The Impact of Micropapillary Component Ratio on the Prognosis of Patients With Invasive Micropapillary Breast Carcinoma

2018 ◽  
Vol 33 (1) ◽  
pp. 31-39
Author(s):  
Cemal Kaya ◽  
Ramazan Uçak ◽  
Emre Bozkurt ◽  
Sinan Ömeroğlu ◽  
Kinyas Kartal ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Component Ratio ◽  
The Impact ◽  
Micropapillary Component

scholarly journals Long-Range Transport Influence on Key Chemical Components of PM2.5 in the Seoul Metropolitan Area, South Korea, during the Years 2012–2016

Atmosphere ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 48 ◽  
Author(s):  
Changhan Bae ◽  
Byeong-Uk Kim ◽  
Hyun Cheol Kim ◽  
Chul Yoo ◽  
Soontae Kim
Keyword(s):  
Long Range ◽  
Metropolitan Area ◽  
Inorganic Ions ◽  
Long Range Transport ◽  
Chemical Components ◽  
Component Ratio ◽  
Seoul Metropolitan Area ◽  
Range Transport ◽  
The Impact ◽  
Pm2.5 Concentration

This study identified the key chemical components based on an analysis of the seasonal variations of ground level PM2.5 concentrations and its major chemical constituents (sulfate, nitrate, ammonium, organic carbon, and elemental carbon) in the Seoul Metropolitan Area (SMA), over a period of five years, ranging from 2012 to 2016. It was found that the mean PM2.5 concentration in the SMA was 33.7 μg/m3, while inorganic ions accounted for 53% of the total mass concentration. The component ratio of inorganic ions increased by up to 61%–63% as the daily mean PM2.5 concentration increased. In spring, nitrate was the dominant component of PM2.5, accounting for 17%–32% of the monthly mean PM2.5 concentrations. In order to quantify the impact of long-range transport on the SMA PM2.5, a set of sensitivity simulations with the community multiscale air-quality model was performed. Results show that the annual averaged impact of Chinese emissions on SMA PM2.5 concentrations ranged from 41% to 44% during the five years. Chinese emissions’ impact on SMA nitrate ranged from 50% (winter) to 67% (spring). This result exhibits that reductions in SO2 and NOX emissions are crucial to alleviate the PM2.5 concentration. It is expected that NOX emission reduction efforts in China will help decrease PM2.5 concentrations in the SMA.

scholarly journals The impact of stage and histology on the long-term clinical course of 163,808 patients with breast carcinoma

Cancer ◽  
1996 ◽  
Vol 77 (8) ◽  
pp. 1459-1464 ◽  
Author(s):  
John W. Gamel ◽  
John S. Meyer ◽  
Eric Feuer ◽  
Barry A. Miller
Keyword(s):  
Breast Carcinoma ◽  
Clinical Course ◽  
The Impact

scholarly journals DEVELOPMENT OF IMPACT RESISTANT POLYMER COMPOSITION ABS/PC FOR AUTOMOTIVE INDUSTRY

2021 ◽  
Vol 6 (2) ◽  
pp. 80-88
Author(s):  
I. Yagrushkina ◽  
M. Dyul'dina ◽  
A. Nogachev ◽  
K. Yakunin
Keyword(s):  
Automotive Industry ◽  
Raw Materials ◽  
Polymer Composite Material ◽  
Polymer Materials ◽  
Polymer Composition ◽  
Component Ratio ◽  
Mixed Composition ◽  
Materials Used ◽  
The Cost ◽  
The Impact

Polymer and composite materials are becoming more and more widely used in the Russian automotive industry. The Russian market of polymer materials for automotive components is characterized by an insufficiently developed production of some types of such materials. And, as a result, the use of imported materials. Styrene plastics are one of the innovative materials for the automotive industry. Using them in a car makes the product more attractive to customers. The use of this type of plastics allows to create a new look for the car. This applies to both the interior and exterior. The aim of this work is to develop the composition of a polymer composition based on ABS plastic from domestic raw materials. In addition, the new mixed composition should replace imported mixed compositions or contain a minimum amount of imported components of the composition, which will significantly reduce the cost of products and accordingly the car. The article analyzes the polymer materials used in the automotive industry. The disadvantages of using these materials in their pure form are revealed. The selection of the components of the composition of the impact-resistant material with the development of its formulation has been made. The composition of an impact-resistant polymer composition based on ABS plastic and PC has been developed, which is not inferior in terms of the complex of properties to the imported material. The influence of the composition of ABS-plastic, various grades of polycarbonate, their ratio in the polymer composite material on the physical, mechanical and technological properties of the obtained composition has been investigated. It is shown that the best set of properties is possessed by a material based on 2020-30 ABS-plastic and PC-3S polycarbonate with a component ratio of 70%:30%.

scholarly journals Survival Outcomes After Breast-Conserving Therapy Compared With Mastectomy for Patients With Early-Stage Invasive Micropapillary Carcinoma of the Breast: A SEER Population-Based Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Song Wang ◽  
Yiyuan Zhang ◽  
Fangxu Yin ◽  
Xiaohong Wang ◽  
Zhenlin Yang
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Breast Carcinoma ◽  
Early Stage ◽  
Survival Outcomes ◽  
Invasive Micropapillary Carcinoma ◽  
Seer Database ◽  
Kaplan Meier ◽  
The Impact ◽  
Mastectomy Group

BackgroundInvasive micropapillary breast carcinoma (IMPC) is a relatively rare pathological type of invasive breast cancer. Little is currently known on the efficacy and safety of breast-conserving treatment (BCT, lumpectomy plus postsurgical radiation) compared with mastectomy in women diagnosed with early-stage IMPC. Accordingly, we sought to investigate the long-term prognostic differences between BCT and mastectomy in patients with T1-3N0-3M0 invasive micropapillary breast carcinoma using data from the Surveillance, Epidemiology, and End Results (SEER) database.Materials and MethodsWe retrospectively analyzed 1,203 female patients diagnosed with early-stage IMPC between 2004 and 2015 from the SEER database. The impact of different surgical approaches on patient prognosis was assessed by the Kaplan-Meier method and Cox proportional risk models.ResultsA total of 609 and 594 patients underwent mastectomy and BCT, respectively. Compared with patients who underwent a mastectomy, patients in the BCT group were older and had lower tumor diameters, lower rates of lymph nodes metastasis, and higher rates of ER receptor positivity and PR receptor positivity (p < 0.05). Kaplan-Meier plots showed that the overall survival (OS) and breast cancer-specific survival (BCSS) were higher in the BCT group than in the mastectomy group. In subgroup analysis, patients with T2 stage in the BCT group had better OS than the mastectomy group. Multivariate analysis showed no statistical difference in OS and BCSS for patients in the mastectomy group compared with the BCT group (hazard ratio (HR) = 0.727; 95% confidence interval (95% CI) 0.369–1.432, p = 0.357; HR = 0.762; 95% CI 0.302–1.923, p = 0.565; respectively). During the multivariate analysis and stratifying for the T stage, a better OS was found for patients with T2 stage in the BCT group than the mastectomy group (HR = 0.333, 95% CI: 0.149–0.741, p = 0.007). There was no significant difference in OS for patients with T1 and T3 stages between the BCT and mastectomy groups (p > 0.05).ConclusionIn women with early-stage IMPC, BCT was at least equivalent to mastectomy in terms of survival outcomes. When both procedures are feasible, BCT should be recommended as the standard surgical treatment, especially for patients with T2 disease.

scholarly journals Clinical profile and management of breast cancer in women in a rural based tertiary care hospital our experience

2017 ◽  
Vol 4 (2) ◽  
pp. 697
Author(s):  
Ambikavathy Mohan ◽  
Chandan Kumar
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Carcinoma ◽  
Health Care Providers ◽  
Diagnostic Methods ◽  
Care Hospital ◽  
Care Providers ◽  
Increased Risk ◽  
The Impact ◽  
Women In India

Background: Breast cancer is the second most common cancer among women in India and accounts for 7% of global burden of breast cancer and one-fifth of all cancers among women in India. The risk factors are related to lifestyle, early menarche, nulli parity, prolonged use of oral contraceptive pills, hormone replacement therapy, not breast‑feeding, alcohol, obesity, lack of exercise, and induced abortion. A woman who attains menopause after fifty five years of age has an increased risk of ovarian, breast, and uterine cancers. The risk is greater if a woman also began menstruating before twelve years of age. A longer exposure to estrogen increases a woman’s risk of breast cancers.Methods: This is a prospective observational study, conducted in the department of surgery, between December 2013 and June 2015(2 years). Patients diagnosed as breast carcinoma and admitted in surgical wards were included, Data pertaining to demography, clinical and pathological tumor profile, and treatment details were collected prospectively for each patient based on patient interviews and medical records. To analyse the Prevalence of breast cancer, clinical presentation, risk factors, diagnostic methods, treatment protocols, difference between pre and post‑menopausal breast cancer women regarding risk factors, assess the impact of treatment given and women’s knowledge about breast cancer.Results: A total number of 25 cases of breast carcinoma based on detailed history, clinical examination, Trucut biopsy, ultrasonography breast and axilla, ultrasound abdomen, mammogram and chest x-ray were analysed. All of them received three cycles of anterior chemotherapy consisting of 5- Fluorouracil 500 mg/m2,Adriamycin 50 mg/m2 Cyclophosphamide 80 mg/m2 (FAC regimen) administered intravenously followed by modified radical mastectomy. There were no recurrences seen on follow up till date.Conclusions: Late stage at presentation of breast cancer is a challenge to the health care providers. Cancer awareness programmes, multidisciplinary approach and evidence‑based strategies for early detection and effective management of the disease can go a long way in prevention.

The impact of molecular subtypes of breast carcinoma on response to neo-adjuvant chemotherapy in Asian population

The Breast ◽  
2019 ◽  
Vol 44 ◽  
pp. S75-S76
Author(s):  
I.U.I. Nasir ◽  
M. Salim ◽  
O. Shakeel ◽  
M. Abubakar ◽  
A. Pervaiz ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Breast Carcinoma ◽  
Molecular Subtypes ◽  
Asian Population ◽  
Neo Adjuvant Chemotherapy ◽  
The Impact

Facility Size and Its Influence on the Presentation and Treatment of in Situ Breast Carcinoma in the United States

2012 ◽  
Vol 78 (7) ◽  
pp. 766-769 ◽  
Author(s):  
Jennifer Salotto ◽  
Jack Sariego
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Breast Carcinoma ◽  
Breast Conservation ◽  
The United States ◽  
Breast Cancer Patients ◽  
Cancer Centers ◽  
Cancer Data ◽  
The Impact

Studies have suggested that outcomes from breast cancer are improved when treatment is rendered at high-volume teaching centers. The current study was undertaken to examine the impact of facility type on the presentation and treatment of “early” breast carcinoma across the United States. Breast cancer data were available from the American College of Surgeons National Cancer Database. The cohort consisted of 305,358 patients presenting with in situ cancers and no prior treatment from 2000 to 2008. Data were stratified by type of treatment facility, “invasive” versus “noninvasive” nature of the tumor, and treatment performed. Only 15 per cent of patients presented to community cancer centers (CCCs). Despite this, a greater percentage presented with invasive disease at CCCs (82.1%) compared with comprehensive community cancer centers (CCCCs; 80%) or teaching/research facilities (T/Rs; 70.2%). In examining the in situ cohort, a higher percentage of patients at CCCs were treated with breast conservation than at CCCCs or T/Rs. Although small, these differences were statistically significant. These data do not support the contention that only “early” cases of breast cancer present and are treated at community centers. In early breast cancer, patients are as likely to receive state-of-the-art treatment at a CCC as they are at a T/R.

Impact of mammographic screening in staging, treatment and prognosis of breast cancer: Early assessment

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10537-10537
Author(s):  
A. Lluch ◽  
I. Chirivella ◽  
A. Insa ◽  
F. Martinez-Ruiz ◽  
A. Santaballa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Cancer Patients ◽  
Breast Conserving Surgery ◽  
Tumor Stage ◽  
Mammographic Screening ◽  
Invasive Breast Carcinoma ◽  
Breast Cancer Patients ◽  
Early Assessment ◽  
The Impact

10537 Background: The use of breast cancer mammographic screening (MS) leads to early detection and has been shown to reduce the mortality rate and to increase the proportion of breast-conserving surgery. The aim of this study is to analyze the impact of mammography in the staging, treatment and prognosis of breast carcinoma. Methods: In 1993, a population-based mammographic screening among women aged from 45 to 70 years was introduced in the community of Valencia. We examined the effects of this MS program by the comparison of two populations. The first one included all the women with screen-detected invasive breast carcinoma between 1993 and 2002 in the community of Valencia. The second one was comprised of all the women with invasive breast carcinoma, diagnosed in the same period, aged 45–70, not attending the MS and treated at H. Clinico of Valencia. Results: Between January, 1993 and December, 2002, 2313 new invasive breast cancer patients were detected by the MS program in the community of Valencia, and 1349 women aged 45–70, not attending de MS were diagnosed with invasive breast carcinoma in H.Clinico of Valencia. The median follow-up period was 45.5 months for the screen-detected breast cancer and 51.9 months for not screen-detected patients. The screen-detected tumors had smaller pathological size (pT1 tumors 70.2% vs 40.5%, p < 0.0001), were more likely to have pathologically confirmed negative nodal status (66.4% vs 52.2%, p < 0.0001) and stage I disease (55.3% vs 26.1%, p < 0.0001). Breast-conserving surgery was performed in 50.4% of patients with screen-detected tumors and in 31.9% of women who had not undergone MS (p < 0.0001). The 5-year estimated survival was 95.5% (SE 0.57) for women with screen-detected breast cancer and 85.5% (SE 1.17) for those with not screen-detected tumors (p < 0.0001). Conclusions: Our data demonstrate a better prognosis in terms of 5-year survival in screen-detected breast cancer patients that may explain why breast carcinoma mortality rates have decreased in recent decades. These patients have also been found to have smaller tumors, a more favorable tumor stage and a higher proportion of breast-conserving surgery. No significant financial relationships to disclose.

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