scholarly journals Influence of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in coronary heart disease patients: a systematic review

2006 ◽  
Vol 95 (5) ◽  
pp. 849-859 ◽  
Author(s):  
Mark Hamer ◽  
Andrew Steptoe
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Vascular Function ◽  
Dietary Intervention ◽  
Vascular Inflammation ◽  
Future Research ◽  
Protective Effects ◽  
Dietary Recommendations ◽  
Chd Risk ◽  
Progression Of Atherosclerosis

Epidemiological evidence suggests that the diet influences CHD risk, although the protective effects of dietary intervention for patients in diseased states has gained less attention. Secondary care prevention strategies for patients often involves drug therapy that is expensive and can result in undesirable side effects. Therefore, it is potentially beneficial to utilise other strategies, such as diet, in the management of CHD. A systematic review was conducted to examine the effects of specific nutrients on progression of atherosclerosis, vascular function, haemostasis and inflammation in CHD patients. Results show substantial evidence for the efficacy ofn–3 oils in reducing cardiovascular mortality and one mechanism may be related to the stabilisation of vulnerable atherosclerotic plaques, although the effects on progression of atherosclerosis, haemostatic activity and vascular inflammation remain equivocal. Promising data also exist for the efficacy of flavonoid-rich foods for improving endothelial function, although strong clinical endpoint evidence is lacking. The variation in the efficacy of certain nutrients in CHD patients may be explained by genetics, existing risk factors, psychosocial factors and methodological issues, although these are often not adequately taken into consideration. We conclude that there is a need to undertake more appropriately designed trials in specific clinical populations, controlling for additional lifestyle and risk factors, examining potential interactions with medications, and also establishing methods to increase compliance to dietary recommendations before specific nutrients can be widely prescribed for secondary prevention. Future research should also utilise techniques that provide a direct measure of atherosclerosis.

Trail running injury risk factors: a living systematic review

2022 ◽  
pp. bjsports-2021-104858
Author(s):  
Carel Viljoen ◽  
Dina C (Christa) Janse van Rensburg ◽  
Willem van Mechelen ◽  
Evert Verhagen ◽  
Bruno Silva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Injury Risk ◽  
Previous History ◽  
Future Research ◽  
Injury Incidence ◽  
Extrinsic Factors ◽  
Factors Associated ◽  
Injury Risk Factors ◽  
Trail Running

ObjectiveTo review and frequently update the available evidence on injury risk factors and epidemiology of injury in trail running.DesignLiving systematic review. Updated searches will be done every 6 months for a minimum period of 5 years.Data sourcesEight electronic databases were searched from inception to 18 March 2021.Eligibility criteriaStudies that investigated injury risk factors and/or reported the epidemiology of injury in trail running.ResultsNineteen eligible studies were included, of which 10 studies investigated injury risk factors among 2 785 participants. Significant intrinsic factors associated with injury are: more running experience, level A runner and higher total propensity to sports accident questionnaire (PAD-22) score. Previous history of cramping and postrace biomarkers of muscle damage is associated with cramping. Younger age and low skin phototypes are associated with sunburn. Significant extrinsic factors associated with injury are neglecting warm-up, no specialised running plan, training on asphalt, double training sessions per day and physical labour occupations. A slower race finishing time is associated with cramping, while more than 3 hours of training per day, shade as the primary mode of sun protection and being single are associated with sunburn. An injury incidence range 0.7–61.2 injuries/1000 hours of running and prevalence range 1.3% to 90% were reported. The lower limb was the most reported region of injury, specifically involving blisters of the foot/toe.ConclusionLimited studies investigated injury risk factors in trail running. Our review found eight intrinsic and nine extrinsic injury risk factors. This review highlighted areas for future research that may aid in designing injury risk management strategies for safer trail running participation.PROSPERO registration numberCRD42021240832.

scholarly journals UK Food Standards Agency α-linolenic acid workshop report

2002 ◽  
Vol 88 (5) ◽  
pp. 573-579 ◽  
Author(s):  
Peter Sanderson ◽  
Yvonne E. Finnegan ◽  
Christine M. Williams ◽  
Philip C. Calder ◽  
Graham C. Burdge ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Dietary Intake ◽  
Beneficial Effect ◽  
Linolenic Acid ◽  
Cardiovascular Health ◽  
Future Research ◽  
Chd Risk ◽  
Food Standards ◽  
Chd Risk Factors

The UK Food Standards Agency convened a group of expert scientists to review current research investigating whether n-3 polyunsaturated fatty acids (PUFA) from plant oils (α-linolenic acid; ALA) were as beneficial to cardiovascular health as the n-3 PUFA from the marine oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The workshop also aimed to establish priorities for future research. Dietary intake of ALA has been associated with a beneficial effect on CHD; however, the results from studies investigating the effects of ALA supplementation on CHD risk factors have proved equivocal. The studies presented as part of the present workshop suggested little, if any, benefit of ALA, relative to linoleic acid, on risk factors for cardiovascular disease; the effects observed with fish-oil supplementation were not replicated by ALA supplementation. There is a need, therefore, to first prove the efficacy of ALA supplementation on cardiovascular disease, before further investigating effects on cardiovascular risk factors. The workshop considered that a beneficial effect of ALA on the secondary prevention of CHD still needed to be established, and there was no reason to look further at existing CHD risk factors in relation to ALA supplementation. The workshop also highlighted the possibility of feeding livestock ALA-rich oils to provide a means of increasing the dietary intake in human consumers of EPA and DHA.

scholarly journals Recalibrating the risk of hamstring strain injury (HSI): A 2020 systematic review and meta-analysis of risk factors for index and recurrent hamstring strain injury in sport

2020 ◽  
Vol 54 (18) ◽  
pp. 1081-1088 ◽  
Author(s):  
Brady Green ◽  
Matthew N Bourne ◽  
Nicol van Dyk ◽  
Tania Pizzari
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Evidence Synthesis ◽  
Meta Analysis ◽  
Significant Risk ◽  
Older Age ◽  
Future Research ◽  
Hamstring Strain ◽  
Best Evidence Synthesis ◽  
History Of

ObjectiveTo systematically review risk factors for hamstring strain injury (HSI).DesignSystematic review update.Data sourcesDatabase searches: (1) inception to 2011 (original), and (2) 2011 to December 2018 (update). Citation tracking, manual reference and ahead of press searches.Eligibility criteria for selecting studiesStudies presenting prospective data evaluating factors associated with the risk of index and/or recurrent HSI.MethodSearch result screening and risk of bias assessment. A best evidence synthesis for each factor and meta-analysis, where possible, to determine the association with risk of HSI.ResultsThe 78 studies captured 8,319 total HSIs, including 967 recurrences, in 71,324 athletes. Older age (standardised mean difference=1.6, p=0.002), any history of HSI (risk ratio (RR)=2.7, p<0.001), a recent HSI (RR=4.8, p<0.001), previous anterior cruciate ligament (ACL) injury (RR=1.7, p=0.002) and previous calf strain injury (RR=1.5, p<0.001) were significant risk factors for HSI. From the best evidence synthesis, factors relating to sports performance and match play, running and hamstring strength were most consistently associated with HSI risk. The risk of recurrent HSI is best evaluated using clinical data and not the MRI characteristics of the index injury.Summary/conclusionOlder age and a history of HSI are the strongest risk factors for HSI. Future research may be directed towards exploring the interaction of risk factors and how these relationships fluctuate over time given the occurrence of index and recurrent HSI in sport is multifactorial.

scholarly journals Research Directions in the Study of Gaming-Related Escapism: a Commentary to Melodia, Canale, and Griffiths (2020)

2021 ◽  
Author(s):  
Alessandro Giardina ◽  
Vladan Starcevic ◽  
Daniel L. King ◽  
Adriano Schimmenti ◽  
Maria Di Blasi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Coping Strategy ◽  
Emotion Dysregulation ◽  
Avoidant Coping ◽  
Future Research ◽  
Assessment Instruments ◽  
Research Directions ◽  
Problematic Gaming

AbstractEscapism motivations and related processes (e.g., avoidance, dissociation, relaxation, and emotion dysregulation) have been identified as risk factors for problematic gaming. However, the escapism construct has often been poorly conceptualized and operationalized in assessment instruments. In their systematic review, Melodia et al. (2020) proposed that conceptualizing escapism as an avoidant coping strategy could provide a sound basis for further study of problematic gaming. In this commentary, we critically examine some terminological and conceptual issues in relation to escapism to guide future research.

scholarly journals Running related biomechanical risk factors for overuse injuries in distance runners: A systematic review considering injury specificity and the potentials for future research

2021 ◽  
Author(s):  
Steffen Willwacher ◽  
Markus Kurz ◽  
Johanna Robbin ◽  
Matthias Thelen ◽  
Joseph Hamill ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
English Language ◽  
Retrospective Studies ◽  
Overuse Injuries ◽  
Future Research ◽  
Comprehensive Overview ◽  
Eligibility Criteria ◽  
Starting Point ◽  
Data Collections

Objective To identify and evaluate the evidence of the most relevant running-related risk factors (RRRFs) for running-related overuse injuries (ROIs) and to suggest future research directions. Design Systematic review considering prospective and retrospective studies. (PROSPERO_ID: 236832) Data sources Pubmed. Connected Papers. The search was performed in February 2021. Eligibility criteria English language. Studies on participants whose primary sport is running addressing the risk for the seven most common ROIs and at least one kinematic, kinetic (including pressure measurements), or electromyographic RRRF. An RRRF needed to be identified in at least one prospective or two retrospective studies. Results Sixty-two articles fulfilled our eligibility criteria. Levels of evidence for specific ROIs ranged from conflicting to moderate evidence. Running populations and methods applied varied considerably between studies. While some RRRFs appeared for several ROIs, most RRRFs were specific for a particular ROI. The biomechanical measurements performed in many studies would have allowed for consideration of many more RRRFs than have been reported, highlighting a potential for more effective data usage in the future. Conclusion This study offers a comprehensive overview of RRRFs for the most common ROIs, which might serve as a starting point to develop ROI-specific risk profiles of individual runners. Future work should use macroscopic (big data) approaches involving long-term data collections in the real world and microscopic approaches involving precise stress calculations using recent developments in biomechanical modelling. However, consensus on data collection standards (including the quantification of workload and stress tolerance variables and the reporting of injuries) is warranted.

scholarly journals Literature Review: Health Impact of Coal Combustion Emissions in Power Plant on Adult Respiratory Systems

2021 ◽  
Vol 13 (2) ◽  
pp. 72
Author(s):  
Basuki Rachmat ◽  
Cita Fitria Puri ◽  
Elvi Sahara Lubis ◽  
Endang Krisnawaty ◽  
Lailatul Qomariyah ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Air Pollution ◽  
Power Plant ◽  
Lung Function ◽  
Literature Review ◽  
Respiratory System ◽  
Power Plants ◽  
Future Research ◽  
Respiratory Systems

Introduction: Coal-fired power plants contribute to air pollution emissions of nearly one-third of global SO2 , 14 % of NOx , and 5 % of PM2.5. This condition could worsen adults’ respiratory health who live close to power plants; WHO estimates that COPD and LRTI cause around 18% of premature deaths related to outdoor air pollution. This literature review aims to conduct a systematic review of the health impacts of coal-fired power plant emissions on adults’ respiratory systems and explore what risk factors lead to decreased lung status. Also, to answer how risk factors influence decreased lung function in adults’ respiratory system from coal-fired power plants’ emissions. Discussion: This study used a literature study method using an online database to of various research data sources with the same topic. The searching of articles was performed based on the inclusion criteria. From an initial collection of 468 articles, after screening and considering its feasibility, four articles were obtained to serve as material for the final systematic review. The literature review showed that there had been a change in lung function of respiratory system of adults due to long-term exposure to emissions from coal-fired power plants. Factors that influence decreased lung function in adults were NOx and SO2 exposure levels, residence distance, wind direction, age, and smoking status. Conclusion: Future research should focus on improving models for assessing exposure to NOx , SO2 , PM10 and PM2.5, considering age and smoking habits in evaluating lung function.

Lipid physiology and nutritional considerations in coronary heart disease

1991 ◽  
Vol 11 (10) ◽  
pp. 28-39 ◽  
Author(s):  
SA Hadley ◽  
L Saarmann
Keyword(s):  
Risk Factors ◽  
Dietary Intervention ◽  
Ideal Body Weight ◽  
Moderate Exercise ◽  
Dietary Regimen ◽  
Chd Risk ◽  
Ideal Body ◽  
Diet And Lifestyle ◽  
Prudent Diet ◽  
Overall Mortality

Most authorities recommend a prudent diet, moderate exercise, and the maintenance of ideal body weight Although lowering total cholesterol and LDL levels has been demonstrated to lower CHD risk, the results of major clinical trials do not indicate a reduction in overall mortality. CHD is a complicated, multifaceted disease. In addition to recognized risk factors, there may be many more that have yet to be identified. With this in mind, it is important that the nurse does not place unmitigated stress on patients to make radical changes in diet and lifestyle. Moderation is the key in striking a balance between a prudent dietary regimen and the stress that such a regimen might induce. It would be wrong to lead patients to believe that dietary intervention will provide a panacea for all their ills. The adoption of a prudent diet can reduce the incidence of CHD morbidity. The benefits of lowering serum cholesterol may lie more in overall physical and psychologic fitness rather than longevity.

Mindfulness-Based Interventions and Cardiovascular Risk Factors in US Racial/Ethnic Minority Populations: A Systematic Review of Implementation Data to Address Health Disparities

2021 ◽  
Author(s):  
Tonya Faye Sanchez ◽  
E. Karina Santamaria ◽  
Dana Rubenstein ◽  
Judson Brewer ◽  
Don Operario
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Contextual Factors ◽  
Cardiovascular Disease Risk ◽  
The United States ◽  
Future Research ◽  
Minority Populations ◽  
Cvd Risk

Abstract Cardiovascular disease (CVD) is a persistent public health challenge. Mindfulness-based Interventions (MBI) have been researched for CVD risk factors, though their effectiveness, generalizability, and potential for implementation to racial and ethnic minorities remain unclear. This review examines studies of MBI on CVD risk for characteristics of and variations in implementation (i.e., intervention design, delivery, uptake, and contextual factors) and analyzes potential barriers and challenges to implementation. A systematic review in February 2020 identified 30 studies from 5 databases and hand searches. Included studies were randomized controlled trials testing meditation or mindfulness-based interventions against any control to measure change or improvement in cardiovascular health measures or risk behaviors in adults living in the United States or territories. Analysis of the implementation characteristics and contextual factors of included studies was conducted using the Oxford Implementation Index. Thirty reports from 26 distinct trials were selected for inclusion, examining outcomes related to diet (k [number of studies] = 13), smoking (k = 11), obesity (k = 9), exercise (k = 4), diabetes (k = 3), and blood lipids (k = 2). All studies were published between 2011 and 2020 and correspond to early stages of research. As such, numerous limitations and implementation characteristics with potential consequence for CVD risk disparities were reported. This review outlines several potential targets for future research. Based on reported findings across all included studies, MBI could be of benefit for cardiovascular disease risk. Further research is needed to explore acceptability, feasibility, and effectiveness in minority populations.

scholarly journals Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy

2012 ◽  
Vol 97 (12) ◽  
pp. 1019-1026 ◽  
Author(s):  
Stephen Franklin Weng ◽  
Sarah A Redsell ◽  
Judy A Swift ◽  
Min Yang ◽  
Cristine P Glazebrook
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Weight Gain ◽  
Meta Analysis ◽  
Childhood Overweight ◽  
Overweight And Obesity ◽  
Future Research ◽  
First Year ◽  
First Year Of Life ◽  
Infant Birth

ObjectiveTo determine risk factors for childhood overweight that can be identified during the first year of life to facilitate early identification and targeted intervention.DesignSystematic review and meta-analysis.Search strategyElectronic database search of MEDLINE, EMBASE, PubMed and CAB Abstracts.Eligibility criteriaProspective observational studies following up children from birth for at least 2 years.ResultsThirty prospective studies were identified. Significant and strong independent associations with childhood overweight were identified for maternal pre-pregnancy overweight, high infant birth weight and rapid weight gain during the first year of life. Meta-analysis comparing breastfed with non-breastfed infants found a 15% decrease (95% CI 0.74 to 0.99; I2=73.3%; n=10) in the odds of childhood overweight. For children of mothers smoking during pregnancy there was a 47% increase (95% CI 1.26 to 1.73; I2=47.5%; n=7) in the odds of childhood overweight. There was some evidence associating early introduction of solid foods and childhood overweight. There was conflicting evidence for duration of breastfeeding, socioeconomic status at birth, parity and maternal marital status at birth. No association with childhood overweight was found for maternal age or education at birth, maternal depression or infant ethnicity. There was inconclusive evidence for delivery type, gestational weight gain, maternal postpartum weight loss and ‘fussy’ infant temperament due to the limited number of studies.ConclusionsSeveral risk factors for both overweight and obesity in childhood are identifiable during infancy. Future research needs to focus on whether it is clinically feasible for healthcare professionals to identify infants at greatest risk.

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