scholarly journals Prolonged Colonization with the Methicillin-Resistant Staphylococcus aureus Strain USA300 among Residents of Extended Care Facilities

2010 ◽  
Vol 31 (8) ◽  
pp. 838-841 ◽  
Author(s):  
Simone M. Shurland ◽  
O. Colin Stine ◽  
Richard A. Venezia ◽  
Jennifer K. Johnson ◽  
Min Zhan ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Odds Ratio ◽  
Retrospective Cohort ◽  
Adjusted Odds Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Aureus Strain ◽  
Methicillin Resistant ◽  
Extended Care ◽  
Care Facilities ◽  
Mrsa Strains

We performed a retrospective cohort study (n = 129) to assess whether residents of extended care facilities who were initially colonized or infected with the methicillin-resistant Staphylococcus aureus (MRSA) strain USA300 were less likely to have prolonged colonization than were residents colonized or infected with other MRSA strains. We found no difference in prolonged colonization (adjusted odds ratio, 1.1 [95% confidence interval, 0.5–2.4]).

scholarly journals Complete Genome Sequence of a USA100 Methicillin-Resistant Staphylococcus aureus Strain

2019 ◽  
Vol 8 (11) ◽  
Author(s):  
George E. Chlipala ◽  
Zhengdeng Arden Lei ◽  
Mark Maienschein-Cline ◽  
Kevin Kunstman ◽  
Koh Okamoto ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Genome Sequence ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Reference Genome ◽  
Aureus Strain ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Methicillin Resistant ◽  
Content Type ◽  
Mrsa Strains

We report the genome sequence of a methicillin-resistant Staphylococcus aureus (MRSA) strain, isolated from a surgical intensive care unit. This completely closed genome of a USA100 isolate contains a major chromosome and a plasmid and will serve as a reference genome for genetic analysis of MRSA strains.

scholarly journals Intranasal octenidine and universal antiseptic bathing reduce methicillin-resistant Staphylococcus aureus (MRSA) prevalence in extended care facilities

2018 ◽  
Vol 146 (16) ◽  
pp. 2036-2041 ◽  
Author(s):  
A. Chow ◽  
P. Y. Hon ◽  
G. Tin ◽  
W. Zhang ◽  
B. F. Poh ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Hospital Stay ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Length Of Hospital Stay ◽  
Nosocomial Transmission ◽  
Post Intervention ◽  
Methicillin Resistant ◽  
Chlorhexidine Bathing ◽  
Extended Care ◽  
Care Facilities

AbstractIntranasal octenidine, an antiseptic alternative to mupirocin, can be used for methicillin-resistant Staphylococcus aureus (MRSA) decolonisation in the prevention of nosocomial transmission. A controlled before–after study was conducted in three extended-care hospitals in Singapore. All inpatients with >48 h stay were screened for MRSA colonisation in mid-2015(pre-intervention) and mid-2016(post-intervention). Hospital A: universal daily chlorhexidine bathing throughout 2015 and 2016, with intranasal octenidine for MRSA-colonisers in 2016. Hospital B: universal daily octenidine bathing and intranasal octenidine for MRSA-colonisers in 2016. Hospital C: no intervention. In 2015, MRSA prevalence was similar among the hospitals (Hospital A: 38.5%, Hospital B: 48.1%, Hospital C: 43.4%, P = 0.288). From 2015 to 2016, MRSA prevalence reduced by 58% in Hospital A (Adj OR 0.42, 95% CI 0.20–0.89) and 43% in Hospital B (Adj OR 0.57, 95% CI 0.39–0.84), but remained similar in Hospital C (Adj OR 1.19, 95% CI 0.60–2.33), after adjusting for age, gender, comorbidities, prior MRSA carriage, prior antibiotics exposure and length of hospital stay. Compared with the change in MRSA prevalence from 2015 to 2016 in Hospital C, MRSA prevalence declined substantially in Hospital A (Adj OR 0.35, 95% CI 0.13–0.97) and Hospital B (Adj OR 0.48, 95% CI 0.22–1.03). Topical intranasal octenidine, coupled with universal daily antiseptic bathing, can reduce MRSA colonisation in extended-care facilities.

scholarly journals Association between Methicillin-Resistant Staphylococcus aureus Colonization and Infection May Not Differ by Age Group

2013 ◽  
Vol 34 (1) ◽  
pp. 93-95 ◽  
Author(s):  
Adebola O. Ajao ◽  
Anthony D. Harris ◽  
J. Kristie Johnson ◽  
Mary-Claire Roghmann ◽  
Eli N. Perencevich ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Age Group ◽  
Subsequent Infection ◽  
Methicillin Resistant ◽  
Mrsa Colonization

We assessed whether age modified the association between methicillin-resistant Staphylococcus aureus (MRSA) anterior nares colonization and subsequent infection. Among 7,405 patients (9,511 admissions), MRSA colonization was significantly associated with infection (adjusted odds ratio, 13.7 [95% confidence interval, 7.325.7]) but did not differ significantly by age group.

Impact of Vancomycin Minimum Inhibitory Concentration on Mortality among Critically Ill Patients witn Methicillin-Resistant Staphylococcus aureus Bacteremia

2012 ◽  
Vol 33 (12) ◽  
pp. 1246-1249 ◽  
Author(s):  
Christian J. Woods ◽  
Anindita Chowdhury ◽  
Vinay M. Patel ◽  
Andrew F. Shorr
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Methicillin Resistant ◽  
Staphylococcus Aureus Bacteremia ◽  
Vancomycin Minimum Inhibitory Concentration ◽  
Probability Of Death

We retrospectively evaluated 99 intensive care unit patients with methicillin-resistant Staphylococcus aureus bacteremia to determine whether having a vancomycin minimum inhibitory concentration (MIC) of 2 mg/L affected mortality. This MIC was found in 5.1% of patients and was associated with the probability of death (adjusted odds ratio, 13.9 [95% confidence interval, 1.1–171.2]) independent of other factors.

scholarly journals Antibiotic Resistance, spa Typing and Clonal Analysis of Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates from Blood of Patients Hospitalized in the Czech Republic

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 395
Author(s):  
Katarina Pomorska ◽  
Vladislav Jakubu ◽  
Lucia Malisova ◽  
Marta Fridrichova ◽  
Martin Musilek ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Czech Republic ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Bloodstream Infections ◽  
Spa Typing ◽  
The Czech Republic ◽  
Methicillin Resistant ◽  
Mrsa Strains ◽  
Spa Types ◽  
Repeat Pattern

Staphylococcus aureus is one of the major causes of bloodstream infections. The aim of our study was to characterize methicillin-resistant Staphylococcus aureus (MRSA) isolates from blood of patients hospitalized in the Czech Republic between 2016 and 2018. All MRSA strains were tested for antibiotic susceptibility, analyzed by spa typing and clustered using a Based Upon Repeat Pattern (BURP) algorithm. The representative isolates of the four most common spa types and representative isolates of all spa clonal complexes were further typed by multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing. The majority of MRSA strains were resistant to ciprofloxacin (94%), erythromycin (95.5%) and clindamycin (95.6%). Among the 618 strains analyzed, 52 different spa types were detected. BURP analysis divided them into six different clusters. The most common spa types were t003, t586, t014 and t002, all belonging to the CC5 (clonal complex). CC5 was the most abundant MLST CC of our study, comprising of 91.7% (n = 565) of spa-typeable isolates. Other CCs present in our study were CC398, CC22, CC8, CC45 and CC97. To our knowledge, this is the biggest nationwide study aimed at typing MRSA blood isolates from the Czech Republic.

scholarly journals Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) prevalence in humans in close contact with animals and measures to reduce on-farm colonisation

2021 ◽  
Vol 74 (1) ◽  
Author(s):  
Daniel Crespo-Piazuelo ◽  
Peadar G. Lawlor
Keyword(s):  
Staphylococcus Aureus ◽  
Animal Species ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Close Contact ◽  
Companion Animals ◽  
Health Care Facilities ◽  
Community Settings ◽  
Methicillin Resistant ◽  
Care Facilities ◽  
On Farm

AbstractSince the 1940s, Staphylococcus aureus has adapted to the use of different antimicrobials to treat infections. Although S. aureus can act as a commensal bacterium, some strains are facultative pathogens and acquiring them can be fatal. In particular, treating infections caused by S. aureus with acquired antimicrobial resistance is problematic, as their treatment is more difficult. Some of these S. aureus variants are methicillin-resistant S. aureus (MRSA) with prevalence across the globe in health-care facilities, community settings and on livestock farms. Apart from humans, MRSA can colonise other animal species, and because of this, resistance to new antimicrobials can appear and jump between species. Livestock and companion animals are particularly important in this regard considering the relatively high usage of antimicrobials in these species. There is a risk to humans who come into direct contact with animals acquiring MRSA but there is also the risk of animals acquiring MRSA from colonised humans. In this review, we summarise studies conducted worldwide to characterise the prevalence of MRSA in veterinarians, farmers and other personnel who come into close contact with animals. Finally, alternative treatment, preventive measures and on-farm strategies to reduce MRSA introduction to a farm and carriage within a herd are discussed.

Multiclonal outbreak of methicillin-resistant Staphylococcus aureus infections on a collegiate football team

2008 ◽  
Vol 137 (1) ◽  
pp. 85-93 ◽  
Author(s):  
A. J. HALL ◽  
D. BIXLER ◽  
L. E. HADDY
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Infection Risk ◽  
Physical Contact ◽  
Soft Tissue Infections ◽  
Risk Of Infection ◽  
Methicillin Resistant ◽  
Football Team ◽  
Mrsa Strains ◽  
Collegiate Football

SUMMARYAn outbreak of methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections (SSTIs) occurred in a college football team in August 2006. Of 109 players on the team roster, 88 (81%) were interviewed during a cohort investigation. Twenty-five cases were identified, six of which were culture-confirmed. Available culture isolates were typed by pulsed-field gel electrophoresis (PFGE), which identified two different MRSA strains associated with the outbreak. Playing positions with the most physical contact (offensive linemen, defensive linemen, and tight ends) had the greatest risk of infection [risk ratio (RR) 5·1, 95% confidence interval (CI) 2·3–11·5. Other risk factors included recent skin trauma (RR 1·9, 95% CI 0·95–3·7), use of therapeutic hydrocollator packs (RR 2·5, 95% CI 1·1–5·7), and miscellaneous training equipment use (RR 2·1, 95% CI 1·1–4·1). The outbreak was successfully controlled through team education and implementation of improved infection-control practices and hygiene policies.

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