scholarly journals Primary role of sweeteners in the body mass indexes of women from developing countries: implications for risk of chronic disease

2004 ◽  
Vol 80 (2) ◽  
pp. 527-528
Author(s):  
William B Grant
Keyword(s):  
Developing Countries ◽  
Chronic Disease ◽  
Body Mass ◽  
The Body ◽  
Primary Role ◽  
Body Mass Indexes

STEROID RECEPTOR PHENOTYPE, EXPRESSION OF HER-2/NEU, PD-1, PD-L1 AND LYMPHOCYTIC-MACROPHAGAL INFILTRATION OF ENDOMETRIAL CARCINOMAS: COMPARISON OF MODERN MOLECULAR BIOLOGICAL TYPES OF THE DISEASE (THE ROLE OF BODY MASS INDEX)

2020 ◽  
Vol 66 (1) ◽  
pp. 71-78
Author(s):  
Lev Bershteyn ◽  
Aleksandr Ivantsov ◽  
Aglaya Ievleva ◽  
A. Venina ◽  
I. Berlev
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Tumor Tissue ◽  
Immunohistochemical Analysis ◽  
The Body ◽  
Molecular Profile ◽  
Total N ◽  
Number Of Patients ◽  
Her 2

The aim of this study was to evaluate steroid receptors’ status of tumor tissue in different molecular biological types of endometrial cancer (EC), subdivided according to the current classification, and their colonization by lymphocytic and macrophage cells, taking into account body mass index of the patients. Materials and methods: Material from treatment-naive patients with EC (total n = 229) was included; the number of sick persons varied depending on the method used. The average age of patients was close to 60 years, and about 90% of them were postmenopausal. It was possible to divide the results of the work into two main subgroups: a) depending on the molecular biological type of the tumor (determined on the basis of genetic and immunohistochemical analysis), and b) depending on the value of the body mass index (BMI). The latter approach was used in patients with EC type demonstrating a defective mismatch repair of the incorrectly paired nucleotides (MMR-D) and with a type without characteristic molecular profile signs (WCMP), but was not applied (due to the smaller number of patients) in EC types with a POLE gene mutation or with expression of the oncoprotein p53. According to the data obtained, when comparing various types of EC, the lowest values of Allred ER and PR scores were revealed for POLE-mutant and p53 types, while the “triple-negative” variant of the tumor (ER-, PR-, HER2/neu-) was most common in POLE-mutant (45.5% of cases) and WCMP (19.4%) types of EC. The p53+ type of EC is characterized by inclination to the higher expression of the macrophage marker CD68 and lymphocytic Foxp3, as well as mRNA of PD-1 and SALL4. In addition to the said above, for WCMP type of EC is peculiar, on the contrary, a decrease in the expression of lymphocytic markers CD8 (protein) and PD-L1 (mRNA). When assessing the role of BMI, its value of >30.0 (characteristic for obesity) was combined with an inclination to the increase of HER-2/neu expression in the case of MMR-D EC type and to the decrease of HER-2 /neu, FOXp3 and ER expression in WCMP type. Conclusions: The accumulated information (mainly describing here hormonal sensitivity of the tumor tissue and its lymphocytic-macrophage infiltration) additionally confirms our earlier expressed opinion that the differences between women with EC are determined by both the affiliation of the neoplasm to one or another molecular biological type (subdivided according to the contemporary classification), as well as by body mass value and (very likely) the associated hormonal and metabolic attributes.

Gender differences and the role of parental education, school types and migration on the body mass index of 2930 Austrian school children

2017 ◽  
Vol 129 (21-22) ◽  
pp. 786-792 ◽  
Author(s):  
Dieter Furthner ◽  
Margit Ehrenmüller ◽  
Ariane Biebl ◽  
Roland Lanzersdorfer ◽  
Gerhard Halmerbauer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gender Differences ◽  
Body Mass ◽  
School Children ◽  
Parental Education ◽  
The Body ◽  
Austrian School ◽  
Education School ◽  
And Migration

scholarly journals Inulin-type fructans and bone health: state of the art and perspectives in the management of osteoporosis

2005 ◽  
Vol 93 (S1) ◽  
pp. S111-S123 ◽  
Author(s):  
Véronique Coxam
Keyword(s):  
Bone Health ◽  
Health Professionals ◽  
State Of The Art ◽  
Human Subjects ◽  
The Body ◽  
Health State ◽  
Primary Role ◽  
Osteoporosis Prevention ◽  
Optimal Health

If the primary role of diet is to provide sufficient nutrients to meet the metabolic requirements of an individual, there is an emerging rationale to support the hypothesis that, by modulating specific target functions in the body, it can help achieve optimal health. Regarding osteoporosis prevention, since Ca is most likely to be inadequate in terms of dietary intake, every strategy targeting an improvement in Ca absorption is very interesting. Actually, this process may be susceptible to manipulation by fermentable substrates. In this light, inulin-type fructans are very interesting, even if we need to gather more data targeting bone metabolism before health professionals can actively advocate their consumption to prevent senile osteoporosis. Besides targeting the prevention of postmenopausal osteoporosis, inulin-type fructans still remain a source for putative innovative dietary health intervention. Indeed, given in combination with isoflavones, they may have a potential for maintaining or improving the bone mass of human subjects, by modulating the bioavailability of phyto-oestrogens.

Agricultural Research in Sri Lanka: An Historical Account

1986 ◽  
Vol 20 (4) ◽  
pp. 755-778 ◽  
Author(s):  
Adam Pain
Keyword(s):  
Developing Countries ◽  
International Research ◽  
New Technologies ◽  
Agricultural Research ◽  
Primary Role ◽  
Research Organizations ◽  
Research Programmes ◽  
The 1960S ◽  
Local Research

An underlying premise of much of the comment on developing countries' agricultural research organizations and capabilities, has been that they are weak, and have been unsuccessful in generating new technologies and meeting farmers' needs. Indeed, one of the very justifications for the setting up of the series of international research institutes, such as the International Rice Research Institute (IRRI) was that national research programmes were seen to lack sufficient strength and organization to be able to respond to the urgent needs of food production that were identified in the 1960s. It was argued that a primary role of the International Centres would be to support and develop such national research programmes both through training and the provision of new plant varieties and technologies, and that the building up of local research capability in developing countries would come only after the International Research Centres had developed and transferred the new technologies.

scholarly journals Dentition and body condition: tooth wear as a correlate of weight loss in roe deer

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Roberta Chirichella ◽  
Anna Maria De Marinis ◽  
Boštjan Pokorny ◽  
Marco Apollonio
Keyword(s):  
Body Mass ◽  
Body Condition ◽  
Physical Condition ◽  
Roe Deer ◽  
Tooth Wear ◽  
The Body ◽  
Permanent Teeth ◽  
Tooth Surface ◽  
Mandible Length

Abstract Background In many mammalian species, once the permanent teeth have erupted, the only change to dentition is a gradual loss of tooth surface/height through wear. The crown of the teeth cannot be repaired once worn. When dental crown tissue has been depleted due to wear, the animal is expected to have a suboptimal body condition. We evaluated the role of tooth wear in causing a reduction of physical condition in adult roe deer females (Capreolus capreolus). Results The progressive wearing of the lower cheek teeth was assessed in a Northern Apennines (Italy) population with a new scoring scheme based on objectively described tooth characteristics (morphotypes) being either present or absent. Eviscerated body mass and mandible length, which is a good proxy for body size in roe deer, were related to the tooth wear score by the use of linear regressions. The sum of wear scores for molariform teeth correlated most strongly with body condition (i.e., eviscerated body mass/mandible length), showing the importance of the entire chewing surface for acquiring energy by food comminution, chewing, and digestion. In comparison with individuals of comparable size experiencing minor tooth wear, the body mass of those with the most advanced stage of tooth wear was decreased by 33.7%. This method was compared to the height and the hypsodonty index of the first molar, the most commonly used indices of tooth wear. The sum of molariform wear scoring scheme resulted in a more suitable index to describe the variation in body condition of roe deer. Conclusions Describing tooth wear patterns in hunted populations and monitoring at which tooth wear level (and therefore dental morphotype) an animal is no longer able to sustain its physical condition (i.e. when it begins to lose body mass) can be a useful tool for improving the management of the most widespread and abundant deer species in Europe. At the same time, such an approach can clarify the role of tooth wear as a proximate cause of senescence in ungulates.

scholarly journals Nonspecific Energy Expenditure of the Body and Body Mass Regulation

2019 ◽  
pp. 328-349
Author(s):  
Pavel Pavlovich Zagoskin
Keyword(s):  
Fatty Acids ◽  
Energy Expenditure ◽  
Oxidative Phosphorylation ◽  
Body Mass ◽  
The Body ◽  
Body Mass Regulation ◽  
Pathological Conditions ◽  
Other Substances ◽  
Principal Possibility

The principal possibility of nonspecific energy expenditure at all stages of the transformation of nutrients in the body is demonstrated. These stages include the processing of food in the mouth, digestion, absorption, interaction with the intestinal micro biome, and interstitial metabolic processes. Particular attention is paid to the role of nonspecific energy expenditure of the body in the regulation of body mass. The data on the pivotal role of reducing nonspecific energy expenditure in the development of obesity and associated pathological conditions are presented. The prospects for using uncouples of oxidative phosphorylation, fatty acids, carnitine, bile acids, sarcolipin and a number of other substances as regulators of the nonspecific energy expenditure and potential means of preventing and treating obesity are analyzed.

scholarly journals Interactions of Overweight, Poor Oral Health, and Stress Related to Chronic Disease in an Aging Population

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Julia W. Albright
Keyword(s):  
Developing Countries ◽  
Chronic Disease ◽  
Oral Health ◽  
Body Mass ◽  
Age Groups ◽  
Aging Population ◽  
The Elderly ◽  
Thrifty Genotype ◽  
Aging Populations

The prevalence of excess body mass (XBM), poor oral health (POH), and stress in a secluded population of aged (≥60 years) Hmong immigrants was surveyed. The findings were related to the prevalence of diabetes in the same population. Diabetes was associated separately with POH (OR 2.4; CL 1.3, 4.2) or with XBM (OR 2.5; CL 1.4, 4.8). The association of diabetes with the combination of XBM and POH was striking (OR 5.1; CL 3.4, 7.5); that apparent synergism has not been fully appreciated. We describe a mechanism that explains the synergism. The concept of “thrifty genotype” is a plausible explanation of XBM in the elderly Hmong immigrants and possibly the current older Laotian population. POH is common among elderly Laotians as it is in most developing countries. We conclude that synergism of XBM and POH significantly elevates the prevalence of diabetes among aging populations and probably other age groups as well.

scholarly journals ENTREPRENEURSHIP EDUCATION IN TERTIARY INSTITUTIONS: A PARADIGM FOR SUSTAINABLE DEVELOPMENT

2019 ◽  
Vol 7 (9) ◽  
pp. 63-70
Author(s):  
Okoye Victor O ◽  
Okoye Chinasa R.
Keyword(s):  
Sustainable Development ◽  
Developing Countries ◽  
Entrepreneurship Education ◽  
Primary Role ◽  
Tertiary Institutions ◽  
Research And Innovation ◽  
Sustainable Future ◽  
Powerful Means ◽  
The Way

The paper attempts to highlight the importance of entrepreneurship education in the quest for sustainable development and the role of tertiary institutions in promoting sound entrepreneurship education. In Nigeria, just like other developed and developing countries, tertiary institutions, through research and innovation, have been saddled with the responsibility of integrating sustainable development into their teachings and learnings. As societies look for solutions that could lead to sustainable development, entrepreneurship education, being offered in tertiary institutions, is becoming increasingly more appealing. Thus, given their primary role as knowledge producers, tertiary institutions, through research and innovation, can serve as powerful means to help create a more sustainable future by engaging in entrepreneurship education. Going forward, this paper also highlights the role of tertiary institutions in this very important subject of sustainable development, the reasons why people choose to be entrepreneurs as well as the importance of entrepreneurship education. The paper concludes by proffering suggestions on the way forward.

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