scholarly journals Caregiver Singing Intervention: do Emotions and Resistance differ between Vascular dementia and Alzheimer’s?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 651-651
Author(s):  
Lena Hammar ◽  
Gabriella Engström ◽  
Anna Swall

Abstract Persons with dementia in residential care commonly express resistance of aggressiveness. Caregivers Singing (CS) - when caregivers sing for or together with persons with dementia during caring, has shown to reduce these expressions and increase communication and cooperation. Previous studies of CS have included both persons with Alzheimer’s disease (AD) and persons with Vascular dementia (VD), but no studies have been done focusing on possible differences regarding these diagnoses. As disabilities and symptoms differ between these diagnoses, the emotions and expressions, such as resistance may differ regarding response to CS. This polit study aims to describe emotions and resistiveness to care among persons with vascular or Alzheimer’s disease. Participants were five persons with AD and five persons with VD living at two different nursing homes. Video observations (VIO) occurred with them and their caregivers during morning care situations four times without CS and four times with CS. In all, 80 VIOs were rated using the Observed Emotion Rating Scale and the Resistiveness to Care Scale. These were then analyzed with descriptive statistics. Results revealed that for both persons with AD and VD, the positive emotion pleasure were never observed without CS while with CS it increased for both groups. In contrast to the positive emotion effect of CS, the negative emotions and resistiveness decreased more for persons with VD than for persons with AD. For persons with VD, the number of observations without anger increased, while observation without anger or anxiety/fear for persons with AD remind the same.

2000 ◽  
Vol 12 (4) ◽  
pp. 537-545 ◽  
Author(s):  
Olav Spigset ◽  
Christer Wilhelmsson ◽  
Tom Mjörndal ◽  
Sture Eriksson

It is well known that abnormalities in the brain serotonin system exist in patients with dementia. The present study was performed in order to investigate whether a peripheral serotonin system marker, the platelet 5-HT2A receptor, is affected in dementia. Thirty-eight patients with Alzheimer's disease (AD), 13 patients with vascular dementia, and 40 healthy controls were included in the study. There were no significant differences in receptor density for 5-HT2A receptor binding between the groups. Affinity of the radioligand to the receptor was significantly lower in AD than in vascular dementia and in the controls (p = .006 and p = .003, respectively), whereas there was no significant difference between the vascular dementia group and the control group. In 12 patients, treatment with citalopram was started due to depression or agitation. This treatment significantly reduced the Behavioral Pathology in Alzheimer's Disease Rating Scale scores (p = .001), but did not affect the platelet 5-HT2A receptor status. There was no correlation between 5-HT2A receptor status before treatment and the therapeutic effect of citalopram. The study indicates that platelet 5-HT2A receptor status is of limited value as a peripheral marker in dementia.


2005 ◽  
Vol 17 (2) ◽  
pp. 207-219 ◽  
Author(s):  
Ajit Shah ◽  
Nalini Ellanchenny ◽  
Guk-Hee Suh

Background: There is a paucity of cross-cultural studies of behavioral and psychological symptoms of dementia (BPSD).Method: BPSD were examined in consecutive series of referrals to a psychogeriatric service in Korea and the U.K. using the Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD) rating scale and the Cornell Scale for Depression in Dementia (CSDD). Results were analyzed separately for Alzheimer's disease and vascular dementia.Results: Koreans in both diagnostic groups had lower Mini-mental State Examination (MMSE) scores and higher BEHAVE-AD total and subscale scores for most subscales. In both countries, for both diagnostic groups, the total BEHAVE-AD score and several subscale scores were negatively correlated with the MMSE scores. Logistic regression analysis for Alzheimer's disease revealed that BEHAVE-AD total and most subscale scores independently predicted the country of origin in addition to the MMSE scores predicting the same.Conclusions: These differences in BPSD are most likely explained by the lower MMSE scores in the Korean sample. However, genuine differences in BPSD between the two countries can only be critically examined in a cross-cultural population-based epidemiological study for both diagnostic categories using validated instruments to measure BPSD and controlling for the influence of MMSE score.


2006 ◽  
Vol 18 (1) ◽  
pp. 87-93 ◽  
Author(s):  
C. Pinto ◽  
R. Seethalakshmi

Background: Differential patterns of brain lesions in patients with Alzheimer's disease (AD) or vascular dementia (VaD) can result in differing clinical courses and presentations.Method: Thirty patients with AD were compared with 29 patients with VaD for differences in behavioral symptoms using the Behavioral Pathology in Alzheimer's Disease (BEHAV-AD) rating scale.Results: Patients with AD had significantly more delusions, hallucinations, anxieties and phobias and caregiver distress than patients with VaD.Conclusions: Behavioral symptoms in both AD and VaD exhibit specific longitudinal patterns. An understanding of the pattern can aid the treating physician in giving appropriate advice to caregivers regarding the course of the illness and also help them in planning appropriate interventions.


2018 ◽  
Vol 5 (4) ◽  
pp. 182-187
Author(s):  
I. Mudrenko

GENDER CHARACTERISTICS OF DEPRESSIVE SYMPTOMS OF DEMENTIA IN PATIENTS WITH SUICIDAL BEHAVIORMudrenko I.H.Dementia is in most cases comorbid, which greatly reduces the quality of patients’ life and increases the risk of suicidal manifestations.The aim of the study is to determine gender characteristics of depressive symptoms in patients with various clinical types of dementia with high suicide risk.The object and methods of research. Thestudy involved examination of 105 patients with dementia of different types (due to Alzheimer's disease, vascularandmixedone) with high suicide risk using the HamiltonDeppression Rating Scale (HDRS).Results of theresearch. Statistical analysisshowedthat a high degree of depression is a markerof suicidal risk in men with a vascular type of dementia, and in women with a mixed type of dementia. Verbalization (statement of suicidal intentions, thoughts) and the behavioral component of suicidal behavior (attempts) with a pronounced torpidity of mental processes are typical for men with Alzheimer's disease and vascular dementia and for women with a mixed type of dementia. In women, affective oscillations during the day increased SR in Alzheimer's disease, and frequent wakening at night in mixed dementia. Physical limitations and inability to perform work, the problems with sexual vigor can be considered a psychogenic factor of high SR in men with vascular impairment.Key words:dementia in Alzheimer’s disease, vascular dementia, mixed dementia, gender differences, depressive symptoms, predictors of suicidal behavior. РезюмеГЕНДЕРНІ ОСОБЛИВОСТІ ДЕПРЕСИВНОЇ СИМПТОМАТИКИ В СТРУКТУРІ ДЕМЕНЦІЙ У ОСІБ З СУЇЦИДАЛЬНОЮ ПОВЕДІНКОЮМудренко І.Г.Деменція у більшості випадків коморбідна з депресією, що значно знижує якість життя хворих та підвищує ризик суїцидальних проявів у даної категорії хворих.Метою нашого дослідження є визначення гендерних особливостей депресивної симптоматики у хворих з різними клінічними варіантами деменції з високим ризиком суїциду. Об’єкт та методи дослідження. Всього обстежено 105 пацієнтів з деменціями різних типів (внаслідок хвороби Альцгеймера, судинною, змішаною)  з високим суїцидальним ризиком за допомогою шкали  Гамільтона  для оцінки  депресії (HDRS).На підставі статистичного аналізу встановлено, що високий ступінь депресії є маркером суїцидального ризику  у чоловіків з судинним типом деменціїі, а у жінок зі змішаним типом дементного процесу. Вербалізація (висловлювання суїцидальних намірів, думок) та поведінковий компонент суїцидальної поведінки (спроби) на фоні вираженої торпідності  психічних процесів притаманні для чоловіків з хворобою Альцгеймера та судинною деменцією та для жінок зі змішаним типом дементного враження. У жінок  підвищували СР при хворобі Альцгеймера афективні коливання на протязі доби, а при змішаній деменції  - часті пробудження вночі. Можна припустити, що психогенним чинником високого СР у чоловіків з судинним враженням є фізичні обмеження та нездатність до виконання робіт, проблеми з потенцією. Ключові слова:деменція при хворобі Альцгеймера, судинна, змішана, гендерні відмінності, депресивна симптоматика, пре диктори суїцидальної поведінки. РезюмеГЕНДЕРНЫЕ ОСОБЕННОСТИ ДЕПРЕССИВНОЙ СИМПТОМАТИКИ В СТРУКТУРЕ ДЕМЕНЦИИ У ЛИЦ С СУИЦИДАЛЬНЫМ ПОВЕДЕНИЕММудренко И.Г.Введение. Деменция в большинстве случаев коморбидна с депрессией, что значительно снижает качество жизни больных и повышает риск суицидальных проявлений у данной категории больных.Целью нашего исследования явилось определение гендерных особенностей депрессивной симптоматики у больных с различными клиническими вариантами деменции с высоким риском суицида. Обследовано 105 пациентов с деменцией различных типов (вследствие болезни Альцгеймера, сосудистой, смешанной) с высоким суицидальным риском (СР) с помощью шкалы Гамильтона для оценки депрессии (HDRS).На основании статистического анализа установлено, что высокая степень депрессии является маркером суицидального риска у мужчин с сосудистым типом деменциии, а у женщин со смешанным типом дементного процесса. Вербализация (высказывания суицидальных намерений, мыслей) и поведенческий компонент суицидального поведения (попытки) на фоне выраженной торпидности психических процессов присущи для мужчин с болезнью Альцгеймера и сосудистой деменцией и для женщин со смешанным типом деменции. У женщин повышали СР при болезни Альцгеймера аффективные колебания в течение суток, а при смешанной деменции - частые пробуждения ночью. Можно предположить, что психогенным фактором высокого СР у мужчин с сосудистым поражением головного мозга являются физические ограничения и неспособность к выполнению работ, проблемы с потенцией.Ключевые слова: деменция при болезни Альцгеймера, сосудистая, смешанная,  гендерные различия, депрессивная симптоматика, предикторы суицидального поведения.


Author(s):  
Burbaeva G.Sh. ◽  
Androsova L.V. ◽  
Vorobyeva E.A. ◽  
Savushkina O.K.

The aim of the study was to evaluate the rate of polymerization of tubulin into microtubules and determine the level of colchicine binding (colchicine-binding activity of tubulin) in the prefrontal cortex in schizophrenia, vascular dementia (VD) and control. Colchicine-binding activity of tubulin was determined by Sherlinе in tubulin-enriched extracts of proteins from the samples. Measurement of light scattering during the polymerization of the tubulin was carried out using the nephelometric method at a wavelength of 450-550 nm. There was a significant decrease in colchicine-binding activity and the rate of tubulin polymerization in the prefrontal cortex in both diseases, and in VD to a greater extent than in schizophrenia. The obtained results suggest that not only in Alzheimer's disease, but also in other mental diseases such as schizophrenia and VD, there is a decrease in the level of tubulin in the prefrontal cortex of the brain, although to a lesser extent than in Alzheimer's disease, and consequently the amount of microtubules.


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