scholarly journals COVID-19 Infection: Impact on Hair

2021 ◽  
Author(s):  
Sandeep Suresh Sattur ◽  
Indu Sandeep Sattur
Keyword(s):  
Latent Period ◽  
Hair Follicle ◽  
Hair Loss ◽  
Direct Impact ◽  
Number Of Patients ◽  
Febrile Episodes

AbstractWith a practice dedicated to hair restoration and hair loss management, the authors have seen a large number of patients presenting with increased hair fall in the last 18 months. Hair fall after a stressfull event such as infections with febrile episodes is known. However, the latent period between the infective episode and hair fall has been shorter after COVID-19 infection than before. This review attempts to look at various pathways responsible for hair fall and if this differs from the conventional hair fall seen after any infection. It also tries to understand if the infection with the SARS-CoV-2 virus has a direct impact on the hair follicle leading to hair fall.

scholarly journals Febrile reaction after hematopoietic stem cell infusion is more frequent if no steroid premedicaton is given which results in more frequent use of antibiotics in early post-transplant phase

2021 ◽  
Vol 40 (3) ◽  
pp. 91-96
Author(s):  
Lucija Romić ◽  
Nadira Duraković ◽  
Radovan Vrhovac ◽  
Lana Desnica ◽  
Zinaida Perić
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Systemic Infection ◽  
Standard Operating Procedure ◽  
Febrile Reaction ◽  
Hematopoietic Stem ◽  
Post Transplant ◽  
Steroid Group ◽  
Number Of Patients ◽  
Febrile Episodes

Background: There is no consensus as to the need for steroid premedication before fresh product hematopoietic stem cell (HSC) infusion. In case of febrile reaction post-HSC infusion, on-call staff frequently prescribe antibiotics empirically. Considering the recent data on the value of microbiota and its influence on GVHD incidence, we analysed the frequency of febrile reactions and the use of antibiotic after HSC infusion in 149 consecutive patients. Methods: In the time period between 1/2018 and 10/2019, 149 patients were subject to transplantation in our institution. Per institutional standard operating procedure (SOP), all the patients received premedication before hematopoietic stem cell infusion consisting of 20 mg chloropyramine-chlorid iv, and in case of ABO incompatible graft 1 mg/kg methylprednisolone iv. Retrospective data was collected by using patient charts. Survival probability was calculated by applying Kaplan-Meier method. Results: Fifty-two patients received steroids, 12 patients (23%) developing fever after graft infusion, 46 patients received no steroids, 26 of them (57%) developed fever (p<0.001). There was no difference in the number of patients having positive blood cultures. Nine (17%) and 16 (35%) patients received IV antibiotics in the “steroid” and no-steroid” group, respectively (p<0.05). There was no difference in survival between “steroid” and “no-steroid” group. Conclusions: Even with no difference in the frequency of febrile episodes caused by systemic infection, a significantly more patients not receiving steroid premedication develop fever and are treated with IV antibiotics, which could potentially have further implications on transplantation outcomes due to its influence on microbiota early post-transplant.

scholarly journals Assessment of Prolonged Dengue Virus Infection in Dermal Fibroblasts and Hair-Follicle Dermal Papilla Cells

Viruses ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 267
Author(s):  
Kai-Che Wei ◽  
Wan-Ju Wei ◽  
Yi-Shan Liu ◽  
Li-Chen Yen ◽  
Tsung-Hsien Chang
Keyword(s):  
Dengue Virus ◽  
Hair Follicle ◽  
Hair Loss ◽  
Human Hair ◽  
Dermal Papilla ◽  
Denv Infection ◽  
Dermal Fibroblasts ◽  
Type I ◽  
Dermal Papilla Cells

Dengue virus (DENV)-mediated hair loss is one of the post-dengue fatigue syndromes and its pathophysiology remains unknown. Whether long-term or persistent infection with DENV in the scalp results in hair loss is unclear. In this study, we cultured human dermal fibroblasts (WS1 cells) and primary human hair-follicle dermal papilla cells (HFDPCs) in the long term with DENV-2 infection. The production of virion, the expression of inflammatory and anti-virus genes, and their signaling transduction activity in the infected cells were analyzed. DENV-2 NS3 protein and DENV-2 5′ UTR RNA were detected in fibroblasts and HFDPCs that were subjected to long-term infection with DENV-2 for 33 days. A significant amount of DENV-2 virion was produced by both WS1 cells and HFDPCs in the first two days of acute infection. The virion was also detected in WS1 cells that were infected in the long term, but HFDPCs failed to produce DENV-2 after long-term culture. Type I and type III interferons, and inflammatory cytokines were highly expressed in the acute phase of DENV infection in HFPDC and WS1 cells. However, in the long-term cultured cells, modest levels of anti-viral protein genes were expressed and we observed reduced signaling activity, which was correlated with the level of virus production changes. Long-term infection of DENV-2 downregulated the expression of hair growth regulatory factors, such as Rip1, Wnt1, and Wnt4. This in vitro study shows that the long-term infection with DENV-2 in dermal fibroblasts and dermal papilla cells may be involved with the prolonged-DENV-infection-mediated hair loss of post-dengue fatigue syndrome. However, direct evidence for viral replication in the human hair of a dengue victim or animal infection model is required.

scholarly journals Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 466 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Hair Loss ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Regrowth ◽  
Hair Follicle Development

The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).

scholarly journals Infective complications in patients with lung cancer

2010 ◽  
Vol 63 (9-10) ◽  
pp. 643-647 ◽  
Author(s):  
Milan Rancic ◽  
Lidija Ristic ◽  
Ivana Stankovic
Keyword(s):  
Lung Cancer ◽  
Therapy Response ◽  
Tracheobronchial Tree ◽  
Hospital Treatment ◽  
Gram Positive ◽  
Gram Negative ◽  
Number Of Patients ◽  
Significant Difference ◽  
Microbiological Agents ◽  
Febrile Episodes

Introduction. This study was aimed at analyzing the site, kind and type of infection which develop in patients having lung cancer at hospital treatment. Material and methods. Clinical data of the patients hospitalized for lung cancer were analyzed at the Clinic for Lung Diseases and Tuberculosis in Knez Selo in the period from January 2002 till December 2007. A great number of patients (1296-75.9%) had non-small cell lung cancer. In 1708 patients with lung cancer, 773 febrile episodes were recorded, i.e. 687 states of infections. Results. Most of the infections were recorded in the tracheobronchial tree (60.9%). The infection was confirmed microbiologically in 38% of infectious states. Predominant Gram positive pathogens were Staphylococcus aureus and Streptococcus, but among Gram negative pathogens there were Escherichia coli and Haemophilus influenzae. Discussion. A significantly better therapy response to antibiotics was found in the group of patients where microbiological agents were isolated (p<0.05). The predominant site of infection in the patients with lung cancer is the tracheobronchial tree without a significant difference between frequency of Gram positive and Gram negative pathogens.

scholarly journals Unraveling the secret life of the hair follicle: from fungi to innovative hair loss therapies

2017 ◽  
Vol 26 (6) ◽  
pp. 471-471 ◽  
Author(s):  
Andrew G Messenger ◽  
Natalia V Botchkareva
Keyword(s):  
Hair Follicle ◽  
Hair Loss

scholarly journals Androgen tic alopecia (AGA) -New Approach

2015 ◽  
Vol 5 (2) ◽  
pp. 64-65
Author(s):  
Md Ahsan Shafique
Keyword(s):  
Hair Follicle ◽  
Ethnic Groups ◽  
Hair Loss ◽  
Characteristic Pattern ◽  
New Approach ◽  
Dental Research ◽  
Men 1 ◽  
Significant Impairment ◽  
Pattern Distribution ◽  
Research And Education

Androgen tic alopecia is a no scarring progressive miniaturization of the hair follicle with a usual characteristic pattern distribution in genetically predisposed men 1. It is the most common hair loss disorder which causes significant impairment of life 2,3. The frequency and severity of male AGA increases with age in all ethnic groups 4.Bangladesh Journal of Dental Research and Education Vol.5(2) 2015: 64-65

scholarly journals 905 Dysfunction of hair follicle mesenchymal progenitors is associated with age-related hair loss

2019 ◽  
Vol 139 (5) ◽  
pp. S156
Author(s):  
W. Shin ◽  
N. Rosin ◽  
H. Sparks ◽  
S. Sinha ◽  
W. Rahmani ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Loss ◽  
Mesenchymal Progenitors ◽  
Age Related

scholarly journals Early Stages ofwe/we wal/walMouse Hair Morphogenesis: Light and Fluorescent Microscopy of the Whole-Mount Epidermis

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Alexandra Rippa ◽  
Olga Leonova ◽  
Vladimir Popenko ◽  
Andrey Vasiliev ◽  
Vasily Terskikh ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Loss ◽  
Early Stage ◽  
Fluorescent Microscopy ◽  
Adult Life ◽  
Hair Follicles ◽  
Whole Mount ◽  
Interfollicular Epidermis ◽  
Embryonic Morphogenesis ◽  
Hair Morphogenesis

In adult skin, hair follicles cyclically self-renew in a manner that recapitulates embryonic hair follicle morphogenesis. The most common pathology of hair in adults is alopecia, which is hair loss to different extent. There are a number of murine models of alopecia including spontaneous mutations. In the present study, we worked with double homozygouswe/we wal/walmice which demonstrate symptoms closely resembling human alopecia. Using whole-mount preparations of epidermis of E18.5 embryos we show that hair follicle defects can be revealed as early as during embryonic morphogenesis in these mutants. The number of hair follicles was reduced almost 1.5-fold in mutant skin. The shape of the early stage small follicles was altered in mutant animals as compared to control ones. Additionally, follicles of mutant embryos were wider at the point of conjunction with interfollicular epidermis. We believe that the mutant mice studied represent a fascinating model to address the problem of hair loss. We demonstrated alterations in the morphogenesis of embryonic hair follicle inwe/we wal/waldouble homozygous mice developing alopecia postnatally. We suppose that incorrect morphogenesis of hair follicles during embryogenesis is closely related to alopecia in the adult life. Unveiling the mechanisms involved in altered embryogenesis may elucidate the pathogenesis of alopecia.

scholarly journals What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

2020 ◽  
Vol 10 (14) ◽  
pp. 4996
Author(s):  
Nicole Braun ◽  
Ulrike Heinrich
Keyword(s):  
Hair Follicle ◽  
Dietary Supplements ◽  
Hair Loss ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
Widespread Occurrence ◽  
Non Invasive ◽  
Anagen Phase

Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

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