scholarly journals Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events

2018 ◽  
Vol 115 (9) ◽  
pp. 2228-2233 ◽  
Author(s):  
Dorothea Hämmerer ◽  
Martina F. Callaghan ◽  
Alexandra Hopkins ◽  
Julian Kosciessa ◽  
Matthew Betts ◽  
...  
Keyword(s):  
Older Adults ◽  
Locus Coeruleus ◽  
Structural Integrity ◽  
Memory Task ◽  
Negative Events ◽  
Older Individuals ◽  
Healthy Older Adults ◽  
Aversive Events ◽  
Strong Motivation ◽  
Noradrenergic Modulation

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC structural integrity and pupillometry as a putative index of LC activation in both younger and older adults. We show that older adults with reduced structural LC integrity show poorer subsequent memory. This effect is more pronounced for emotionally negative events, in accord with a greater role for noradrenergic modulation in encoding salient or aversive events. In addition, we found that salient stimuli led to greater pupil diameters, consistent with increased LC activation during the encoding of such events. Our study presents novel evidence that a decrement in noradrenergic modulation impacts on specific components of cognition in healthy older adults. The findings provide a strong motivation for further investigation of the effects of altered LC integrity in pathological aging.

scholarly journals Memory-Related Frontal Brainwaves Predict Transition to Mild Cognitive Impairment in Healthy Older Individuals Five Years Before Diagnosis

2020 ◽  
pp. 1-11
Author(s):  
Yang Jiang ◽  
Juan Li ◽  
Frederick A. Schmitt ◽  
Gregory A. Jicha ◽  
Nancy B. Munro ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Performance ◽  
Memory Task ◽  
Cognitive Status ◽  
Older Individuals ◽  
Increased Risk ◽  
Differentiation Pattern

Background: Early prognosis of high-risk older adults for amnestic mild cognitive impairment (aMCI), using noninvasive and sensitive neuromarkers, is key for early prevention of Alzheimer’s disease. We have developed individualized measures in electrophysiological brain signals during working memory that distinguish patients with aMCI from age-matched cognitively intact older individuals. Objective: Here we test longitudinally the prognosis of the baseline neuromarkers for aMCI risk. We hypothesized that the older individuals diagnosed with incident aMCI already have aMCI-like brain signatures years before diagnosis. Methods: Electroencephalogram (EEG) and memory performance were recorded during a working memory task at baseline. The individualized baseline neuromarkers, annual cognitive status, and longitudinal changes in memory recall scores up to 10 years were analyzed. Results: Seven of the 19 cognitively normal older adults were diagnosed with incident aMCI for a median 5.2 years later. The seven converters’ frontal brainwaves were statistically identical to those patients with diagnosed aMCI (n = 14) at baseline. Importantly, the converters’ baseline memory-related brainwaves (reduced mean frontal responses to memory targets) were significantly different from those who remained normal. Furthermore, differentiation pattern of left frontal memory-related responses (targets versus nontargets) was associated with an increased risk hazard of aMCI (HR = 1.47, 95% CI 1.03, 2.08). Conclusion: The memory-related neuromarkers detect MCI-like brain signatures about five years before diagnosis. The individualized frontal neuromarkers index increased MCI risk at baseline. These noninvasive neuromarkers during our Bluegrass memory task have great potential to be used repeatedly for individualized prognosis of MCI risk and progression before clinical diagnosis.

scholarly journals DNA methylation and cognitive functioning in healthy older adults

2011 ◽  
Vol 107 (5) ◽  
pp. 744-748 ◽  
Author(s):  
Olga J. G. Schiepers ◽  
Martin P. J. van Boxtel ◽  
Renate H. M. de Groot ◽  
Jelle Jolles ◽  
Frans J. Kok ◽  
...  
Keyword(s):  
Older Adults ◽  
Dna Methylation ◽  
Folic Acid ◽  
Cognitive Functioning ◽  
Cognitive Performance ◽  
Global Dna Methylation ◽  
Older Individuals ◽  
Healthy Older Adults ◽  
Study Results ◽  
The Relationship

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status and non-pathological cognitive functioning in human subjects has not yet been investigated. The present study investigated the associations between global DNA methylation and key domains of cognitive functioning in healthy older adults. Global DNA methylation, defined as the percentage of methylated cytosine to total cytosine, was measured in leucocytes by liquid chromatography–MS/MS, in 215 men and women, aged 50–70 years, who participated in the Folic Acid and Carotid Intima-Media Thickness (FACIT) study (clinical trial registration number NCT00110604). Cognitive performance was assessed by means of the Visual Verbal Word Learning Task, the Stroop Colour-Word Interference Test, the Concept Shifting Test, the Letter–Digit Substitution Test and the Verbal Fluency Test. Using hierarchical linear regression analyses adjusted for age, sex, level of education, alcohol consumption, smoking status, physical activity, erythrocyte folate concentration and 5,10-methylenetetrahydrofolate reductase 677 C → T genotype, we found that global DNA methylation was not related to cognitive performance on any of the domains measured. The present study results do not support the hypothesis that global DNA methylation, as measured in leucocytes, might be associated with cognitive functioning in healthy older individuals.

scholarly journals Aging and Sensitivity to Illusory Target Motion With or Without Secondary Tasks

2018 ◽  
Vol 31 (3-4) ◽  
pp. 227-249 ◽  
Author(s):  
Alix L. de Dieuleveult ◽  
Anne-Marie Brouwer ◽  
Petra C. Siemonsma ◽  
Jan B. F. van Erp ◽  
Eli Brenner
Keyword(s):  
Older Adults ◽  
Visual Information ◽  
Sensory Information ◽  
Older Individuals ◽  
Younger Adults ◽  
Secondary Tasks ◽  
Healthy Older Adults ◽  
The Right ◽  
Task Irrelevant ◽  
Background Motion

Older individuals seem to find it more difficult to ignore inaccurate sensory cues than younger individuals. We examined whether this could be quantified using an interception task. Twenty healthy young adults (age 18–34) and twenty-four healthy older adults (age 60–82) were asked to tap on discs that were moving downwards on a screen with their finger. Moving the background to the left made the discs appear to move more to the right. Moving the background to the right made them appear to move more to the left. The discs disappeared before the finger reached the screen, so participants had to anticipate how the target would continue to move. We examined how misjudging the disc’s motion when the background moves influenced tapping. Participants received veridical feedback about their performance, so their sensitivity to the illusory motion indicates to what extent they could ignore the task-irrelevant visual information. We expected older adults to be more sensitive to the illusion than younger adults. To investigate whether sensorimotor or cognitive load would increase this sensitivity, we also asked participants to do the task while standing on foam or counting tones. Background motion influenced older adults more than younger adults. The secondary tasks did not increase the background’s influence. Older adults might be more sensitive to the moving background because they find it more difficult to ignore irrelevant sensory information in general, but they may rely more on vision because they have less reliable proprioceptive and vestibular information.

scholarly journals Catecholaminergic modulation of the cost of cognitive control in healthy older adults

2019 ◽  
Author(s):  
Monja Isabel Froböse ◽  
Andrew Westbrook ◽  
Mirjam Bloemendaal ◽  
Esther Aarts ◽  
Roshan Cools
Keyword(s):  
Older Adults ◽  
Decision Making ◽  
Cognitive Control ◽  
Memory Task ◽  
Drug Effects ◽  
Study Drug ◽  
Healthy Older Adults ◽  
Subjective Value ◽  
Undermining Effect ◽  
Back Task

Catecholamines have long been associated with cognitive control and value-based decision-making. More recently, we have shown that catecholamines also modulate value-based decision-making about whether or not to engage in cognitive control. Yet it is unclear whether catecholamines influence these decisions by altering the subjective value of control. Thus, we tested whether tyrosine, a catecholamine precursor altered the subjective value of performing a demanding working memory task among healthy older adults (60-75 years). Contrary to our prediction, tyrosine administration did not significantly increase the subjective value of conducting an N-back task for reward, as a main effect. Instead, in line with our previous study, drug effects varied as a function of participants’ trait impulsivity scores. Specifically, tyrosine increased the subjective value of conducting an N-back task in low impulsive participants, while reducing its value in more impulsive participants. One implication of these findings is that the over-the-counter tyrosine supplements may be accompanied by an undermining effect on the motivation to perform demanding cognitive tasks, at least in certain older adults. Taken together, these findings indicate that catecholamines can alter cognitive control by modulating motivation (rather than just the ability) to exert cognitive control.

scholarly journals Effects of Prolonged Whey Protein Supplementation and Resistance Training on Biomarkers of Vitamin B12 Status: A 1-Year Randomized Intervention in Healthy Older Adults (the CALM Study)

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2015
Author(s):  
Eva Greibe ◽  
Søren Reitelseder ◽  
Rasmus L. Bechshøft ◽  
Jacob Bülow ◽  
Grith W. Højfeldt ◽  
...  
Keyword(s):  
Older Adults ◽  
Resistance Training ◽  
Whey Protein ◽  
Methylmalonic Acid ◽  
Protein Supplementation ◽  
Older Individuals ◽  
Sample Collection ◽  
Total Study Population ◽  
Healthy Older Adults ◽  
Study Population

We investigated the effect of long-term whey supplementation on biomarkers of B12 status in healthy older adults subjected to different schemes of supplements and exercise. The total study population examined at baseline consisted of 167 healthy older adults (age ≥ 65 year) who were randomized to 1-y intervention with two daily supplements of (1) whey protein (3.1 µg B12/day) (WHEY-ALL), (2) collagen (1.3 µg B12/day) (COLL), or (3) maltodextrin (0.3 µg B12/day) (CARB). WHEY-ALL was comprised of three groups, who performed heavy resistance training (HRTW), light resistance training (LITW), or no training (WHEY). Dietary intake was assessed through 3-d dietary records. For the longitudinal part of the study, we included only the participants (n = 110), who met the criteria of ≥ 50% compliance to the nutritional intervention and ≥ 66% and ≥ 75% compliance to the heavy and light training, respectively. Fasting blood samples collected at baseline and 12 months and non-fasting samples collected at 6 and 18 months were examined for methylmalonic acid, B12 and holotranscobalamin. At baseline, the study population (n = 167) had an overall adequate dietary B12 intake of median (range) 5.3 (0.7–65) µg/day and median B12 biomarker values within reference intervals. The whey intervention (WHEY-ALL) caused an increase in B12 (P < 0.0001) and holotranscobalamin (P < 0.0001). In addition, methylmalonic acid decreased in the LITW group (P = 0.04). No change in B12 biomarkers was observed during the intervention with collagen or carbohydrate, and the training schedules induced no changes. In conclusion, longer-term daily whey intake increased plasma B12 and holotranscobalamin in older individuals. No effect of intervention with collagen or carbohydrate or different training regimes was observed. Interestingly, the biomarkers of B12 status appeared to be affected by fasting vs. non-fasting conditions during sample collection.

scholarly journals Optimistic update bias increases in older age

2013 ◽  
Vol 44 (9) ◽  
pp. 2003-2012 ◽  
Author(s):  
R. Chowdhury ◽  
T. Sharot ◽  
T. Wolfe ◽  
E. Düzel ◽  
R. J. Dolan
Keyword(s):  
Older Adults ◽  
Well Being ◽  
Older Age ◽  
Anterior Cingulate ◽  
Subjective Rating ◽  
Grey Matter Volume ◽  
Negative Events ◽  
Healthy Older Adults ◽  
Positivity Bias ◽  
Age Related

BackgroundHealthy older adults report greater well-being and life satisfaction than their younger counterparts. One potential explanation for this is enhanced optimism. We tested the influence of age on optimistic and pessimistic beliefs about the future and the associated structural neural correlates.MethodEighteen young and 18 healthy older adults performed a belief updating paradigm, measuring differences in updating beliefs for desirable and undesirable information about future negative events. These measures were related to regional brain volume, focusing on the anterior cingulate cortex (ACC) because this region is strongly linked to a positivity bias in older age.ResultsWe demonstrate an age-related reduction in updating beliefs when older adults are faced with undesirable, but not desirable, information about negative events. This greater ‘update bias’ in older age persisted even after controlling for a variety of variables including subjective rating scales and poorer overall memory. A structural brain correlate of this greater ‘update bias’ was evident in greater grey matter volume in the dorsal ACC in older but not in young adults.ConclusionsWe show a greater update bias in healthy older age. The link between this bias and relative volume of the ACC suggests a shared mechanism with an age-related positivity bias. Older adults frequently have to make important decisions relating to personal, health and financial issues. Our findings have wider behavioural implications in these contexts because an enhanced optimistic update bias may skew such real-world decision making.

scholarly journals P089 Loneliness and sleep duration among healthy older adults in Southeast Queensland, Australia

2021 ◽  
Vol 2 (Supplement_1) ◽  
pp. A50-A50
Author(s):  
J Lam ◽  
D Mann ◽  
C Pattinson ◽  
A Allan ◽  
S Smith ◽  
...  
Keyword(s):  
Older Adults ◽  
Sleep Duration ◽  
Sleep Onset ◽  
Onset Time ◽  
Older Individuals ◽  
Healthy Older Adults ◽  
Wake Time ◽  
Sleep Timing ◽  
Adverse Health Outcomes ◽  
Timing Variability

Abstract Introduction The relationship between sleep duration and loneliness among healthy older adults is not fully understood. Shorter sleep duration and increased variability of sleep timing (sleep onset and wake time) have recently been shown to have adverse health outcomes in younger adults. While physiological stressors associated with loneliness are likely distinct, we hypothesise that older adults who identify as lonely have reduced sleep duration and increased variability of sleep timing. Methods Older individuals (N=60) without significant co-morbidities were recruited via convenience sampling. Participants completed the de Jong Giervield Loneliness Scale and wore an actigraph for up to 2 weeks. Sleep metrics from actigraphy (sleep onset and wake times, and SD) were determined by algorithm assisted human scoring. Results Valid data was retrieved from N=37 participants (age 83±6.8 years [mean±SD]). There were no significant differences in demographics between those in the lonely (N=19) and not lonely (N=18) groupings. There was substantial heterogeneity in individual participant’s sleep metrics, both within and between groupings. The average sleep onset time was similar between groups, however lonely participants typically woke earlier resulting in slightly shorter sleep duration. Variability in sleep onset and wake times was reduced in lonely participants. Discussion While shorter sleep duration was expected, we did not anticipate the reduction in sleep timing variability amongst those defined as lonely; more regular sleep periods have previously been associated with better outcomes. We did not see statistically significant differences between our groups, possibly due to sample size limitations, however, the unexpected trend warrants further investigation.

scholarly journals Evaluation of Episodic and Lexical Metamemory and Executive Function in Healthy Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 704-705
Author(s):  
Atsuko Hayashi
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Episodic Memory ◽  
Stroop Task ◽  
Memory Performance ◽  
Memory Task ◽  
Lexical Memory ◽  
Healthy Older Adults ◽  
Self Evaluation ◽  
Age Related

Abstract In older adults, it is important to maintain awareness of memory as well as memory performance. However, it is not clear whether the awareness of episodic and lexical memory changes with age and is related to self-evaluation of memory and executive function. Here age-related changes and the relationship between metamemory, executive function, and metamemory scale were investigated. Healthy old (n=40) and young (n=34) groups participated in this study. In the episodic memory task, participants were asked to memorize ten Kanji words and to estimate the number of words they could recall after ten minutes. In the lexical memory task, they rated the likelihood that they could write a target Kanji word written in hiragana and then wrote them down. They were also asked to complete the metamemory in adulthood(MIA) and the position stroop task. In the episodic and lexical memory and the position stroop task and MIA subscales, the performances of the younger group were significantly better than those of the older group. In the episodic memory task, there were correlations between the metamemory and MIA subscales in both groups, but in the lexical memory task, only in the old group. No correlation was found between the results of both memory tasks and the stroop test. These results suggest that older people overestimate memory performances in the episodic and lexical memory tasks and metamemory performances may be associated with self-evaluation of memory. In addition, metamemory might not be related to frontal lobe function as shown in executive function tasks.

scholarly journals Gauging Working Memory Capacity From Differential Resting Brain Oscillations in Older Individuals With A Wearable Device

2021 ◽  
Vol 13 ◽  
Author(s):  
Soheil Borhani ◽  
Xiaopeng Zhao ◽  
Margaret R. Kelly ◽  
Karah E. Gottschalk ◽  
Fengpei Yuan ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Memory Retrieval ◽  
Working Memory Capacity ◽  
Memory Capacity ◽  
Older Individuals ◽  
Brain Oscillations ◽  
Healthy Older Adults ◽  
Eyes Closed ◽  
The Right

Working memory is a core cognitive function and its deficits is one of the most common cognitive impairments. Reduced working memory capacity manifests as reduced accuracy in memory recall and prolonged speed of memory retrieval in older adults. Currently, the relationship between healthy older individuals’ age-related changes in resting brain oscillations and their working memory capacity is not clear. Eyes-closed resting electroencephalogram (rEEG) is gaining momentum as a potential neuromarker of mild cognitive impairments. Wearable and wireless EEG headset measuring key electrophysiological brain signals during rest and a working memory task was utilized. This research’s central hypothesis is that rEEG (e.g., eyes closed for 90 s) frequency and network features are surrogate markers for working memory capacity in healthy older adults. Forty-three older adults’ memory performance (accuracy and reaction times), brain oscillations during rest, and inter-channel magnitude-squared coherence during rest were analyzed. We report that individuals with a lower memory retrieval accuracy showed significantly increased alpha and beta oscillations over the right parietal site. Yet, faster working memory retrieval was significantly correlated with increased delta and theta band powers over the left parietal sites. In addition, significantly increased coherence between the left parietal site and the right frontal area is correlated with the faster speed in memory retrieval. The frontal and parietal dynamics of resting EEG is associated with the “accuracy and speed trade-off” during working memory in healthy older adults. Our results suggest that rEEG brain oscillations at local and distant neural circuits are surrogates of working memory retrieval’s accuracy and processing speed. Our current findings further indicate that rEEG frequency and coherence features recorded by wearable headsets and a brief resting and task protocol are potential biomarkers for working memory capacity. Additionally, wearable headsets are useful for fast screening of cognitive impairment risk.

scholarly journals Disrupted Neural Synchrony Mediates the Relationship between White Matter Integrity and Cognitive Performance in Older Adults

2020 ◽  
Vol 30 (10) ◽  
pp. 5570-5582 ◽  
Author(s):  
T Hinault ◽  
M Kraut ◽  
A Bakker ◽  
A Dagher ◽  
S M Courtney
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Cognitive Performance ◽  
Structural Integrity ◽  
Phase Locking ◽  
Inferior Frontal Gyrus ◽  
Individual Variability ◽  
White Matter Integrity ◽  
Older Individuals ◽  
Phase Locking Value

Abstract Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of cognitive performance in older adults. Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and cognitive performance were assessed. We found that the association between white matter microstructural integrity and cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better cognitive control performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and cognitive performance during normal aging.

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