Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3

2017 ◽  
Vol 24 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Asmaa M.S. Gomaa ◽  
Ebtihal A. Abd El-Aziz
Keyword(s):  
Vitamin D ◽  
Weight Gain ◽  
High Fat Diet ◽  
Caspase 3 ◽  
Interleukin 10 ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein

Nutrient-Adjusted High-Fat Diet is Associated with Absence of Periepididymal Adipose Tissue Inflammation: Is there a Link with Adequate Micronutrient Levels?

2013 ◽  
Vol 83 (5) ◽  
pp. 299-310 ◽  
Author(s):  
Monica Yamada ◽  
Marina Maintinguer Norde ◽  
Maria C. Borges ◽  
Tatiane Mieko de Meneses Fujii ◽  
Patrícia Silva Jacob ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Weight ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
C Reactive Protein ◽  
High Fat ◽  
Tissue Inflammation ◽  
Reactive Protein ◽  
Tnf Α

The aim of this study was to investigate the real impact of dietary lipids on metabolic and inflammatory response in rat white adipose tissue. Male healthy Wistar rats were fed ad libitum with a control diet (CON, n=12) or with an adjusted high-fat diet (HFD, n=12) for 12 weeks. Oral glucose and insulin tolerance tests were performed during the last week of the protocol. Plasma fatty acid, lipid profile, body adiposity, and carcass chemical composition were analyzed. Plasma concentration of leptin, adiponectin, C-reactive protein (CRP), TNF-α, IL-6, and monocyte chemotactic protein (MCP-1) was measured. Periepididymal adipose tissue was employed to evaluate TNF-α, MCP-1, and adiponectin gene expression as well as NF-κB pathway and AKT proteins. Isocaloric intake of the adjusted HFD did not induce hyperphagia, but promoted an increase in periepididymal (HFD = 2.94 ± 0.77 vs. CON = 1.99 ± 0.26 g/100 g body weight, p = 0.01) and retroperitoneal adiposity (HFD = 3.11 ± 0.81 vs. CON = 2.08 ± 0.39 g/100 g body weight, p = 0.01) and total body lipid content (HFD = 105.3 ± 20.8 vs. CON = 80.5 ± 7.6 g carcass, p = 0.03). Compared with control rats, HFD rats developed glucose intolerance (p=0.01), dyslipidemia (p = 0.02) and exhibited higher C-reactive protein levels in response to the HFD (HFD = 1002 ± 168 vs. CON = 611 ± 260 ng/mL, p = 0.01). The adjusted HFD did not affect adipokine gene expression or proteins involved in inflammatory signaling, but decreased AKT phosphorylation after insulin stimulation in periepididymal adipose tissue (p = 0.01). In this study, nutrient-adjusted HFD did not induce periepididymal adipose tissue inflammation in rats, suggesting that the composition of HFD differently modulates inflammation in rats, and adequate micronutrient levels may also influence inflammatory pathways.

scholarly journals Aggravated osteoarthritis development in mice transgenic for human C-reactive protein on a high fat diet

2016 ◽  
Vol 24 ◽  
pp. S375
Author(s):  
A. Kozijn ◽  
F. van den Ham ◽  
F. Casbas ◽  
C. Hodgman ◽  
J. Bacardit ◽  
...  
Keyword(s):  
High Fat Diet ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein

scholarly journals Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet

2019 ◽  
Vol 27 (1) ◽  
pp. 118-128 ◽  
Author(s):  
A.E. Kozijn ◽  
M.T. Tartjiono ◽  
S. Ravipati ◽  
F. van der Ham ◽  
D.A. Barrett ◽  
...  
Keyword(s):  
High Fat Diet ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein

scholarly journals A Possible Role for Chemerin; a Novel Adipokine in the Haemostatic and Atherogenic Disorders Related to Obesity in White Albino Rats

2013 ◽  
Vol 5 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Enas N. Morgan ◽  
Husam M. Edrees
Keyword(s):  
High Fat Diet ◽  
Bleeding Time ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Albino Rats ◽  
C Reactive Protein ◽  
High Fat ◽  
Reactive Protein ◽  
Group I ◽  
Insignificant Correlation

A strong link between obesity, hypercoagulability and thrombogenesis, had been recognized. Chemerin is a novel adipokine that has been activated by the coagulation process and suggested to play an important role in the pathogenesis of metabolic syndrome. We aimed to identify the possible relationship between chemerin levels and haemostatic changes in the high fat diet (HFD) fed rats. A total number of 20 adult male albino rats were divided into two groups of 10 rats each. Group I, rats served as controls; Group II: rats received high fat diet (58% fat) for 8 weeks. In both groups, serum levels of glucose, insulin, chemerin, total cholesterol (TC), triglycerides (TG), HDL, LDL were measured. As well as the bleeding time (BT), whole blood clotting time (WBCT), Prothrombin time (PT), Activated partial thromboplastin time (aPTT), fibrinogen level and C- reactive protein (CRP) were measured. Moreover HOMA-IR was calculated for both groups. The results of the current study revealed that chemerine level increased significantly in the HFD- fed rats (p< 0.001). In addition, a significant positive correlation was detected for the serum chemerin levels with body weight, insulin levels, HOMA-IR, the levels of TC, TG, LDL and CRP, while a significant negative correlation was found between its levels and serum levels of HDL. Moreover chemerin was correlated negatively with the BT, WBCT, PT, aPTT and positively correlated with plasma fibrinogen, while there was insignificant correlation with platelet count. These results suggested that chemerin may represent a novel link between obesity and its haemostatic and atherogenic complication.

scholarly journals 25-Hydroxycholecalciferol Concentration Is Associated with Protein Loss and Serum Albumin Level during the Acute Phase of Burn Injury

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2780
Author(s):  
Andrzej Krajewski ◽  
Krzysztof Piorun ◽  
Dominika Maciejewska-Markiewicz ◽  
Marta Markowska ◽  
Karolina Skonieczna-Żydecka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Protein Concentration ◽  
Serum Albumin Level ◽  
Burn Injury ◽  
Albumin Level ◽  
Albumin Concentration ◽  
Transaminase Activity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
25 Hydroxycholecalciferol

Background: Burned patients have an increased need for vitamin D supply related to the maintenance of calcium–phosphate homeostasis and the regulation of cell proliferation/differentiation. This study aimed to analyze the concentration of 25-hydroxycholecalciferol and its relationship with severe condition after burn injury. Methods: 126 patients were enrolled in the study. Patients were qualified due to thermal burns—over 10% of total body surface area. On the day of admission, the following parameters were assessed: 25-hydroxycholecalciferol concentration, total protein concentration, albumin concentration, aspartate transaminase activity, alanine transaminase activity, albumin concentration, creatinine concentration, c-reactive protein concentration, procalcitonin concentration, and interleukin-6 concentration. Results: Almost all patients (92%) in the study group had an improper level of vitamin D (<30 ng/mL), with the average of 11.6 ± 10.7 ng/mL; 17.5% of patients had levels of vitamin D below the limit of determination—under 3 ng/mL. The study showed that there are several factors which correlated with vitamin D concentration during the acute phase of burn injury, including: total protein (r = 0.42, p < 0.01), albumin, (r = 0.62, p < 0.01), percentage of body burns (r = 0.36, p < 0.05), aspartate aminotransferase (r = 0.21, p < 0.05), and c-reactive protein (r = 0.22, p < 0.05). We did not find any significant correlation between vitamin D concentration and body mass index. Conclusions: The burn injury has an enormous impact on the metabolism and the risk factors of the deficiency for the general population (BMI) have an effect on burned patients. Our study showed that concentration of 25-hydroxycholecalciferol is strongly correlated with serum albumin level, even more than total burn surface area and burn degrees as expected. We suspect that increased supplementation of vitamin D should be based on albumin level and last until albumin levels are balanced.

scholarly journals Partial Deficiency of Zfp217 Resists High-Fat Diet-Induced Obesity by Increasing Energy Metabolism in Mice

2021 ◽  
Vol 22 (10) ◽  
pp. 5390
Author(s):  
Qianhui Zeng ◽  
Nannan Wang ◽  
Yaru Zhang ◽  
Yuxuan Yang ◽  
Shuangshuang Li ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Weight Gain ◽  
Insulin Sensitivity ◽  
Energy Metabolism ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Chow Diet ◽  
High Fat ◽  
Glycolipid Metabolism ◽  
Partial Deficiency

Obesity-induced adipose tissue dysfunction and disorders of glycolipid metabolism have become a worldwide research priority. Zfp217 plays a crucial role in adipogenesis of 3T3-L1 preadipocytes, but about its functions in animal models are not yet clear. To explore the role of Zfp217 in high-fat diet (HFD)-induced obese mice, global Zfp217 heterozygous knockout (Zfp217+/−) mice were constructed. Zfp217+/− mice and Zfp217+/+ mice fed a normal chow diet (NC) did not differ significantly in weight gain, percent body fat mass, glucose tolerance, or insulin sensitivity. When challenged with HFD, Zfp217+/− mice had less weight gain than Zfp217+/+ mice. Histological observations revealed that Zfp217+/− mice fed a high-fat diet had much smaller white adipocytes in inguinal white adipose tissue (iWAT). Zfp217+/− mice had improved metabolic profiles, including improved glucose tolerance, enhanced insulin sensitivity, and increased energy expenditure compared to the Zfp217+/+ mice under HFD. We found that adipogenesis-related genes were increased and metabolic thermogenesis-related genes were decreased in the iWAT of HFD-fed Zfp217+/+ mice compared to Zfp217+/− mice. In addition, adipogenesis was markedly reduced in mouse embryonic fibroblasts (MEFs) from Zfp217-deleted mice. Together, these data indicate that Zfp217 is a regulator of energy metabolism and it is likely to provide novel insight into treatment for obesity.

Sign in / Sign up

Export Citation Format

Share Document