scholarly journals Leveraging the potential of machine learning for assessing vascular ageing: state-of-the-art and future research

Author(s):  
Vasiliki Bikia ◽  
Terence Fong ◽  
Rachel E Climie ◽  
Rosa- Maria Bruno ◽  
Bernhard Hametner ◽  
...  

Abstract Vascular ageing biomarkers have been found to be predictive of cardiovascular risk independently of classical risk factors, yet are not widely used in clinical practice. In this review we present two basic approaches for using machine learning (ML) to assess vascular age: parameter estimation and risk classification. We then summarize their role in developing new techniques to assess vascular ageing quickly and accurately. We discuss the methods used to validate ML-based markers, the evidence for their clinical utility, and key directions for future research. The review is complemented by case studies of the use of ML in vascular age assessment which can be replicated using freely available data and code.

2019 ◽  
Vol 74 (12) ◽  
pp. 1903-1909 ◽  
Author(s):  
Meredith L Wallace ◽  
Daniel J Buysse ◽  
Susan Redline ◽  
Katie L Stone ◽  
Kristine Ensrud ◽  
...  

Abstract Background Sleep characteristics related to duration, timing, continuity, and sleepiness are associated with mortality in older adults, but rarely considered in health recommendations. We applied machine learning to: (i) establish the predictive ability of a multidimensional self-reported sleep domain for all-cause and cardiovascular mortality in older adults relative to other established risk factors and (ii) to identify which sleep characteristics are most predictive. Methods The analytic sample includes N = 8,668 older adults (54% female) aged 65–99 years with self-reported sleep characterization and longitudinal follow-up (≤15.5 years), aggregated from three epidemiological cohorts. We used variable importance (VIMP) metrics from a random survival forest to rank the predictive abilities of 47 measures and domains to which they belong. VIMPs > 0 indicate predictive variables/domains. Results Multidimensional sleep was a significant predictor of all-cause (VIMP [99.9% confidence interval {CI}] = 0.94 [0.60, 1.29]) and cardiovascular (1.98 [1.31, 2.64]) mortality. For all-cause mortality, it ranked below that of the sociodemographic (3.94 [3.02, 4.87]), physical health (3.79 [3.01, 4.57]), and medication (1.33 [0.94, 1.73]) domains but above that of the health behaviors domain (0.22 [0.06, 0.38]). The domains were ranked similarly for cardiovascular mortality. The most predictive individual sleep characteristics across outcomes were time in bed, hours spent napping, and wake-up time. Conclusion Multidimensional sleep is an important predictor of mortality that should be considered among other more routinely used predictors. Future research should develop tools for measuring multidimensional sleep—especially those incorporating time in bed, napping, and timing—and test mechanistic pathways through which these characteristics relate to mortality.


2021 ◽  
Author(s):  
Bing Xue ◽  
Mengjie Zhang ◽  
William Browne ◽  
X Yao

Feature selection is an important task in data miningand machine learning to reduce the dimensionality of the dataand increase the performance of an algorithm, such as a clas-sification algorithm. However, feature selection is a challengingtask due mainly to the large search space. A variety of methodshave been applied to solve feature selection problems, whereevolutionary computation techniques have recently gained muchattention and shown some success. However, there are no compre-hensive guidelines on the strengths and weaknesses of alternativeapproaches. This leads to a disjointed and fragmented fieldwith ultimately lost opportunities for improving performanceand successful applications. This paper presents a comprehensivesurvey of the state-of-the-art work on evolutionary computationfor feature selection, which identifies the contributions of thesedifferent algorithms. In addition, current issues and challengesare also discussed to identify promising areas for future research. Index Terms—Evolutionary computation, feature selection,classification, data mining, machine learning. © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.


2021 ◽  
Vol 11 (6) ◽  
pp. 7824-7835
Author(s):  
H. Alalawi ◽  
M. Alsuwat ◽  
H. Alhakami

The importance of classification algorithms has increased in recent years. Classification is a branch of supervised learning with the goal of predicting class labels categorical of new cases. Additionally, with Coronavirus (COVID-19) propagation since 2019, the world still faces a great challenge in defeating COVID-19 even with modern methods and technologies. This paper gives an overview of classification algorithms to provide the readers with an understanding of the concept of the state-of-the-art classification algorithms and their applications used in the COVID-19 diagnosis and detection. It also describes some of the research published on classification algorithms, the existing gaps in the research, and future research directions. This article encourages both academics and machine learning learners to further strengthen the basis of classification methods.


2021 ◽  
Author(s):  
Bing Xue ◽  
Mengjie Zhang ◽  
William Browne ◽  
X Yao

Feature selection is an important task in data miningand machine learning to reduce the dimensionality of the dataand increase the performance of an algorithm, such as a clas-sification algorithm. However, feature selection is a challengingtask due mainly to the large search space. A variety of methodshave been applied to solve feature selection problems, whereevolutionary computation techniques have recently gained muchattention and shown some success. However, there are no compre-hensive guidelines on the strengths and weaknesses of alternativeapproaches. This leads to a disjointed and fragmented fieldwith ultimately lost opportunities for improving performanceand successful applications. This paper presents a comprehensivesurvey of the state-of-the-art work on evolutionary computationfor feature selection, which identifies the contributions of thesedifferent algorithms. In addition, current issues and challengesare also discussed to identify promising areas for future research. Index Terms—Evolutionary computation, feature selection,classification, data mining, machine learning. © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.


2020 ◽  
Vol 36 (4) ◽  
pp. 1769-1801 ◽  
Author(s):  
Yazhou Xie ◽  
Majid Ebad Sichani ◽  
Jamie E Padgett ◽  
Reginald DesRoches

Machine learning (ML) has evolved rapidly over recent years with the promise to substantially alter and enhance the role of data science in a variety of disciplines. Compared with traditional approaches, ML offers advantages to handle complex problems, provide computational efficiency, propagate and treat uncertainties, and facilitate decision making. Also, the maturing of ML has led to significant advances in not only the main-stream artificial intelligence (AI) research but also other science and engineering fields, such as material science, bioengineering, construction management, and transportation engineering. This study conducts a comprehensive review of the progress and challenges of implementing ML in the earthquake engineering domain. A hierarchical attribute matrix is adopted to categorize the existing literature based on four traits identified in the field, such as ML method, topic area, data resource, and scale of analysis. The state-of-the-art review indicates to what extent ML has been applied in four topic areas of earthquake engineering, including seismic hazard analysis, system identification and damage detection, seismic fragility assessment, and structural control for earthquake mitigation. Moreover, research challenges and the associated future research needs are discussed, which include embracing the next generation of data sharing and sensor technologies, implementing more advanced ML techniques, and developing physics-guided ML models.


Cervical Cancer is considered the fourth most common female malignancy worldwide and represents a major global health challenge. As a result, in recent years, various proposals and researches have been conducted. This study aims to analyze the data presented in current researches regarding cervical cancer and contribute to future research, all through the framework of literature review, based on 3 research questions: Q1: What are the risk factors that cause cervical cancer? Q2: What preventive measures are currently established for cervical cancer? and, Q3: What are the techniques to detect cervical cancer? Findings show that detection techniques are complementary since they are categorized under machine learning. Therefore, we recommend that further study be promoted in these techniques as they are helpful in the detection process. In addition, risk factors can be considered for a greater scope in detection, such as HPV infection, since it is the most relevant factor for the development of cervical cancer. Finally, we suggest to conduct further research on preventive measures for cervical cancer.


Author(s):  
Vijay Bhagat ◽  
Shubhangi Baviskar ◽  
Abhay B. Mudey ◽  
Ramachandra Goyal

Background: Considering the complex interaction of risk factors in causation of CVD; assessment of vascular ageing among the high risk group through non-interventional statistical models was useful in controlling CVD. While, many CVD risk assessment models were especially designed for application in the specific population or region such as SCORE scales for Europeans, ASSIGN scores for people of Scotland. The Framingham Risk Score were modified, validated and used in several countries. Though Indians have significantly higher predilection for CVD, no indigenous scores were developed or validated to assess the CV risk. The objective of the study were to determine vascular age of the study participants using Framingham risk prediction model, to assess its relationship with development of cardiovascular disease and to develop, validate and compare cardiovascular risk prediction model based on the follow up observations of the study participants.Methods: Community based cohort study will be conducted in large urban and rural population aged 31-60 years of age those who have no evidence of CVD. The study population will be followed up for three years and will be assessed for development of CVD. The vascular age will be determined using Framingham Risk Scores. Based on the risk factors associated with occurrence of CVD during the study period, the risk prediction model will be designed and tested for validity and accuracy. Results: The newly developed CVD risk prediction will be more accurate in assessment of CV risk among the study subjects. Conclusions: The newly developed and validated CV risk prediction model specific for Indians may be one of the first prospective CV risk assessment cohort study. 


Author(s):  
Peter H. Charlton ◽  
Birutė Paliakaitė‬‬‬ ◽  
Kristjan Pilt ◽  
Martin Bachler ◽  
Serena Zanelli ◽  
...  

The photoplethysmogram (PPG) signal is widely measured by clinical and consumer devices, and it is emerging as a potential tool for assessing vascular age. The shape and timing of the PPG pulse wave are both influenced by normal vascular ageing, changes in arterial stiffness and blood pressure, and atherosclerosis. This review summarises research into assessing vascular age from the PPG. Three categories of approaches are described: (i) those which use a single PPG signal (based on pulse wave analysis); (ii) those which use multiple PPG signals (such as pulse transit time measurement); and (iii) those which use PPG and other signals (such as pulse arrival time measurement). Evidence is then presented on the performance, repeatability and reproducibility, and clinical utility of PPG-derived parameters of vascular age. Finally, the review outlines key directions for future research to realise the full potential of photoplethysmography for assessing vascular age.


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