children with NT1 significantly improved on total IQ score, and on the WISC indices processing speed, and perceptual organization 1 year after treatment. At follow-up, test scores of treated children were largely comparable to those of the control group at baseline. Conclusions Children with NT1 show improvement in several cognitive domains 1 year after start of treatment. Our findings stress the need for early detection and treatment of narcolepsy in childhood.

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Level of Internet use among Greek adolescents with type 1 diabetes

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2016-0140 ◽

2017 ◽

Vol 31 (1) ◽

Author(s):

Katerina Daniilidou ◽

Panagiota Triantafyllou ◽

Maria Resta ◽

Meropi Dimitriadou ◽

Athanasios Christoforidis

Keyword(s):

Type 1 Diabetes ◽

Glycemic Control ◽

Internet Use ◽

Insulin Pump ◽

Addictive Behavior ◽

The Internet ◽

Control Group ◽

Healthy Children ◽

Diabetes Clinic

Abstract Background Compulsive Internet use has emerged as a contemporary addictive behavior. Our aim was to investigate the reasons for Greek adolescents with type 1 diabetes mellitus (T1DM) and their families to use the Internet and additionally to investigate the level of Internet use and its associations to demographic, socio-economic parameters and glycemic control. Methods Patients with T1DM, aged >12 years and their parents were recruited during their regular visits to the Pediatric Diabetes Clinic. A similar group of healthy children, age- and sex-matched served as a control group. All participants were asked to fill out the Greek translated version of the Internet Addiction Test (IAT). Caregivers of patients with T1DM were asked to complete a second questionnaire consisting of questions regarding demographic and socio-economic data of the family and data concerning disease management. Results Thirty-five patients with T1DM (mean decimal age of 14.95 ± 1.90 years) and 35 controls participated in the study. Nine patients were on an insulin pump whereas the rest were on multiple daily injections. The mean total score of the patients’ IAT questionnaires was significantly lower compared to the controls (26.26 ± 12.67 vs. 39.91 ± 18.55, p = 0.003). Controls were characterized as exhibiting moderate addictive behavior at a significantly higher percentage than patients (31.43% vs. 2.86%, p = 0.002). All patients on insulin pumps demonstrated normal Internet use. Mild addictive behavior was associated with a lower parental educational level. Finally, level of Internet use (IAT score) was positively associated to glycemic control (HbA1c value) with a correlation that was approaching significance (r = 0.315, p = 0.065). Conclusions Adolescents with T1DM and especially those on an insulin pump exhibit normal Internet use compared to their healthy peers. Time consumed on Internet correlates reversibly with glycemic control.

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Evaluation of the quality-of-life (QOL) and socio-demographic characteristics of patients with leukemia and lymphoma: Comparison with sibling and control group.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e22524 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e22524-e22524

Author(s):

Nurdan Tacyildiz ◽

Tugba Karakose ◽

Emel Cabi Unal ◽

Handan Dincaslan ◽

Gulsah Tanyildiz ◽

...

Keyword(s):

Quality Of Life ◽

Patient Group ◽

Active Treatment ◽

Healthy Control Group ◽

Control Group ◽

Healthy Children ◽

Healthy Control ◽

And Control ◽

Sibling Group

e22524 Background: Pediatric cancer patients have increased survival rates with intensive and effective treatment methods which causing some chronic health problems and lower quality of life in long term follow up. In our study, patients in their active treatment period compared to patients who have completed their treatment in recent 5 years and more than 5 years groups, besides compared with their own siblings and healthy control group,evaluated in terms of quality of life ( QOL). Methods: This study has been daone in the Department of Pediatric Hematology-Oncology, Ankara University School of Medicine. A total of 191 children were included in the study, including 36 sibling, 76 children with leukemia (n:31) and lymphoma (n:45) besides 79 healthy children. The Turkish translation of the PedsQL questionnaire was used to evaluate the patients' quality of life. IBM SPSS-25 package program was used for statistical analysis. Results: When the sociodemographic characteristics of the patient, sibling and control group were examined; we determined that the patients, siblings and control groups were similar in age, age and gender. However, we found that the education level for the patient group was statisticaly signicantly lower then the siblings and the control group. In addition, physical and mental functionning and friendship capasity scores were lower in patient group than the other two groups. According to timing of the treatment; patients and parents quality of life scores were significantly lower than the patients that finished their treatment in recent 5 years or more than 5 years. QOL scores were higest in survivors and parents group that were in more than 5 years after completed the treatment. The risk of lower QOL in patients under treatment was 7.48 times higher than the children who had ≥5 years of treatment (OR = 7,48; p < 0,05), and 2.64 times higher than those who were treated < 5 years (OR = 2,64; p > 0,05). In this study, there were no independent variables that had an impact on QOL of the sibling group. Conclusions: The QOLof patients diagnosed with leukemia and lymphoma is significantly lower than siblings and healthy group. No statistically significant difference was found between the sibling group and the healthy control group. After the end of active treatment, the QOL of the patients was reflecting important increase by the time .

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Cardioviruses Are Genetically Diverse and Cause Common Enteric Infections in South Asian Children

Journal of Virology ◽

10.1128/jvi.02085-08 ◽

2009 ◽

Vol 83 (9) ◽

pp. 4631-4641 ◽

Cited By ~ 100

Author(s):

Olga Blinkova ◽

Amit Kapoor ◽

Joseph Victoria ◽

Morris Jones ◽

Nathan Wolfe ◽

...

Keyword(s):

Preliminary Evidence ◽

Encephalomyocarditis Virus ◽

Viral Metagenomics ◽

Healthy Children ◽

Single Strain ◽

High Frequencies ◽

Respiratory Problems ◽

Enteric Infections ◽

Rna Fragments

ABSTRACT Cardioviruses cause enteric infections in mice and rats which when disseminated have been associated with myocarditis, type 1 diabetes, encephalitis, and multiple sclerosis-like symptoms. Cardioviruses have also been detected at lower frequencies in other mammals. The Cardiovirus genus within the Picornaviridae family is currently made up of two viral species, Theilovirus and Encephalomyocarditis virus. Until recently, only a single strain of cardioviruses (Vilyuisk virus within the Theilovirus species) associated with a geographically restricted and prevalent encephalitis-like condition had been reported to occur in humans. A second theilovirus-related cardiovirus (Saffold virus [SAFV]) was reported in 2007 and subsequently found in respiratory secretions from children with respiratory problems and in stools of both healthy and diarrheic children. Using viral metagenomics, we identified RNA fragments related to SAFV in the stools of Pakistani and Afghani children with nonpolio acute flaccid paralysis (AFP). We sequenced three near-full-length genomes, showing the presence of divergent strains of SAFV and preliminary evidence of a distant recombination event between the ancestors of the Theiler-like viruses of rats and those of human SAFV. Further VP1 sequencing showed the presence of five new SAFV genotypes, doubling the reported genetic diversity of human and animal theiloviruses combined. Both AFP patients and healthy children in Pakistan were found to be excreting SAFV at high frequencies of 9 and 12%, respectively. Further studies are needed to examine the roles of these highly common and diverse SAFV genotypes in nonpolio AFP and other human diseases.

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The Role of Hemic Hypoxia in the Development of Sensorineural Hearing Loss in Children Associated with Hepatitis B

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2019/v30i330176 ◽

2019 ◽

pp. 1-6

Author(s):

D. Sh. Islomov ◽

A. A. Khadjimetov ◽

E. Sh. Amonov

Keyword(s):

Hearing Loss ◽

Hepatitis B ◽

Sensorineural Hearing Loss ◽

Complete Blood Count ◽

Sensorineural Hearing ◽

Diagnostic Methods ◽

Control Group ◽

Healthy Children ◽

Fetal Haemoglobin ◽

Somatic Diseases

Background: There are not enough studies and evidenced researches conducted related to this topic. Therefore, we studied fetal haemoglobin in various somatic diseases in children with sensorineural hearing loss associated with hepatitis B. Materials and Methods: 26 children with sensorineural hearing loss associated with hepatitis B, aged from 5 to 18 years, were examined. The comparison group consisted of 8 children with sensorineural hearing loss without concomitant somatic pathology. The control group consisted of 12 healthy children. The compulsory examination plan for patients included generally accepted laboratory and instrumental diagnostic methods: complete blood count, urine, feces, Wasserman reaction, ECG. Results: Hb concentration in blood inpatient children with sensorineural hearing loss of the associated chronic hepatitis B (CHB) was reduced significantly by 58% compared with the healthy children. In children with Sensorineural Hearing Loss (CHT) without CHB, the studied parameter decreased when compared with healthy children by 25%. Analysis of the results showed a significant increase in the level of fetal haemoglobin in the blood of children with CHT associated with hepatitis B on average by 1.5 times, indicating hypoxia. Conclusion: Dependence of the indices of partial oxygen in the blood and, to a greater extent, HbF, on the blood content of the vasoconstrictor endothelin-1, von Willebrand factor, indicates the pathogenetic significance of the leading markers of endothelial dysfunction in the development of tissue hypoxia in children with sensorineural hearing loss combined liver disease.

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EVALUATION OF THE RELATIONSHIP BETWEEN DENTAL CARIES AND OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY

10.22541/au.161717895.53907771/v1 ◽

2021 ◽

Author(s):

Ahmet Güzelçiçek ◽

Mahmut Demir ◽

Adnan Kirmit ◽

MEHMET DOGAN

Keyword(s):

Oxidative Stress ◽

Dental Caries ◽

Patient Group ◽

Total Antioxidant Status ◽

Stress Index ◽

Control Group ◽

Healthy Children ◽

Markers Of Oxidative Stress ◽

The Relationship ◽

And Oxidative Stress

Background Dental caries can be affected or altered by the body’s oxidant / antioxidant balance and oxidative stress. Aim/Hypothesis To examine the relationship between dental caries and Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI). Design The study group consisted of 52 children with dental caries (DMFS/dfs ≥ 5), and the control group consisted of 42 healthy children (DMFS/dfs = 0). The saliva samples, unstimulated and mid-morning, were collected from all children. Participants’ saliva samples were acquired by spitting for 5 minutes, after which the samples were frozen and stored at 4 ° C and kept at -80 ° C until analysis. NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) was used for the statistical analysis. Results TOS of the patient group cases were statistically significantly higher than those of the control group (p=0,004; p<0,01). OSI values of the patient group cases were statistically significantly higher than those of the control group (p=0,008; p<0,01). Conclusion OSI and TOS as markers of oxidative stress levels were found to be significantly higher in the group of patients with dental caries than in the healthy group.

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The Eveluation of Pulmonary Functions in Children with Sickle Cell Anemia.

Blood ◽

10.1182/blood.v114.22.4628.4628 ◽

2009 ◽

Vol 114 (22) ◽

pp. 4628-4628

Author(s):

Cem Kurt ◽

Ilgen Sasmaz ◽

Bulent Antmen ◽

Yurdanur Kilinc ◽

Sadi Kurdak ◽

...

Keyword(s):

Patient Group ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Exercise Test ◽

Acute Chest Syndrome ◽

Control Group ◽

Healthy Children ◽

Diffusion Test ◽

Pulmonary Functions

Abstract Abstract 4628 Aim In this study we evaluated to pulmonary functions and determined relations of these findings with clinical parameters in children with sickle cell anemia (SCA) who were at follow up in our pediatric heamatology clinic. Materials and Methods 24 children with sickle cell anemia and 9 healthy children as control group include to the study. Complete blood count, hemoglobin electrophoresis and biochemical values were eveluated for both groups. At pulmonology department, the carbonmonoxide diffusion test performing for both groups. At the same day spirometric respiratory function evaluation and exercise test performed both groups at department of sports physiology. The data recieved are compared statistics. Results HbS, HbF, SGPT, ferritin, total bilirubine, direkt bilirubine and Fe++ values were high at patient group (p<0.05). Hemoglobin and hematocrit values were low at patient group according to control group as expected (p<0.05). The number of SCA patient who had one-three venoocclusive crises (VOC) were 14 (58.3%), patient who had three or more VOC were 7 (29.2%) and patient who had no VOC were 3 (12.5%). The number of patient who had acute chest syndrome (ACS) were 5 (20.9%) and 19 patients had no ACS (79.1%). Ýmpaired isole carbonmonoxide diffusion test was established at the 62.5% of the patient's. At patient group, spirometric FEV1 and MEF25 measurement were found lower than the control group (p<0.05). At exercise test VO2/HR rate were lower for patient group (p<0.05). VE/VO2 rate (p=0.023) and R (p=0.016) measurement were found higher. Conclusion Pulmonary gas transfer was found difficult in patients with SCA. Respiratory airways established obstructed in spirometric evaluation. Obstructive defficiensies have to be follow up. Oxygen pulse and respiratory exchange rates were determined low and more oxygen usage was observed for aerobic metabolic activity. With these results, ýt can be say that chronic inflamation process at lung due to oxygen radicals and hipoksemia in sickle cell patients, the aerobic respiratory load was increased. Disclosures: No relevant conflicts of interest to declare.

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Cochlear And Vestibular Involvement In Children With Henoch Schönlein Vasculitis

10.21203/rs.3.rs-782567/v1 ◽

2021 ◽

Author(s):

Abdulkadir Bucak ◽

Ayşegül Bükülmez ◽

Selcuk Kuzu ◽

Çağlar Günebakan ◽

Erkan Yıldız ◽

...

Keyword(s):

Hearing Loss ◽

Otoacoustic Emissions ◽

Vestibular Function ◽

Tertiary Hospital ◽

Control Group ◽

Healthy Children ◽

Vestibular Evoked Myogenic Potential ◽

Distortion Product ◽

Significant Difference ◽

And Control

Abstract Purpose: In this study, our purpose is to evaluate cochlear and vestibular function in juveniles with HSV using audiometry, DPOAEs, and cVEMP tests.Methods: 40 children diagnosed with HSV from the pediatry clinic and 40 age and sex-matched healthy children were evaluated with distortion product otoacoustic emissions, audiometry, and cervical vestibular evoked myogenic potential (cVEMP) test in a tertiary hospital.Results: The audiometry average values for both ears of HSV group and the control subjects were compared, and as a result, median 4.7 dB sensorineural hearing loss (SHL) was found for HSV group compared to control group at 250 Hz and it was statistically significant (p <0.001). An average of 6.4 dB SHL was detected at 8000 Hz (p <0.001). There was a statistically significant difference among HSV and control group regarding measurement results of average p1-n1 latency time of both ears (0.9 milliseconds (ms) increase, P = 0.035). In HSV patients, the median amplitude difference of both ears' average p1 n1 was found to be 5,6 millivolt, statistically significantly decreased compared to the control group (p = 0.003).Conclusion: This study, firstly in literature, demonstrated that HSV may cause hearing loss and vestibular dysfunction in children. We think this might be due to autoimmune mechanisms.

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