Fagus sylvatica C4 Trituration Proving and Clinical Applications

2021 ◽  
Vol 34 (04) ◽  
pp. 263-266
Author(s):  
Hélène Renoux
Keyword(s):  
Fagus Sylvatica ◽  
Clinical Applications ◽  
European History ◽  
Homeopathic Medicine ◽  
The Many

Abstract Fagus sylvatica, the beech, has long been linked to European history, along with the oak. This homeopathic trituration proving reports on the main pathogenetic themes which led to successful prescriptions. Stiffness of the shoulders, alternating symptoms and love for forests appear to be key symptoms. More study of this remedy, and more prescriptions would be necessary to explore widely the many possibilities of this homeopathic medicine.

Exploiting antibody biology for the treatment of cancer

Immunotherapy ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 255-267 ◽  
Author(s):  
Vidhi Khanna ◽  
Jayanth Panyam ◽  
Thomas S Griffith
Keyword(s):  
Antibody Therapy ◽  
Cancer Therapeutics ◽  
High Specificity ◽  
Mechanisms Of Action ◽  
Clinical Applications ◽  
Combination Therapies ◽  
Rational Combination ◽  
The Many ◽  
Key Aspects ◽  
Target Effects

Over the last decade, antibodies have become an important component in the arsenal of cancer therapeutics. High-specificity, low off-target effects, desirable pharmacokinetics and high success rate are a few of the many attributes that make antibodies amenable for development as drugs. To design antibodies for successful clinical applications, however, it is critical to have an understanding of their structure, functions, mechanisms of action and pharmacokinetic/pharmacodynamic properties. This review highlights some of these key aspects, as well as certain limitations encountered, with monoclonal antibody therapy. Further, we discuss rational combination therapies for clinical applications, some of which could help overcome the limitations.

Handbook of neurolinguistics. B. Stemmer and H. A. Whitaker (Eds.). San Diego: Academic, 1998. Pp. 788.

2000 ◽  
Vol 21 (4) ◽  
pp. 557-559
Author(s):  
Edgar B. Zurif
Keyword(s):  
Cognitive Neuroscience ◽  
San Diego ◽  
State Of The Art ◽  
Clinical Applications ◽  
The Many

Of the cognitive neuroscience handbooks recently published, this, to my knowledge, is the only one that is entirely devoted to the neurology of language. In the editors' words, it is “intended as a state-of-the-art reference and resource book describing current research and theory in the many subfields of neurolinguistics and their clinical applications.” It is intended for “the newcomer to the field, as well as the expert.”

Writing Europe into the History of the British Empire

2017 ◽  
Author(s):  
Jan Rüger
Keyword(s):  
British Empire ◽  
European History ◽  
Recent Past ◽  
The Public ◽  
Clear Cut ◽  
The United Kingdom ◽  
The World ◽  
History Of ◽  
The Many ◽  
The Relationship

How should we think of the relationship between Europe and the British empire? Much of the public debate in the recent past has suggested a clear-cut answer: the empire prevented Britain from being drawn ‘into Europe’; it was thanks to its imperial possessions that the United Kingdom could afford not to play a more active European role. Empire and Europe, in short, presented opposite poles in Britain’s engagement with the world. The essay challenges this widely held assumption. It investigates the many ways in which European and imperial experiences were bound up with each other in British life. By doing so, it explores strategies for writing the British empire into European history and European history into the imperial British past.

scholarly journals The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications

2019 ◽  
Vol 33 (03) ◽  
pp. 185-189 ◽  
Author(s):  
Daniel K. Chang ◽  
Matthew R. Louis ◽  
Alejandro Gimenez ◽  
Edward M. Reece
Keyword(s):  
Basic Science ◽  
Clinical Applications ◽  
Burn Wounds ◽  
Anatomic Location ◽  
Reconstructive Ladder ◽  
Dermal Regeneration Template ◽  
Dermal Regeneration ◽  
The Many ◽  
Acellular Dermal

AbstractFirst developed for coverage of burn wounds, Integra (Integra LifeSciences) is a synthetic acellular dermal regeneration template that provides a base for revascularization and neodermal formation. The use of Integra has slowly grown and has now become an important consideration along the reconstructive ladder. This article reviews the basic science of Integra and provides an overview of the many expanding applications based on anatomic location.

scholarly journals Clinical applicability of optogenetic gene regulation

2020 ◽  
Author(s):  
Nina Wichert ◽  
Martin Witt ◽  
Thomas Scheper ◽  
Cornelia Blume
Keyword(s):  
Gene Regulation ◽  
Mammalian Cells ◽  
Gene Transfection ◽  
Clinical Applications ◽  
Control Of Gene Expression ◽  
Advantages And Disadvantages ◽  
Transfection Method ◽  
Gene And Protein Expression ◽  
The Many

The field of optogenetics is rapidly growing in relevance and number of developed tools. Amongst other things, the optogenetic repertoire includes light-responsive ion channels and methods for gene regulation. This review will be confined to the optogenetic control of gene expression in mammalian cells as suitable models for clinical applications. Here optogenetic gene regulation might offer an excellent method for spatially and timely regulated gene and protein expression in cell therapeutic approaches. Well-known systems for gene regulation, such as the LOV-, CRY2/CIB-, PhyB/PIF-systems, as well as other, in mammalian cells not yet fully established systems will be described. Advantages and disadvantages with regard to clinical applications are outlined in detail. Among the many unanswered questions concerning the application of optogenetics, we discuss items such as the use of exogenous chromophores and their effects on the biology of the cells and methods for a gentle, but effective gene transfection method for optogenetic tools for in vivo applications.

Phonetic considerations in restorative dentistry

Dental Update ◽  
2019 ◽  
Vol 46 (9) ◽  
pp. 880-893
Author(s):  
Emad S Elsubeihi ◽  
Yaser Elkareimi ◽  
Haitham Elbishari
Keyword(s):  
Clinical Relevance ◽  
Patient Management ◽  
Daily Practice ◽  
Clinical Applications ◽  
Speech Sounds ◽  
Restorative Dentistry ◽  
Basic Principles ◽  
The Many ◽  
Partially Dentate

The use of phonetics is one of several guides that can be used by the restorative dentist during the assessment and restoration of structurally compromised teeth. To accomplish this, an understanding of the basic mechanisms involved in producing sounds during speech can facilitate the application of these techniques during patient management. This review discusses the basic principles of speech sounds production. This is followed by a discussion of the clinical applications of the different phonetic tests in the assessment and management of dentate and partially dentate patients with structurally compromised dentitions. CPD/Clinical Relevance: Phonetic tests are among the many guides used in the assessment and management of dentate patients with structurally compromised dentitions. The clinician should be familiar with the basic principles and applications of these tests to be able to assess and manage patients in daily practice.

Identifying suboptimalities with factorial model comparison

2018 ◽  
Vol 41 ◽  
Author(s):  
Wei Ji Ma
Keyword(s):  
Experimental Design ◽  
Model Comparison ◽  
Process Models ◽  
Multiple Forms ◽  
Factorial Experimental Design ◽  
Factorial Model ◽  
Multiple Components ◽  
The Many

AbstractGiven the many types of suboptimality in perception, I ask how one should test for multiple forms of suboptimality at the same time – or, more generally, how one should compare process models that can differ in any or all of the multiple components. In analogy to factorial experimental design, I advocate for factorial model comparison.

Representing utility and deploying the body

2020 ◽  
Vol 43 ◽  
Author(s):  
David Spurrett
Keyword(s):  
Functional Activity ◽  
Degrees Of Freedom ◽  
The Body ◽  
Target Article ◽  
Processing Demands ◽  
The Many

Abstract Comprehensive accounts of resource-rational attempts to maximise utility shouldn't ignore the demands of constructing utility representations. This can be onerous when, as in humans, there are many rewarding modalities. Another thing best not ignored is the processing demands of making functional activity out of the many degrees of freedom of a body. The target article is almost silent on both.

The many faces of obligation

2020 ◽  
Vol 43 ◽  
Author(s):  
Michael Tomasello
Keyword(s):  
Third Party ◽  
The Many ◽  
Sense Of Obligation

Abstract My response to the commentaries focuses on four issues: (1) the diversity both within and between cultures of the many different faces of obligation; (2) the possible evolutionary roots of the sense of obligation, including possible sources that I did not consider; (3) the possible ontogenetic roots of the sense of obligation, including especially children's understanding of groups from a third-party perspective (rather than through participation, as in my account); and (4) the relation between philosophical accounts of normative phenomena in general – which are pitched as not totally empirical – and empirical accounts such as my own. I have tried to distinguish comments that argue for extensions of the theory from those that represent genuine disagreement.

Hydrogen Cyanide Polymers from the Impact of Comet P/Shoemaker-Levy 9 on Jupiter

1997 ◽  
Vol 161 ◽  
pp. 179-187
Author(s):  
Clifford N. Matthews ◽  
Rose A. Pesce-Rodriguez ◽  
Shirley A. Liebman
Keyword(s):  
Amino Acids ◽  
Solar System ◽  
Hydrogen Cyanide ◽  
Nitrogen Heterocycles ◽  
Laboratory Studies ◽  
Heterogeneous Solids ◽  
The Many ◽  
Comet Halley ◽  
The Impact ◽  
By Products

AbstractHydrogen cyanide polymers – heterogeneous solids ranging in color from yellow to orange to brown to black – may be among the organic macromolecules most readily formed within the Solar System. The non-volatile black crust of comet Halley, for example, as well as the extensive orangebrown streaks in the atmosphere of Jupiter, might consist largely of such polymers synthesized from HCN formed by photolysis of methane and ammonia, the color observed depending on the concentration of HCN involved. Laboratory studies of these ubiquitous compounds point to the presence of polyamidine structures synthesized directly from hydrogen cyanide. These would be converted by water to polypeptides which can be further hydrolyzed to α-amino acids. Black polymers and multimers with conjugated ladder structures derived from HCN could also be formed and might well be the source of the many nitrogen heterocycles, adenine included, observed after pyrolysis. The dark brown color arising from the impacts of comet P/Shoemaker-Levy 9 on Jupiter might therefore be mainly caused by the presence of HCN polymers, whether originally present, deposited by the impactor or synthesized directly from HCN. Spectroscopic detection of these predicted macromolecules and their hydrolytic and pyrolytic by-products would strengthen significantly the hypothesis that cyanide polymerization is a preferred pathway for prebiotic and extraterrestrial chemistry.

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