The International Infections in Pregnancy Study: group B streptococcal colonization in pregnant women

2004 ◽  
Vol 15 (4) ◽  
pp. 267-274 ◽  
Author(s):  
CG Whitney ◽  
S Daly ◽  
S Limpongsanurak ◽  
MR Festin ◽  
KK Thinn ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Study Group ◽  
Group B ◽  
In Pregnancy

Fluoroless catheter ablation of supraventricular and ventricular arrhythmias in pregnancy: validation of a standard approach in a large multicenter registry

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Stec ◽  
K Styczkiewicz ◽  
J Sledz ◽  
A Sledz ◽  
M Chrabaszcz ◽  
...  
Keyword(s):  
Catheter Ablation ◽  
Ventricular Arrhythmia ◽  
Pregnant Women ◽  
Ventricular Arrhythmias ◽  
Study Group ◽  
Heart Team ◽  
Femoral Access ◽  
Electroanatomic Mapping System ◽  
Multicenter Registry ◽  
In Pregnancy

Abstract Background An increasing experience in zero- (ZF) or near-zero fluoroscopy catheter ablation (CA) supports the implementation of early, fluoroless approach for recurrent, symptomatic arrhythmias in pregnancy. Purpose The aim of the study was to evaluate the feasibility, efficacy, and safety of CA with a standardized ZF approach during pregnancy. Methods Data were derived from a large prospective multicenter registry (ELEKTRO-RARE-A-CAREgistry). Between 2012 and 2019, more than 2655 CA procedures were performed in women in intention-to-treat using a ZF fluoroscopy approach. The procedures were performer using: 1) femoral access, 2) double-catheter technique, without intracardiac echocardiography, 3) electroanatomic mapping system (Ensite, Abbott, USA) for mapping and navigation, 4) conscious, light sedation. Shared decision making approach was applied, including a pregnancy heart team consultations. Results The study group consisted of 18 pregnant women (mean age: 30.3±5.0 years; range: 19–38 years; mean gestational age during CA: 21.4±9.2 weeks; range: 7–36 weeks). All pregnant women had no overt structural heart disease. Among women in reproductive age, pregnant women referred for ZF-CA approach accounted for approximately 2% of procedures. In the study group, the major indications for CA included: AVNRT (n=10); OAVRT/WPW (n=2); focal idiopathic ventricular arrhythmia (n=4), AT (n=1) and AF (n=1). Five women had double substrate for CA. In AF case general anesthesia and transesophageal echocardiography were used to monitor ZF-transseptal puncture and right-sided pulmonary vein isolation. All procedures were successfully completed without fluoroscopy, and without serious maternal or fetal complications. The procedure and ablation application times were 55.0±30.0 min and 394±338 s, respectively. In one patient second procedure for idiopathic ventricular arrhythmia was postponed after delivery. Conclusion Implementation of pregnancy heart team and a standard fluoroless protocol for CA in daily electrophysiological practice allowed an early, safe, and effective CA of maternal supraventricular tachycardia and idiopathic ventricular arrhythmias in pregnancy. Funding Acknowledgement Type of funding source: None

scholarly journals Distribution of thyroid peroxidase positivity and its effects on thyroid function in normal pregnant women during 1st trimester in Dhaka city

2014 ◽  
Vol 4 (1) ◽  
pp. 15-20
Author(s):  
Ohida Sultanaa ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Farzana Mahmudad ◽  
Tazdik G Chowdhurye
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Study Group ◽  
Cross Sectional ◽  
Total Study Population ◽  
Group B

Objective: To measure the distribution of TPO-Ab positivity and to observe the effect of thyroid peroxidase positivity on thyroid function during first trimester in normal pregnancy. Method: A cross sectional among 120 subjects were taken in this study and divided into control and study groups. Control group (Group A) consisted of 60 healthy non pregnant women age ranged between 20 to 35 years. Study group (Group B) consisted of 60 normal pregnant women of same age range. Group B was further subdivided into group B1 and group B2according to the level of TPO-Ab. Group B1 consisted of TPO-Ab positive pregnant women and group B2 consisted of TPO- Ab negative pregnant women. Control group was selected from personal contacts and study group from Out Patient Department (OPD) of Obstetrics and Gynecology of Sir Salimullah Medical College and Mitford Hospital. For assessment of thyroid function, serum free thyroxine (FT4), thyroid stimulating hormone (TSH) were measured. Serum FT4, TSH were measured by Enzyme link immunosorbant (ELISA) method. Again, serum TPO-Ab of total study population and hCG of all the pregnant women were measured. Serum TPO-Ab by Micro particle Enzyme Immunoassay (MEIA) method and hCG was estimated by ELISA. Statistical analysis was done by SPSS version 17. Results: In this study, serum FT4 and was significantly (P<0.001) higher and TSH level was significantly (P<0.001) lower in normal pregnant women during 1st trimester in comparison to those of non pregnant women. Again, 18% of pregnant women showed TPO-Ab positivity. However, serum FT4 level was significantly (P<0.001) lower whereas, TSH level was significantly (p<0.001) higher in TPO-Ab positive pregnant women in comparison to those of TPO-Ab negative pregnant women. Conclusion: TPO-Ab positivity increases during 1st trimester of normal pregnancy which decreases the hyper functional state of thyroid hormones. So, thyroid screening should be done routinely during pregnancy. DOI: http://dx.doi.org/10.3329/updcj.v4i1.21160 Update Dent. Coll. j: 2014; 4 (1): 15-20

scholarly journals Utilidad diagnóstica de la relación plaquetas/linfocitos en embarazadas con preeclampsia

2021 ◽  
Vol 81 (01) ◽  
pp. 5-12
Author(s):  
Eduardo Reyna-Villasmil ◽  
◽  
Jorly Mejía-Montilla ◽  
Nadia Reyna-Villasmil ◽  
Duly Torres-Cepeda ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Predictive Value ◽  
Control Group ◽  
Study Group ◽  
Diagnostic Efficacy ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio ◽  
A Value ◽  
Group A ◽  
Group B

Objective: To establish the diagnostic utility of the platelet-lymphocyte ratio in pregnant women with preeclampsia. Methods: A case-control study was carried out at the Hospital Central “Dr. Urquinaona” Maracaibo, Venezuela. A total of 180 pregnant women were selected. Ninety preeclamptic women were included as the study group (group A) and a control group selected for their age and body mass index similar to the study group, which consisted of 90 healthy normotensive pregnant women (group B). The general characteristics, platelet-lymphocyte ratio values and diagnostic efficacy were determined. Results: Group A patients presented lower platelet and lymphocyte values compared to group B patients (p <0.001). However, no statistically significant differences were found in platelet-lymphocyte ratio between group A patients (115.2 ± 32.7) and group B patients (122.3 ± 23.8; p = 0, 0971). A cut-off value of the platelets-lymphocyte ratio of 117 presented a value below the curve of 0.57, the sensitivity of 47.8%, the specificity of 50.0%, the positive predictive value of 48.9%, and the negative predictive value of 52.2%, with a diagnostic accuracy of 48.9%. Conclusion: Platelet-lymphocyte ratio is not a useful tool in the diagnosis of preeclampsia, since patients with the syndrome present similar values to normotensive pregnant women. Keywords: Platelet-lymphocyte ratio, Preeclampsia, Diagnosis, Pregnancy.

Continuous Exercise Coaching Through Smartphone to Improve Quality of Sleep for Pregnant Women: A Prospective Cohort Study (Preprint)

2020 ◽  
Author(s):  
Guiying Wang ◽  
Xiao-Xian Yang ◽  
Ziyu Xiong ◽  
Daniel J Corsi ◽  
Shi Wu Wen ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Pregnant Women ◽  
Categorical Variables ◽  
Global Score ◽  
Subjective Sleep Quality ◽  
Continuous Exercise ◽  
Group A ◽  
Improve Sleep Quality ◽  
Group B ◽  
In Pregnancy

BACKGROUND Sleep quality is often affected by pregnancy, and exercise may improve sleep quality in pregnancy. However, the literature on the effect of integrating smartphones with continuous exercise coaching to improve sleep is sparse. OBJECTIVE This study aimed to explore the effect of continuous exercise coaching through smartphone on sleep quality for pregnant women. METHODS Pregnant women who met the eligibility criteria and agreed to participate at their first prenatal visit were enrolled and divided into two groups: group A (with continuous exercise coaching through smartphone) and group B (without exercise coaching). Pittsburgh Sleep Quality Index (PSQI) scale was used to measure the sleep quality. Chi-square test was used for categorical variables and t-test was used for continuously distributed variables for the comparison between the two groups. RESULTS In the 2nd trimester, means (SDs) of global score (9.46 (SD 3.46)), subjective sleep quality score (1.64 (SD 0.72)), and daytime dysfunction score (0.98 (SD 0.82) in group A (50 women)) were lower than in group B (50 women): 11.34 (SD 3.93), 2.02 (SD 0.74), and 1.48 (SD 0.84), respectively. In the 3rd trimester, means (SDs) of global score (10.16 (SD 3.00)), sleep efficiency score (1.64 (SD 0.72)), and daytime dysfunction score (1.86 (SD 0.67)) in group A were lower than in group B: 12.10 (SD 3.51), 1.82 (SD 0.80), and 1.78 (SD 0.76), respectively. In group A, global score of PSQI decreased from the 1st to 2nd trimester and from the 2nd to 3rd trimester. No inter-trimester change in global score of PSQI was observed in group B. CONCLUSIONS Our preliminary analysis suggests that continuous exercise coaching through smartphone by health professionals may be an effective way to improve sleep quality in pregnancy.

Relationship of Serum Lactate Dehydrogenase (LDH) Level with Severity of Preeclampsia

2016 ◽  
Vol 25 (Number 1) ◽  
pp. 8-14
Author(s):  
R Afroz ◽  
Q S Akhter ◽  
H Sadia ◽  
S Sultana ◽  
F Farid
Keyword(s):  
Lactate Dehydrogenase ◽  
Pregnant Women ◽  
Serum Lactate ◽  
High Serum ◽  
Serum Lactate Dehydrogenase ◽  
Study Group ◽  
Medical College ◽  
Group A ◽  
Severity Of The Disease ◽  
Group B

Preeclampsia is a pregnancy specific disease and associated with multisystem complications. This crosssectional study was carried out in the Department of Physiology, Dhaka Medical College (DMC), Dhakafrom January'14 to December'14 to assess the relationship between serum lactate dehydrogenase (LDH) levelwith the severity of the disease in preeclampsia. For this purpose, a total number of 105 pregnant women atthird trimester (28-40 weeks) with age ranging from 18 to 35 years were selected from DMC Hospital,Dhaka. Among them, 70 pregnant women with preeclampsia were selected as study group (Group B) which wasfurther subdivided as mild preeclamptic women (Group B1) and severe preeclamptic women (Group B2)consisting of 35 subjects in each subgroup. Age matched 35 healthy pregnant women were considered ascontrol group (Group A) for comparison. Serum LDH level was estimated by continuous spectrophotometricmethod. In this study, serum LDH level showed positive correlation with progressive rise of blood pressure inthe study group. The frequency of symptoms and complications of preeclampsia were more in patients with LDH>600 U/L compared with those who had lower levels. The present study showed that high serum LDH levelpositively correlates with the severity of the disease in patients of preeclampsia.

scholarly journals The Effect of Artemisinin-based Combination Therapy (ACT) Antimalaria Drugs on Liver Enzymes in Pregnancy

2019 ◽  
pp. 1-6
Author(s):  
Ajibade Oluwagbenga Oyeyemi ◽  
Ayobola Abimbola Sonuga
Keyword(s):  
Pregnant Women ◽  
Malaria Parasite ◽  
Harmful Effect ◽  
Antenatal Clinic ◽  
Significant Difference ◽  
Group A ◽  
Student’S T ◽  
Group B ◽  
And Control ◽  
In Pregnancy

Aims: Artemisinin-based Combination Therapies (ACTs) are employed as first-line agents in malaria chemotherapy. This study is aimed at assessing the effects of ACTs on renal function of pregnant women. Study Design: Comparative study. Place and Duration of Study: Pregnant women aged 18 to 50 years were recruited from antenatal clinic of Obstetrics and Gynecology Department of Ekiti State Hospital, Ado Ekiti, Nigeria between 2016 and 2018 Methodology: One hundred and eighty pregnant women were grouped into three which include:  Sixty pregnant women with malaria parasite on ACT drugs (Group A), sixty pregnant women with malaria parasite not on ACT drugs (Group B), sixty pregnant women without malaria parasite (Group C/control). Plasma Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT) and Lactate Dehydrogenase (LDH) activities were evaluated by standard methods. The data collected were analyzed using one-way analysis of variance (ANOVA) and Student’s t test to compare the data between the test groups and control. Results: Results showed there was a significant decrease (P=.05) in Body Mass Index in the pregnant women with malaria on ACT and those that were not on ACT when compared with control (24.1± 0.32 versus (25+ 2.30 vs 27± 1.62). A significant increase (P=.05) occurred in the levels of ALP,AST, ALT and LDH  in pregnant women with malaria not on ACT drugs when compared the control (168.45±0.19, 10.0±0.27, 8.19±0.25, 4.5±0.21) versus (143.20±0.12, 8.71±0.30, 5.99±0.21, 2.08±0.19),while no significant difference occurred in the levels of ALP,AST, ALT and LDH in pregnant women with malaria on ACT when compared with control (141.60±0.78, 8.02±0.32, 6.10±0.30, 2.75+ 0.20) vs (143.20±0.12, 8.71±0.30, 5.99±0.21, 2.08±0.19). Conclusion: Normal therapeutic dose of ACT has no harmful effect on the liver in pregnancy.

scholarly journals Clinical and microbiological rationale for the prophylaxis of obstetric and perinatal pathology caused by group B streptococci

2018 ◽  
Vol 67 (1) ◽  
pp. 73-84
Author(s):  
Vladislav O. Khvan ◽  
Elena V. Shipitsyna ◽  
Svetlana L. Zatsiorskaya ◽  
Galina V. Grinenko ◽  
Kira V. Shalepo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preterm Birth ◽  
Antibiotic Therapy ◽  
Pregnant Women ◽  
Clinical Samples ◽  
Group B Streptococci ◽  
Perinatal Pathology ◽  
Group B ◽  
Preterm Rupture Of Membranes ◽  
In Pregnancy

Background. Bacteriuria caused by group B streptococci (GBS) is a major risk factor for neonatal GBS associated pathology and a risk factor for pregnancy complications such as preterm birth and preterm rupture of membranes. Objective. Clinical and microbiological rationale for the prophylaxis of obstetrical and perinatal pathology associated with group B streptococci. Methods. A total of 496 pregnant women who made their first prenatal visit within first 12 weeks of gestation were invited to participate. As clinical samples, mid-stream urine, vaginal swabs, rectal swabs from women and inguinal swabs, urine, meconium from newborn infants were used. GBS detection was performed using culture and PCR. Results. The frequency of GBS detection was 16.3%. GBS associated bacteriuria was detected in 9.8% of the women. The women having GBS in urine at the beginning of pregnancy were significantly more often colonized with the microorganism late in pregnancy in comparison with the women with GBS-colonization of the vagina and/or rectum. Microbiological efficiency of antibiotic therapy of GBS associated bacteriuria using amoxicillin/clavulanic acid exceeded 70%. Clinical efficiency of the therapy consisted in the reduction of preterm birth and preterm rupture of membranes by 25% and 40%, respectively. Conclusions. Antibiotic therapy of GBS associated bacteriuria results in a decrease of pregnancy complication, which necessitate its use. GBS-colonization of the vagina and rectum in pregnant women is transitory therefore antenatal screening for GBS aimed to prevent neonatal GBS-infection should be performed late in pregnancy or before delivery.

scholarly journals ROLE OF MATERNAL ERYTHROCYTE ARGINASE ACTIVITY IN PREGNANCY – A PILOT STUDY

2011 ◽  
Vol 01 (01/03) ◽  
pp. 30-32
Author(s):  
Sukanya Shetty ◽  
Ashalatha V. Rao ◽  
Roopa Bhandary
Keyword(s):  
Pregnant Women ◽  
Growth And Development ◽  
Urea Cycle ◽  
Arginase Activity ◽  
Study Group ◽  
Cycle Enzyme ◽  
Complete Set ◽  
Urea Cycle Enzyme ◽  
In Pregnancy

Abstract Introduction Arginase is an urea cycle enzyme which catalyzes the cleavage of L arginine to L- ornithine and urea. It is expressed in liver, erythrocyte, brain, kidney, mammary gland and intestine. The arginase activity detected in nonhepatic tissues that lacka complete set of urea cycle enzymes is thought to provide ornithine, the biosynthetic precursor of proline, an important constituent of collagen, andthe polyamines, which are important for cell proliferation. Aim and objectives In the current study arginase level in maternal erythrocytes were determined to ascertain any possible role in pregnancy. Study design The study group comprised of total 45 subjects including twenty non – pregnant women (mean age 31.0 ± 6.0 years) and twenty five pregnant women (mean age 29.6 ± 6.1 years) of gestational age between 28 – 38 weeks. Results We found a significant increase in the level of maternal erythrocyte arginase (p 0.05) in pregnant women when compared to non – pregnant women. Conclusion Our study suggests that the increased maternal erythrocyte arginase activity may have a role in fetal growth and development.

scholarly journals Oxytocin in Induction of Labor in Pregnancy with Group B Streptococcal Portage

2020 ◽  
Vol 25 (3) ◽  
pp. 42-47
Author(s):  
Mihaela Corina Radu ◽  
Anca Irina Dumitrescu ◽  
Adrian Calin Boeru ◽  
Loredana Sabina Cornelia Manolescu ◽  
Oana Roxana Dumitrescu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Streptococcus Agalactiae ◽  
Group B Streptococcus ◽  
Perinatal Transmission ◽  
Induction Of Labor ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Induced Labor ◽  
Group B ◽  
In Pregnancy

AbstractIn the last two decades, group B streptococcus (GBS) infection has established itself as a major cause of perinatal morbidity and mortality. The purpose of this study is to identify if the electively induced labor with oxytocin in women with positive cultures of Streptococcus agalactiae, namely the group B streptococcus (GBS), helps the mother and fetus and decreases the risk associated with perinatal transmission of GBS compared with the spontaneous labor. Results associated with induction of labor with oxytocin compared with spontaneous labor in pregnant women who have GBS - positive cervical cultures, are also used to determine whether induction of labor decreases the risk of complications from GBS infection.

scholarly journals The influence of bacterial vaginosis on gestational week of the completion of delivery and biochemical markers of inflammation in the serum

2014 ◽  
Vol 71 (10) ◽  
pp. 931-935 ◽  
Author(s):  
Ana Jakovljevic ◽  
Mirjana Bogavac ◽  
Aleksandra Nikolic ◽  
Mirjana Milosevic-Tosic ◽  
Zoran Novakovic ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Pregnant Women ◽  
Preterm Delivery ◽  
Biochemical Markers ◽  
Control Group ◽  
Vaginal Fluid ◽  
Study Group ◽  
Markers Of Inflammation ◽  
Increased Risk ◽  
In Pregnancy

Bacground/Aim. Preterm delivery is one of the most common complications in pregnancy, and it is the major cause (75- 80%) of all neonatal deaths. Bacterial vaginosis predisposes to an increased risk of preterm delivery, premature rupture of membrane and miscarriage. In this syndrome normal vaginal lactobacilli, which produce protective H2O2, are reduced and replaced with anaerobic, gram-negative bacteria and others. The aim of this study was to evaluate the influence of bacterial vaginosis on the week of delivery and biochemical markers of inflammation in the serum. Methods. A total of 186 pregnant women were included into this study, between the week 16 and 19 of pregnancy. In the study group there were 76 pregnant women with diagnosed bacterial vaginosis by the criteria based on vaginal Gram-stain Nugent score and Amsel criteria. In the control group there were 110 healthy women with normal vaginal flora. Ultrasound examination was performed in both groups. Vaginal fluid and blood samples were taken to determine biochemical markers with colorimetric methods. Results. The week of delivery was statistically significantly shorter in the study group and the levels of biochemical markers of inflammation (C-reactive protein and fibrinogen in the serum) were statistically significantly higher in women with bacterial vaginosis comparing to the control group. Also the levels of uric acid and white blood cells in the serum were higher in the study group compared to the control one. Conclusion. Our study indicates that the pregnancy complicated with bacterial vaginosis ends much earlier than the pregnancy without it. Also, higher levels of biochemical markers of inflammation in the serum in the study group, similarly to results of other studies, suggest that pathophysiological processes responsible for preterm delivery can begin very early in pregnancy.

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