Low Carbohydrate, High Fat Diet Increases C-Reactive Protein during Weight Loss

2007 ◽  
Vol 26 (2) ◽  
pp. 163-169 ◽  
Author(s):  
Janet W. Rankin ◽  
Abigail D. Turpyn
Keyword(s):  
Weight Loss ◽  
High Fat Diet ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein ◽  
Low Carbohydrate

Nutrient-Adjusted High-Fat Diet is Associated with Absence of Periepididymal Adipose Tissue Inflammation: Is there a Link with Adequate Micronutrient Levels?

2013 ◽  
Vol 83 (5) ◽  
pp. 299-310 ◽  
Author(s):  
Monica Yamada ◽  
Marina Maintinguer Norde ◽  
Maria C. Borges ◽  
Tatiane Mieko de Meneses Fujii ◽  
Patrícia Silva Jacob ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
C Reactive Protein ◽  
High Fat ◽  
Tissue Inflammation ◽  
Reactive Protein ◽  
Tnf Α

The aim of this study was to investigate the real impact of dietary lipids on metabolic and inflammatory response in rat white adipose tissue. Male healthy Wistar rats were fed ad libitum with a control diet (CON, n=12) or with an adjusted high-fat diet (HFD, n=12) for 12 weeks. Oral glucose and insulin tolerance tests were performed during the last week of the protocol. Plasma fatty acid, lipid profile, body adiposity, and carcass chemical composition were analyzed. Plasma concentration of leptin, adiponectin, C-reactive protein (CRP), TNF-α, IL-6, and monocyte chemotactic protein (MCP-1) was measured. Periepididymal adipose tissue was employed to evaluate TNF-α, MCP-1, and adiponectin gene expression as well as NF-κB pathway and AKT proteins. Isocaloric intake of the adjusted HFD did not induce hyperphagia, but promoted an increase in periepididymal (HFD = 2.94 ± 0.77 vs. CON = 1.99 ± 0.26 g/100 g body weight, p = 0.01) and retroperitoneal adiposity (HFD = 3.11 ± 0.81 vs. CON = 2.08 ± 0.39 g/100 g body weight, p = 0.01) and total body lipid content (HFD = 105.3 ± 20.8 vs. CON = 80.5 ± 7.6 g carcass, p = 0.03). Compared with control rats, HFD rats developed glucose intolerance (p=0.01), dyslipidemia (p = 0.02) and exhibited higher C-reactive protein levels in response to the HFD (HFD = 1002 ± 168 vs. CON = 611 ± 260 ng/mL, p = 0.01). The adjusted HFD did not affect adipokine gene expression or proteins involved in inflammatory signaling, but decreased AKT phosphorylation after insulin stimulation in periepididymal adipose tissue (p = 0.01). In this study, nutrient-adjusted HFD did not induce periepididymal adipose tissue inflammation in rats, suggesting that the composition of HFD differently modulates inflammation in rats, and adequate micronutrient levels may also influence inflammatory pathways.

scholarly journals Aggravated osteoarthritis development in mice transgenic for human C-reactive protein on a high fat diet

2016 ◽  
Vol 24 ◽  
pp. S375
Author(s):  
A. Kozijn ◽  
F. van den Ham ◽  
F. Casbas ◽  
C. Hodgman ◽  
J. Bacardit ◽  
...  
Keyword(s):  
High Fat Diet ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein

Sequential Diets and Weight loss: Including a Low Carbohydrate High Fat Diet With and Without Time Restricted Feeding

Nutrition ◽  
2021 ◽  
pp. 111393
Author(s):  
Rebecca A.G. Christensen ◽  
Sasha High ◽  
Sean Wharton ◽  
Elham Kamran ◽  
Maral Dehlehhosseinzadeh ◽  
...  
Keyword(s):  
Weight Loss ◽  
High Fat Diet ◽  
Restricted Feeding ◽  
High Fat ◽  
Low Carbohydrate

scholarly journals Low-Carbohydrate High-Fat Diet and Exercise: Effect of a 10-Week Intervention on Body Composition and CVD Risk Factors in Overweight and Obese Women—A Randomized Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 110
Author(s):  
Thorhildur Ditta Valsdottir ◽  
Bente Øvrebø ◽  
Thea Martine Falck ◽  
Sigbjørn Litleskare ◽  
Egil Ivar Johansen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Loss ◽  
Body Composition ◽  
High Fat Diet ◽  
Normal Diet ◽  
Obese Women ◽  
High Fat ◽  
Post Intervention ◽  
Diet And Exercise ◽  
Low Carbohydrate

We assessed the effect of weight-loss induced with a low-carbohydrate-high-fat diet with and without exercise, on body-composition, cardiorespiratory fitness and cardiovascular risk factors. A total of 57 overweight and obese women (age 40 ± 3.5 years, body mass index 31.1 ± 2.6 kg∙m−2) completed a 10-week intervention using a low-carbohydrate-high-fat diet, with or without interval exercise. An equal deficit of 700 kcal∙day−1 was prescribed, restricting diet only, or moderately restricting diet and adding exercise, producing four groups; normal diet (NORM); low-carbohydrate-high-fat diet (LCHF); normal diet and exercise (NORM-EX); and low-carbohydrate-high-fat diet and exercise (LCHF-EX). Linear Mixed Models were used to assess between-group differences. The intervention resulted in an average 6.7 ± 2.5% weight-loss (p < 0.001). Post-intervention % fat was lower in NORM-EX than NORM (40.0 ± 4.2 vs. 43.5 ± 3.5%, p = 0.024). NORM-EX reached lower values in total cholesterol than NORM (3.9 ± 0.6 vs. 4.7 ± 0.7 mmol/L, p = 0.003), and LCHF-EX (3.9 ± 0.6 vs. 4.9 ± 1.1 mmol/L, p = 0.004). Post intervention triglycerides levels were lower in NORM-EX than NORM (0.87 ± 0.21 vs. 1.11 ± 0.34 mmol/L, p = 0.030). The low-carbohydrate-high-fat diet had no superior effect on body composition, V˙O2peak or cardiovascular risk factors compared to a normal diet, with or without exercise. In conclusion, the intervention decreased fat mass, but exercise improved body composition and caused the most favorable changes in total cholesterol and triglycerides in the NORM-EX. Exercise increased cardiorespiratory fitness, regardless of diet.

scholarly journals Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet

2019 ◽  
Vol 27 (1) ◽  
pp. 118-128 ◽  
Author(s):  
A.E. Kozijn ◽  
M.T. Tartjiono ◽  
S. Ravipati ◽  
F. van der Ham ◽  
D.A. Barrett ◽  
...  
Keyword(s):  
High Fat Diet ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein

scholarly journals A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic and Atherogenic Disorders Related to Obesity in White Albino Rats

2013 ◽  
Vol 5 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Enas N. Morgan ◽  
Husam M. Edrees
Keyword(s):  
High Fat Diet ◽  
Bleeding Time ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Albino Rats ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein ◽  
Group I ◽  
Insignificant Correlation

A strong link between obesity, hypercoagulability and thrombogenesis, had been recognized. Chemerin is a novel adipokine that has been activated by the coagulation process and suggested to play an important role in the pathogenesis of metabolic syndrome. We aimed to identify the possible relationship between chemerin levels and haemostatic changes in the high fat diet (HFD) fed rats. A total number of 20 adult male albino rats were divided into two groups of 10 rats each. Group I, rats served as controls; Group II: rats received high fat diet (58% fat) for 8 weeks. In both groups, serum levels of glucose, insulin, chemerin, total cholesterol (TC), triglycerides (TG), HDL, LDL were measured. As well as the bleeding time (BT), whole blood clotting time (WBCT), Prothrombin time (PT), Activated partial thromboplastin time (aPTT), fibrinogen level and C- reactive protein (CRP) were measured. Moreover HOMA-IR was calculated for both groups. The results of the current study revealed that chemerine level increased significantly in the HFD- fed rats (p< 0.001). In addition, a significant positive correlation was detected for the serum chemerin levels with body weight, insulin levels, HOMA-IR, the levels of TC, TG, LDL and CRP, while a significant negative correlation was found between its levels and serum levels of HDL. Moreover chemerin was correlated negatively with the BT, WBCT, PT, aPTT and positively correlated with plasma fibrinogen, while there was insignificant correlation with platelet count. These results suggested that chemerin may represent a novel link between obesity and its haemostatic and atherogenic complication.

scholarly journals Associations between Pre-Bariatric High-Sensitivity C-Reactive Protein and Post-Surgery Outcomes

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 721
Author(s):  
Tannaz Jamialahmadi ◽  
Mohsen Nematy ◽  
Simona Bo ◽  
Valentina Ponzo ◽  
Ali Jangjoo ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Success Rate ◽  
Liver Stiffness ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Post Surgery ◽  
Hs Crp

Background: Obesity is a chronic inflammatory condition associated with increased circulating levels of C-reactive protein (CRP). Bariatric surgery has been reported to be effective in improving both inflammatory and liver status. Our aims were to elucidate the relationships between pre-surgery high sensitivity-CRP (hs-CRP) values and post-surgery weight loss and liver steatosis and fibrosis in patients with severe obesity undergoing Roux-en-Y gastric bypass. Methods: We conducted an observational prospective study on 90 individuals with morbid obesity, who underwent gastric bypass. Anthropometric indices, laboratory assessment (lipid panel, glycemic status, liver enzymes, and hs-CRP), liver stiffness and steatosis were evaluated at baseline and 6-months after surgery. Results: There was a significant post-surgery reduction in all the anthropometric variables, with an average weight loss of 33.93 ± 11.79 kg; the mean percentage of total weight loss (TWL) was 27.96 ± 6.43%. Liver elasticity was significantly reduced (from 6.1 ± 1.25 to 5.42 ± 1.52 kPa; p = 0.002), as well as liver aminotransferases, nonalcoholic fatty liver disease fibrosis score (NFS) and the grade of steatosis. Serum hs-CRP levels significantly reduced (from 9.26 ± 8.45 to 3.29 ± 4.41 mg/L; p < 0.001). The correlations between hs-CRP levels and liver fibrosis (elastography), steatosis (ultrasonography), fibrosis-4 index, NFS, and surgery success rate were not significant. Regression analyses showed that serum hs-CRP levels were not predictive of liver status and success rate after surgery in both unadjusted and adjusted models. Conclusions: In patients with morbid obesity, bariatric surgery caused a significant decrease in hs-CRP levels, liver stiffness and steatosis. Baseline hs-CRP values did not predict the weight-loss success rate and post-surgery liver status.

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