scholarly journals nEXO: neutrinoless double beta decay search beyond 1028 year half-life sensitivity

2021 ◽  
Vol 49 (1) ◽  
pp. 015104
Author(s):  
G Adhikari ◽  
S Al Kharusi ◽  
E Angelico ◽  
G Anton ◽  
I J Arnquist ◽  
...  
Keyword(s):  
Parameter Space ◽  
Half Life ◽  
Substantial Reduction ◽  
Double Beta Decay ◽  
Detailed Knowledge ◽  
Normal Ordering ◽  
The One ◽  
Almost All ◽  
Time Projection ◽  
Detector Materials

Abstract The nEXO neutrinoless double beta (0νββ) decay experiment is designed to use a time projection chamber and 5000 kg of isotopically enriched liquid xenon to search for the decay in 136Xe. Progress in the detector design, paired with higher fidelity in its simulation and an advanced data analysis, based on the one used for the final results of EXO-200, produce a sensitivity prediction that exceeds the half-life of 1028 years. Specifically, improvements have been made in the understanding of production of scintillation photons and charge as well as of their transport and reconstruction in the detector. The more detailed knowledge of the detector construction has been paired with more assays for trace radioactivity in different materials. In particular, the use of custom electroformed copper is now incorporated in the design, leading to a substantial reduction in backgrounds from the intrinsic radioactivity of detector materials. Furthermore, a number of assumptions from previous sensitivity projections have gained further support from interim work validating the nEXO experiment concept. Together these improvements and updates suggest that the nEXO experiment will reach a half-life sensitivity of 1.35 × 1028 yr at 90% confidence level in 10 years of data taking, covering the parameter space associated with the inverted neutrino mass ordering, along with a significant portion of the parameter space for the normal ordering scenario, for almost all nuclear matrix elements. The effects of backgrounds deviating from the nominal values used for the projections are also illustrated, concluding that the nEXO design is robust against a number of imperfections of the model.

CORRECTING α3(MZ) in the NMSGUT

2009 ◽  
Vol 24 (21) ◽  
pp. 1711-1719 ◽  
Author(s):  
CHARANJIT S. AULAKH ◽  
SUMIT KUMAR GARG
Keyword(s):  
Parameter Space ◽  
World Average ◽  
Central Value ◽  
The One ◽  
Almost All

We show that superheavy threshold corrections in the New Minimal Supersymmetric GUT based on the SO(10) Higgs system [Formula: see text] can comfortably correct the prediction for the value of α3(MZ) from the relatively large value predicted by the two-loop RG equations to the central value determined by the current world average. The unification scale is raised above the one-loop value over almost all of the viable parameter space.

scholarly journals Neutrinoless double beta decay in minimal left–right symmetric model with universal seesaw

2018 ◽  
Vol 33 (35) ◽  
pp. 1850198 ◽  
Author(s):  
Debasish Borah ◽  
Arnab Dasgupta ◽  
Sudhanwa Patra
Keyword(s):  
Beta Decay ◽  
Parameter Space ◽  
Half Life ◽  
Mass Matrix ◽  
Neutrinoless Double Beta Decay ◽  
New Physics ◽  
Double Beta Decay ◽  
Model Parameters ◽  
Symmetric Model ◽  
Neutrino Mixing

We present a detailed discussion on neutrinoless double beta decay [Formula: see text] within left–right symmetric models based on the gauge symmetry of type [Formula: see text] as well as [Formula: see text] where fermion masses including that of neutrinos are generated through a universal seesaw mechanism. We find that one or more of the right-handed neutrinos could be as light as a few keV if left–right symmetry breaking occurs in the range of a few TeV to 100 TeV. With such light right-handed neutrinos, we perform a detailed study of new physics contributions to [Formula: see text] and constrain the model parameters from the latest experimental bound on such a rare decay process. We find that the new physics contribution to [Formula: see text] in such a scenario, particularly the heavy–light neutrino mixing diagrams, can individually saturate the existing experimental bounds, but their contributions to total [Formula: see text] half-life cancel each other due to unitarity of the total [Formula: see text] mass matrix. The effective contribution to half-life therefore, arises from the purely left and purely right neutrino and gauge boson mediated diagrams. We find that the parameter space saturating the [Formula: see text] bounds remains allowed from the latest experimental bounds on charged lepton flavor violating decays like [Formula: see text]. We finally include the bounds from cosmology and supernova to constrain the parameter space of the model.

scholarly journals On Prospects for Exploration of Supersymmetry in Double Beta Decay Experiments

1997 ◽  
Vol 12 (04) ◽  
pp. 233-241 ◽  
Author(s):  
V. A Bednyakov ◽  
V. B. Brudanin ◽  
S. G. Kovalenko ◽  
Ts. D. Vylov
Keyword(s):  
Lower Bound ◽  
Large Class ◽  
Beta Decay ◽  
Parameter Space ◽  
Half Life ◽  
Double Beta Decay ◽  
Physical Criterion ◽  
Susy Models ◽  
Selection Of

We analyze constraints on the parameters of the Rp violating supersymmetry ([Formula: see text] SUSY) which can be extracted from non-observation of the neutrinoless nuclear double beta decay (0νββ) at a given half-life lower bound. Our analysis covers a large class of phenomenologically viable [Formula: see text] SUSY models. We introduce special characteristics: the SUSY sensitivity of a ββ-decaying isotope and the SUSY reach of a 0νββ-experiment. The former provides a physical criterion for a selection of the most promising isotopes for SUSY searches and the latter gives a measure of success for a 0νββ-experiment in exploring the [Formula: see text] SUSY parameter space. On this basis we discuss prospects for exploration of supersymmetry in various 0νββ-experiments.

scholarly journals Sensitivity of a tonne-scale NEXT detector for neutrinoless double-beta decay searches

2021 ◽  
Vol 2021 (8) ◽  
Author(s):  
◽  
C. Adams ◽  
V. Álvarez ◽  
L. Arazi ◽  
I. J. Arnquist ◽  
...  
Keyword(s):  
High Pressure ◽  
Beta Decay ◽  
Parameter Space ◽  
Half Life ◽  
Neutrinoless Double Beta Decay ◽  
Double Beta Decay ◽  
Neutrino Masses ◽  
Neutrino Experiment ◽  
Order Of Magnitude ◽  
Better Than

Abstract The Neutrino Experiment with a Xenon TPC (NEXT) searches for the neutrinoless double-beta (0νββ) decay of 136Xe using high-pressure xenon gas TPCs with electroluminescent amplification. A scaled-up version of this technology with about 1 tonne of enriched xenon could reach in less than 5 years of operation a sensitivity to the half-life of 0νββ decay better than 1027 years, improving the current limits by at least one order of magnitude. This prediction is based on a well-understood background model dominated by radiogenic sources. The detector concept presented here represents a first step on a compelling path towards sensitivity to the parameter space defined by the inverted ordering of neutrino masses, and beyond.

scholarly journals The Diagnosis and Therapy of Degenerative Knee Joint Disease: Expert Consensus from the Chinese Pain Medicine Panel

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Dong Huang ◽  
Yan-Qing Liu ◽  
Li-Shuang Liang ◽  
Xue-Wu Lin ◽  
Tao Song ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Diagnosis And Treatment ◽  
Joint Disease ◽  
Knee Joints ◽  
Reproduction Rate ◽  
Pain Specialist ◽  
Chinese Association ◽  
The One ◽  
Almost All ◽  
Based Medicine

At present, there are many constantly updated guidelines and consensuses on the diagnosis and treatment of osteoarthritis both at home and abroad. The recommendations established using methods of evidence-based medicine has experienced strict research on controlling bias and promoting reproduction rate. As a result, the previous evidence was reevaluated, and a lot of changes were provoked in the diagnosis and treatment concept of osteoarthritis. However, several methods not recommended by foreign guidelines are still in use in the current clinical practice in China. On the one hand, Chinese experts have not reached extensive consensus on whether it is necessary to make changes according to foreign guidelines. On the other hand, almost all the current relevant guidelines are on osteoarthritis, but the lesions around knee joints which, as a whole, bear the largest weight in human body, cannot be ignored. For this purpose, Chinese Association for the Study of Pain (CASP) organized some leading experts to formulate this Chinese Pain Specialist Consensus on the diagnosis and treatment of degenerative knee osteoarthritis (DKOA) in combination with the guidelines in foreign countries and the expert experience of clinical practice in China. The consensus, which includes the definition, pathophysiology, epidemiology, clinical manifestation, diagnostic criteria, and treatments of DKOA, is intended to be used by first-line doctors, including pain physicians to manage patients with DKOA.

scholarly journals The ScotoSinglet Model: a scalar singlet extension of the Scotogenic Model

2021 ◽  
Vol 2021 (6) ◽  
Author(s):  
Ankit Beniwal ◽  
Juan Herrero-García ◽  
Nicholas Leerdam ◽  
Martin White ◽  
Anthony G. Williams
Keyword(s):  
Parameter Space ◽  
Direct Detection ◽  
Neutrino Masses ◽  
Minimal Models ◽  
Flavour Violation ◽  
The One ◽  
Relic Abundance ◽  
Electroweak Precision ◽  
Scalar Singlet ◽  
Lepton Flavour

Abstract The Scotogenic Model is one of the most minimal models to account for both neutrino masses and dark matter (DM). In this model, neutrino masses are generated at the one-loop level, and in principle, both the lightest fermion singlet and the lightest neutral component of the scalar doublet can be viable DM candidates. However, the correct DM relic abundance can only be obtained in somewhat small regions of the parameter space, as there are strong constraints stemming from lepton flavour violation, neutrino masses, electroweak precision tests and direct detection. For the case of scalar DM, a sufficiently large lepton-number-violating coupling is required, whereas for fermionic DM, coannihilations are typically necessary. In this work, we study how the new scalar singlet modifies the phenomenology of the Scotogenic Model, particularly in the case of scalar DM. We find that the new singlet modifies both the phenomenology of neutrino masses and scalar DM, and opens up a large portion of the parameter space of the original model.

scholarly journals Application of Hyperspectral Imaging in the Assessment of Drought and Salt Stress in Magneto-Primed Triticale Seeds

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 835
Author(s):  
Jose Alvarez ◽  
Elvira Martinez ◽  
Belén Diezma
Keyword(s):  
Salt Stress ◽  
Hyperspectral Imaging ◽  
Human Observer ◽  
Negative Effects ◽  
Stress Symptoms ◽  
Data Variability ◽  
Drought And Salt Stress ◽  
The One ◽  
Almost All ◽  
Germination Parameters

Hyperspectral imaging is an appropriate method to thoroughly investigate the microscopic structure of internally heterogeneous agro-food products. By using hyperspectral technology, identifying stress symptoms associated with salinity, before a human observer, is possible, and has obvious benefits. The objective of this paper was to prove the suitability of this technique for the analysis of Triticale seeds subjected to both magneto-priming and drought and salt stress conditions, in terms of image differences obtained among treatments. It is known that, on the one hand, drought and salt stress treatments have negative effects on seeds of almost all species, and on the other hand, magneto-priming enhances seed germination parameters. Thus, this study aimed to relate hyperspectral imaging values—neither positive nor negative in themselves—to the effects mentioned above. Two main conclusions were reached: Firstly, the hyperspectral application is a feasible method for exploring the Triticale structure and for making distinctions under different drought and salt stress treatments, in line with the data variability obtained. Secondly, the lower spectral reflectance in some treatments—in the 400–1000 nm segment—is the result of a great number of chemical compounds in the seed that could be related to magneto-priming.

scholarly journals Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling

2020 ◽  
Vol 21 (12) ◽  
pp. 4364
Author(s):  
Giuseppa De Luca ◽  
Barbara Cardinali ◽  
Lucia Del Mastro ◽  
Sonia Lastraioli ◽  
Franca Carli ◽  
...  
Keyword(s):  
Substantial Reduction ◽  
Breast Cancer Patients ◽  
Dna Templates ◽  
Molecular Tagging ◽  
Mutational Profiling ◽  
Optimized Protocol ◽  
Set Up ◽  
Detection Of Mutations ◽  
Almost All ◽  
Next Generation Sequencing Ngs

Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations while skipping the WGA step. MDA-MB-231 and MCF-7 cell lines, as well as leukocytes, were sorted into pools (2–5 cells) using a DEPArray™ system and were employed to set up the overall NGS procedure. A substantial reduction of reagent volume for the preparation of libraries was performed, in order to fit the limited DNA templates directly derived from cell lysates. Known variants in TP53, KRAS, and PIK3CA genes were detected in almost all the cell line pools (35/37 pools, 94.6%). No additional alterations, other than those which were expected, were found in all tested pools and no mutations were detected in leukocytes. The translational value of the optimized NGS workflow is confirmed by sequencing CTCs pools isolated from eight breast cancer patients and through the successful detection of variants. In conclusion, this study shows that the proposed NGS molecular tagging approach is technically feasible and, compared to traditional NGS approaches, has the advantage of filtering out the artifacts generated during library amplification, allowing for the reliable detection of mutations and, thus, making it highly promising for clinical use.

Comparison of a Non Electrostatic Surface Complexation Model and Surface Phase Theories for Prediction of Future Sorption Properties.

2004 ◽  
Vol 824 ◽  
Author(s):  
Allan T. Emrén ◽  
Anna-Maria Jacobsson
Keyword(s):  
Aqueous Solution ◽  
Chemical Potential ◽  
Surface Complexation ◽  
Sorption Properties ◽  
Phase Method ◽  
Detailed Knowledge ◽  
Surface Phase ◽  
Surface Complexation Model ◽  
Advantages And Disadvantages ◽  
The One

AbstractIn performance assessments, sorption of radionuclides dissolved in groundwater is mostly handled by the use of fixed Kd values. It has been well known that this approach is unsatisfying. Only during the last few years, however, tools have become available that make it possible to predict the actual Kd value in an aqueous solution that differs from the one in which the sorption properties were measured.One such approach is surface complexation (SC) that gives a detailed knowledge of the sorption properties. In SC, one tries to find what kinds of sorbed species are available on the surface and the thermodynamics for their formation from species in the bulk aqueous solution. Recently, a different approach, surface phase method (SP), has been developed. In SP, a thin layer including the surface is treated as a separate phase. In the bulk aqueous solution, the surface phase is treated as a virtual component, and from the chemical potential of this component, the sorption properties can be found.In the paper, we compare advantages and disadvantages of the two kinds of models. We also investigate the differences in predicted sorption properties of a number of radionuclides (Co, Np, Th and U). Furthermore, we discuss under which circumstances, one approach or the other is preferable.

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