Bracken and cancer

1982 ◽  
Vol 81 (1-2) ◽  
pp. 79-83 ◽  
Author(s):  
W. F. H. Jarrett
Keyword(s):  
Dna Sequences ◽  
Beef Cows ◽  
Malignant Tumours ◽  
Viral Dna ◽  
Papilloma Virus ◽  
Multi Stage ◽  
High Incidence ◽  
History Of ◽  
Stage Process ◽  
The Relationship

SynopsisThere is a high incidence of cancer in beef cows in certain sharply localised geographic calf-rearing areas in Britain and also in cattle in several other parts of the world. The tumours occur on farms which are highly infested with bracken fern and which have a history of bracken poisoning. Bracken is known to cause intestinal and bladder cancer in rats and recently the flavonol, quercetin, has been shown to be a mitogen and to be carcinogenic in rats. Bracken contains large amounts of quercetin. In addition the animals have a high incidence of papillomas of the alimentary tract and these transform to malignant tumours. A new and unique papilloma virus has been isolated from these tumours. Studies using genetic engineering and DNA hybridisation techniques have shown that both alimentary and urinary bladder tumours contain viral DNA sequences. The relationship between bracken, quercetin and viral DNA sequences is under investigation both in cattle and at the molecular biology level as two possible stages in a multi-stage process in the aetiology of a high incidence naturally occurring cancer.

Bladder Condyloma Acuminatum, A Case Report

2020 ◽  
pp. 1-3
Author(s):  
Villalba Bachur Roberto ◽  
◽  
Spagnuolo Juan Ignacio ◽  
Cora Florencia ◽  
◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Hpv Infection ◽  
Cancer Case ◽  
World Population ◽  
Single Episode ◽  
Papilloma Virus ◽  
High Incidence ◽  
Bladder Cancer Case ◽  
History Of ◽  
Laser Enucleation

Background: Human Papilloma virus (HPV) infection is a high incidence entity in the world population. It is highly related to cervical carcinoma, as well as anogenital carcinoma, among others. The presences of bladder HPV lesions are infrequent and there is an association between it and the development of bladder cancer. Case presentation: We present a case of bladder HPV in a woman with a cervical carcinoma history that was presented clinically as a single episode of gross hematuria. We performed a cystoscopy and Holmium laser enucleation of the bladder tumors. Conclusion: We highlight the importance of consider HPV as a differential diagnosis of a bladder tumor, mainly in patients with history of pathologies related with the virus.

Collaborative Technologies and Innovation in SMEs

2010 ◽  
pp. 204-217
Author(s):  
Angel L. Meroño-Cerdan ◽  
Pedro Soto-Acosta ◽  
Carolina Lopez-Nicolas
Keyword(s):  
The Other ◽  
Research Model ◽  
Firm Level ◽  
Collaborative Technologies ◽  
Other Hand ◽  
Multi Stage ◽  
Stage Process ◽  
The One ◽  
The Impact ◽  
The Relationship

This study seeks to assess the impact of collaborative technologies on innovation at the firm level. Collaborative technologies’ influence on innovation is considered here as a multi-stage process that starts at adoption and extends to use. Thus, the effect of collaborative technologies on innovation is examined not only directly, the simple presence of collaborative technologies, but also based on actual collaborative technologies’ use. Given the fact that firms can use this technology for different purposes, collaborative technologies’ use is measured according to three orientations: e-information, e-communication and e-workflow. To achieve these objectives, a research model is developed for assessing, on the one hand, the impact of the adoption and use of collaborative technologies on innovation and, on the other hand, the relationship between adoption and use of collaborative technologies. The research model is tested using a dataset of 310 Spanish SMEs. The results showed that collaborative technologies’ adoption is positively related to innovation. Also, as hypothesized, distinct collaborative technologies were found to be associated to different uses. In addition, the study found that while e-information had a positive and significant impact on innovation, e-communication and e-workflow did not.

MEASURING THE CONTRIBUTIONS OF KNOWLEDGE MANAGEMENT SYSTEMS TO THE STRATEGIC COMPETITIVENESS OF ORGANIZATIONS: A REVIEW AND A MODEL

2010 ◽  
Vol 07 (02) ◽  
pp. 89-107 ◽  
Author(s):  
ELIE GEISLER
Keyword(s):  
Knowledge Management ◽  
Information Systems ◽  
Absorptive Capacity ◽  
Knowledge Systems ◽  
Management Systems ◽  
Knowledge Management Systems ◽  
Multi Stage ◽  
Intermediate Outcomes ◽  
Stage Process ◽  
The Relationship

Why and how do Knowledge Management Systems (KMS) contribute to the strategic competitiveness of organizations? This paper reviews the literature and proposes a model in which KMS is viewed from three different perspectives: (1) crucial resource; (2) driver of absorptive capacity; and (3) innovation adopted by the organization. The paper critiques the method used by KMS researchers whereby co-variation of KMS and competitiveness is utilized to study the relationship between these variables. The model proposed here is a multi-stage process. The successful use of KMS generates intermediate outcomes that in turn impact the organization and produces improved strategic competitiveness. The different approaches to KMS and the stage-process allow for the unique attributes of knowledge systems, different from information systems. The advantages and limitations of the model are discussed.

The association of acne and menstrual symptoms among young women (18–25 years) in Egypt: a population-based cross-sectional study

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ahmed Arafa ◽  
Alshimaa Mostafa ◽  
Yasser Khamis
Keyword(s):  
Young Women ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Multi Stage ◽  
Menstrual Symptoms ◽  
History Of ◽  
The Relationship ◽  
Age Of Menarche

AbstractBackgroundAcne and menstrual symptoms are highly prevalent among young women. Since both acne and menstrual symptoms have similar hormonal pathogenesis, it is highly suggested that the two conditions are associated. Herein, we conducted this study to assess the relationship between acne and menstrual symptoms among young women.Subjects and methodsIn this population-based cross-sectional study, a multi-stage random sampling approach was used to include 3065 young women (18–25 years) from Egypt. Women were interviewed for their socio-demographic characteristics, gynecological history, premenstrual and menstrual symptoms, and history of acne and perimenstrual acne flare during the past 6 months.ResultsThe mean age of women was 21.5 ± 2.2 and their age of menarche was 13.1 ± 1.5 years. During the previous 6 months, 44.8% of participants had acne. After adjusting for socio-demographic and gynecological characteristics, acne was associated with most menstrual symptoms with odds ratios (ORs) and 95% confidence intervals (CIs) as follows: [premenstrual symptoms: 1.23 (1.05–1.44) for irritation or nervousness, 1.45 (1.24–1.68) for fatigue, 1.37 (1.15–1.62) for breast tenderness, 1.48 (1.21–1.80) for abdominal bloating, and 1.36 (1.11–1.66) for nausea or vomiting], [menstrual symptoms: 1.63 (1.19–2.23) for dysmenorrhea and 1.24 (1.06–1.45) for dysmenorrhea requiring drugs], and [symptoms severity: 1.44 (1.24–1.68) for missing events and 1.38 (1.16–1.64) for medical consultation]. Of acne patients, 56.7% reported perimenstrual acne flare: 58.5% before menses, 35% during menses, and 6.5% after menses.ConclusionThis study supports the concept that acne is associated with menstrual symptoms. Physicians should consider screening for menstrual symptoms among young women with acne.

scholarly journals HISTORY OF GLASS-MAKING FROM ANCIENT TIMES TO THE LATE 1st - EARLY 2nd MILLENNIUM AD: DISCOVERIES, METHODS AND RESEARCH RESULTS PART 1. LATE BRONZE AGE

2021 ◽  
pp. 447-465
Author(s):  
О. С. Румянцева
Keyword(s):  
Bronze Age ◽  
Early Stage ◽  
Asia Minor ◽  
Late Bronze Age ◽  
Glass Making ◽  
Archaeological Methods ◽  
Ancient Glass ◽  
Multi Stage ◽  
History Of ◽  
Stage Process

Статья представляет собой обзор итогов ведущих мировых исследований 1990-2010-х гг. в области древнего стеклоделия эпохи поздней бронзы на территории Месопотамии, Египта, Греции и Малой Азии. Особое внимание уделено новым методам и подходам к изучению древнего стеклоделия (исследование концентраций следовых элементов и изотопного состава стекла), позволившим ставить и решать новые задачи при определении происхождения стекла. Согласно их итогам, стеклоделие уже на раннем этапе существования являлось многоэтапным процессом, в котором варка стекла и изготовление из него изделий были двумя специализированными видами ремесла. Для рассмотренного периода существование стекловаренных центров однозначно подтверждается для Египта и Месопотамии, причем в последнем случае ведущую роль в их выделении играют итоги лабораторных исследований, археологическими методами они не фиксируются. Мастерские микенской Греции и Малой Азии работали на привозных полуфабрикатах их Египта и Месопотамии. Выявлены признаки, позволяющие различать стекло, сваренное в Египте и различных центрах Месопотамии. The paper provides an overview of key world studies conducted in the 1990s-2010s on ancient glass-making in Mesopotamia, Egypt, Greece and Asia Minor during the Late Bronze Age. It focuses on new methods and approaches to the studies of ancient glass-making (examination of the concentration of trace elements and the isotopic composition of glass) that offered an opportunity to raise and address new tasks in determining glass provenance. The results of the studies show that, from the very early stage, glass-making was a multi-stage process where melting glass and making glass items were two specialized crafts. For the studied period existence of glass-making centers is reliably established for Egypt and Mesopotamia, in the latter case laboratory studies are of great importance as archaeological methods have not revealed any centers. Glass-making workshops in Mycenaean Greece and Asia Minor used imported raw glass from Egypt and Mesopotamia. Features that can distinguish between the production of Egyptian and Mesopotamian glassmaking centres were singled out.

scholarly journals Delimitation of the experience factor in the decision to select international markets by Spanish SMEs: The influence of psychic distance

2021 ◽  
Vol 5 (2) ◽  
pp. e368
Author(s):  
Pedro María Martínez Villar
Keyword(s):  
International Markets ◽  
International Experience ◽  
Decision Making Process ◽  
Psychic Distance ◽  
Export Markets ◽  
Know How ◽  
Multi Stage ◽  
Stage Process ◽  
Experience Factor ◽  
The Relationship

The internationalization of SMEs is generally characterized by a progressive multi-stage process, in which organizations gradually acquire knowledge and skills that strengthen their commitment to the outside world. International experience – a form of autonomous accumulation of know-how that allows the understanding of potential markets – influences the decision-making process for selecting export markets. Although gradual acquisition of international experience allows an increase in export activity in more physically distant markets, this gradualist postulate does not have an indefinite validity. This paper analyzes the limits of this international experience in terms of psychic distance, examining whether those SMEs that have obtained enough international experience to develop markets of greater complexity tend to select more complex, i.e., more psychically distant, countries. The findings generally support the idea that the relationship between international experience and psychically distant markets ceases when SMEs have obtained enough international experience, after which it is the objectives of a strictly business nature which condition the decision to select potential markets. For these reasons, when the organization has obtained enough skills and international experience to develop markets of greater complexity, the managers choose to select more complex i.e., more psychically distant, countries.

scholarly journals GLEJAK WIELOPOSTACIOWY – POSTĘP WIEDZY NA TEMAT PATOGENEZY NOWOTWORU

2016 ◽  
Vol 60 (2) ◽  
Author(s):  
Paweł Wańkowicz ◽  
Przemysław Nowacki
Keyword(s):  
Glioblastoma Multiforme ◽  
Genetic Disorders ◽  
Primary Brain Tumor ◽  
Malignant Tumours ◽  
Current State ◽  
Multi Stage ◽  
Average Survival ◽  
The Central Nervous System ◽  
Stage Process

Glioblastoma multiforme is a particularly malignant form of primary brain tumor. This cancer represents 12–15% of all brain tumors. Despite advances in neurosurgery, radiation and chemotherapy, the average survival rate is only from 12.1 to 14.6 months. Glioblastoma multiforme is characterized by its diverse histological and cellular features. Like other malignant tumours, it is formed in a multi -stage process of somatic cell transformations, accumulating several genetic disorders. The last decade was a period of particular interest in stem cells. These cells have so far been identified in a variety of primary tumours in the brain. They are probably responsible for the recurrence and progression of cancer. Given the current state of knowledge, it is likely that modifications to the previously used morphological classification of tumours of the CNS will be made by the WHO, as well as the extension of its molecular criteria. In particular, such strategies are awaited for Glioblastoma multiforme – the most malignant primary tumor of the central nervous system, with so far very poor prognosis.

scholarly journals Regression of Multiple Meningiomas after Discontinuation of Chronic Hormone Therapy: A Case Report

2021 ◽  
Vol 82 (04) ◽  
pp. e38-e42
Author(s):  
Maryam N. Shahin ◽  
Stephen G. Bowden ◽  
Nasser K. Yaghi ◽  
Jacob H. Bagley ◽  
Seunggu J. Han ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Direct Action ◽  
Fertility Treatment ◽  
Multiple Meningiomas ◽  
Younger Age ◽  
Gender Reassignment ◽  
High Incidence ◽  
History Of ◽  
Exogenous Progesterone ◽  
The Relationship

Abstract Introduction Meningiomas are more common in females and frequently express progesterone and estrogen receptors. Recent studies have revealed a high incidence of meningiomas in situations in which estrogen/progesterone levels are increased such as pregnancy, gender reassignment therapy, and fertility treatment. While the relationship remains unclear and controversial, these findings suggest exposure to high levels of endogenous or exogenous hormones may increase the risk of developing a meningioma. Patients and Methods A 40-year-old female with a history of endometriosis treated with chronic progesterone therapy presented with a visual deficit and was found to have multiple meningiomas, which regressed after cessation of exogenous progesterone. Conclusion A history of chronic hormone therapy should be included when evaluating patients diagnosed with meningiomas, particularly at a younger age and with multiple meningiomas. Cessation of exogenous progesterone resulting in regression of meningiomas suggests a direct action of progesterone on growth. Future studies are warranted to better elucidate this relationship.

scholarly journals WORSPACE OF THE COGNITIVE PROCESS AS A SPACE OF MENTAL CONSTRUCTS OF THE COGNITIVE MECHANISM OF THINKING

2020 ◽  
Vol 1 (191) ◽  
pp. 74-77
Author(s):  
Tetyana Еmelyanova ◽  
Keyword(s):  
Cognitive Abilities ◽  
Model Representation ◽  
Memory Space ◽  
Cognitive Mechanism ◽  
Multi Stage ◽  
Stage Process ◽  
Cognitive Memory ◽  
The Individual ◽  
Mental Constructs ◽  
The Relationship

The article is dedicated the workspace of cognitive activities of the individual as a space of mental constructs of the cognitive mechanism of thinking. The relationship between of the mental constructs of cognitive space and the degree of development of cognitive abilities of the individual is studied. Thinking is considered as an unconscious process of constructing a modified model representation. The cognitive mechanism of thinking is represented as a multi-stage process of unconscious construction of the response signal in the form of a model representation of the sensory signal with consideration of information encoded in the cognitive memory space. The workspace of the thought process is considered from the perspective of modern cognitive science on modeling the activity of the neural system in the framework of the concept of neurodynamic organization and functional modes of the cognitive memory space. This approach allows us to understand the relationship between the workspace, mental constructs, the cognitive space of memory and cognitive abilities. The architecture, properties, internal mechanisms, and characteristics of the workspace are discussed. Since the workspace is formed by mental constructs, the analysis of the organization and functioning of internal mechanisms of mental constructs is performed. A dynamic instability of the workspace was found, which is caused by the dynamics of mental constructs. The study of the dynamics of mental spaces is revealed the stages of forming a response by mental constructs to a sensory signal. They can be defined as creating a mental space, creating response signal as the modified model representation, the fading of mental spaces with the display of the generated response in the cognitive memory space. Understanding thinking as a multi-stage process of "unconscious reinterpretation" of the received information can contribute to the improvement of educational technologies for the development of cognitive mechanisms of the cognitive process of the individual.

scholarly journals Phylogenetics of the plant genera Dracaena and Pleomele (Asparagaceae)

1970 ◽  
Vol 7 ◽  
pp. 64-72 ◽  
Author(s):  
Pei-Luen Lu ◽  
Clifford Morden
Keyword(s):  
Chloroplast Dna ◽  
Dna Sequences ◽  
World Wide ◽  
Significant Contribution ◽  
Molecular Taxonomy ◽  
Phylogenetic Reconstruction ◽  
Intergenic Spacer ◽  
Natural Resource Conservation ◽  
History Of ◽  
The Relationship

This research focuses on the biodiversity and the evolutionary history of the world-wide medicinal plant genus, Dracaena, and the plant genus Pleomele. The debate concerning the relationship between Dracaena and Pleomele has continued till date - some botanists continue to include Pleomele within Dracaena but others claimed to separate the two genera. Dracaena is a genus comprising of about 40-100 species world wide, mainly in tropics and subtropics, with the exception of America. Pleomele is a genus that has been circumscribed consisting of 10-50 species in Asia. Till date, its center of biodiversity is unknown. Pleomele is only classified well in Hawaii, but confused with Dracaena in the other parts of Asia. Phylogenetic relationship among the 33 taxa within the Dracaena and Pleomele were reconstructed. DNA sequences from the chloroplast DNA intergenic spacer, trnL-trnF and trnH-psbA were analyzed. A phylogeny was reconstructed using neighbor-joining, maximum parsimony in PAUP*, and likelihood criteria in RAxML, and Bayesian inference in MrBayes. The phylogeny with Agave missionum and Agave attenuata as outgroup taxa indicates that Pleomele is mixed with Dracaena. This study provides the first phylogenetic reconstruction with taxonomic sampling of the Dracaena and Pleomele to resolve their questionable placement. The relationships of the climate change adaptation, biogeography, and conservation with the two plant genera will be further discussed in this study. Some suggestions for the benefits of the biodiversity and natural resource conservation in Himalaya regions will be addressed. One significant contribution of this research will be in promoting molecular taxonomy to solve problems in systematics especially in cases when the classification is in debate. Key-words: Phylogeny; chloroplast DNA; Asparagaceae; Dracaena; Pleomele. DOI: 10.3126/botor.v7i0.4385Botanica Orientalis – Journal of Plant Science (2010) 7: 64-72

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