THE LIVER COPPER STATUS ALTERS THE DEVELOPMENT OF STEATOSIS IN MICE

2021 ◽  
Author(s):  
A Gottlieb ◽  
L Devine ◽  
A Canbay ◽  
S Lutsenko
Keyword(s):  
Liver Copper ◽  
Copper Status

Studies on copper and cobalt therapy of cattle in central coastal Queensland

1967 ◽  
Vol 18 (1) ◽  
pp. 169 ◽  
Author(s):  
GI Alexander ◽  
JM Harvey ◽  
JH Lee ◽  
WC Stubbs
Keyword(s):  
Growth Response ◽  
Copper Deficiency ◽  
Copper Metabolism ◽  
Subcutaneous Injections ◽  
Liver Copper ◽  
Copper Status ◽  
Period 2 ◽  
Copper Supplementation ◽  
Copper Therapy ◽  
Effect Of Copper

Four experiments described determined the effect of copper and cobalt therapy on the growth and productivity of cattle on the marine plains of central coastal Queensland. Copper was administered by subcutaneous injections of copper glycinate, and cobalt by dosing per os with heavy cobalt pellets. The growth of weaned cattle was significantly improved by copper, particularly from June to October when limited palatable feed on the high ground forced the animals to forage on the para grass swamps. During the same period, 2-year-old heifers also showed a growth response to copper. Their conception rate increased after 19 months of copper therapy but not after 10.5 months. The growth rate of their calves bas significantly increased by copper supplementation. Liver copper concentrations were always low in untreated cattle. Copper therapy maintained these reserves at higher levels, which varied according to the season and the rate of growth of the animals. Calves born to treated cows had higher initial liver copper reserves than those from untreated cows, but in the absence of copper therapy these reserves declined to low and comparable levels in all calves at weaning. Pasture analyses suggest that the copper deficiency revealed was due to interference with copper metabolism rather than to a low copper status in the diet; this interference did not appear to be due to molybdenum. Weaned cattle appeared to respond to cobalt during 1960 but not subsequently, while the cows and calves showed no response. The vitamin B12 status in liver and serum appeared adequate in both treated and untreated cattle.

A kinetic model of copper metabolism in sheep

1980 ◽  
Vol 31 (4) ◽  
pp. 773 ◽  
Author(s):  
KM Weber ◽  
RC Boston ◽  
DD Leaver
Keyword(s):  
Rate Constants ◽  
Copper Content ◽  
Copper Metabolism ◽  
Normal Liver ◽  
Dry Weight ◽  
Compartment Model ◽  
Flow Rates ◽  
Liver Copper ◽  
Copper Status ◽  
Three Compartment Model

A three-compartment model was developed to provide a simple kinetic description of the metabolism of copper in six sheep with liver copper concentrations of 433�51 ppm ( mean � SD dry weight). This was achieved by measuring the radioactivity in samples of blood, liver, urine and bile as a function of time after the intravenous administration of c. 1.4 mCi of 64Cu. Sizes of compartments, flow rates and rate constants were evaluated and validated experimentally by measuring the excretion of copper in urine and bile and its accumulation in the liver. The model postulates two separate mechanisms for the handling of copper by the liver, and biliary copper excretion was not related to total liver copper content. The model was tested in sheep with a wider range of liver copper concentrations, and the copper in the two compartments (C2 and C3), attributed to liver, corresponded to the actual liver copper content when this was between 30 and 70 mg. The rate constants also responded consistently to increased liver copper status. Within the 'normal' liver copper range of 50-70 mg, the three-compartment model was closed but outside this range, the undefined parameter K03 was no longer zero. This response suggests that copper is moving from C2 and C3 to either supply tissue requirements or be redistributed in an additional storage compartment.

Copper-molybdenum-sulphate-manganese interaction and the copper status of cattle

1958 ◽  
Vol 9 (3) ◽  
pp. 373 ◽  
Author(s):  
PJ Mylrea
Keyword(s):  
Manganese Content ◽  
Basal Diet ◽  
Sulphate Content ◽  
Liver Copper ◽  
Copper Status ◽  
South Wales ◽  
Definite Effect ◽  
Inorganic Sulphate ◽  
The Mean ◽  
Low Levels

The influence of molybdenum, inorganic sulphate, and manganese upon the copper status of cattle was investigated. The mean liver copper concentration increased for steers on a basal diet containing 7.6 p.p.m. copper, 2.4 p.p.m. molybdenum, 91 p.p.m. manganese, and 0.03 per cent. sulphate. In steers on a similar diet but with the sulphate content increased to 0.55 per cent., with or without an increase in the manganese content to 391 p.p.m., there was a highly significant reduction (P=0.01) in the liver copper concentrations but not to low levels. There was also a significant (P=0.01) increase in the serum inorganic sulphate levels. On increasing the molybdenum content to 9.2 p.p.m. there was a further reduction, to low levels, in the liver and blood copper concentrations of steers on the high sulphate diets but there was no definite effect on those on the low sulphate diet. Manganese again appeared to be without effect. It was concluded that there was a molybdenum-sulphate interaction with copper in cattle but that, under the conditions of this trial, manganese was without effect. Despite the very low liver and blood copper levels attained, and maintained for 15 weeks, there was no clinical evidence of hypocuprosis. The mineral and sulphate levels applied in some of these treatments are similar to those found in pastures from areas in New South Wales where copper deficiency in cattle occurs. The levels in pastures, as related to the results of this trial, are discussed.

THE EFFECTS OF SULPHATE REMOVAL FROM THE DRINKING WATER ON THE PLASMA AND LIVER COPPER AND ZINC CONCENTRATIONS OF BEEF COWS AND THEIR CALVES

1986 ◽  
Vol 66 (3) ◽  
pp. 669-680 ◽  
Author(s):  
M. E. SMART ◽  
R. COHEN ◽  
D. A. CHRISTENSEN ◽  
C. M. WILLIAMS
Keyword(s):  
Drinking Water ◽  
Water Treatment ◽  
Reverse Osmosis ◽  
Copper Concentration ◽  
Beef Cows ◽  
Liver Copper ◽  
Copper Status ◽  
Copper And Zinc ◽  
Zinc Concentrations ◽  
Positive Effect

Pregnant Hereford cows (n = 99) and heifers (n = 98) whose ration contained 10 mg Cu kg−1 DM and 20 mg Zn kg−1 DM were assigned to two treatments. The water supply (sulphated water) for one group contained 500 mg S L−1 as sulphates. The sulphates in the water (desulphated) for the other group had been decreased to 42 mg S L−1 by reverse osmosis. Changes in plasma and liver copper and zinc concentrations were monitored in the cows and their calves during the winter drylot and pasture periods. The initial plasma and liver copper concentrations in all cows indicated a deficient status. At calving, the plasma copper concentration had declined in both groups. The greatest decrease was evident in the cows on sulphated water. At calving, the liver copper concentration had declined in both water treatment groups but was lowest in the cattle on the sulphated water. After calving, plasma and liver copper concentrations in both groups increased; this increase was greatest in the cows drinking the desulphated water. Water treatment had no effect on the copper status of the nursing calves. Water purification had a positive effect on the body weights of first and second calf heifers. Although the zinc status was normal, the plasma zinc declined and liver zinc increased in the cows at calving. These changes were independent of water treatment. When the sulphur in the drinking water was decreased to 42 mg L−1 by reverse osmosis there was a positive effect on the copper status of beef cows. Further research is required into higher dietary copper intakes, as 10 mg Cu kg−1 DM was not adequate in improving the deficient copper status of these cattle. Key words: Water sulphates, copper, zinc, beef cattle

Oxidized copper wire particles for copper therapy in sheep

1982 ◽  
Vol 33 (6) ◽  
pp. 1073 ◽  
Author(s):  
GJ Judson ◽  
TH Brown ◽  
D Gray ◽  
DW Dewey ◽  
JB Edwards ◽  
...  
Keyword(s):  
Copper Oxide ◽  
Copper Wire ◽  
Significant Proportion ◽  
Clinical Signs ◽  
Copper Toxicity ◽  
Liver Copper ◽  
Copper Status ◽  
Copper Supplementation ◽  
Copper Therapy ◽  
Higher Doses

Ninety Merino weaner sheep were assigned to one of six groups on the basis of liveweight and liver copper concentrations. Sheep in four groups each received one oral dose of oxidized copper wire particles, viz. 2.5, 5, 10 or 20 g per animal. Sheep in another group each received a subcutaneous injection of 12 mg copper as diethylamino cupro-oxyquinoline sulfonate and another group of sheep did not receive any copper supplement. Liver copper concentrations responded positively to copper oxide load. The 2.5 g dose of copper oxide wire was more efficacious than the commercial injectable product in raising copper status, but the higher doses of oxide raised liver copper concentrations to values similar to those recorded in cases of copper poisoning. Copper concentrations in blood plasma, muscle and kidney were not altered by the copper load. No clinical signs, nor biochemical or histological evidence of acute copper toxicity, were found. Liver copper values fell in all sheep from 10 weeks after copper therapy until the end of the trial at 50 weeks post-therapy. Over this period of 40 weeks, the rate of mobilization of liver copper was linear and was positively related to the initial concentration of copper in the liver. A significant proportion of the oxidized copper wire dosed to sheep was recovered in the forestomachs and abomasa of selected sheep 4 weeks after dosing. No evidence of abomasal damage due to particles could be established. It is concluded that oral dosing of oxidized copper wire is a safe and effective method of copper supplementation to sheep.

COPPER AND MOLYBDENUM STATUS OF GROWING BEEF CATTLE IN A SELENIUM DEFICIENT AREA OF NORTHERN ONTARIO

1970 ◽  
Vol 50 (2) ◽  
pp. 279-284 ◽  
Author(s):  
M. HIDIROGLOU ◽  
K. J. JENKINS ◽  
J. R. LESSARD ◽  
R. B. CARSON
Keyword(s):  
Copper Deficiency ◽  
Copper Level ◽  
Northern Ontario ◽  
Liver Copper ◽  
Copper Status ◽  
Significant Difference ◽  
Plasma Copper ◽  
Milk Substitute ◽  
Deficient Area ◽  
Copper Plasma

A study was conducted on the effect of nutritional muscular dystrophy (NMD) on the copper and molybdenum contents of various tissues from calves under three months of age. Fifty-one calves were employed from an area in northern Ontario where NMD is common and 12 calves from a dystrophy-free area. The latter animals were fed a milk substitute which contained some 4.5 times as much copper as the milk received by the calves in the NMD area. For suckled calves in northern Ontario, no significant difference in liver copper concentrations was observed between healthy and NMD-affected animals. In calves fed the milk substitute, the liver copper level was markedly higher [204.4 ± 71.0 (SD)] than in suckled calves with dystrophy (55.5 ± 36.3) or without the disorder (60.8 ± 53.7). The copper concentrations (μg/g DM) of other tissues from NMD-affected calves were: kidney 14.8 ± 3.3, heart 14.0 ± 2.5, lung 6.5 ± 2.0, spleen 4.3 ± 1.6 and muscle 3.0 ± 1.4. No significant differences in these copper levels occurred between NMD-affected and healthy calves, or those reared on the milk substitute. Similarly, there were no significant differences in tissue molybdenum concentrations. The data indicated that the calves reared in northern Ontario had a marginal copper deficiency. Tissue copper and molybdenum levels appeared to be unaffected by the development of myopathy in the calves. The copper status of two groups, of six calves each, wintered outdoors or indoors, also was compared. Hypocuprosis and copper plasma levels were not influenced by exposure to the severe outwintering conditions of northern Ontario. Plasma copper levels showed a gradual decrease from 66 ± 16 μg per 100 ml plasma at 1 week of age to 51 ± 10 μg per 100 ml at 19 weeks.

The liver copper status alters the development of steatosis in mice

2020 ◽  
Author(s):  
A Gottlieb ◽  
A Muchenditsi ◽  
S Lutsenko
Keyword(s):  
Liver Copper ◽  
Copper Status

The copper status of cattle and buffalo in Malaya

1962 ◽  
Vol 59 (3) ◽  
pp. 409-414 ◽  
Author(s):  
R. Hill ◽  
Rajeswary Thambyah ◽  
S. P. Wan ◽  
C. S. Shanta
Keyword(s):  
Intestinal Tract ◽  
Good Condition ◽  
Zebu Cattle ◽  
Poor Condition ◽  
Liver Copper ◽  
Copper Status ◽  
Liver Flukes ◽  
Almost All ◽  
Gastro Intestinal Tract

1. Liver samples were taken from 95 mature zebu cattle and buffalo in Malaya for determinations of copper. A larger proportion were from Perak than from other States but whether the Perak samples were considered alone or with the remainder about 80% had liver copper values below 20 p.p.m.2. Among Perak animals (all cattle) almost all those with low copper values were in moderate to poor condition but among the remainder about 50% of these with low copper values were in good condition.3. In 12 Perak animals the numbers of parasites of the gastro-intestinal tract and of pancreatic and liver flukes were determined as well as the concentrations of liver copper. There were very few parasites other than pancreatic and liver flukes. Liver flukes may have caused low copper values in some animals but in general there was little evidence for a relationship between parasites and a low copper status. Anaemia did not accompany low liver copper values in these animals.

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