A Method for Prediction of Accessible Sites on an mRNA Sequence for Target Selection of Hammerhead Ribozymes

2002 ◽  
Vol 9 (4) ◽  
pp. 641-653 ◽  
Author(s):  
Alberto Mercatanti ◽  
Giuseppe Rainaldi ◽  
Laura Mariani ◽  
Roberto Marangoni ◽  
Lorenzo Citti
Keyword(s):  
Target Selection ◽  
Mrna Sequence ◽  
Hammerhead Ribozymes ◽  
Selection Of

A Target Selection Algorithm of Seeker Based on the Prior Information and SVM

2013 ◽  
Vol 734-737 ◽  
pp. 3071-3074
Author(s):  
Guo Dong Zhang ◽  
Zhong Liu
Keyword(s):  
Prior Information ◽  
Simulation Experiment ◽  
Target Selection ◽  
Support Vector ◽  
Selection Algorithm ◽  
Distribution Law ◽  
Surface Ship ◽  
False Target ◽  
Target Characteristics ◽  
Selection Of

Aiming at the phenomenon that the chaff and corner reflector released by surface ship can influence the selection of missile seeker, this paper proposed a multi-target selection method based on the prior information of false targets distribution and Support Vector Machine (SVM). By analyzing the false targets distribution law we obtain two classification principles, which are used to train the SVM studies the true and false target characteristics. The trained SVM is applied to the seeker in the target selection. This method has advantages of simple programming and high classification accuracy, and the simulation experiment in this paper confirms the correctness and effectiveness of this method.

Electrophysiological Correlates of Similarity-based Interference during Detection of Visual Forms

2006 ◽  
Vol 18 (6) ◽  
pp. 880-888 ◽  
Author(s):  
Markus Conci ◽  
Klaus Gramann ◽  
Hermann J. Müller ◽  
Mark A. Elliott
Keyword(s):  
Target Selection ◽  
Event Related Potentials ◽  
Form Perception ◽  
Psychological Review ◽  
Physiological Basis ◽  
Related Potentials ◽  
Kanizsa Figure ◽  
Global And Local ◽  
Selection Of ◽  
Form Information

Illusory figure completion demonstrates the ability of the visual system to integrate information across gaps. Mechanisms that underlie figural emergence support the interpolation of contours and the filling-in of form information [Grossberg, S., & Mingolla, E. Neural dynamics of form perception: Boundary completion, illusory figures and neon colour spreading. Psychological Review, 92, 173–211, 1985]. Although both processes contribute to figure formation, visual search for an illusory target configuration has been shown to be susceptible to interfering form, but not contour, information [Conci, M., Müller, H. J., & Elliott, M. A. The contrasting impact of global and local object attributes on Kanizsa figure detection. Submitted]. Here, the physiological basis of form interference was investigated by recording event-related potentials elicited from contour- and surface-based distracter interactions with detection of a target Kanizsa figure. The results replicated the finding of form interference and revealed selection of the target and successful suppression of the irrelevant distracter to be reflected by amplitude differences in the N2pc component (240–340 msec). In conclusion, the observed component variations reflect processes of target selection on the basis of integrated form information resulting from figural completion processes.

LINGUOCULTURAL POTENTIAL OF EUPHEMISMS-AMULETS

2021 ◽  
pp. 68-74
Author(s):  
SERGEY I. ROMANOV ◽  
Keyword(s):  
Target Selection ◽  
Cultural Factors ◽  
Point Of View ◽  
Negative Consequences ◽  
Cultural Community ◽  
Magical Power ◽  
Selection For ◽  
Cultural Code ◽  
Russian Linguistic ◽  
Selection Of

The article deals with a special type of euphemisms-amulets, that is, linguocultural units endowed with the function of protection. There are two types of euphemisms-amulets from the point of view of relevance: obsolete and current units. Obsolete euphemisms- amulets have targets that are not recognized as dangerous by the modern linguistic and cultural community. Current euphemisms-amulets, although not always consciously, are used by representatives of the modern Russian linguistic and cultural community to protect against something bad. The paper establishes that the use of the euphemism-amulet is based on the transla- tion of the target's representation into another cultural code. The work reveals that the euphemisms-amulets are directed not to mitigate an unwanted nomination but how to replace it. An undesirable nomination is endowed with negative magical properties, which is why the linguocultural community imposes a ban on its use. A protective cultural function is superim- posed on the euphemism. The main pragmatic explanation for the use of the euphemism- amulet is the speaker's desire not to predict an encounter with an unwanted object, which is based on belief in the magical power of the word. The factors that determine the linguocultural specificity of euphemisms-amulets are revealed. The first factor is target selection. For the Russian linguocultural community, such targets include a totemic animal, evil forces representing another world, death. The second factor is the selection of nominations for the euphemistic function, which is determined by culturally marked background knowledge, ideas, and typical practices. The communicative- pragmatic platform for the use of euphemisms-amulets is the belief in the magical power of the word, in the fact that the use of the forbidden word can lead to negative consequences (in particular, to cause the appearance of something dangerous, undesirable). The work proves that the identified cultural factors are universal, based on universal archetypes: one's own / another's, permission / prohibition, life / death. At the same time, the fact of the appearance of the euphemism-amulet, the choice of its internal form is determined by national and cultural factors.

Military Targeting in the Context of Self-Defence Actions

2015 ◽  
Vol 84 (1) ◽  
pp. 3-28 ◽  
Author(s):  
James A. Green ◽  
Christopher P.M. Waters
Keyword(s):  
Target Selection ◽  
Jus In Bello ◽  
Customary International Law ◽  
Jus Ad Bellum ◽  
Conceptual Clarity ◽  
Starting Point ◽  
Definition Of ◽  
The Relationship ◽  
Self Defence ◽  
Selection Of

For self-defence actions to be lawful, they must be directed at military targets. The absolute prohibition on non-military targeting under the jus in bello is well known, but the jus ad bellum also limits the target selection of states conducting defensive operations. Restrictions on targeting form a key aspect of the customary international law criteria of necessity and proportionality. In most situations, the jus in bello will be the starting point for the definition of a military targeting rule. Yet it has been argued that there may be circumstances when the jus ad bellum and the jus in bello do not temporally or substantively overlap in situations of self-defence. In order to address any possible gaps in civilian protection, and to bring conceptual clarity to one particular dimension of the relationship between the two regimes, this article explores the independent sources of a military targeting rule. The aim is not to displace the jus in bello as the ‘lead’ regime on how targeting decisions must be made, or to undermine the traditional separation between the two ‘war law’ regimes. Rather, conceptual light is shed on a sometimes assumed but generally neglected dimension of the jus ad bellum’s necessity and proportionality criteria that may, in limited circumstances, have significance for our understanding of human protection during war.

Computer Control by Gaze

2012 ◽  
pp. 78-102 ◽  
Author(s):  
Henrik Skovsgaard ◽  
Kari-Jouko Räihä ◽  
Martin Tall
Keyword(s):  
Eye Gaze ◽  
Computer Control ◽  
Target Selection ◽  
Specific Area ◽  
Head Movements ◽  
Interaction Techniques ◽  
Information Spaces ◽  
Speed Up ◽  
Small Targets ◽  
Selection Of

This chapter provides an overview of gaze-based interaction techniques. We will first explore specific techniques intended to make target selection easier and to avoid the Midas touch problem. We will then take a look at techniques that do not require the use of special widgets in the interface but instead manipulate the rendering on the basis of eye gaze to facilitate the selection of small targets. Dwell-based interaction makes use of fixations; recent research has looked into the other option, using saccades as the basis for eye gestures. We will also discuss examples of how eye gaze has been used with other input modalities (blinks and winks, keyboard and mouse, facial gestures, head movements, and speech) to speed up interaction. Finally, we will discuss examples of interaction techniques in the context of a specific area of application: navigating information spaces.

scholarly journals Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mathias Vormehr ◽  
Barbara Schrörs ◽  
Sebastian Boegel ◽  
Martin Löwer ◽  
Özlem Türeci ◽  
...  
Keyword(s):  
Target Selection ◽  
Efficient Production ◽  
Patient Centered ◽  
Sequencing Technologies ◽  
Cost Efficient ◽  
Potent Drug ◽  
Personalized Cancer ◽  
The Cost ◽  
Synthetic Mrna ◽  
Selection Of

Advances in nucleic acid sequencing technologies have revolutionized the field of genomics, allowing the efficient targeting of mutated neoantigens for personalized cancer vaccination. Due to their absence during negative selection of T cells and their lack of expression in healthy tissue, tumor mutations are considered as optimal targets for cancer immunotherapy. Preclinical and early clinical data suggest that synthetic mRNA can serve as potent drug format allowing the cost efficient production of highly efficient vaccines in a timely manner. In this review, we describe a process, which integrates next generation sequencing based cancer mutanome mapping,in silicotarget selection and prioritization approaches, and mRNA vaccine manufacturing and delivery into a process we refer to as MERIT (mutanome engineered RNA immunotherapy).

Precision and Variability in Postsynaptic Target Selection of Inhibitory Cells in the Hippocampal CA3 Region

1993 ◽  
Vol 5 (12) ◽  
pp. 1729-1751 ◽  
Author(s):  
Attila I. Gulyás ◽  
Richard Mlles ◽  
Norbert Hájos ◽  
Tamás F. Freund
Keyword(s):  
Target Selection ◽  
Hippocampal Ca3 ◽  
Selection Of ◽  
Postsynaptic Target ◽  
Ca3 Region

scholarly journals Separable Influences of Reward on Visual Processing and Choice

2021 ◽  
Vol 33 (2) ◽  
pp. 248-262
Author(s):  
Alireza Soltani ◽  
Mohsen Rakhshan ◽  
Robert J. Schafer ◽  
Brittany E. Burrows ◽  
Tirin Moore
Keyword(s):  
Eye Movements ◽  
Visual Processing ◽  
Visual Motion ◽  
Target Selection ◽  
Wide Range ◽  
Reward Value ◽  
Similarities And Differences ◽  
Visual Targets ◽  
Reinforcement Learning Models ◽  
Selection Of

Primate vision is characterized by constant, sequential processing and selection of visual targets to fixate. Although expected reward is known to influence both processing and selection of visual targets, similarities and differences between these effects remain unclear mainly because they have been measured in separate tasks. Using a novel paradigm, we simultaneously measured the effects of reward outcomes and expected reward on target selection and sensitivity to visual motion in monkeys. Monkeys freely chose between two visual targets and received a juice reward with varying probability for eye movements made to either of them. Targets were stationary apertures of drifting gratings, causing the end points of eye movements to these targets to be systematically biased in the direction of motion. We used this motion-induced bias as a measure of sensitivity to visual motion on each trial. We then performed different analyses to explore effects of objective and subjective reward values on choice and sensitivity to visual motion to find similarities and differences between reward effects on these two processes. Specifically, we used different reinforcement learning models to fit choice behavior and estimate subjective reward values based on the integration of reward outcomes over multiple trials. Moreover, to compare the effects of subjective reward value on choice and sensitivity to motion directly, we considered correlations between each of these variables and integrated reward outcomes on a wide range of timescales. We found that, in addition to choice, sensitivity to visual motion was also influenced by subjective reward value, although the motion was irrelevant for receiving reward. Unlike choice, however, sensitivity to visual motion was not affected by objective measures of reward value. Moreover, choice was determined by the difference in subjective reward values of the two options, whereas sensitivity to motion was influenced by the sum of values. Finally, models that best predicted visual processing and choice used sets of estimated reward values based on different types of reward integration and timescales. Together, our results demonstrate separable influences of reward on visual processing and choice, and point to the presence of multiple brain circuits for the integration of reward outcomes.

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