scholarly journals Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

2021 ◽  
Vol 82 (04) ◽  
pp. e38-e42
Author(s):  
Maryam N. Shahin ◽  
Stephen G. Bowden ◽  
Nasser K. Yaghi ◽  
Jacob H. Bagley ◽  
Seunggu J. Han ◽  
...  

Abstract Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.

2019 ◽  
Vol 143 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Maryam N. Shahin ◽  
Stephen T. Magill ◽  
Cecilia L. Dalle Ore ◽  
Jennifer A. Viner ◽  
Pamela N. Peters ◽  
...  

Author(s):  
W. F. H. Jarrett

SynopsisThere is a high incidence of cancer in beef cows in certain sharply localised geographic calf-rearing areas in Britain and also in cattle in several other parts of the world. The tumours occur on farms which are highly infested with bracken fern and which have a history of bracken poisoning. Bracken is known to cause intestinal and bladder cancer in rats and recently the flavonol, quercetin, has been shown to be a mitogen and to be carcinogenic in rats. Bracken contains large amounts of quercetin. In addition the animals have a high incidence of papillomas of the alimentary tract and these transform to malignant tumours. A new and unique papilloma virus has been isolated from these tumours. Studies using genetic engineering and DNA hybridisation techniques have shown that both alimentary and urinary bladder tumours contain viral DNA sequences. The relationship between bracken, quercetin and viral DNA sequences is under investigation both in cattle and at the molecular biology level as two possible stages in a multi-stage process in the aetiology of a high incidence naturally occurring cancer.


2005 ◽  
Vol 16 (12) ◽  
pp. 789-793 ◽  
Author(s):  
E M Mbizvo ◽  
S E Msuya ◽  
B Stray-Pedersen ◽  
M Z Chirenje ◽  
A Hussain

Women in developing countries often present for medical care with advanced cervical cancer, although this condition is preventable through regular screening and early treatment. This study sought to identify the prevalence and risk factors for cervical dyskaryosis among women in Zimbabwe with and without HIV. In a cross-sectional study, 200 consenting women were screened for cervical dyskaryosis and sexually transmitted infections (STI). The relationship between various risk factors for cervical dyskaryosis was examined. The overall prevalence of cervical dyskaryosis was high (19%), and significantly higher among HIV-infected women at 30% compared with 13% among seronegative women, with a peak at a younger age among seropositive women. Use of intravaginal herbs, practising intravaginal cleansing, being single, a history of three or more lifetime sexual partners and a history of previous STI were associated with cervical dysplasia. The high frequency of cervical abnormality lends weight to the demand for implementation of regular screening programmes and health education.


Author(s):  
Ruth Kinna

Anarchism developed as a distinctive strain within radical and revolutionary thought in the mid-19th century. The political theory, often associated with Pierre-Joseph Proudhon (b. 1809–d. 1865), Michael Bakunin (b. 1814–d. 1876), and Peter Kropotkin (b. 1842–d. 1921), appeared in parallel with a worldwide, international movement that shaped anarchist practices and that gave expression to a critique of capitalist exploitation, state tyranny, and an idea of rebelliousness that has been influential in sociopolitical, economic, and cultural realms. Contemporary anarchists argue about both the continuities and the discontinuities between the historical and modern movements and the antecedents of European anarchism, but there is a strong consensus that anarchism cannot be reduced to a single set of principles, conceptual arrangements, or theoretical positions that might be applied in practice, analysis, or critique. Because canonical approaches to the history of anarchist ideas are typically resisted, and because the ideological boundaries of anarchism remain contested, anarchist approaches to sociological issues are distinguished by their diversity and are difficult to pin down. However, the anarchists’ traditional opposition to processes associated with state formation, and their interrogation of the complex relationships between these processes and capitalism, society, technology, and culture, are important frames for the discussion of perennial themes, notably, domination, organization, and transformation. Reflections on the rise of the modern European state and the possibility of nonstate organization have long encouraged an interest in anthropology, supporting strongly normative accounts of mutuality, cooperation, and reciprocity. In the anticapitalist mainstream, anarchism supports a rich tradition of thinking about self-regulation, self-management, and decentralized federation. The anarchists’ principled rejection of authority has fostered an interest in systems of education, law, punishment, concepts of crime, and the institutionalization of love in heterosexual relationships, generating cultural practices and literatures that are at once subversive and utopian. Anarchist utopianism is in turn an important strain in urban design, art, and ecology. The anarchist eschewal of institutional politics and advocacy of direct action have focused attention on issues of struggle, protest, and violence as well as the theorization of direct action and prefigurative change. Notwithstanding anarchist suspicions of the elitism and complicity of academic institutions, anarchism has had an influence on mainstream sociology and is equally influenced by critical strains within it. The relationship with Marxism, though often unhappy, has provided one route into sociology. Max Weber’s engagements with anarchism have provided another; and, in late-20th- and early-21st-century history, anarchists have begun to develop approaches to sociology that resonate with both traditions.


1927 ◽  
Vol 23 (12) ◽  
pp. 1207-1209
Author(s):  
A. A. Sukhov

The history of organotherapy is as old as human history, but some stages of its transition to the rational-scientific basis are of great interest for modern evolution of organotherapy as well. It is especially timely to recall now the almost forgotten works of our compatriots, Prof. A.V. Pel and Prof. I.R. Tarkhanov, concerning the relationship between radio- and radiotherapy and organotherapy and the possibility to strengthen the hormone therapy effect of organ drugs by their radioactivation.


2021 ◽  
Author(s):  
Sandra Pekic ◽  
Marko Stojanovic ◽  
Vera Popovic

Pituitary adenomas are benign neoplasms of the pituitary. The most prevalent are prolactinomas and nonfunctioning pituitary adenomas, followed by growth hormone- and ACTH-secreting adenomas. Most pituitary adenomas seem to be sporadic and their persistent growth is very atypical. No molecular markers predict their behavior. The occurrence of pituitary adenomas and malignancies in the same patient can be either pure coincidence or caused by shared underlying genetic susceptibility involved in tumorigenesis. Detailed family history on cancers/tumors in the first, second and third generation of family members on each side of the family has been reported in a few studies. They found an association of pituitary tumors with positive family history for breast, lung and colorectal cancer. We have reported that in about 50% of patients with pituitary adenomas an association with positive family history for cancer has been found independent of secretory phenotype (acromegaly, prolactinoma, Cushingʼs disease or non-functioning pituitary adenomas). We also found earlier onset of pituitary tumors (younger age at diagnosis of pituitary tumors) in patients with strong family history of cancer. In our recent unpublished series of 1300 patients with pituitary adenomas, 6.8% of patients were diagnosed with malignancy. The latency period between the diagnosis of pituitary adenoma and cancer was variable and in 33% of patients was longer than 5 years. Besides the inherited trophic mechanisms (shared underlying genetic variants), the potential influence of shared complex epigenetic influences (environmental and behavioral factors -obesity, smoking, alcohol intake, insulin resistance) is discussed. Further studies are needed to better understand if patients with pituitary adenomas are at increased risk for cancer.


2008 ◽  
Vol 39 (4) ◽  
pp. 665-673 ◽  
Author(s):  
N. Archer ◽  
R. G. Brown ◽  
S. Reeves ◽  
H. Nicholas ◽  
H. Boothby ◽  
...  

BackgroundThere may be important public health implications of increasing our knowledge of factors associated with age of dementia onset. The pre-morbid personality domain of Neuroticism constituted an interesting and theoretically plausible, yet uninvestigated, candidate for such an association. We aimed to examine whether midlife Neuroticism was associated with earlier age of onset of Alzheimer's disease (AD).MethodThis was a case–comparison study of 213 patients with probable AD. Detailed clinical information was collected for all patients including age of onset of dementia symptoms. One or two knowledgeable informants rated each patient's midlife personality retrospectively using the Neuroticism, Extraversion, Openness Five-Factor Inventory (NEO-FFI) questionnaire. The relationship between midlife Neuroticism and age of dementia onset was evaluated using both correlational analysis and backward linear regression analysis.ResultsMidlife Neuroticism predicted younger age of dementia onset in females but not in males. The association found in females was independent of pre-morbid history of affective disorder.ConclusionsThis finding and its potential mechanism warrant further investigation.


Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.


Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.


Author(s):  
Jesse Schotter

The first chapter of Hieroglyphic Modernisms exposes the complex history of Western misconceptions of Egyptian writing from antiquity to the present. Hieroglyphs bridge the gap between modern technologies and the ancient past, looking forward to the rise of new media and backward to the dispersal of languages in the mythical moment of the Tower of Babel. The contradictory ways in which hieroglyphs were interpreted in the West come to shape the differing ways that modernist writers and filmmakers understood the relationship between writing, film, and other new media. On the one hand, poets like Ezra Pound and film theorists like Vachel Lindsay and Sergei Eisenstein use the visual languages of China and of Egypt as a more primal or direct alternative to written words. But Freud, Proust, and the later Eisenstein conversely emphasize the phonetic qualities of Egyptian writing, its similarity to alphabetical scripts. The chapter concludes by arguing that even avant-garde invocations of hieroglyphics depend on narrative form through an examination of Hollis Frampton’s experimental film Zorns Lemma.


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