scholarly journals Postprandial Glucose and Insulin Response to a Cookie with or Without Added RS4 Wheat Starch After 3 Days of Pre-Feeding: A Double Blind, Randomized, Controlled Clinical Trial (P08-081-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Alexandra Jenkins ◽  
Clodualdo Maningat ◽  
Paul Seib ◽  
Janice Campbell ◽  
Adish Ezatagha ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Resistant Starch ◽  
Healthy Subjects ◽  
Postprandial Glucose ◽  
Wheat Starch ◽  
Feeding Period ◽  
Double Blind ◽  
Blood Samples ◽  
Glucose Levels ◽  
Gi Symptoms

Abstract Objectives Research on the effect of resistant starch on postprandial glucose levels has mainly focused on the attenuation achieved by substituting it for the available carbohydrate (avCarb), few studies have looked at the effect on glucose levels when the resistant starch is added to avCarb. The objective of this study was therefore to investigate the acute effect on postprandial glycemia and insulinemia of a cross-linked RS4 wheat starch (Fibersym® RW) in a test cookie compared to a control cookie matched for available carbohydrate after a 3-day habituation period. Methods This study used a double blind, randomized, cross-over design. Nineteen healthy subjects were screened of which 16 were eligible and randomized into the study. A total of 15 subjects completed the study (5M:10F; 32 ± 11y; 24.9 ± 2.5 kg/m2; BP 112/70 mmHg). After 3-day pre-feeding of Control (dietary fiber 1.6 g/d) or Fibersym sugar snap cookies (dietary fiber 29 g/d), the subjects, after an overnight fast, consumed either the respective Control or Fibersym cookie, both meals contained 40 g avCarb. Blood samples were collected over 2 h. Gastrointestinal (GI) symptoms were recorded during the pre-feeding period and during the postprandial visit. Subjective appetite scores were measured at the same time points when blood samples were collected. Results The 90-min blood glucose incremental area under the curve (IAUC) was statistically significantly lower after ingesting the Fibersym cookie (71.9 ± 8.5 mmolxmin/L) compared to the Control cookie (86.7 ± 9.3 mmolxmin/L) (P < 0.02). In addition, the peak glucose concentrations at 30 and 45 min after consumption of the Fibersym cookie was significantly lower than the Control cookie (P < 0.05). Insulin levels at 90-min (P < 0.016) and the 2-h (P < 0.02) insulin IAUC's were significantly lower after consumption of the Fibersym cookie compared to the Control cookie. There were no significant differences in GI symptoms over the 3-day pre-feeding period and during the 2 h postprandial visit between the two cookies and neither did the appetite scores differ significantly. Conclusions The cross-linked RS4 wheat starch, Fibersym, when formulated into a cookie, is well tolerated and attenuates blood glucose and insulin levels in healthy subjects compared to a Control cookie containing the same amount of available carbohydrate. Funding Sources MGP Ingredients, Inc.

scholarly journals Consumption of Cross-Linked Resistant Starch (RS4XL) on Glucose and Insulin Responses in Humans

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Enas K. Al-Tamimi ◽  
Paul A. Seib ◽  
Brian S. Snyder ◽  
Mark D. Haub
Keyword(s):  
Dietary Fiber ◽  
Resistant Starch ◽  
Area Under The Curve ◽  
Postprandial Glucose ◽  
Wheat Starch ◽  
Blood Samples ◽  
Serial Blood ◽  
Insulin Levels ◽  
Insulin Responses ◽  
First Time

Objective. The objective was to compare the postprandial glycemic and insulinemic responses to nutrition bars containing either cross-linked RS type 4 (RS4XL) or standard wheat starch in normoglycemic adults (n= 13; age = 27±5 years; BMI = 25±3 kg/m2).Methods. Volunteers completed three trials during which they consumed a glucose beverage (GLU), a puffed wheat control bar (PWB), and a bar containing cross-linked RS4 (RS4XL) matched for available carbohydrate content. Serial blood samples were collected over two hours and glucose and insulin concentrations were determined and the incremental area under the curve (iAUC) was calculated.Results. TheRS4XLpeak glucose and insulin concentrations were lower than the GLU and PWB (P<.05). The iAUC for glucose and insulin were lower following ingestion of RS4 compared with the GLU and PWB trials.Conclusions. These data illustrate, for the first time, that directly substituting standard starch withRS4XL, while matched for available carbohydrates, attenuated postprandial glucose and insulin levels in humans. It remains to be determined whether this response was due to the dietary fiber and/or resistant starch aspects of theRS4XLbar.

scholarly journals Different Types of Resistant Starch Elicit Different Glucose Reponses in Humans

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Mark D. Haub ◽  
Kelcie L. Hubach ◽  
Enas K. Al-tamimi ◽  
Sammy Ornelas ◽  
Paul A. Seib
Keyword(s):  
Resistant Starch ◽  
Healthy Subjects ◽  
Area Under The Curve ◽  
Wheat Starch ◽  
Glucose Response ◽  
Blood Samples ◽  
Different Types ◽  
Finger Stick

The purpose of this study was to determine whether different types of resistant starch (RS) elicited different glycemic responses. Eleven healthy subjects consumed solutions containing 30 g of either dextrose (DEX), resistant starch type 2 (RS2), or cross-linked resistant wheat starch type 4 () on three separate occasions, which were assigned randomly. Finger stick blood samples were collected before and over the following two hours and measured for glucose. The incremental area under the curve (iAUC) for the glucose response was calculated for all trials. The two types of resistant starch significantly () decreased iAUC compared with DEX. The response with was significantly decreased compared with the RS2 trial. These data demonstrate that different types of resistant starch elicit significantly different glycemic responses.

scholarly journals Effects of Blenderized Watermelon With the Rind on Satiety, Bowel Movement, and Postprandial Glucose

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 348-348
Author(s):  
Trisha Molina ◽  
Samantha Johansen ◽  
Timothy Nishimura ◽  
Martin Jr Rosas ◽  
Kristine Giltvedt ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Metabolic Diseases ◽  
Bowel Movement ◽  
Postprandial Glucose ◽  
Double Blind ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Watermelon Juice ◽  
Watermelon Rind ◽  
Bowel Movements

Abstract Objectives Many studies have examined the beneficial effects of watermelon flesh on metabolic diseases, yet fewer studies have investigated the effects of watermelon rind. While normally discarded, rind consumption not only reduces food waste but contains fiber (pectin) and healthful bioactive compounds such as citrulline. This study examined the effects of watermelon rind consumption on postprandial glucose, satiety and bowel movements. It was hypothesized that consumption of blenderized watermelon juice with rind would lower postprandial glucose, increase satiety and improve bowel movement habits. Methods In a double-blind randomized crossover study, 21 participants (age 26.3 ± 5.7 y, BMI 22.6 ± 2.8 kg/m2) consumed one cup (8 fl. oz) of blenderized watermelon juice with or without rind. A visual analogue scale was used to measure satiety at baseline, immediately after, 20, 40, 60 and 90 minutes post juice consumption. Blood glucose was measured at baseline, 20, 40, 60 and 90 minutes post juice consumption. Bowel movement questionnaires were administered two days before and after each trial. Results Both blenderized watermelon juices (with and without rind) increased satiety with more fullness in watermelon juice with rind (P &lt; 0.05). Watermelon juice with rind also stabilized blood glucose levels in comparison to watermelon juice (P &lt; 0.001). No significant differences between the two trials for bowel movements were found, but no evidence of constipation or discomfort was presented among the participants. Conclusions These results suggest that watermelon juice with rind has favorable effects on postprandial glucose and satiety levels but no effect on bowel movements. Therefore, further research into the benefits of watermelon rind is important and could offer potential clinical applications and disease prevention. Funding Sources NUTR 302L Advanced Nutrition Laboratory San Diego State University and National Watermelon Promotion Board (NWPB 19–20).

scholarly journals Effect of exercise timing on elevated postprandial glucose levels

2017 ◽  
Vol 123 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Yoichi Hatamoto ◽  
Ryoma Goya ◽  
Yosuke Yamada ◽  
Eichi Yoshimura ◽  
Sena Nishimura ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Effect Size ◽  
Exercise Intervention ◽  
Intermittent Exercise ◽  
Random Order ◽  
Postprandial Glucose ◽  
Glucose Levels ◽  
Exercise Timing ◽  
Daily Exercise ◽  
Blood Glucose Concentrations

There is no consensus regarding optimal exercise timing for reducing postprandial glucose (PPG). The purpose of the present study was to determine the most effective exercise timing. Eleven participants completed four different exercise patterns 1) no exercise; 2) preprandial exercise (jogging); 3) postprandial exercise; and 4) brief periodic exercise intervention (three sets of 1-min jogging + 30 s of rest, every 30 min, 20 times total) in a random order separated by a minimum of 5 days. Preprandial and postprandial exercise consisted of 20 sets of intermittent exercise (1 min of jogging + 30 s rest per set) repeated 3 times per day. Total daily exercise volume was identical for all three exercise patterns. Exercise intensities were 62.4 ± 12.9% V̇o2peak. Blood glucose concentrations were measured continuously throughout each trial for 24 h. After breakfast, peak blood glucose concentrations were lower with brief periodic exercise (99 ± 6 mg/dl) than those with preprandial and postprandial exercise (109 ± 10 and 115 ± 14 mg/dl, respectively, P < 0.05, effect size = 0.517). After lunch, peak glucose concentrations were lower with brief periodic exercise than those with postprandial exercise (97 ± 5 and 108 ± 8 mg/dl, P < 0.05, effect size = 0.484). After dinner, peak glucose concentrations did not significantly differ among exercise patterns. Areas under the curve over 24 h and 2 h postprandially did not differ among exercise patterns. These findings suggest that brief periodic exercise may be more effective than preprandial and postprandial exercise at attenuating PPG in young active individuals. NEW & NOTEWORTHY This was the first study to investigate the effect of different exercise timing (brief periodic vs. preprandial vs. postprandial exercise) on postprandial glucose (PPG) attenuation in active healthy men. We demonstrated that brief periodic exercise attenuated peak PPG levels more than preprandial and postprandial exercise, particularly in the morning. Additionally, PPG rebounded soon after discontinuing postprandial exercise. Thus, brief periodic exercise may be better than preprandial and postprandial exercise at attenuating PPG levels.

Association of Acrochordons with Diabetes Mellitus - A Hospital based Case Control Study

2021 ◽  
Vol 4 (1) ◽  
pp. 51-60
Author(s):  
Sunita Karki ◽  
Anjan Rai ◽  
Manish Pradhan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Postprandial Glucose ◽  
Early Screening ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
Skin Tags ◽  
And Gender ◽  
Control Study

Introduction Acrochordons or skin tags are common benign cutaneous tumors that occur especially over the neck and major flexures. A possible association between diabetes mellitus and dyslipidemia is observed in numerous past studies with varying results. We aim to find out the association of diabetes mellitus with acrochordons Methods: One hundred patients were enrolled in our study. Among them, 50 (27 males and 23 females) with skin tags were selected as cases and 50 with other dermatologic diseases after matching age and gender were taken as controls. Blood glucose levels including both fasting and postprandial glucose levels were determined for both cases and controls and compared. Results: There was a higher frequency of Diabetes Mellitus and impaired glucose tolerance in patients with skin tags in comparison to controls (p<0.001). Moreover, there were higher odds of acquiring skin tags in patient with abnormal blood glucose levels. Conclusions: There is an increased risk of developing DM in patients with skin tags. It is highly recommended that suspicion for Diabetes Mellitus is to be done in patients with skin tags for early screening and diagnosis of Diabetes.

PSIII-2 Effect of Piglet Characteristics on Blood Glucose Levels at Birth

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 154-155
Author(s):  
Rafael Ovidio Bautista Rivas ◽  
Naomi C Willard ◽  
Katherine D Vande Pol ◽  
Jenny R Morris ◽  
Alicia Olivo Espinal ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Birth Weight ◽  
Birth Order ◽  
Experimental Unit ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Blood Samples ◽  
Limited Mobility ◽  
Glucose Levels ◽  
Blood Glucose Levels

Abstract Blood glucose levels in piglets at birth are potentially associated with survival, however, there has been limited research to quantify these and to establish any associations with piglet characteristics. This study, which evaluated the effects of a number of piglet characteristics on blood glucose levels at birth, was conducted as a cross-sectional survey involving 32 litters. Litter was the experimental unit; piglet was a sub-sample of litter. At birth, piglets were weighed and assigned a vitality score [1 = high vitality; 2 = low vitality (limited mobility and/or respiration)]. Piglets were then dried with a cellulose-based desiccant, and blood samples were collected from half of the piglets in each litter with a vitality score of 1 (n = 226) and all piglets with a vitality score of 2 (n = 7). Samples (1.2 μL) were collected from the vena subcutanea abdominis; blood glucose was measured using a glucometer (Accuchek Aviva; Roche Diabetes Care, Inc., Indianapolis, IN). Effects of piglet characteristics and relationships with blood glucose levels were analyzed using PROC MIXED, PROC GLIMMIX, and PROC REG of SAS, as appropriate. There were no effects (P &gt; 0.05) of piglet birth weight or gender on blood glucose levels. Piglets with a vitality score of 2 had higher (P &lt; 0.05) blood glucose levels than those with a score of 1. Blood glucose levels increased linearly (P &lt; 0.05) with birth order (0.8 mg/dL for each piglet increase). In conclusion, blood glucose levels at birth were higher for piglets with low compared to high vitality and for those born later in the birth order. Further research is needed to establish relationships between blood glucose levels in piglets at birth and subsequent survival.

THE EFFECT OF ADRENALECTOMY, DIHYDROERGOTAMINE, AND DIBENZYLINE ON THE SENSITIVITY OF RATS TO TOLBUTAMIDE

1963 ◽  
Vol 41 (10) ◽  
pp. 2189-2195 ◽  
Author(s):  
Rosemary D. Hawkins ◽  
R. E. Haist
Keyword(s):  
Blood Glucose ◽  
The Other ◽  
Compensatory Mechanisms ◽  
Blood Samples ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference ◽  
Tail Blood ◽  
Adrenalectomized Rats ◽  
Intact Rats

In the rat, the magnitude of the hypoglycaemic response to a dose of tolbutamide (50 mg/kg per os) which does not depress blood glucose levels to the point where adrenal compensatory mechanisms are stimulated is unaffected by adrenalectomy. On the other hand, when a dose is given which induces a greater hypoglycaemia (100 mg/kg per os) a very significant difference between adrenalectomized and sham-operated animals is observed, the adrenalectomized rats displaying a far greater sensitivity to the hypoglycaemic action of this compound. In intact rats, the hypoglycaemia induced by tolbutamide (100 mg/kg per os) is lessened by pretreatment of the animals with Dibenzyline (4 mg/kg) but enhanced by the prior injection of dihydroergotamine (2 mg/kg). Larger doses of dihydroergotamine alone cause a reduction in glucose levels of tail blood which is greater than that found in carotid blood samples withdrawn at the same times.

scholarly journals Baking Effect on Resistant Starch Digestion from Composite Bread Produced with Partial Wheat Flour Substitution

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Rafael Grassi de Alcântara ◽  
Heidge Fukumasu ◽  
Paulo Cesar Fabricio Raspantini ◽  
Leonila Ester Reinert Raspantini ◽  
Caroline Joy Steel ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wheat Flour ◽  
Resistant Starch ◽  
Composite Flour ◽  
Corn Flour ◽  
Glucose Levels ◽  
Baked Goods ◽  
Blood Glucose Levels ◽  
Green Banana

The consumption of composite flour, such as green banana and corn flour, is related to maintain stable blood glucose levels, due to high resistant starch levels. However, most of these studies have conducted analyses of unprocessed food such as flour. Therefore, this study aimed to evaluate the effect of baking on resistant starch concentration and digestion from bread produced with partial wheat flour substitution. Response surface methodology was used to evaluate bread physical-chemical characteristics, and then, sensorial and nutritional qualities of the bread were evaluated. The feasibility of incorporating 40% of corn flour was demonstrated, while incorporation of 20% produced bread with similar characteristics to the control; for green banana flour, these levels were 20 and 10%, respectively. Resistant starch levels of composite breads were also enhanced by in vitro analyses. On the other hand, in vivo blood glucose levels evidenced that the ingestion of breads produced with partial wheat flour substitution by green banana or corn flour promoted a more important peak in blood glucose levels in comparison with control bread, which was never previously presented in the literature. Bread ingestion rapidly increased the blood glucose levels of rats; once during the baking process, starch granules become gelatinized and therefore easily digestible. Furthermore, this study also highlighted the lack and need for future investigation of wheat flour-substituted baked goods, in order to better understand mechanical properties formation and also product digestibility.

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