scholarly journals Cloning and characterization of four murine homeobox genes.

1996 ◽  
Vol 93 (20) ◽  
pp. 10691-10696 ◽  
Author(s):  
A. C. Rovescalli ◽  
S. Asoh ◽  
M. Nirenberg
Keyword(s):  
Homeobox Genes

scholarly journals Characterization of wheat Bell1-type homeobox genes in floral organs of alloplasmic lines with Aegilops crassa cytoplasm

2011 ◽  
Vol 11 (1) ◽  
pp. 2 ◽  
Author(s):  
Kota Mizumoto ◽  
Hitoshi Hatano ◽  
Chizuru Hirabayashi ◽  
Koji Murai ◽  
Shigeo Takumi
Keyword(s):  
Homeobox Genes ◽  
Alloplasmic Lines ◽  
Floral Organs ◽  
Aegilops Crassa

Characterization of HOX Gene Expression During Myelopoiesis: Role of HOX A5 in Lineage Commitment and Maturation

Blood ◽  
1999 ◽  
Vol 93 (10) ◽  
pp. 3391-3400 ◽  
Author(s):  
John F. Fuller ◽  
Jeanne McAdara ◽  
Yifah Yaron ◽  
Mark Sakaguchi ◽  
John K. Fraser ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Bone Marrow Cells ◽  
Homeobox Genes ◽  
Erythroid Differentiation ◽  
Erythroid Progenitors ◽  
Effector Cells ◽  
Gm Csf ◽  
Important Regulator ◽  
Macrophage Colony

During the process of normal hematopoiesis, proliferation is tightly linked to maturation. The molecular mechanisms that lead to production of mature effector cells with a variety of phenotypes and functions from a single multipotent progenitor are only beginning to be elucidated. It is important to determine how these maturation events are regulated at the molecular level, because this will provide significant insights into the process of normal hematopoiesis as well as leukemogenesis. Transcription factors containing the highly conserved homeobox motif show considerable promise as potential regulators of hematopoietic maturation events. In this study, we focused on identification and characterization of homeobox genes of the HOX family that are important in regulating normal human myeloid differentiation induced by the hematopoietic growth factor, granulocyte-macrophage colony-stimulating factor (GM-CSF). We have identified three homeobox genes, HOX A5, HOX B6, and HOX B7, which are expressed during early myelopoiesis. Treating bone marrow cells with antisense oligodeoxynucleotides to HOX A5 resulted in inhibition of granulocytic/monocytic hematopoiesis and increased the generation of erythroid progenitors. Also, overexpression of HOX A5 inhibited erythroid differentiation of the K562 cell line. Based on these observations, we propose that HOX A5 functions as an important regulator of hematopoietic lineage determination and maturation.

scholarly journals Identification and Characterization of TALE Homeobox Genes in the Endangered Fern Vandenboschia speciosa

Genes ◽  
2017 ◽  
Vol 8 (10) ◽  
pp. 275 ◽  
Author(s):  
Mercedes Ruiz-Estévez ◽  
Mohammed Bakkali ◽  
Rubén Martín-Blázquez ◽  
Manuel Garrido-Ramos
Keyword(s):  
Homeobox Genes ◽  
Identification And Characterization

scholarly journals A TALE of shrimps: Genome-wide survey of homeobox genes in 120 species from diverse crustacean taxa

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 71
Author(s):  
Wai Hoong Chang ◽  
Alvina G. Lai
Keyword(s):  
Homeobox Genes ◽  
Whole Body ◽  
Model Organisms ◽  
Data Sets ◽  
Crop Species ◽  
Physiological Processes ◽  
Genome Wide ◽  
Wide Range ◽  
Identification And Characterization

The homeodomain-containing proteins are an important group of transcription factors found in most eukaryotes including animals, plants and fungi. Homeobox genes are responsible for a wide range of critical developmental and physiological processes, ranging from embryonic development, innate immune homeostasis to whole-body regeneration. With continued fascination on this key class of proteins by developmental and evolutionary biologists, multiple efforts have thus far focused on the identification and characterization of homeobox orthologs from key model organisms in attempts to infer their evolutionary origin and how this underpins the evolution of complex body plans. Despite their importance, the genetic complement of homeobox genes has yet been described in one of the most valuable groups of animals representing economically important food crops. With crustacean aquaculture being a growing industry worldwide, it is clear that systematic and cross-species identification of crustacean homeobox orthologs is necessary in order to harness this genetic circuitry for the improvement of aquaculture sustainability. Using publicly available transcriptome data sets, we identified a total of 4183 putative homeobox genes from 120 crustacean species that include food crop species, such as lobsters, shrimps, crayfish and crabs. Additionally, we identified 717 homeobox orthologs from 6 other non-crustacean arthropods, which include the scorpion, deer tick, mosquitoes and centipede. This high confidence set of homeobox genes will now serve as a key resource to the broader community for future functional and comparative genomics studies.

Characterization of KNOX Homeobox Genes in Medicago truncatula as a Resource for Genetic Improvement of Legume Species

2010 ◽  
Vol 150 ◽  
pp. 495-495
Author(s):  
E. Di Giacomo ◽  
S. Iafrate ◽  
M.A. Iannelli ◽  
R.A. Rodrigues-Pousada ◽  
G. Testone ◽  
...  
Keyword(s):  
Medicago Truncatula ◽  
Genetic Improvement ◽  
Homeobox Genes ◽  
Legume Species

scholarly journals Identification and characterization of homeobox genes in Eucalyptus

2005 ◽  
Vol 28 (3 suppl) ◽  
pp. 511-519 ◽  
Author(s):  
Graça Celeste Gomes Rocha ◽  
Régis Lopes Corrêa ◽  
Anna Cristina Neves Borges ◽  
Claudio Bustamante Pereira de Sá ◽  
Márcio Alves-Ferreira
Keyword(s):  
Homeobox Genes ◽  
Identification And Characterization

A new Drosophila homeobox gene, bsh, is expressed in a subset of brain cells during embryogenesis

Development ◽  
1993 ◽  
Vol 117 (2) ◽  
pp. 793-806 ◽  
Author(s):  
B. Jones ◽  
W. McGinnis
Keyword(s):  
Homeobox Genes ◽  
Homeobox Gene ◽  
Brain Morphology ◽  
Genetic Screens ◽  
Internal Structures ◽  
Drosophila Brain ◽  
And Function ◽  
The Brain

Homeobox genes have been shown to control the determination of positional, tissue and cellular identity during the development of the fruitfly Drosophila melanogaster. Because genes involved in the determination of internal structures derived from neural, mesodermal and endodermal tissues may have been overlooked in conventional genetic screens, we undertook the identification of new homeobox genes expressed in these internal tissues. Here we describe the characterization of one of these new Drosophila homeobox genes, called brain-specific-homeobox (bsh). In embryos, bsh is expressed exclusively in the brain. bsh protein accumulates in approximately 30 cells in each brain hemisphere. One of these bsh expressing cells is closely associated with the terminus of the larval visual nerve (Bolwig's nerve). While deletions of chromosomal interval containing the bsh gene show no dramatic changes in embryonic brain morphology, the expression pattern of the bsh gene suggests that it may play a highly specialized role in the determination and function of cell type in the Drosophila brain.

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