scholarly journals Analysis of corrected QT dispersion, tp-e values in small heart syndrome patients

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
E Ibisoglu
Keyword(s):  
Patient Group ◽  
Qt Dispersion ◽  
Control Group ◽  
P Value ◽  
Female Patients ◽  
Funding Sources ◽  
Heart Patients ◽  
Small Heart ◽  
Chest X Ray ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Background and objectives We aimed to evaluate the marker of ventricular arrhythmias such as Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios in ‘Small Heart Syndrome’ female patients and also aimed to evaluate the association between ‘small heart syndrome’ and fibromyalgia in female patients. Methods A total of 94 female, including 47 small-heart and 47 normal-heart patients, who applied from March 2018 to February 2020 and who were examined by a physical therapy and rehabilitation specialist, were included in the study by calculating their cardiothoracic ratios (CTR) from the chest x-ray. QTmax, QTmin,QRS, JT and Tp-e intervals were measured. In addition, Tp-e/QTmax, Tp-e/QTc max, Tp-e/JT and Tp-e/JTc rates and QTc max, QTc min, cQTd and JTc intervals were calculated. Results cQTd (24,246 ± 9,046 ms vs. 35,495 ± 14,358 ms, p < 0.001), Tp-e (67,32 ± 11,661 ms vs. 72,67 ± 11,028 ms, p = 0.04), Tp-e/QTc max (0,166 ± 0.028 vs. 0.181 ± 0.027, p = 0,012), Tp-e/JTc (0,214 ± 0.038 vs. 0.232 ± 0.034, p = 0,022) values were significantly higher in small heart patient group. QT min (330,68 ± 26,611 ms vs. 323,04 ± 30,829 ms, p = 0,202) values were significantly lower in patient group. Conclusion Compared to control group potential ECG repolarization predictors were significantly increased in ‘Small Heart Syndrome’ patients. TableElectrocardiographic findings o Control group(n = 47) Patient group(n = 47) P value Heart rate, bpm 87,81 + 15,532 83,81 + 14,372 0,223 QRS; ms 83,23 + 6,948 81,91 + 10,052 0,206 QT max; ms 354,93 + 26,796 358,54 + 28,434 0,528 QT min; ms 330,68 + 26,611 323,04 + 30,829 0,202 JT; ms 265,7 + 25,16 271,88 + 23,104 0,218 QTc max; ms 403,59 + 18,208 400,20 + 18,336 0,371 QTc min; ms 379,34 + 20,064 364,71 + 23,149 0,004* JTc; ms 314,37 + 21,325 313,55 + 22,526 0,856 cQTd; ms 24,246 + 9,046 35,495 + 14,358 <0,001* Tp-e; ms 67,32 + 11,661 72,67 + 11,028 0,040* Tp-e/QT max 0,190 + 0,034 0,203 + 0,031 0,063 Tp-e/QTc max 0,166 + 0,028 0,181 + 0,027 0,012* Tp-e/JT 0,255 + 0,047 0,267 + 0,036 0,295 Tp-e/JTc 0,214 + 0,038 0,232 + 0,034 0,022*

Rising patients" adherence to CVD preventive treatment via medical and psychological counseling using remote technologies

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
OV Kopylova ◽  
NA Sirota ◽  
VM Yaltonsky
Keyword(s):  
Risk Factors ◽  
Medical Treatment ◽  
Healthy Lifestyle ◽  
Preventive Treatment ◽  
Control Group ◽  
Psychological Counselling ◽  
Funding Sources ◽  
Item Questionnaire ◽  
Experimental Group ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Low adherence to healthy lifestyle and CVD preventive medical treatment is a seriouse problem in lowering of CVD morbidity and mortality. Using modern medical, psychological and remote technologies may help to increase patients" adherence. Purpose To study the efficacy of medical and psychological counselling using remote technologies in rising patients" adherence to CVD preventive treatment. Methods The study included 140 patients with risk factors for cardiovascular disease (RF CVD), who were divided into two comparable groups: group of medical and psychological counselling with the use of remote technologies (n = 70) and group of control (n = 70).  The study lastet 12 months. Level of adherence was measured via standard Morisky-Green"s 4-item questionnaire as well as via additional questionnaire developed by authors for this study. Results Comparative analysis of the level of adherence in the two groups did not reveal statistically significant differences at baseline. After 12 months, the experimental group showed a statistically significant increase in adherence to preventive treatment compared with the control group (р=0,001) Conclusion(s) Medical and psychological counselling using remote technologies is an effective method for rising patients" adherence to CVD preventive medical treatment

The G allele in IL-10-1082 G/A may have a role in lowering the susceptibility to panic disorder in female patients

2016 ◽  
Vol 28 (6) ◽  
pp. 357-361 ◽  
Author(s):  
Han-Joon Kim ◽  
Yong-Ku Kim
Keyword(s):  
Panic Disorder ◽  
Patient Group ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Female Patients ◽  
Immune System Activation ◽  
Tnf Α ◽  
System Activation ◽  
And Control

BackgroundImmune system activation is involved in the pathophysiology of panic disorder (PD). We investigated INF-γ+874 A/T, TNF-α-308 G/A, and IL-10-1082 G/A single nucleotide polymorphisms (SNPs) to determine their association with PD.MethodThis study enroled 135 PD patients and 135 healthy controls. INF-γ+874 A/T (rs2430561), TNF-α-308 G/A (rs1800629), and IL-10-1082 G/A (rs1800896) were genotyped.ResultsThere were no differences in genotypes or allele frequencies between the patient and control groups, regardless of accompanying agoraphobia. However, for female patients, the G allele frequency in IL-10 SNP was higher in the control group than in the patient group. Additionally, the female control group had a higher frequency of the A/G and G/G genotype in the IL-10 SNP than the female patient group.ConclusionWe suggest that the G allele in IL-10-1082 G/A might have a role in reducing the manifestations of PD in female patients. Further studies are needed to extend and confirm our findings.

scholarly journals Evaluation of Cardiac Repolarization Indices in Epilepsy Patients Treated with Carbamazepine and Valproic Acid

Medicina ◽  
2020 ◽  
Vol 56 (1) ◽  
pp. 20
Author(s):  
Ramazan Asoğlu ◽  
Mahmut Özdemir ◽  
Nesim Aladağ ◽  
Emin Asoğlu
Keyword(s):  
Valproic Acid ◽  
Qt Interval ◽  
Qt Dispersion ◽  
Clonic Seizure ◽  
Control Group ◽  
Cardiac Repolarization ◽  
Healthy Controls ◽  
Male Population ◽  
Female Patients ◽  
Male Patients

Background and Objectives: Epilepsy patients have a higher risk of sudden unexplained death compared to the rest of the population. Cardiac repolarization abnormalities might be seen in epilepsy during interictal periods. We aimed to evaluate the changes in electrocardiography (ECG) parameters in generalized tonic-clonic seizure patients treated with carbamazepine or valproic acid (VPA) drug. Materials and Methods: A totally of 129 subjects (66 epilepsy patients, 63 healthy subjects) were enrolled in the study. Of the patients, 36 were on carbamazepine and 30 were on VPA. There were 12-lead ECGs obtained from all participants. RR interval (time between consecutive R peaks), QT interval (defines the period of ventricular repolarization), corrected QT (QT interval corrected for heart rate; QTc), QTc-maximum (QTc-max), QTc-minimum (QTc-min), QTc dispersion (QTcd), P (atrial depolarization )-maximum (P-max), P-minimum (P-min) and P dispersion (Pd) were measured. Results: QTd (QT dispersion), QTcd, and Pd values were significantly higher in the patients compared to the controls (p < 0.01). QTcd, Pd, and P-max values were statistically higher in male patients compared to healthy male controls. QTcd values were significantly higher in female patients using carbamazepine compared to the female patients on VPA and healthy controls (p = 0.01). Male patients using VPA had significantly higher QTcd values against the male population in carbamazepine and control groups. Conclusions: This study demonstrated that QTd, QTcd, and Pd values were significantly higher in epilepsy patients than in healthy controls. In addition, female patients using carbamazepine and male patients using VPA were prone to ventricular arrhythmia compared to the control group.

scholarly journals Leadless pacemakers: where is the device?

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
M Elrefai ◽  
C Menexi ◽  
P Roberts
Keyword(s):  
Heart Diseases ◽  
Sinus Node ◽  
X Rays ◽  
Funding Sources ◽  
Safety And Reliability ◽  
Chest X Ray ◽  
Implantation Sites ◽  
The Right ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Leadless pacemakers (LPs) were designed to avoid lead-related complications associated with transvenous pacing. To minimise the risk of complications, there is preference towards implanting LPs into the septal aspect of the right ventricle rather than the apex or free wall. The Transcatheter Pacing Study (TPS) and the international post-approval registry demonstrated the safety and reliability of the LP systems in real-world settings. The registry demonstrated that more than half of the LPs were implanted into the septum and most required &lt;2 attempts at deployment. We report a radiological method of defining LP position. Methods We reviewed the first 100 LPs implanted at our centre. Two independent observers who didn’t implant LPs reviewed the patients’ post-implant fluoroscopy images and/or post-implant CXRs when available. The reviewers assessed the devices’ positions in postero-anterior (PA) and/or right anterior oblique (RAO) views based on conventional fluoroscopic criteria for lead position. We used the proposed criteria interchangeably on fluoroscopic images and post implant CXRs (Figure). Differences in classification of device position were resolved by consensus. Results Three experienced operators implanted 100 LPs at our centre. Patients (61% male) 56.6 ± 22.2 years had normal hearts (74%), ischaemic cardiomyopathies (12%), congenital heart diseases (6%), valvular pathologies (5%) and dilated cardiomyopathies (3%). Indications for pacing were symptomatic sinus node dysfunction (36%), followed by high grade atrio-ventricular block (33%), bradyarrhythmia associated with atrial tachyarrhythmias (27%) and other indications for pacing (4%). We had a 100% successful implant rate, 88% required ≤2 attempts and 70% required one attempt. There were no major complications. We were able to classify the site of the LPs implants in a total of 90 patients who had fluoroscopic projections or chest x-rays that would allow us to classify the implant sites. A total of 32 implants were in the apex (35.6%). 28 were in mid-septum (31.1 %), 15 in the apical septum (16.7%), 14 on the septal aspect of the right ventricular inflow (15.5%) and 1 implant (1.1%) in the septum of the RV outflow tract. Conclusion Our proposed method of defining LP position demonstrated that the rate of implants into the true apex at our centre was highly comparable to that of the international registry. It also showed that we had lower rates of implants into the mid-septum in favour of apical septum. There were no pericardial effusions or cardiac perforations resulting from our implant procedures regardless of the site of the implant. We utilised widely used fluoroscopic and chest x-ray criteria for categorisation of the LPs implantation sites. However, a recognised limitation to our analysis is that our findings were not validated using other imaging modalities such as echocardiogram or cardiac computerised tomography (CT). Abstract Figure. Criteria to classify device position

scholarly journals Serum progranulin levels in axial spondyloarthropathy and relationship with clinical features

2021 ◽  
Author(s):  
Didem İldemir Doğangün ◽  
Meliha Kasapoğlu Aksoy ◽  
Lale Altan
Keyword(s):  
Disease Activity ◽  
Patient Group ◽  
Symptom Severity ◽  
High Body Mass Index ◽  
Control Group ◽  
Healthy Individuals ◽  
Female Patients ◽  
Asas Criteria ◽  
Axial Spondyloarthropathy ◽  
Pgrn Level

Objectives: In this study, we aimed to investigate the serum progranulin (PGRN) levels in patients with axial spondyloarthropathy (AxSpA) and to identify the correlation between disease activity, symptom severity, acute phase reactant (APR), and serum PGNR levels in patients with AxSpA. Patients and methods: This prospective, cross-sectional study included a total of 152 patients (105 males, 47 females; mean age: 41.8±10.3; range 20 to 65 years) with AxSpA according to the 2009 Assessment of SpondyloArthritis Society (ASAS) criteria who received treatment and 100 healthy individuals (61 males, 39 females; mean age 43.4±14.2; range 20 to 65 years) between February 2018 and February 2019. Serum PGRN levels from the venous blood were analyzed in both groups. The clinical AxSpA assessment scales were used in the patient group. Erythrocyte sedimentation rate and C-reactive protein levels were examined. Results: The mean serum PGRN level was 6.9±5.4 ng/mL in the patient group and 11.2±6.0 ng/mL in the control group. Serum PGRN level was significantly higher in the control group (p<0.001). No significant correlation was found between the PGRN levels and disease activity, symptom severity, duration of disease, and age of the patient (p>0.05). Serum PGRN levels were significantly higher in female patients in the patient group (p<0.01). In the control group, the serum PGRN levels of individuals with a high body mass index were significantly higher (p=0.001). Conclusion: Serum PGRN levels of patients with AxSpA who are under treatment and follow-up are significantly lower than healthy individuals. Serum PGRN levels in female patients with AxSpA are also significantly higher than male patients. Serum PGRN levels do not seem to be related to disease activity.

Micro structural abnormalities of the Cingulum in children with focal epilepsy: DTI study

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Laila Ahmad Abdurrahman ◽  
Neveen Tawakol Younis ◽  
Shaimaa Abdelsattar Mohammad ◽  
Aly Haggag Aly Nour El Dein
Keyword(s):  
Patient Group ◽  
Focal Epilepsy ◽  
Control Group ◽  
P Value ◽  
Fiber Tractography ◽  
Fiber Tracts ◽  
Mri Protocol ◽  
Group A ◽  
White Matter Fiber Tracts ◽  
And Control

Abstract Aim of the work The aim of this study is to evaluate the microstructural alteration implicating the Cingulum (CG) as one of the major limbic system white matter fiber tracts; in children with focal epilepsy. Patients and methods Our study was carried out on twenty-one children with the clinical and EEG diagnosis of focal epilepsy and 22 control subjects who were age and sex matched to patient group in the study. All patients underwent an epilepsy specific MRI protocol. DTI and fiber tractography was performed to all subjects as well. Fractional anisotropy (FA), axial diffusivity, radial diffusivity (RD) and trace were calculated for CG. DTI metrics were compared between both hemispheres as well as between both groups patient group and control group. A p-value less than .05 was considered significant. Results Asymmetry in FA, RD, trace and AD values of the CG was demonstrated in patients with focal epilepsy between both hemispheres with significantly lower FA and higher diffusivity values reaching p &lt; 0.001in CG in both hemispheres in patients with focal epilepsy when compared together regardless the seizure focus. Compared with controls, patients with left focal epilepsy demonstrated significant lower FA and higher diffusivity indices in both ipsilateral and contralateral fiber tracts as well p &lt; 0.05. Patients with right focal epilepsy showed no significant asymmetry in different DTI metrics when compared to controls. Conclusion Reduction in FA values along with increased diffusivity measures in the CG reflects the microstructural changes taking place in children with focal epilepsy.

scholarly journals The Importance of Thrombotic Risk Factors in the Development of Idiopathic Sudden Hearing Loss

2008 ◽  
Vol 14 (3) ◽  
pp. 356-359 ◽  
Author(s):  
Zuleyha Yildiz ◽  
Arzu Ulu ◽  
Armagan Incesulu ◽  
Yalcin Ozkaptan ◽  
Nejat Akar
Keyword(s):  
Hearing Loss ◽  
Patient Group ◽  
Sudden Hearing Loss ◽  
Cell Protein ◽  
Control Group ◽  
P Value ◽  
Factor V ◽  
Plasminogen Activator Inhibitor 1 ◽  
Thrombotic Risk ◽  
Pai 1

Impaired cochlear blood circulation has been suggested to cause sudden hearing loss. In this study, the role of factor V 1691 G-A (FV 1691 G-A), prothrombin 20210 G-A (PT 20210 G-A), methylene tetrahydrofolate reductase 677 C-T (MTHFR 677 C-T), factor V 4070 A-G (FV 4070 A-G), endothelial cell protein C receptor (EPCR) gene 23-bp insertion, and plasminogen activator inhibitor-1 (PAI-1) 4G/5G mutation was assessed. Fifty-three patients with idiopathic sudden sensorineural hearing loss and 80 individuals comprising the control group were included in this study. The frequency for FV 1691 A was 6.2% in the patient group and 3.7% in the control group, PT 20210 G-A was 1.2% in the patient group and 1.9% in the control group, and FV 4070 A-G was 7.5% in the patient group and 11.3% in the control group. The frequency of MTHFR 677 C-T was significantly higher in the patient group than in the control group, with a P value of .03. PAI-1-675 4G/5G polymorphism was found to be 71.2% and 69.8%, in the control group and the patient group, respectively. The EPCR 23-bp insertion was 0% in the control group and was found in 3 patients (3.7%), which needs further study.

scholarly journals Prevalence and main causes of myocardial infarction type 2 in the structure of in-hospital mortality

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
I Leonova ◽  
D Oblavatsky ◽  
S Boldueva
Keyword(s):  
Myocardial Infarction ◽  
Causes Of Death ◽  
Surgical Patients ◽  
Control Group ◽  
Type Ii ◽  
Funding Sources ◽  
Cardiology Department ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. Purpose the assessment of the proportion of myocardial infarction (MI) type 2 in the structure of mortality in a multidisciplinary hospital Material and methods. A retrospective study was made of 1,574 autopsy protocols carried out in a multidisciplinary hospital in the period from 01.01.10 to 31.12.16, of which a group with postmortem type II MI was identified. The control group was composed of persons who died from proven atherothrombotic type 1 MI Results. In 360 cases (22.87%), the cause of death was MI. Of these, 137 cases were due to type 2 MI. The ratio of men and women was the same. Type 2 MI more often developed in elderly (48.2%) and senile (34.3%) ages; the average age of patients with type 2 MI was 71.7 ± years (68.2 ± 3 years among men and 75.3 ± 4 years among women p &lt;0.05), which did not differ from the group with fatal type 1 MI. The main causes of death in type 2 MI were tachysystolic arrhythmias - 59.12% of cases, severe hypoxia of any etiology - 35.04%. The absence of significant stenoses of coronary artery (CA) is significantly more common in type 2 MI, and multivessel disease - in type 1 MI. In the group of patients with type 1 MI, 67.29% had multivessel lesions (Table 1). When comparing mortality in different departments of a multidisciplinary hospital, it turned out that only 29.2% of patients with type 2 MI were initially hospitalized in the cardiology department; 45.3% of patients - therapeutic, 25.5% of patients – surgical. Conclusion. Nearly one in four patients dies as a result of MI, with more than 1/3 of fatal MIs occurring in type 2 MI. The main reasons for the development of type 2 MI: tachysystolic arrhyhythmias - 59.12%, hypoxia of various origins - 35.04%, sepsis - 2.2%. 25% of fatal type 2 MIs occurred in surgical patients. Table 1. CA in type 1 and 2 MISign1 type MI (n = 223)2 type MI (n = 137)рNo significant stenosis2,24%32,85%0,001Single CA significant stenosis8.07%12,41%0,1932-CA significant stenosis23,3%23,36%0,272Multivessel stenosis66,4%31,38%0,005Occlusion of at least one СА48,9%4,38%0,001

scholarly journals P-Wave and QT Dispersion in Children With βeta-Thalassemia

2020 ◽  
pp. 38-45
Author(s):  
Marwa Salama ◽  
Shimaa El-Nemr ◽  
Ibrahim Badraia ◽  
Amr Zoair
Keyword(s):  
Qt Dispersion ◽  
Wave Dispersion ◽  
Thalassemia Major ◽  
Left Ventricular ◽  
P Wave ◽  
Control Group ◽  
P Value ◽  
Internal Diameter ◽  
P Wave Dispersion ◽  
Lv Mass

Aim: This study aimed at assessing P-wave and QT interval dispersion in children with β-thalassemia and to correlate them with various laboratory and echocardiographic data. Methodology: Subjects comprised of 30   children with β-thalassemia major as the patient group. 30 healthy children matched for age and sex served as the control group. All patients were evaluated clinically as well as by echocardiography and 12 leads ECG. The type of study is prospective case control study. Results: There was a statistically significant increase of Interventricular Septal end diastole (IVSd), Interventricular Septal end systole (IVSs), Left Ventricular Internal Diameter end diastole (LVIDd), Left Ventricular Internal Diameter end systole (LVIDs) and Left Ventricular Posterior Wall end diastole (LVPWd) in patients as compared to controls (Mean ±SD = 0.950±0.166, 0.863±0.103, 3.983±0.456, 2.947±0.535a nd 0.797±0.165 respectively) (P < 0.05). Moreover, there were a significant increase of LV mass (Mean ±SD = 107.267±26.736, P= 0.002) and LV mass index of the studied patients (Mean ±SD = 106.900±22.651, P = 0.005) compared to the controls. There were significant decrease of ejection fraction (EF%)( Mean ±SD = 60.373 ± 8.088,  P = 0.032)and fractional shortening (FS%) (Mean ±SD = 29.495 ± 4.171, P = 0.026) of the studied patients compared to control group.  Both P wave dispersion (PWd) (Mean ±SD = 33.667 ± 13.767, P =     0.029) and QT dispersion (QTd) (Mean ±SD = 53.000 ± 18.411, P = 0.001) were significantly higher in patients compared to controls.  There was a significant positive correlation between PWd and serum ferritin (r =0.551, P-value= 0.002), LVIDd (r =0.406, P-value= 0.026), LVPWd (r =0.461, P-value= 0.010), LV mass (r =0.412, P-value= 0.024), and LV mass index(r = 0.379, P-value= 0.039). While, there were a significant positive correlations between QTd and serum ferritin (r =0.654, P-value <0.001), LVIDd (r = 0.388, P-value = 0.034), LV mass (r = 0.454, P-value = 0.012) and LV mass index (r = 0.456, P-value = 0.011). Conclusion: P wave dispersion and QT dispersion were prolonged in children with β-thalassemia major denoting cardiac autonomic dysfunction with homogeneity disorders of atrial conduction and ventricular repolarization in these patients. 

Predictors of atrial fibrillation in patients with cryptogenic stroke and fifteen-days electrocardiographic monitoring. Preliminary results of the DECRYPTORING study

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Vera Sainz ◽  
A Cecconi ◽  
P Martinez Vives ◽  
A Ximenez Carrillo ◽  
C Aguirre ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Retrospective Studies ◽  
Cryptogenic Stroke ◽  
P Value ◽  
Ecg Monitoring ◽  
Funding Sources ◽  
Electrocardiographic Monitoring ◽  
3D Volume ◽  
Funding Acknowledgements

Abstract Funding Acknowledgements Type of funding sources: None. onbehalf DECRYPTORING study Introduction Cryptogenic stroke (CS) represents up to 30% of all stroke types.  In one third of CS, atrial fibrillation (AF) is identified as the underlying cause. Predictors of AF in the setting of CS have been described, however these findings were based on retrospective studies and with maximum ECG monitoring of 72 hours. To overcome these limitations, we designed the prospective Decryptoring study whose objective is to create a comprehensive predictive model for AF in patients with CS. Methods From April 2019, 41 consecutive patients with a CS and age &gt; 60 years were included. On admission, a transthoracic echocardiogram with 3D volume and left atrial (LA) strain was performed. All patients were monitored with a 15-day ECG-Holter after discharge. Patients were classified according to AF detection. Results AF was detected in 9 patients (22%). Patients with AF were older (75.9 ± 8 vs. 81.9 ± 4.3 years, p = 0.041). There was no difference in T-troponin levels. NTproBNP was higher in the group with AF (350 ± 586 pg / ml vs. 1084 ± 1416 pg / ml, p = 0.018). Regarding LA strain, patients with AF presented reservoir LA strain (25.5 ± 8.2% vs 17.4 ± 4.3%; p = 0.006) and conduct LA strain (12 ± 5.2% vs 7.2 ± 1.5%; p = 0.01) lower than patients without AF. There were no differences in contraction LA strain or other echocardiographic variables. The risk of developing AF was higher in patients with NTproBNP&gt; 165 pg / ml (OR 11.3 [95% CI 1.2-102.9] p = 0.031), LA reservoir strain &lt;19.1% (OR 7.7 [IC 95 % 1.5-40.0] p = 0.016) and LA conduct strain &lt;9.1% (OR 7.8 [95% CI 1.3-45.0] p = 0.022) (Table). Conclusions This prospective study, demonstrates that high NTproBNP, low reservoir LA strain and low conduct LA strain are associated with underlying AF in patients with cryptogenic stroke. No AF (n = 32) AF (n = 9) P value Age (years) 75.9 ± 8 81.9 ± 4.3 p = 0.041 NTPROBNP (pg/ml) 350 ± 586 1084 ± 1416 P = 0.018 LA indexed diastolic volume (ml/m2) 30 ± 11.8 33.8 ± 9.8 P = 0.35 LA EF (%) 45 ± 16.7 45 ± 12.8 P = 1 Reservoir LA strain (%) 25.5± 8.2 17.4± 4.3 P = 0.006 Conduct LA strain (%) 12 ± 5.2 7.2 ± 1.5 P = 0.01 Contraction LA strain (%) 13.5 ±5.3 10.2± 3.9 P = 0.10 NTPROBNP &gt; 165 pg/ml 12 (41%) 8 (89%) OR 11.3 [IC 95% 1.2-102.9]; p = 0.031 Reservoir LA strain &lt;19.1% 6 (20%) 6 (67%) OR 7.7 [IC 95% 1.5-40.0]; p = 0.016 Conduct LA strain &lt;9.1% 9 (31%) 7 (78%) OR 7.8 [IC 95% 1.3-45.1]; p = 0.022

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