scholarly journals Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 1795-1809
Author(s):  
Walaa Ebrahim Abd El Hady ◽  
Osama Abd El-Aazeem Soliman ◽  
Hassan Mohamed El Sabbagh ◽  
Elham Abdelmonem Mohamed
Keyword(s):  
Delivery System ◽  
Polyethylene Oxide ◽  
Gastroprotective Activity ◽  
Crosslinked Chitosan

scholarly journals Ionically Crosslinked Chitosan Membranes Used as Drug Carriers for Cancer Therapy Application

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 2051 ◽  
Author(s):  
Alecsandra Ferreira Tomaz ◽  
Sandra Sobral de Carvalho ◽  
Rossemberg Cardoso Barbosa ◽  
Suédina L. Silva ◽  
Marcos Sabino Gutierrez ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Delivery System ◽  
Drug Carriers ◽  
In Vitro Cytotoxicity ◽  
Cytotoxicity Studies ◽  
Chitosan Membranes ◽  
Crosslinked Chitosan ◽  
Cross Linker

The aim of this paper was to prepare, by the freeze-drying method, ionically crosslinked chitosan membranes with different contents of pentasodium tripolyphosphate (TPP) and loaded with 1,4-naphthoquinone (NQ14) drug, in order to evaluate how the physical crosslinking affects NQ14 release from chitosan membranes for cancer therapy application. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), swelling degree, and through in vitro drug release and cytotoxicity studies. According to the results, the molecular structure, porosity and hydrophilicity of the chitosan membranes were affected by TPP concentration and, consequently, the NQ14 drug release behavior from the membranes was also affected. The release of NQ14 from crosslinked chitosan membranes decreased when the cross-linker TPP quantity increased. Thus, depending on the TPP amount, the crosslinked chitosan membranes would be a potential delivery system to control the release of NQ14 for cancer therapy application. Lastly, the inhibitory potential of chitosan membranes ionically crosslinked with TPP and loaded with NQ14 against the B16F10 melanoma cell line was confirmed through in vitro cytotoxicity studies assessed via MTT assay. The anti-proliferative effect of prepared membranes was directly related to the amount of cross-linker and among all membranes prepared, such that one crosslinked with 0.3% of TPP may become a potential delivery system for releasing NQ14 drug for cancer therapy.

Sequential release of drugs form a dual-delivery system based on pH-responsive nanofibrous mats towards wound care

2020 ◽  
Vol 8 (8) ◽  
pp. 1759-1770 ◽  
Author(s):  
Huiwen Guo ◽  
Shaojie Tan ◽  
Jing Gao ◽  
Lu Wang
Keyword(s):  
Delivery System ◽  
Polyethylene Oxide ◽  
Wound Care ◽  
Coaxial Electrospinning ◽  
Ph Responsive ◽  
The Core ◽  
Sequential Release

Using Chitosan/PEO as the shell and PCL as the core, chitosan–polyethylene oxide/polycaprolactone nanofibrous mats were prepared successfully by coaxial electrospinning for co-load and sequential co-delivery of two drugs.

scholarly journals Characteristic of ascorbic acid in crosslinked chitosan edible film as drug delivery system membrane

2018 ◽  
Vol 154 ◽  
pp. 01027 ◽  
Author(s):  
Lilis Kistriyani ◽  
Wahyu Sulistyawan ◽  
Sapta Hadi Kesuma
Keyword(s):  
Drug Delivery ◽  
Ascorbic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Spectrophotometric Analysis ◽  
Common Type ◽  
Edible Film ◽  
Microbial Properties ◽  
Crosslinked Chitosan

Chitosan is a polysaccharide compound in the form of a linear polysaccharide consisting of N-acetyl glucosamine (GlcNAc) and D-glucosamine (GlcN) monomer, which is a derivative of deacetylization of chitin polymer. Chitin is one of common type of polysaccharide on earth after the excess cellulose from inveterbrata skeletons. Chitosan has anti-microbial properties. Based on this properties, chitosan is potentially used to be an edible film as drug delivery system membrane. Edible film was made by dissolving chitosan in 100 mL acetic acid 1%, then the plasticizer and crosslinker was added while heated at 60° C. It was molded and dried in oven at 50°C for 48 hours. Drug loading in the edible film could be controlled by remodeling membrane characteristics in the presence of crosslinker additions. The purpose of this study was to estimate the mass transfer coefficient (kCa) of drug loading in various concentrations of ascorbic acid in the edible film. The characteristics of ascorbic acid in chitosan edible film could be seen from the number of drugs that could be loaded through the uv-vis spectrophotometric analysis. The higher concentration of ascorbic acid was added, the drug would be loaded more into edible film.

Preparation of Crosslinked Chitosan/Silk Fibroin Blend Films for Drug Delivery System

2003 ◽  
Vol 3 (10) ◽  
pp. 604-611 ◽  
Author(s):  
Ratana Rujiravanit ◽  
Sopon Kruaykitanon ◽  
Alexander M. Jamieson ◽  
Seiichi Tokura
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Silk Fibroin ◽  
Delivery System ◽  
Blend Films ◽  
Crosslinked Chitosan

Polyethylene Oxide Based pH-independent Drug Delivery System: Formulation and Optimization by Central Composite Design

2013 ◽  
Vol 3 (3) ◽  
pp. 220-232 ◽  
Author(s):  
Dharmik Mehta ◽  
Punit Parejiya ◽  
Bhavesh Barot ◽  
Disha Suthar ◽  
Pragna Shelat
Keyword(s):  
Drug Delivery ◽  
Central Composite Design ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyethylene Oxide ◽  
Central Composite

scholarly journals Formulation Optimization of Polyox Based Modified Release Drug Delivery System

2019 ◽  
Vol 9 (4-s) ◽  
pp. 551-561 ◽  
Author(s):  
Sunil Shah ◽  
Dilip Shukla ◽  
Harish Pandey
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyethylene Oxide ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Modified Release ◽  
Metoprolol Succinate ◽  
Drug Content ◽  
Release Drug

Polyethylene Oxide (PEOs) offer specific advantages to be used in pharmaceutical products as release modifiers by forming a hydrogel around the dosage form in aqueous environment causing the drug to follow a diffusional path before releasing into the media. The strength of the hydrogel governs the release retardation capacity of the PEO system. The objective of this dissertation work was to use the Design of Experiments methodology to develop and optimize a PEO based modified release formulation of a highly water-soluble drug like Metoprolol succinate. The effect of the different viscosity grade PEOs, their concentration with respect to the drug, combination of two different viscosity grades, % drug content in the formulation and the use of water soluble / insoluble fillers on the dissolution of metoprolol succinate was studied. The critical formulation parameters namely PEO concentration and % drug content were chosen as input factors and dissolution at 1, 4, 8 and 20 hours was recorded as responses to carry out optimization using the DOE approach. The results obtained after statistical treatment of data provided a design space that can be used for achieving the desired formulation profile. The model has been validated to predict the effect of the input factors (PEO type and concentration and % drug content) on the responses (in vitro dissolution). Keywords: Polyethylene Oxide, Modified Release Drug Delivery System, Metoprolol

Structures Formed by Cryoprotective Agents Used in Freezc-Etching

1971 ◽  
Vol 29 ◽  
pp. 448-449
Author(s):  
G. G. Cocks ◽  
C. E. Cluthe
Keyword(s):  
Aqueous Solution ◽  
Polyethylene Oxide ◽  
Liquid Nitrogen Temperature ◽  
Ice Crystals ◽  
Etching Technique ◽  
Structural Constituent ◽  
Cryoprotective Agents ◽  
Quick Freezing ◽  
Freeze Etching ◽  
Fractured Surface

The freeze etching technique is potentially useful for examining dilute solutions or suspensions of macromolecular materials. Quick freezing of aqueous solutions in Freon or propane at or near liquid nitrogen temperature produces relatively large ice crystals and these crystals may damage the structures to be examined. Cryoprotective agents may reduce damage to the specimem, hut their use often results in the formation of a different set of specimem artifacts.In a study of the structure of polyethylene oxide gels glycerol and sucrose were used as cryoprotective agents. The experiments reported here show some of the structures which can appear when these cryoprotective agents are used.Figure 1 shows a fractured surface of a frozen 25% aqueous solution of sucrose. The branches of dendritic ice crystals surrounded hy ice-sucrose eutectic can be seen. When this fractured surface is etched the ice in the dendrites sublimes giving the type of structure shown in Figure 2. The ice-sucrose eutectic etches much more slowly. It is the smooth continuous structural constituent surrounding the branches of the dendrites.

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