scholarly journals Inulin-type fructans and bone health: state of the art and perspectives in the management of osteoporosis

2005 ◽  
Vol 93 (S1) ◽  
pp. S111-S123 ◽  
Author(s):  
Véronique Coxam

If the primary role of diet is to provide sufficient nutrients to meet the metabolic requirements of an individual, there is an emerging rationale to support the hypothesis that, by modulating specific target functions in the body, it can help achieve optimal health. Regarding osteoporosis prevention, since Ca is most likely to be inadequate in terms of dietary intake, every strategy targeting an improvement in Ca absorption is very interesting. Actually, this process may be susceptible to manipulation by fermentable substrates. In this light, inulin-type fructans are very interesting, even if we need to gather more data targeting bone metabolism before health professionals can actively advocate their consumption to prevent senile osteoporosis. Besides targeting the prevention of postmenopausal osteoporosis, inulin-type fructans still remain a source for putative innovative dietary health intervention. Indeed, given in combination with isoflavones, they may have a potential for maintaining or improving the bone mass of human subjects, by modulating the bioavailability of phyto-oestrogens.

2018 ◽  
Vol 115 (48) ◽  
pp. 12313-12318 ◽  
Author(s):  
Gang Wu ◽  
Marc D. Ruben ◽  
Robert E. Schmidt ◽  
Lauren J. Francey ◽  
David F. Smith ◽  
...  

Skin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. The epidermal layer shows rhythmic physiological responses to daily environmental variation (e.g., DNA repair). We investigated the role of the circadian clock in the transcriptional regulation of epidermis using a hybrid experimental design, in which a limited set of human subjects (n = 20) were sampled throughout the 24-h cycle and a larger population (n = 219) were sampled once. We found a robust circadian oscillator in human epidermis at the population level using pairwise correlations of clock and clock-associated genes in 298 epidermis samples. We then used CYCLOPS to reconstruct the temporal order of all samples, and identified hundreds of rhythmically expressed genes at the population level in human epidermis. We compared these results with published time-series skin data from mice and found a strong concordance in circadian phase across species for both transcripts and pathways. Furthermore, like blood, epidermis is readily accessible and a potential source of biomarkers. Using ZeitZeiger, we identified a biomarker set for human epidermis that is capable of reporting circadian phase to within 3 hours from a single sample. In summary, we show rhythms in human epidermis that persist at the population scale and describe a path to develop robust single-sample circadian biomarkers.


Author(s):  
Radostina A. Angelova

The thermophysiological comfort is one of the aspects of the human comfort. It is related to the thermoregulatory system of the body and its reactions to the temperature of the surrounding air, activity and clothing. The aim of the chapter is to present the state of the art in the wearable technologies for helping the human thermophysiological comfort. The basic processes of body's thermoregulatory system, the role of the hypothalamus, the reactions of the body in hot and cold environment, together with the related injuries, are described. In the second part of the chapter smart and intelligent clothing, textiles and accessories are presented together with wearable devices for body's heating/cooling.


2011 ◽  
Vol 84 (2) ◽  
pp. 239-248 ◽  
Author(s):  
Alan A. Sneddon

Selenium (Se) is an important dietary micronutrient required for sustaining optimal health. Se is incorporated into proteins, many of which are antioxidants that protect the body against oxidative damage. As oxidative damage may contribute to the development of chronic diseases including cardiovascular disease (CVD), Se has been proposed to provide a protective role against this disease. Studies in vitro and in animals continue to provide increasing insight into the role of Se in promoting vascular health and ameliorating CVD. Se within vascular cells limits the adhesion together of such cells, an important early step in the development of vascular disease. Organic forms of Se may also afford vascular cells greater protection against oxidative challenge compared to inorganic forms. Nevertheless, current studies in humans investigating the relationship between Se and CVD have so far proved equivocal; larger randomized trials with different Se exposures in populations spanning the broad physiological Se status are needed to determine the criteria whereby Se may influence CVD outcome within different populations. Further studies are also needed to explore the effects of different Se species and the role of different selenoprotein genotypes in modifying Se status and their resultant impact on cardiovascular function.


2018 ◽  
Author(s):  
Gang Wu ◽  
Marc D. Ruben ◽  
Robert E. Schmidt ◽  
Lauren J. Francey ◽  
David F. Smith ◽  
...  

AbstractSkin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. Like other tissues, skin is subject to temporal fluctuations in physiological responses under both homeostatic and stressed states. To gain insight into these fluctuations, we investigated the role of the circadian clock in the transcriptional regulation of epidermis using a hybrid experimental design, where a limited set of human subjects (n=20) were sampled throughout the 24 h cycle and a larger population (n=219) were sampled once. By looking at pairwise correlations of core clock genes in 298 skin samples, we found a robust circadian oscillator in skin at the population level. Encouraged by this, we used CYCLOPS to reconstruct the temporal order of all samples and identified hundreds of rhythmically-expressed genes at the population level in human skin. We compared these results with published time-series skin data from mouse and show strong concordance in circadian phase across species for both transcripts and pathways. Further, like blood, skin is readily accessible and a potential source of biomarkers. Using ZeitZeiger, we identified a biomarker set for human skin that is capable of reporting circadian phase to within 3 h from a single sample. In summary, we show rhythms in human skin that persist at the population scale and a path to develop robust single-sample circadian biomarkers.One Sentence SummaryHuman epidermis shows strong circadian rhythms at the population scale and provides a better source for developing robust, single-sample circadian phase biomarkers than human blood.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Cividini A ◽  

At the beginning of 2020, Covid-19 pandemic has deeply and quickly changed healthcare transforming our hospitals and challenging health professionals both as clinicians and humans. We found ourselves fighting an invisible, unknown enemy, facing an unpredictable disease and had no choice but adapting and reacting to an overgrowing emergency situation. Whole hospitals were dedicated to Covid-19 patients and many specialized physicians had to quickly learn about treating Sars-Cov-2 infection. Over the last year better knowledge of pathophysiology and treatment as well as the establishment of redesigned organizational models have contributed to reduce the role of chance, fear and unexpected, but as the pandemic keeps unfolding, healthcare workers are still under pressure. As a result, they are exposed to a high risk of post-traumatic stress disorder as well as burn-out syndrome. As a neurosurgeon working in a Covid-converted hospital and an hypnologist I realized it was my duty to use my skills to help colleagues in need. I started offering hypnosis sessions to help colleagues to stay in-balance and react to this situation in a resilient way. In this letter I underline some features which I find to be peculiar to the Covid-19 pandemic (some of them more relevant to the first waves), describe their consequences on health professionals’ life and suggest the potential role of hypnosis as a tool to promote mental health. • Loss of anchors: entire hospitals or wards have been turned into Covid-dedicated areas, thus requiring professionals to change their daily habits, to quickly learn new skills and to be exposed to a constantly changing situation. The sudden and continuous loss of such anchors is deeply destabilizing. • Change in social engagement: self-quarantine, limiting of social activities, avoidance of close contacts and having to wear disposable equipment partially covering the face impact on the usual way of being socially involved. Paradoxically, family and community can’t offer a safe shelter in a moment of major need. • Identification: before vaccines became available, the high number of health professionals affected by the disease, the unfortunately common unavailability of proper personal protective equipment and the need for a constant monitoring of self health status, often lead to identification with patients or victims. • Lack of control: such a level of uncertainty and lack of knowledge is new to many young doctors who have been raised studying diagnosis and treatment of mostly well-defined and known conditions. • Social media impact: being connected inevitably exposes users to a constant flow of bad or fake news. Besides being a reason to recall a healthier digital lifestyle, this leads to rumination and prevents people from using spare time to fully recover from the fatigue. Carers who asked for hypnosis sessions mainly complained about sleep-related problems, panic attacks, rumination, anxiety and fear (of dying alone, of not being able to make plans for the future, of not being able to reconnect with loved ones, of transmitting the disease to family members or colleagues, of not being able to breathe). The reiteration of such symptoms puts health professionals on the dangerous road to burn-out and eventually PTSD. Hypnosis, as well as all disciplines aimed at improving mental health (mind-body techniques, mindfulness, meditation, yoga, deep relaxation..) may offer help in preventing them. Healthcarers who required hypnosis sessions were invited to join after or before their shift. I treated clinicians and nurses, aged 25-55 yo, mainly female. A short introductory talk was aimed at identifying their perception of the situation and potential topics to work on during the session. Being all the patients highly motivated in feeling better, almost none had difficulties in trance-induction. Sessions had a mean duration of 45-60’ and were held in the hospital facilities. I found the following techniques being particularly useful: • Focus on breathing: being Covid-19 disease mainly a respiratory illness and due to the need to work wearing uncomfortable masks, focus on breathing is crucial. Reconnecting people to their natural breath may help in keeping a healthy connection to the body and preventing panic attacks. • Safe place: visualizing and then anchoring a “safe place” help subjects to realize that they can actively choose to feel better going back to their safe place every time they need it. • Metaphors: the use of subject-tailored metaphors is particularly effective, giving immediate relief as well as working on a longer-lasting deeper level. • Temporal dissociation and retrieving happy memories: in difficult and uncertain times, reestablishing a connection with happy memories and with past achievements helps subjects to discover their own value, be self-confident and get rid of harmful helplessness feeling. • Future reorienting: for all the aforementioned reasons future reorienting techniques may be useful for those people feeling afraid of not being able to look beyond this challenging times All subjects were satisfied with the session, found it helpful and most of them asked to repeat the treatment. I hope this letter may contribute to increase institutions’ awareness on the need for measures aimed at maintaining and supporting mental health of all professionals involved in fighting the ongoing pandemic. Besides, it’s also addressed to professionals as a reminder to promptly identify stress-related red flags and ask for help. Hypnosis is a powerful, effective and safe tool.


2019 ◽  
Vol 62 ◽  
pp. 28-29 ◽  
Author(s):  
Isabel M. Perera

Abstract Some of the most immediate health effects of the 2008 economic crisis concerned the mind, not the body. Rates of generalized anxiety, chronic depression, and even suicide spiked in many European societies. This viewpoint highlights the role of mental health professionals in responding to this emergency, and argues that their sustained mobilization is necessary to its long-term resolution.


2019 ◽  
Vol 12 (3) ◽  
pp. 119 ◽  
Author(s):  
Marija Lesjak ◽  
Surjit K. S. Srai

Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron homeostasis is maintained by modifying dietary iron absorption. Several dietary factors, such as flavonoids, are known to greatly affect iron absorption. Recent evidence suggests that flavonoids can affect iron status by regulating expression and activity of proteins involved the systemic regulation of iron metabolism and iron absorption. We provide an overview of the links between different dietary flavonoids and iron homeostasis together with the mechanism of flavonoids effect on iron metabolism. In addition, we also discuss the clinical relevance of state-of-the-art knowledge regarding therapeutic potential that flavonoids may have for conditions that are low in iron such as anaemia or iron overload diseases.


2006 ◽  
Vol 4 (1) ◽  
pp. 43-48
Author(s):  
Grażyna Nowicka

The primary role of the diet is to provide adequate quantities of nutrients to meet metabolic requirements and maintain optimal health. However, it has been shown that certain types of food or specific food components can affect a variety of body functions and provide specific health benefits. Diet containing such types of food may promote better health and play an important role in disease prevention by reducing the risk of certain chronic diseases. Vegetable proteins, especially legume proteins, have been recognized as factors influencing lipid metabolism. Hypocholesterolemic effects of different legume proteins have been documented. Hypotensive action of bioactive peptides derived from soy and lupin proteins has been reported. In soy a peptide of anti-mitotic activity was found and it may play a significant role in suppression of tumor development and cancer prevention. Diet rich in vegetables and vegetable proteins is related to lower risk of cardiovascular and cancer mortality.


Author(s):  
Su-bin Hwang ◽  
Ramachandran Chelliah ◽  
Ji Eun Kang ◽  
Momna Rubab ◽  
Eric Banan-MwineDaliri ◽  
...  

Shiga toxin-producing Escherichia coli (STEC) is a global foodborne bacterial pathogen that is often accountable for colon disorder or distress. STEC commonly induces severe diarrhea in hosts but can cause critical illnesses due to the Shiga toxin virulence factors. To date, there have been a significant number of STEC serotypes have been evolved. STECs vary from nausea and hemorrhoid (HC) to possible lethal hemolytic-based uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP). Inflammation-based STEC is usually a foodborne illness with Shiga toxins (Stx 1 and 2) thought to be pathogenesis. The STEC’s pathogenicity depends significantly on developing one or more Shiga toxins, which can constrain host cell protein synthesis leading to cytotoxicity. In managing STEC infections, antimicrobial agents are generally avoided, as bacterial damage and discharge of accumulated toxins are thought the body. It has also been documented that certain antibiotics improve toxin production and the development of these species. Many different groups have attempted various therapies, including toxin-focused antibodies, toxin-based polymers, synbiotic agents, and secondary metabolites remedies. Besides, in recent years, antibiotics’ efficacy in treating STEC infections has been reassessed with some encouraging methods. Nevertheless, the primary role of synbiotic effectiveness (probiotic and prebiotic) against pathogenic STEC and other enteropathogens is less recognized. Additional studies are required to understand the mechanisms of action of probiotic bacteria and yeast against STEC infection. Because of the consensus contraindication of antimicrobials for these bacterial pathogens, the examination was focused on alternative remedy strategies for STEC infections. The rise of novel STEC serotypes and approaches employed in its treatment are highlighted.


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