scholarly journals SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 ◽  
Vol 122 (3) ◽  
pp. 467-481 ◽  
Author(s):  
Phil Gold ◽  
Samuel O. Freedman
Keyword(s):  
Digestive System ◽  
Malignant Tumors ◽  
Specific Antigen ◽  
Fetal Tissues ◽  
Cancer Antigens ◽  
Adult Tissues ◽  
Specific Cancer ◽  
Carcinoembryonic Antigens ◽  
Liver And Pancreas ◽  
Human Digestive System

A wide variety of human adult and fetal tissues were studied by immune-diffusion techniques in agar gel to determine whether they contained the tumor-specific antigen(s) previously found in coionic cancers. In the adult tissues it was demonstrated that identical antigens were present in all tested specimens of malignant tumors of the entodermally derived epithelium of the gastrointestinal tract and pancreas, but were absent from all other tested adult tissues. The common antigenic constituents, therefore, represent system-specific cancer antigens of the human digestive system. System-specific cancer antigens have not previously been demonstrated in humans. Experiments with fetal tissues demonstrated that identical antigens were also present in fetal gut, liver, and pancreas between 2 and 6 months of gestation. These components were named "carcinoembryonic" antigens of the human digestive system. On the basis of the present findings and the recent work regarding control of the expression of genetic potentialities in various types of cells, it was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.

scholarly journals Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Bingyi Zhou ◽  
Deliang Liu ◽  
Yuyong Tan
Keyword(s):  
Cardiovascular Diseases ◽  
Gastrointestinal Cancer ◽  
Histone Deacetylases ◽  
Digestive System ◽  
Malignant Tumors ◽  
Clinicopathological Characteristics ◽  
Cancer Occurrence ◽  
Tumor Tissues ◽  
Human Digestive System

Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development; in addition, the deacetylation process is regulated by histone deacetylases (HDACs). Among the 18 human HDACs that have been reported, HDAC6 has been widely studied. There is upregulated HDAC6 expression in numerous types of tumor tissues and is closely associated with clinicopathological characteristics. Moreover, several HDAC6 inhibitors have been identified; furthermore, there has been extensive research on their ability to inhibit the growth of many tumors. This review summarizes the roles of HDAC6 in different primary digestive system malignancies.

scholarly journals PHYSICOCHEMICAL STUDIES OF THE CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1968 ◽  
Vol 128 (3) ◽  
pp. 387-398 ◽  
Author(s):  
John Krupey ◽  
Phil Gold ◽  
Samuel O. Freedman
Keyword(s):  
Digestive System ◽  
Metastatic Tumor ◽  
Amino Acid Residues ◽  
Normal Tissues ◽  
Cancer Metastases ◽  
Carcinoembryonic Antigens ◽  
Probable Presence ◽  
Human Digestive System ◽  
System Tumor ◽  
High Degree

A procedure has been described for the purification of the carcinoembryonic antigens (CEA) of the human digestive system. Tumor tissue extraction in 0.6 M perchloric acid followed by paper block electrophoresis and column chromatography on Sephadex G-200 resulted in highly purified CEA preparations as determined by both immunological and physicochemical criteria. The properties and composition of five different purified CEA preparations derived from digestive system cancer metastases were examined. The findings demonstrated a high degree of uniformity amongst these samples. Sedimentation coefficients ranged from 6.9 to 8S. Each sample showed the presence of 14 different amino acid residues and six different carbohydrate constituents (four of which could be quantitated with the amount of material available for analyis). Studies of a purified CEA preparation from a primary hepatoma yielded results which, in some respects, differed from those obtained with the CEA samples of metastatic tumor origin. The implications of these variations were discussed with regard to the probable presence of non-CEA components in the hepatoma preparation. Of primary importance was the observation that the few normal adult digestive system tissues tested failed to show the presence of constituents similar to the CEA. This finding would seem to indicate that, in the adult, the carcinoembryonic antigens of the human digestive system are qualitatively tumor-specific and are not dectectable in comparable normal tissues.

The Tomato Pip's Story: Creative Narratives as Bridging Cultural and Science Discourses for Indigenous Students

2017 ◽  
Vol 47 (2) ◽  
pp. 171-184
Author(s):  
Lorrin Ruihi Shortland ◽  
Terry Locke
Keyword(s):  
Digestive System ◽  
Indigenous Education ◽  
Disciplinary Literacy ◽  
Word Count ◽  
Indigenous Students ◽  
Science Discourse ◽  
Group Data ◽  
Focus Group Data ◽  
Human Digestive System

This article reports on what happened when a Rumaki pūtaiao kaiako (Science) teacher at a New Zealand high school trialled the use of creative narratives with her Year-10 students as a way of developing their understanding of the human digestive system. These students were members of the school's Māori immersion unit, and creative narratives were in part utilised as a bridge between science discourse and the cultural knowledges these students brought to their learning. In this case study, students developed ‘Tomato Pip’ narratives through four versions, which told the story of a tomato pip travelling through the human digestive system. Word-count data based on these versions and from a summative test were analysed and correlations found between test scores and three categories of word-count total (total words, total science words and total discrete science words). A discourse analysis of one student's narratives identified two distinct voices in these texts: the personal narrator and the emerging biologist. Questionnaire and focus-group data indicated that the use of creative narratives was both motivational to these students and effective as a bridge into science discourse mastery. It is argued that the findings have implications for disciplinary literacy theory, Indigenous education and science instruction.

scholarly journals ABO histo-blood groups and Rh systems in relation to malignant tumors of the digestive tract in Bosnia and Herzegovina

2008 ◽  
Vol 60 (4) ◽  
pp. 593-599 ◽  
Author(s):  
Snezana Jovanovic-Cupic ◽  
Gorana Stamenkovic ◽  
Jelena Blagojevic ◽  
N. Vanis ◽  
B. Stanojevic ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Digestive Tract ◽  
Digestive System ◽  
Malignant Tumors ◽  
Blood Groups ◽  
Liver Carcinoma ◽  
Abo Blood Groups ◽  
Rhesus Factor ◽  
Clinical Center ◽  
Group B

The distribution of ABO blood groups and the Rhesus factor was analyzed in 279 patients who suffered from malignant tumors of the digestive system. Patients were registered retrospectively in the Gastroenterohepatology Clinic, Clinical Center, University of Sarajevo over a discontinuous period of 88 months. From the results obtained, it was concluded that: (a) men became ill from gastric cancer significantly more frequently than women; (b) the frequency of liver carcinoma was three times higher than the global frequency and the frequency neighboring ethnic groups; and (c) patients with blood group B and patients with RhD(-) exhibited a significantly higher proportion of disease.

scholarly journals ESTUDO SOBRE POSSÍVEIS AVANÇOS NO PROCESSO DE APRENDIZAGEM DE ALUNOS COM BAIXA VISÃO UTILIZANDO MATERIAL DE ENSINO ADAPTADO PARA AULAS DE CIÊNCIAS

2020 ◽  
Vol 5 (1) ◽  
pp. 306-324
Author(s):  
Camila Maria Gonçalves de Castro ◽  
Giovana Evangelista Alves ◽  
Cláudio Alves Pereira
Keyword(s):  
Students With Disabilities ◽  
Inclusive Education ◽  
Digestive System ◽  
Low Vision ◽  
Structured Interviews ◽  
School Life ◽  
Human Digestive System ◽  
Visually Impaired Students ◽  
Study Type

Resumo: O artigo apresenta a discussão sobre materiais didáticos que auxiliam na educação inclusiva de alunos que possuem deficiência visual. As pesquisas têm apontado carência de recursos didáticos adaptados ao cotidiano escolar dos alunos com deficiência. O objetivo deste trabalho é apresentar um material didático adaptado que se mostrou eficiente e contribuiu para o avanço do processo de aprendizagem de uma aluna com baixa visão no estudo do conteúdo Sistema Digestório Humano. A pesquisa é do tipo estudo de caso e o seu paradigma é do tipo qualitativo. O desenho metodológico incluiu a organização de duas entrevistas semiestruturadas com uma aluna com baixa visão, sendo uma anterior e outra posterior à prática com o uso do material adaptado. Com o presente estudo, foi possível concluir que a utilização de recursos didáticos demonstra potencial positivo na promoção da aprendizagem significativa de alunos com deficiência visual na disciplina de Ciências.Palavras-chave: Educação Inclusiva; Recursos Didáticos; Ciências. Abstract: This article presents the discussion about the didatic materials that help in inclusive education for students with visual impairment. Research has pointed to a lack of didactic resources adapted to the daily school life of students with disabilities. The objective of this paper is to present an adapted didatic material that proved to be efficient and contributed to the advancement of the learning process of a student with low vision in the study of the Human Digestive System content. The research is of the case study type and its paradigm is of the qualitative type. The methodological design included the organization of two semi-structured interviews with a student with low vision, one before and one after the practice with the use of adapted material. With the present study, it was possible to conclude that the use of didactic resources demonstrates positive potential in promoting the meaningful learning of visually impaired students in the Science discipline.Keywords: Inclusive Education; Didactic Resources; Sciences.

scholarly journals A Review on the Research Progress of Inducible Nitric Oxide Synthase in the Pathogenesis of Pancreatic Malignancy

2021 ◽  
Vol 5 (4) ◽  
pp. 151-153
Author(s):  
Huimin Xiong ◽  
Ruiyao Wang ◽  
Chao Zhang
Keyword(s):  
Nitric Oxide ◽  
Pancreatic Cancer ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Digestive System ◽  
Malignant Tumors ◽  
Research Progress ◽  
Pancreatic Malignancy ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pancreatic cancer is a common tumor of the digestive system, at present, the pathogenesis is still unclear, but in the current research on the pathogenesis of pancreatic malignant tumors, the research on inducible nitric oxide synthase is particularly extensive. Therefore, this article focuses on the research progress of inducible nitric oxide synthase in the pathogenesis of pancreatic cancer. This is a review.

scholarly journals Animal and Human Digestive System Material of the Fifth Grade Elementary School in the form of Pop-Up Book Media

2020 ◽  
Vol 4 (2) ◽  
pp. 161
Author(s):  
Dewa Ayu Putu Mega Noviyanti ◽  
I Gede Margunayasa
Keyword(s):  
Elementary School ◽  
Natural Science ◽  
Digestive System ◽  
Rating Scale ◽  
Fifth Grade ◽  
Average Score ◽  
Developmental Research ◽  
Science Content ◽  
School Students ◽  
Human Digestive System

The limited relevant learning resources and the lack of development on natural science content on the topic of the animals and human digestive system were the reasons for this research. This research aimed at developing Pop-Up book media on the topic of animal and human digestive system in which the validity had been tested. This research was developmental research by using some steps, such as analyze, design, development, implementation, and evaluation models. However, the implementation steps and the evaluation steps were not conducted due to time limitations. The data collection method used in this research was a questionnaire method. The subject of this research was a learning media in the form of a Pop-Up book on the topic of animal and human digestive system on the fifth-grade elementary school students and the object of this research was the validity on learning media for Pop-Up book media. The instrument used in this developmental research was the rating scale. From the results of the assessment by four experts, an average score of 4.79 was obtained into very good qualification. Based on the results of the assessment, it could be concluded that the Pop-Up book media on the topic of animal and human digestive system was valid with a very good qualification. The existence of a Pop-Up book media was useful to assist the teachers’ tasks in implementing learning specifically in developing natural science materials on the topic of animal and human digestive system.

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