Endemic arsenocosis (chronic arsenic poisoning) in China comes from two sources of arsenic (As). One source is drinking water, with As concentrations 2-40 times that of the state standard of 0.05 mg/l As. The second is smoke pollution from combustion of coal with high concentrations of As; this can be inhaled or ingested from smoke-contaminated food. Over 2,000,000 people live in areas of high geological As concentrations (Cao 1996), and more than 17,000 arsenocosis patients in 21 counties of five provinces or Autonomous Regions have been identified. Long-term exposure to As in air, diet, or drinking water can result in permanent and severe damage to health, including lesions of the skin, mucous membranes of the digestive, respiratory, circulatory, and nervous systems, and rhagades (skin cleft on palm and feet). Elevated As intake is also associated with skin, liver, and lung cancers (Centeno 2000, Liang 1999, Wang Lianfang 54-61 1997). At present, there are few studies of efficient measurement of treatment of endemic arsenocosis patients. Our study demonstrates that treatment of these patients with dietary selenium (Se) can cause both excretion (elimination) of As accumulated in the human body and remediation of some health damages. We report the results of this experiment. Data were collected on 3 test groups of people: 186 patients, from BaYinMaoDao Farm in Inner Mongolia suffering from endemic arsenocosis, were divided into a treatment group (100 patients) and a control group (86 patients). A third group, consisting of 70 families, received no treatment but drank ambient well water, >0.10 mg/l As. All participants had been exposed to high-As drinking water (>0.10 mg/l) since 1983. Throughout the experiment, water containing 0.05 mg/1 As was supplied for both treatment and control groups. Of the 186 patients, 100 were treated with Se-enriched yeast tablets, containing 100 μg Se/tablet. The treatment lasted 14 months. Treated patients received 100-200 μg Se/day. All patients were examined for clinical criteria of arsenocosis: characteristic pigmentation, depigmentation, hyperkeratosis, rhagades (skin cleft), and incidence of secondary symptoms of headaches, dizziness, thoracalgia (chest pain), numbness of hands or feet, convulsions, or lumbago.