Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors

2019 ◽  
Vol 29 (8) ◽  
pp. 3666-3682 ◽  
Author(s):  
Dongsheng Chen ◽  
Chunlian Wang ◽  
Meiyi Li ◽  
Xinyu She ◽  
Yonggui Yuan ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Social Interactions ◽  
Social Communication ◽  
Low Dose ◽  
Emotional Disorder ◽  
Membrane Excitability ◽  
Cellular Basis ◽  
Foxg1 Syndrome ◽  
Cognitive Defects

Abstract FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional disorder, and limited social communication. To elucidate the contribution of somatostatin-expressing interneurons (SST-INs) to the cellular basis underlying FOXG1 syndrome, here, by crossing SST-cre with a Foxg1fl/fl line, we selectively ablated Foxg1. Loss of Foxg1 resulted in an obvious reduction in the number of SST-INs, accompanied by an altered ratio of subtypes. Foxg1-deficient SST-INs exhibited decreased membrane excitability and a changed ratio of electrophysiological firing patterns, which subsequently led to an excitatory/inhibitory imbalance. Moreover, cognitive defects, limited social interactions, and depression-like behaviors were detected in Foxg1 cKO mice. Treatment with low-dose of clonazepam effectively alleviated the defects. These results identify a link of SST-IN development to the aberrant emotion, cognition, and social capacities in patients. Our findings identify a novel role of Foxg1 in SST-IN development and put new insights into the cellular basis of FOXG1 syndrome.

scholarly journals Using Fish Models for Assessing the Role of Sociality on the Microbiome: The Next Step for Translational Microbiome Research?

2019 ◽  
Author(s):  
Marta C. Soares ◽  
Jo Cable ◽  
Monica Lima-Maximino ◽  
Caio Maximino ◽  
Raquel Xavier
Keyword(s):  
Central Nervous System ◽  
Social Interactions ◽  
Social Communication ◽  
Social Behaviour ◽  
Ornamental Fish ◽  
Fish Model ◽  
Research Fields ◽  
Microbiome Research ◽  
And Function

Recent research has revealed surprisingly important connections between animals’ microbiome and social behaviour. Social interactions can affect the composition and function of the microbiome; conversely, the microbiome affects social communication by influencing the hosts’ central nervous system and peripheral chemical communication. These discoveries set the stage for novel research venues focusing on the evolution and physiology of animal social behaviour in relation to microbial transmission strategies. Here, we discuss the emerging roles of teleost fish model candidates and their key potential for advancing research fields linked to sociality and microbial regulation. We argue that fish models, such as the zebrafish, sticklebacks, guppies and cleaner-client dyads, will provide valuable insights into the roles of microbiome in shaping social behaviour and vice versa, while also being of direct relevance to the food and ornamental fish trades.

scholarly journals Depression in Adults With Mild Intellectual Disability: Role of Stress, Attributions, and Coping

2009 ◽  
Vol 114 (3) ◽  
pp. 147-160 ◽  
Author(s):  
Sigan L. Hartley ◽  
William E. MacLean
Keyword(s):  
Intellectual Disability ◽  
Coping Strategies ◽  
Social Interactions ◽  
Causal Attributions ◽  
Mild Intellectual Disability ◽  
Depressed Group ◽  
Negative Attribution ◽  
And Coping ◽  
Similar Experience

Abstract The experience of stressful social interactions, negative causal attributions, and the use of maladaptive coping efforts help maintain depression over time in the general population. We investigated whether a similar experience occurs among adults with mild intellectual disability. We compared the frequency and stress impact of such interactions, identified causal attributions for these interactions, and determined the coping strategies of 47 depressed and 47 nondepressed adults with mild intellectual disability matched on subject characteristics. The depressed group reported a higher frequency and stress impact of stressful social interactions, more negative attribution style, and more avoidant and less active coping strategies did than the nondepressed group. Findings have implications for theory building and development of psychotherapies to treat depression.

scholarly journals Using Fish Models for Assessing the Role of Sociality on the Microbiome: The Next Step for Translational Microbiome Research?

2018 ◽  
Author(s):  
Marta C. Soares ◽  
Jo Cable ◽  
Monica Lima-Maximino ◽  
Caio Maximino ◽  
Raquel Xavier
Keyword(s):  
Central Nervous System ◽  
Social Interactions ◽  
Social Communication ◽  
Social Behaviour ◽  
Ornamental Fish ◽  
Fish Model ◽  
Research Fields ◽  
Microbiome Research ◽  
And Function

Recent research has revealed surprisingly important connections between animals’ microbiome and social behaviour. Social interactions can affect the composition and function of the microbiome; conversely, the microbiome affects social communication by influencing the hosts’ central nervous system and peripheral chemical communication. These discoveries set the stage for novel research venues focusing on the evolution and physiology of animal social behaviour in relation to microbial transmission strategies. Here, we discuss the emerging roles of teleost fish model candidates and their key potential for advancing research fields linked to sociality and microbial regulation. We argue that fish models, such as the zebrafish, sticklebacks, guppies and cleaner-client dyads, will provide valuable insights into the roles of microbiome in shaping social behaviour and vice versa, while also being of direct relevance to the food and ornamental fish trades.

scholarly journals Mosaic and non-mosaic pcdh19 mutation leads to neuronal hyperexcitability in zebrafish

2021 ◽  
Author(s):  
Barbara K Robens ◽  
Xinzhu Yang ◽  
Christopher M McGraw ◽  
Laura H Turner ◽  
Carsten Robens ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Neurological Disorders ◽  
Early Onset ◽  
Inhibitory Synapse ◽  
Inhibitory Interneurons ◽  
Down Regulation ◽  
Linked Gene ◽  
Neuronal Hyperexcitability ◽  
Cellular Basis

Epilepsy is one of the most common neurological disorders. The X-linked gene PCDH19 is associated with sporadic and familial epilepsy in humans, typically with early-onset clustering seizures and intellectual disability in females but not in so-called carrier males, suggesting that mosaic PCDH19 expression is required to produce epilepsy. To characterize the role of loss of PCDH19 function in epilepsy, we generated zebrafish with truncating pcdh19 variants. We observed hyperexcitability phenotypes in both mosaic and non-mosaic pcdh19+/- and -/- mutant larvae, indicating that Pcdh19 cellular mosaicism is not required for network hyperexcitability in zebrafish. Further, zebrafish with non-mosaic pcdh19 mutation display reduced numbers of inhibitory interneurons and transcriptional down-regulation of key inhibitory synapse components, suggesting a potential cellular basis for the observed hyperexcitability. Our findings in both mosaic and non-mosaic pcdh19 mutant zebrafish challenge the prevailing theory that mosaicism governs all PCDH19-related phenotypes and point to interneuron-mediated mechanisms underlying these phenotypes.

Value-driven issues throughout the development of sociological theory

2020 ◽  
pp. 147-160
Author(s):  
Gulbarshyn Chepurko ◽  
Valerii Pylypenko
Keyword(s):  
Social Interactions ◽  
Social System ◽  
Sociological Theory ◽  
Social Scientists ◽  
Social Sphere ◽  
Technological Advances ◽  
The Social ◽  
The Individual ◽  
Different Levels

The paper examines and compares how the major sociological theories treat axiological issues. Value-driven topics are analysed in view of their relevance to society in times of crisis, when both societal life and the very structure of society undergo dramatic change. Nowadays, social scientists around the world are also witnessing such a change due to the emergence of alternative schools of sociological thought (non-classical, interpretive, postmodern, etc.) and, subsequently, the necessity to revise the paradigms that have been existed in sociology so far. Since the above-mentioned approaches are often used to address value-related issues, building a solid theoretical framework for these studies takes on considerable significance. Furthermore, the paradigm revision has been prompted by technological advances changing all areas of people’s lives, especially social interactions. The global human community, integral in nature, is being formed, and production of human values now matters more than production of things; hence the “expansion” of value-focused perspectives in contemporary sociology. The authors give special attention to collectivities which are higher-order units of the social system. These units are described as well-organised action systems where each individual performs his/her specific role. Just as the role of an individual is distinct from that of the collectivity (because the individual and the collectivity are different as units), so too a distinction is drawn between the value and the norm — because they represent different levels of social relationships. Values are the main connecting element between the society’s cultural system and the social sphere while norms, for the most part, belong to the social system. Values serve primarily to maintain the pattern according to which the society is functioning at a given time; norms are essential to social integration. Apart from being the means of regulating social processes and relationships, norms embody the “principles” that can be applied beyond a particular social system. The authors underline that it is important for Ukrainian sociology to keep abreast of the latest developments in the field of axiology and make good use of those ideas because this is a prerequisite for its successful integration into the global sociological community.

SUSTAINABLE LIVELIHOOD THROUGH SKILL DEVELOPMENT AMONG RURAL YOUTH: ROLE OF MICRO-FINANCE IN THE DEVELOPMENTAL PARADIGM

2017 ◽  
Vol 14 (1) ◽  
pp. 156-173
Author(s):  
Vikram Singh
Keyword(s):  
Social Interactions ◽  
Skill Development ◽  
Well Being ◽  
Rural Youth ◽  
Inclusive Development ◽  
Sustainable Livelihood ◽  
Theoretical Understanding ◽  
Societal Structure ◽  
Policy Shifts

This  article  attempts to  analyse  the  process  of  sustainable  livelihood  through skill development and its conceptual and theoretical understanding in India with reference to rural youth. In India skill development is demanded for economic growth and inclusive development; hence the rural population cannot be overlooked. Employable skills alone have not been able to generate sufficient employment among rural youth or address/promote well-being and sustainable livelihood. Various frameworks associated with skill development leave scope for reforms to strengthen the implementation of various policy shifts in respect of rural development and government/non-government organisations. The process of skill development for rural youth through the establishment of institutions, launch of policy/programmes and their linkages with micro-finance are considered, as the distinctive nature and features of micro-finance in relation to the forces of societal structure, social relationships, and social interactions leading towards collective interests and norms that shape the lives of rural youth. Lastly, analysis is done and conclusions drawn on the basis of discussion.

The Relationship between social skills and percived smartphone usage

2019 ◽  
Author(s):  
Rageshawari Munderia ◽  
Rajbala Singh
Keyword(s):  
Social Skills ◽  
Social Relationships ◽  
Social Communication ◽  
Regression Method ◽  
Emotional Control ◽  
Smartphone Addiction ◽  
Adult Participants ◽  
Multiple Regression Method ◽  
The Relationship

Social skills play an instrumental role in individuals’ life. It helps individuals to communicate and maintain social relationships. Presently, the smartphone has completely changed the mode of social communication, and social skills may play a crucial role in this regard. Thus, the aim of the present study is to investigate the association between social skills and perceived smartphone usage (both positive and negative usage). The perceived negative usage of the smartphone has been assessed in terms of smartphone addiction. Sample of the present study comprised of (n=509) adult participants. Pearson’s product moment correlation (r) and multiple regression method was employed to assess the relationship between the proposed variables. Findings of the study demonstrated that social skills are significantly related with both perceived positive usage of smartphone and smartphone addiction. Social expressivity and emotional control emerged as significant predictors for both positive usage of smartphone and smartphone addiction. The findings of the study may have important implications for bringing awareness among the individuals regarding the role of social skills for effective usage of smartphone as well as for future researches in this direction. Keywords: social skill, perceived positive smartphone usage, smartphone addiction, emotion expressivity, emotional control

New Democracy in Digital Era through Social Media and News Online

Humaniora ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 13
Author(s):  
Abitassha Az Zahra ◽  
Eko Priyo Purnomo ◽  
Aulia Nur Kasiwi
Keyword(s):  
Social Media ◽  
Social Network ◽  
Communication Networks ◽  
Social Communication ◽  
Development Policy ◽  
Online News ◽  
Digital Era ◽  
The Social ◽  
New Democracy

The research aimed to explain the pattern of social communication on the issue of rejection of the PLTU Batang development policy. It used data on Twitter accounts involved in the rejection of the PLTU Batang development policy. In analyzing existing data, qualitative methods and social analysis networks were used. To see social networks in the rejection of the PLTU Batang development policy, the research used the NodeXL application to find out the patterns of social communication networks in #TolakPLTUBatang. From the results, it can be seen that in the dissemination of social networking information, the @praditya_wibby account is the most central account in the social network and has a strong influence on the social network. The @praditya_wibby account has a role in moving the community through Twitter to make a critical social movement. This means that in the current digital era, democracy enters a new form through the movement of public opinion delivery through social media. Besides, by encouraging the role of online news, the distribution of information becomes faster to form new perceptions of an issue. This is evident from the correlation network where the @praditya_wibby account has correlations with several compass online media accounts, tirto.id, okezonenews, vice, antaranews, BBCIndonesia, and CNN Indonesia.

A Phenomenology of Rhythm

2018 ◽  
Author(s):  
Lexi Eikelboom
Keyword(s):  
Social Sciences ◽  
Social Interactions ◽  
Henri Lefebvre ◽  
Theoretical Perspectives ◽  
The Social ◽  
Analytical Importance ◽  
Jazz Performance

This chapter proposes a framework for approaching the theological significance of rhythm through phenomenology, prosody, and the social sciences. In accordance with the general categories of phenomenology established by Merleau-Ponty and the “rhythmanalysis” of Henri Lefebvre, the chapter investigates two experiences of rhythm: approaches to analysing the human encounter with rhythm in the reading of poetry and the role of rhythm in social interactions introduced through commonalities between rhythm in conversation and in jazz performance. These explorations establish two features of rhythm that are of analytical importance for the chapters that follow: (1) the synchronic and the diachronic as two necessary but distinct theoretical perspectives on rhythm, each of which emphasizes different features of rhythm and (2) the importance of interruption for understanding rhythm’s significance.

scholarly journals In the Ear of the Listener: The Role of Foreign Accent in Interethnic Friendships and Partnerships

2021 ◽  
pp. 019791832098883
Author(s):  
Irena Kogan ◽  
Jörg Dollmann ◽  
Markus Weißmann
Keyword(s):  
Social Interactions ◽  
Social Distance ◽  
Children Of Immigrants ◽  
Longitudinal Survey ◽  
Foreign Accent ◽  
Interethnic Relations ◽  
Accented Speech ◽  
Interethnic Friendships ◽  
Communicative Power

This article examines the association between accented speech and the formation of friendships and partnerships among immigrants and native-born majority residents in Germany. Drawing on the sixth wave of the German extension of the Children of Immigrants Longitudinal Survey in Four European Countries, we analyze a neglected aspect of language — pronunciation — and find that speaking with a foreign accent is a more important correlate of the incidence of interethnic partnerships than of interethnic friendships. We argue that beyond its primary function of understandability, accented speech possesses socially communicative power. Accent transmits signals of an individual’s foreignness and cultural differences and, thus, becomes an additional marker of social distance. Such signals serve as a greater obstacle to more consequential intimate interethnic relations such as partnerships. Our findings extend the scholarly debate on the role of symbolic boundaries in social interactions between ethnic groups by yet another important boundary maker — accent.

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