scholarly journals The mediating effect of lifestyles on the association between social factors and DNA methylation

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Maugeri ◽  
M Barchitta ◽  
G Favara ◽  
C La Mastra ◽  
MC La Rosa ◽  
...  
Keyword(s):  
Physical Activity ◽  
Dna Methylation ◽  
Socioeconomic Status ◽  
Mediterranean Diet ◽  
Educational Level ◽  
Methylation Level ◽  
Mediating Effect ◽  
High Educational Level ◽  
Age Related ◽  
High Educational

Abstract Background Social disadvantage and unhealthy lifestyles may induce molecular changes associated with aging and age-related diseases. For instance, previous studies reported socioeconomic difference in DNA methylation, which in turn led to aberrant gene expression and genome instability. Socioeconomic status (SES) alone, however, does not completely explain this difference, and further studies are needed to unveil what factors contribute to it. Methods We conducted a cross-sectional study on 349 Italian women, aged 25-64 years, to assess SES differences in LINE-1 methylation level - a surrogate marker of global DNA methylation - and to examine the mediating effect of lifestyles (i.e. diet, smoking habits, physical activity, and weight status). Educational level was used as SES indicator. The adherence to Mediterranean diet (MD) was assessed by the Mediterranean Diet Score (MDS). Leukocyte LINE-1 methylation was assessed by pyrosequencing. Mediation analysis was conducted using the PROCESS macro for the SPSS software. Results We first observed that women with high educational level were more likely to be normal weight (p < 0.001) and to adhere to MD (p = 0.018), and less likely to perform physical activity (p = 0.012) than their less educated counterpart. Moreover, age-adjusted linear regression demonstrated that LINE-1 methylation level increased with increasing educational level (β = 0.016; SE = 0.003; p < 0.001). In line, mediation analysis demonstrated an indirect effect of high educational level on LINE-1 methylation through the adherence to MD (β = 0.003; 95%CI=0.001-0.006). Specifically, the mediator could account for 9.5% of the total effect. None of the other lifestyles, instead, exhibited a significant mediating effect. Conclusions To our knowledge, this is the first study demonstrating the mediation of diet in the relationship between SES and DNA methylation. Thus, our findings add even more value to the promotion of healthy dietary habits among social disadvantaged people. Key messages Social disadvantage is associated with epigenetic changes related to aging and age-related diseases. Adherence to the Mediterranean diet might mediate the association between socioeconomic status and DNA methylation.

scholarly journals Lifestyle, socioeconomic status and healthcare seeking among women with gynaecological cancer alarm symptoms: a combined questionnaire-based and register-based population study

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021815 ◽  
Author(s):  
Kirubakaran Balasubramaniam ◽  
Sandra Elnegaard ◽  
Sanne Rasmussen ◽  
Peter Fentz Haastrup ◽  
René dePont Christensen ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Educational Level ◽  
Lifestyle Factors ◽  
Gynaecological Cancer ◽  
High Educational Level ◽  
Postmenopausal Bleeding ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Recent Onset ◽  
High Educational

ObjectivesTo determine the proportion of contacts to general practitioner (GP) with recent onset gynaecological cancer alarm symptoms (pelvic pain, postmenopausal bleeding, bleeding during intercourse or pain during intercourse) and to analyse the associations between lifestyle factors, socioeconomic status and GP contact for these symptoms.DesignCross-sectional survey combined with data from national registers.SettingThe general Danish population.ParticipantsA total of 25 866 non-pregnant women ≥20 years completed the survey. Women reporting at least one of four gynaecological alarm symptoms within the preceding 6 months form the study base (n=2957).ResultsThe proportion of women reporting GP contact ranged from 21.1% (pain during intercourse) to 32.6% (postmenopausal bleeding). Women aged 60+ years had higher odds of reporting GP contact for at least one of the four gynaecological cancer alarm symptoms compared with those aged 20–39 years (OR 2.56, 95% CI 1.69 to 3.89), and immigrants had higher odds of reporting GP contact for at least one of the symptoms (OR 1.56, 95% CI 1.13 to 2.15) compared with ethnic Danish individuals. Among those reporting postmenopausal bleeding and/or bleeding during intercourse, women in the age group 60+ years had higher odds of reporting GP contact compared with those aged 20–39 years (OR 2.79, 95% CI 1.33 to 5.87). A high educational level (>12 years) was positively associated with reporting GP contact for postmenopausal bleeding and/or bleeding during intercourse compared with a low educational level (<10 years) (OR 2.23, 95% CI 1.19 to 4.19). No associations were found with lifestyle factors.ConclusionsFew women contacted their GP with recent onset gynaecological cancer alarm symptoms. Higher age, being immigrant and higher educational level increased the odds of GP contact. Future studies should explore the reasons for these findings as this may aid in prompting early diagnosis and thereby improve the prognosis of gynaecological cancer.

Predicting Physical Activity and Lifelong Health Through Personal Control and Educational Attainment

2021 ◽  
pp. 003151252110292
Author(s):  
Jinyi Zhou ◽  
Xuesong Ding ◽  
Yuefan Zhai ◽  
Qing Yi
Keyword(s):  
Physical Activity ◽  
Educational Level ◽  
Personal Development ◽  
Educational Achievement ◽  
Personal Control ◽  
Well Being ◽  
Mediating Effect ◽  
Data Set ◽  
Education And Health ◽  
Proposed Model

Prior studies have shown that physical activity (PA) is strongly associated with lifelong health and well-being. Thus, analyses of relationships among individual differences, PA, education, and health may provide important insights into the sustainability of PA-related personal development efforts. In this longitudinal study, we tested a proposed model in a data set of 12,686 participants from the National Longitudinal Survey of Youth 1979 (NLSY 79). We used hierarchical regressions and bootstrapping to test hypotheses concerning the main effect of personal control on lifetime health, the mediating effect of PA, and the moderating effect of educational achievement. We found that individuals’ self-reported PA was positively related to their health status. Additionally, there was a positive mediating effect of self-reported PA on the relationship between personal control and health when the individual’s educational level was high, and there was a negative mediating effect of self-reported PA when an individual’s educational level was low. Based on these results, we provide relevant government policy suggestions for increasing fitness participation, constructing sports facilities, and encouraging educational institutions to include health education in their efforts.

scholarly journals Pregnant women and risk factors: a cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
V L a Fauci ◽  
R Squeri ◽  
C Genovese ◽  
V Alessi ◽  
A Facciolà
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Health Education ◽  
Pregnant Women ◽  
Educational Level ◽  
Demographic Characteristics ◽  
Alcoholic Beverages ◽  
High Educational Level ◽  
Significant Difference ◽  
High Educational

Abstract Background Many investigations have shown the important role played by risk factors such as tobacco and alcohol in the development of congenital anomalies. Methods Through the administration of an hoc questionnaire, we evaluated the attitude towards smoking and alcohol of a sample of 200 pregnant women at the University Hospital of Messina. The questionnaire was structured to collect information about socio-demographic characteristics, type of gynaecological assistance and their lifestyles (smoking and alcohol). Statistical analysis was performed using version 10 of StatSoftVR software. Results 14% of the women continued to smoke despite pregnancy; the majority of these were young adults, divorced, employed and with a high educational level. Correlating the smoking habit with the socio-demographic characteristics of the studied women, we found a statistically significant difference for the marital status, with a higher number of smokers among the single women (p &lt; 0.05).Moreover, we found a statistically significant difference also for the profession with a higher number of smokers in the worker women (p &lt; 0.05). About the drinking habit, the 4.3% declared to be moderate drinkers (occasional use of alcohol equal to 2-3 glasses a week) despite pregnancy, the 34.4% stated they do not drink alcohol during pregnancy and the 56% stated do not usually drink alcohol. Particularly, about the drinkers' socio-demographic characteristics, the 50% of them were 24-25 years old and the 75% were married. About the type of alcoholic beverages consumed, 86% stated they usually drink bier during the weekend. Conclusions Our study shows that the awareness of the women about the importance of these risk factors is still rather poor. In order to improve the awareness of pregnant women on the importance of avoiding these risk factors and prevent CAs, health education campaigns at various levels surely represent the public health cornerstone. Key messages In our sample 14% of the pregnant women continued to smoke and 4.3% to drink despite pregnancy and they generally were young or young adults and with a high educational level. Our results highlight the importance of continuous health education about the risk to smoke and drink during pregnancy.

scholarly journals Prevalence of low back pain in different educational levels: a systematic review

2017 ◽  
Vol 30 (suppl 1) ◽  
pp. 351-361 ◽  
Author(s):  
Alexandre Apolinário de Souza Batista ◽  
Nicholas Henschke ◽  
Vinícius Cunha Oliveira
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Educational Level ◽  
Critical Appraisal ◽  
Meta Analysis ◽  
High Educational Level ◽  
Low Back ◽  
Educational Levels ◽  
Educational Differences ◽  
High Educational

Abstract Introduction: Non-specific low back pain (LBP) can be understood through the interaction of biopsychosocial factors such as education. Unfortunately, it remains unclear whether education can be considered an important risk and prognostic factor for the occurrence of LBP. Objective: To investigate the association between education and LBP. Methods: The following databases were searched: MEDLINE, EMBASE, Cochrane, AMED and PsyINFO. Results: Thirteen studies were included in the review. The Prevalence Critical Appraisal Instrument (PCAI) was used to assess risk of bias. Methodological quality scores ranged from 7 to 10 on a scale of 0-10. There was a 23% (95% CI, 13-37) prevalence of LBP (10,582 out of a total of 99,457 cases) in the general sample at the time of assessment. The meta-analysis of studies on the prevalence of LBP in people with low, medium or high educational level found the following results, respectively: 24% (95% CI, 12-43), 27% (95% CI, 9-56), and 18% (95% CI, 5-50). The meta-regression identified heterogeneity among the studies included in the review. This can be explained by educational differences (p < 0.05). Conclusion: Occurrence of LBP varies according to educational level. Individuals with higher educational levels are less often affected by LBP than individuals with medium or low educational levels.

NUTRITIONAL STATUS OF ADOLESCENTS IN THE CONTEXT OF THE MOROCCAN NUTRITIONAL TRANSITION: THE ROLE OF PARENTAL EDUCATION

2011 ◽  
Vol 44 (4) ◽  
pp. 481-494 ◽  
Author(s):  
PILAR MONTERO LÓPEZ ◽  
KARIM ANZID ◽  
MOHAMED CHERKAOUI ◽  
ABDELLATIF BAALI ◽  
SANTIAGO RODRIGUEZ LOPEZ
Keyword(s):  
High School Students ◽  
Nutritional Status ◽  
Educational Level ◽  
Parental Education ◽  
Educational Background ◽  
Overweight And Obesity ◽  
High Educational Level ◽  
Nutritional Transition ◽  
Lower Height ◽  
High Educational

SummaryIn Morocco, the beginning of the nutritional transition is closely linked to social and economic transformations and changes in behaviour and traditional lifestyles. The objective of this study is to describe the current pattern of food consumption and the nutritional status of adolescents in the province of Ouarzazate and its association with parents' educational level. The sample comprises 327 high school students from Ouarzazate: 135 (41.3%) boys and 192 (58.7%) girls (age range 15–20 years). For both boys and girls, the results show lower height and BMI z-scores than the WHO reference values. Adolescents whose parents have a low educational level have lower height/age and BMI/age z-scores than those whose fathers have a high educational level. No differences are observed in total daily energy intake depending on fathers' educational level, but the energy provided by lipids is higher in adolescents whose fathers have a high educational background. The quality of fats consumed (MUFA+PUFA/SFA) is better among those boys whose fathers have low education, but no differences are observed for girls. The process of nutritional transition is not uniform in the sample, but depends on the socioeconomic characteristics of population groups, which include, among others, accessibility of certain food, differences in habits and lifestyles related to energy expenditure, and higher prevalence of overweight and obesity in more favoured groups.

[P3-521]: AGE AS A DEMOGRAPHIC VARIABLE RELATED WITH LACK OF METACOGNITION IN MIDDLE-AGED AND OLDER ADULTS WITH HIGH EDUCATIONAL LEVEL

2017 ◽  
Vol 13 (7S_Part_24) ◽  
pp. P1177-P1177
Author(s):  
Alvaro Teixeira da Costa ◽  
Renata Brant de Souza Melo ◽  
Antonio Pereira Gomes Neto ◽  
Ronnielly Melo Tavares
Keyword(s):  
Older Adults ◽  
Educational Level ◽  
Demographic Variable ◽  
High Educational Level ◽  
Middle Aged ◽  
High Educational

Parental Socialization Styles, Parents' Educational Level, and Sexist Attitudes in Adolescence

2012 ◽  
Vol 15 (2) ◽  
pp. 592-603 ◽  
Author(s):  
Maite Garaigordobil ◽  
Jone Aliri
Keyword(s):  
Negative Correlation ◽  
Educational Level ◽  
Ambivalent Sexism ◽  
High Educational Level ◽  
Parental Socialization ◽  
Mothers And Fathers ◽  
Low Level ◽  
Sexist Attitudes ◽  
Mother's Educational Level ◽  
High Educational

The aims of this study were to analyze the differences in the mothers' and fathers' socialization styles depending on their children's sex; whether there are differences in hostile, benevolent, and ambivalent sexism, and neosexism as a function of both parents' socialization styles; and whether the parents' educational level affects their level of sexism and their children's sexism. The sample included 1,455 adolescents and their parents (764 mothers and 648 fathers). The results showed no differences in the socialization style of the father with his children's sexism, but the mother used a more authoritarian style with her daughters. The parents' socialization style had little influence on their children's sexism, although it had a higher impact on the sons' sexism. The father's style had less influence than the mother's on their sons' sexism, and it had no influence on their daughters' sexism. The indulgent style of both parents had the highest relation with a low level of sexism. Moreover, a negative correlation was found between the parents' educational level and their level of sexism, as well as between the mother's educational level and her daughters' sexism. To conclude, the indulgent style and the mother's high educational level promote fewer sexist attitudes.

Identifying consumers’ profile and factors associated with the valorization of pulque: A traditional fermented beverage in Central Mexico

2020 ◽  
Vol 26 (7) ◽  
pp. 593-602 ◽  
Author(s):  
Edgar Rojas-Rivas ◽  
Facundo Cuffia
Keyword(s):  
Low Income ◽  
Educational Level ◽  
Binary Logistic Regression ◽  
High Educational Level ◽  
Central Mexico ◽  
Binary Logistic Regression Model ◽  
Factors Associated ◽  
Consumption Frequency ◽  
Fermented Beverage ◽  
High Educational

The aims of this work were to (i) identify the consumers’ profile of pulque through their consumption frequency and their sensory perception of this beverage and (ii) identify the factors that contribute to the valorization of pulque among Mexican consumers. A survey was designed and conducted with 221 consumers in pulque-selling locations (pulquerías) in a place of Central Mexico. Consumers were characterized according to their consumption frequency. Factors associated with the valorization of pulque were identified through Binary Logistic Regression model. Two types of consumers were identified: Frequent Consumers and Not Frequent Consumers. Both groups were comprised mostly of men, including students with medium to high levels of education. However, the first group showed more traditional and conservative behavior patterns since there was a higher proportion of consumers with a low educational level ( p < 0.05) and they had more years of consumption, spend more time in the selling locations, and preferred “natural pulque.” The second group of consumers was comprised mostly ( p < 0.05) of women, including students with a high educational level who prefer “cured pulque.” In this sense, our results showed that gender and time spent in the pulquerías together with sensory, cultural, and functional characteristics associated with the beverage influence its valorization among consumers. These results can help both producers and marketers to classify segments of consumers according to their preferences and consumption patterns in order to revalorize the pulque market. Finally, it is necessary to highlight that young consumers with high educational level show interest in this beverage, since for years its consumption has been associated with low-income populations.

Wienhausen Hs 80: Überlegungen zu Kontext und Performanz des Objekts

2018 ◽  
Vol 78 (1) ◽  
pp. 75-101
Author(s):  
Carla Dauven-van Knippenberg ◽  
Elisabeth Meyer
Keyword(s):  
Educational Level ◽  
16Th Century ◽  
High Educational Level ◽  
Lower Saxony ◽  
Devotional Practices ◽  
Personal Use ◽  
Scholarly Attention ◽  
High Educational

AbstractThe former Cistercian convent of Wienhausen in Lower Saxony contains a unique collection of miniature-manuscripts from the 14th till 16th century. These little and on first sight unimpressive booklets – most of them comprise no more than a few folia – have drawn little scholarly attention as a group. When studied, scholars were mainly interested in their content (prayers etc.), but less in their material distinctiveness, namely the very small size and the fact that a relatively large number of these booklets has been preserved. Most of these booklets contain Latin texts, demonstrating the high educational level of the cloistered women, but also showing that Latin is the language of divine vicinity. Using the example of the Wienhäuser Manuscript 80 we suggest that the women made those little booklets from the blank folia-margins of discarded larger parchment manuscripts. The use of scraps probably offered a possibility for the women to produce booklets for their very personal use and belongings aside from all other manuscripts for daily devotional practices. We suggest that the meaning of the small booklets lays not only or primarily in the texts, but also in the objects themselves, their tininess and the fact that the women made and owned them. A future dna-analysis could throw light on the relation between these tiny scrap booklets and other preserved manuscripts from the convent.

Prevalence and Correlates of Criminal Behavior Among the Non-institutionalized Elderly: Results From the National Survey on Drug Use and Health

2018 ◽  
Vol 31 (4) ◽  
pp. 211-222 ◽  
Author(s):  
Elias Ghossoub ◽  
Rita Khoury
Keyword(s):  
Drug Use ◽  
National Survey ◽  
Educational Level ◽  
Criminal Behavior ◽  
High Educational Level ◽  
Regression Analyses ◽  
Driving While Intoxicated ◽  
The Past ◽  
The Law ◽  
High Educational

Objectives: First to explore the prevalence of criminal behavior committed by the non-institutionalized geriatric American population. Second to determine the correlates of criminal behavior among this population. Methods: We used data of the non-institutionalized adults aged ≥65 years in the National Survey on Drug Use and Health from 2008 through 2014. We compared socio-demographic and mental health profiles of arrestees to non-arrestees and lawbreakers to non-lawbreakers and then determined the correlates of being arrested and breaking the law through regression analyses. Results: Around 0.4% of the population reported being arrested, and 5% reported breaking the law in the past year. The most prevalent offense was driving while intoxicated. Arrestees were significantly more likely to be male and to have had an alcohol or a drug(s) use disorder in the past year. Lawbreakers had a significant likelihood of being male, having a high educational level, and having an alcohol or a drug(s) use disorder in the past year. Conclusions: Elderly lawbreakers seem to have distinct characteristics that not just separate them from non-offenders but also probably from younger lawbreakers.

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