scholarly journals Polyion Complex Micelles for Protein Delivery

2018 ◽  
Vol 71 (10) ◽  
pp. 768 ◽  
Author(s):  
Fan Chen ◽  
Martina H. Stenzel
Keyword(s):  
Protein Delivery ◽  
Hydrolytic Degradation ◽  
Protective Layer ◽  
Drug Market ◽  
The Body ◽  
Interpolyelectrolyte Complex ◽  
Polyion Complex ◽  
Block Ionomer Complexes ◽  
Block Ionomer ◽  
Oppositely Charged

Proteins are ubiquitous in life and next to water, they are the most abundant compounds found in human bodies. Proteins have very specific roles in the body and depending on their function, they are for example classified as enzymes, antibodies or transport proteins. Recently, therapeutic proteins have made an impact in the drug market. However, some proteins can be subject to quick hydrolytic degradation or denaturation depending on the environment and therefore require a protective layer. A range of strategies are available to encapsulate and deliver proteins, but techniques based on polyelectrolyte complex formation stand out owing to their ease of formulation. Depending on their isoelectric point, proteins are charged and can condense with oppositely charged polymers. Using block copolymers with a neutral block and a charged block results in the formation of polyion complex (PIC) micelles when mixed with the oppositely charged protein. The neutral block stabilises the charged protein–polymer core, leading to nanoparticles. The types of micelles are also known under the names interpolyelectrolyte complex, complex coacervate core micelles, and block ionomer complexes. In this article, we discuss the formation of PIC micelles and their stability. Strategies to enhance the stability such as supercharging the protein or crosslinking the PIC micelles are discussed.

Dynamic Properties of Block Ionomer Complexes with Polyion Complex Cores

2008 ◽  
Vol 41 (15) ◽  
pp. 5863-5868 ◽  
Author(s):  
Yuan Li ◽  
Tatiana K. Bronich ◽  
Pavel S. Chelushkin ◽  
Alexander V. Kabanov
Keyword(s):  
Dynamic Properties ◽  
Polyion Complex ◽  
Block Ionomer Complexes ◽  
Block Ionomer

scholarly journals Solubilization of Charged Porphyrins in Interpolyelectrolyte Complexes: A Computer Study

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 502
Author(s):  
Karel Šindelka ◽  
Zuzana Limpouchová ◽  
Karel Procházka
Keyword(s):  
Dissipative Particle Dynamics ◽  
Water Soluble ◽  
Coarse Grained ◽  
Core Shell ◽  
Computer Study ◽  
Interpolyelectrolyte Complex ◽  
The Core ◽  
Porphyrin Derivatives ◽  
Oppositely Charged ◽  
Positively Charged

Using coarse-grained dissipative particle dynamics (DPD) with explicit electrostatics, we performed (i) an extensive series of simulations of the electrostatic co-assembly of asymmetric oppositely charged copolymers composed of one (either positively or negatively charged) polyelectrolyte (PE) block A and one water-soluble block B and (ii) studied the solubilization of positively charged porphyrin derivatives (P+) in the interpolyelectrolyte complex (IPEC) cores of co-assembled nanoparticles. We studied the stoichiometric mixtures of 137 A10+B25 and 137 A10−B25 chains with moderately hydrophobic A blocks (DPD interaction parameter aAS=35) and hydrophilic B blocks (aBS=25) with 10 to 120 P+ added (aPS=39). The P+ interactions with other components were set to match literature information on their limited solubility and aggregation behavior. The study shows that the moderately soluble P+ molecules easily solubilize in IPEC cores, where they partly replace PE+ and electrostatically crosslink PE− blocks. As the large P+ rings are apt to aggregate, P+ molecules aggregate in IPEC cores. The aggregation, which starts at very low loadings, is promoted by increasing the number of P+ in the mixture. The positively charged copolymers repelled from the central part of IPEC core partially concentrate at the core-shell interface and partially escape into bulk solvent depending on the amount of P+ in the mixture and on their association number, AS. If AS is lower than the ensemble average ⟨AS⟩n, the copolymer chains released from IPEC preferentially concentrate at the core-shell interface, thus increasing AS, which approaches ⟨AS⟩n. If AS>⟨AS⟩n, they escape into the bulk solvent.

scholarly journals Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 5
Author(s):  
Noriko Nakamura ◽  
Yuki Mochida ◽  
Kazuko Toh ◽  
Shigeto Fukushima ◽  
Horacio Cabral ◽  
...  
Keyword(s):  
Physicochemical Characteristics ◽  
Charge Ratio ◽  
Structural Variations ◽  
Polyion Complex ◽  
Functional Capabilities ◽  
The Stability ◽  
Biological Performance ◽  
Complex Micelles ◽  
Oppositely Charged

Self-assembled supramolecular structures based on polyion complex (PIC) formation between oppositely charged polymers are attracting much attention for developing drug delivery systems able to endure harsh in vivo environments. As controlling polymer complexation provides an opportunity for engineering the assemblies, an improved understanding of the PIC formation will allow constructing assemblies with enhanced structural and functional capabilities. Here, we focused on the influence of the mixing charge ratio between block aniomers and catiomers on the physicochemical characteristics and in vivo biological performance of the resulting PIC micelles (PIC/m). Our results showed that by changing the mixing charge ratio, the structural state of the core was altered despite the sizes of PIC/m remaining almost the same. These structural variations greatly affected the stability of the PIC/m in the bloodstream after intravenous injection and determined their biodistribution.

scholarly journals Thermosensitive polyion complex micelles prepared by self-assembly of two oppositely charged diblock copolymers

2013 ◽  
Vol 31 (2) ◽  
pp. 318-324 ◽  
Author(s):  
Pan He ◽  
Chang-wen Zhao ◽  
Chun-sheng Xiao ◽  
Zhao-hui Tang ◽  
Xue-si Chen
Keyword(s):  
Self Assembly ◽  
Diblock Copolymers ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Complex Micelles ◽  
Oppositely Charged

Formation of Amphiphilic Polyion Complex Vesicles from Mixtures of Oppositely Charged Block Ionomers

2003 ◽  
Vol 36 (5) ◽  
pp. 1417-1420 ◽  
Author(s):  
Stefan Schrage ◽  
Reinhard Sigel ◽  
Helmut Schlaad
Keyword(s):  
Polyion Complex ◽  
Block Ionomers ◽  
Oppositely Charged

Preparation and Characterization of Polyion Complex Micelles with a Novel Thermosensitive Poly(2-isopropyl-2-oxazoline) Shell via the Complexation of Oppositely Charged Block Ionomers†

Langmuir ◽  
2007 ◽  
Vol 23 (1) ◽  
pp. 138-146 ◽  
Author(s):  
Joon-Sik Park ◽  
Yoshitsugu Akiyama ◽  
Yuichi Yamasaki ◽  
Kazunori Kataoka
Keyword(s):  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Block Ionomers ◽  
Complex Micelles ◽  
Oppositely Charged

Cross-linked Polymeric Micelles based on Block Ionomer Complexes

2013 ◽  
Vol 23 (4) ◽  
pp. 179-186 ◽  
Author(s):  
Jong Oh Kim ◽  
Thiruganesh Ramasamy ◽  
Chul Soon Yong ◽  
Natalia V. Nukolov ◽  
Tatiana K. Bronich ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Block Ionomer Complexes ◽  
Block Ionomer

Encapsulation of Myoglobin in PEGylated Polyion Complex Vesicles Made from a Pair of Oppositely Charged Block Ionomers: A Physiologically Available Oxygen Carrier

2007 ◽  
Vol 119 (32) ◽  
pp. 6197-6200 ◽  
Author(s):  
Akihiro Kishimura ◽  
Aya Koide ◽  
Kensuke Osada ◽  
Yuichi Yamasaki ◽  
Kazunori Kataoka
Keyword(s):  
Oxygen Carrier ◽  
Polyion Complex ◽  
Block Ionomers ◽  
Oppositely Charged

scholarly journals Effects of the electrosprayed polycaprolactone microparticles morphology on the polycaprolactone degradation

2019 ◽  
Vol 3 (2) ◽  
pp. 65-73
Author(s):  
Nguyen-Vu Viet Linh ◽  
Nguyen Quoc Viet ◽  
Huynh Dai Phu
Keyword(s):  
Electron Microscopy ◽  
Flow Rate ◽  
Protein Delivery ◽  
Gel Permeation Chromatography ◽  
Processing Parameters ◽  
The Body ◽  
Processing Parameter ◽  
Gel Permeation ◽  
Polymeric Microparticles ◽  
Scanning Electron

The polycaprolactone (PCL) microparticles fabricated by electrospray technique have been studied and applied in drug and protein delivery system. The degradation of PCL and the release of drug/protein from the polymeric microparticles (MPs) were desired to happen simultaneously. When the new dosage was administrated, the PCL MPs were degraded and eliminated out of the body. This research indicated that the degradation of PCL was influenced by the various morphology of electrosprayed microparticles. The different sizes of 11.8 μm and 5.17 μm and the various shapes of the PCL MPs such as hollow, porous and wrinkle particles and spheres were investigated the PCL degradation in the PBS solution, at pH 7.4. The morphology of PCL MPs was designed by controlling the polymer solution and the electrosprayed processing parameters such as the flow rate and collecting distance. Scanning electron microscopy and gel permeation chromatography were order to determine the change of the morphology and number molecule weight (Mn) of PCL MPs. The porous, distorted and smaller particles reduced the Mn faster than the microspheres because of the larger surface area of MPs contacted with PBS solution. After 77 days, PCL MPs which were fabricated by the processing parameter, including 2.5% PCL in DCM, flow rate of 0.8 mL/h, voltage of 18 kV, collecting distance of 25 cm, reduced 49.96% molecular weight (decreasing from Mn= 80,438 g/mol to 40,225 g/mol).  

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