scholarly journals COGNITIVE IMPAIRMENT AND SLEEP DIFFICULTIES OVER 10 YEARS IN A NATIONAL SAMPLE OF OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S453-S453
Author(s):  
Rebecca Robbins ◽  
Amanda Sonnega ◽  
Robert W Turner II ◽  
Girardin Jean-Louis ◽  
Kenneth Langa
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Functioning ◽  
Summary Score ◽  
Linear Regression Models ◽  
Sleep Difficulty ◽  
Falling Asleep ◽  
Nationally Representative ◽  
Sleep Difficulties ◽  
Over Time

Abstract Prior studies suggest that sleep difficulties (e.g., trouble falling asleep) may be associated with cognitive impairment. We used a large, nationally representative longitudinal survey of adults over the age of 50 in the US to examine the relationship between sleep difficulties and cognitive functioning. Generalized estimation equation (GEE) linear regression models were used to analyze data from the 2004-2014 waves of the Health and Retirement Study. We examined sleep difficulties and cognitive functioning within participants and across time (n=17,642). Sleep difficulty was measured as trouble falling asleep, nocturnal awakenings, and waking too early scored as 1= rarely/never, 2=sometimes, and 3=most of the time. A summary score indicated cognitive functioning (range 0-27). Models controlled for age, gender, race/ethnicity, marital status, education, chronic medical conditions, depressive symptoms, and body mass index (BMI). Compared to those with no sleep difficulties, those who reported difficulty falling asleep [“sometimes” OR=0.83,95%CI:0.71-0.96 and “most of the time” OR=0.79,95%CI: 0.64-0.98] and waking too early [“most of the time” OR=0.79,95%CI: 0.63-0.98] had worse cognitive functioning. Compared to those with no sleep difficulties, those who reported nocturnal awakenings [“most of the time” OR=1.29,95%CI:1.08-1.54] had higher cognitive functioning. Over time, lower cognitive function was more likely among those reporting difficulty falling asleep (OR=0.73,95%CI:0.54-0.97), nocturnal awakenings (OR=0.77,95%CI:0.61-0.97) and waking too early (OR=0.65,95%CI: 0.47-0.88). In this nationally representative, longitudinal sample of older US adults, we found that over time lower cognitive function was more likely among those who reported difficulty falling asleep, nocturnal awakenings, and waking too early.

scholarly journals Sleep Difficulties and Cognition for 10 Years in a National Sample of U.S. Older Adults

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Rebecca Robbins ◽  
Amanda Sonnega ◽  
Robert W Turner ◽  
Girardin Jean-Louis ◽  
Mark Butler ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
The United States ◽  
Early Morning ◽  
Sleep Difficulty ◽  
Waking Up ◽  
Time Varying Covariates ◽  
The Relationship ◽  
Sleep Difficulties ◽  
Over Time

Abstract Background and Objectives Sleep difficulties are common among older adults and are associated with cognitive decline. We used data from a large, nationally representative longitudinal survey of adults aged older than 50 in the United States to examine the relationship between specific sleep difficulties and cognitive function over time. Research Design and Methods Longitudinal data from the 2004–2014 waves of the Health and Retirement Study were used in the current study. We examined sleep difficulties and cognitive function within participants and across time (n = 16 201). Sleep difficulty measures included difficulty initiating sleep, nocturnal awakenings, early morning awakenings, and waking up feeling rested from rarely/never (1) to most nights (3). The modified Telephone Interview for Cognitive Status was used to measure cognitive function. Generalized linear mixed models were used with time-varying covariates to examine the relationship between sleep difficulties and cognitive function over time. Results In covariate-adjusted models, compared to “never” reporting sleep difficulty, difficulty initiating sleep “most nights” was associated with worse cognitive function over time (Year 2014: b = −0.40, 95% CI: −0.63 to −0.16, p < .01) as was difficulty waking up too early “most nights” (Year 2014: b = −0.31, 95% CI: −0.56 to −0.07, p < .05). In covariate-adjusted analyses, compared to “never” reporting waking up feeling rested, cognitive function was higher among those who reported waking up feeling rested “some nights” (Year 2010: b = 0.21, 95% CI: 0.02 to 0.40, p < .05). Discussion and Implications Our findings highlight an association between early morning awakenings and worse cognitive function, but also an association between waking up feeling rested and better cognitive function over time.

scholarly journals The Association Between Depressive Symptoms and Cognitive Functioning in Older Hispanic/Latino Adults Enrolled in an Exercise Intervention: Results From the “¡Caminemos!” Study

2017 ◽  
Vol 30 (6) ◽  
pp. 843-862 ◽  
Author(s):  
Rosalba Hernandez ◽  
Elaine Cheung ◽  
Minli Liao ◽  
Seth W. Boughton ◽  
Lisett G. Tito ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Cognitive Function ◽  
Cognitive Functioning ◽  
Chronic Conditions ◽  
Exercise Intervention ◽  
Longitudinal Analyses ◽  
Symptoms Of Depression ◽  
Intervention Method

Objective: We examined the association between depressive symptoms and cognitive functioning in older Hispanics/Latinos enrolled in an exercise intervention. Method: We analyzed baseline, 1-year, and 2-year in-person interview data collected from Hispanics/Latinos aged ≥60 years participating in an exercise intervention across 27 senior centers ( N = 572). Results: Mean age was 73.13 years; 77% female. At baseline, older adults screening positive for depression were 1.58 times more likely to experience cognitive impairment ( p = .04); controlling for demographics and comorbid chronic conditions. Compared to peers with little to no depressive symptoms, lower cognitive functioning scores were evident at each follow-up assessment point where elevated depressive symptoms were present, but baseline depression was not associated with cognitive function in longitudinal analyses. Discussion: In older Hispanics/Latinos enrolled in an exercise intervention, though baseline depression did not predict cognitive function over time, elevated symptoms of depression were associated with greater cognitive impairment at every point in this study.

scholarly journals Social Activity and Cognitive Functioning Over Time: A Coordinated Analysis of Four Longitudinal Studies

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Cassandra L. Brown ◽  
Laura E. Gibbons ◽  
Robert F. Kennison ◽  
Annie Robitaille ◽  
Magnus Lindwall ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Cognitive Functioning ◽  
Longitudinal Studies ◽  
Cognitive Abilities ◽  
Growth Models ◽  
Social Activity ◽  
Semantic Knowledge ◽  
Activity Levels ◽  
Rate Of Decline ◽  
Over Time

Social activity is typically viewed as part of an engaged lifestyle that may help mitigate the deleterious effects of advanced age on cognitive function. As such, social activity has been examined in relation to cognitive abilities later in life. However, longitudinal evidence for this hypothesis thus far remains inconclusive. The current study sought to clarify the relationship between social activity and cognitive function over time using a coordinated data analysis approach across four longitudinal studies. A series of multilevel growth models with social activity included as a covariate is presented. Four domains of cognitive function were assessed: reasoning, memory, fluency, and semantic knowledge. Results suggest that baseline social activity is related to some, but not all, cognitive functions. Baseline social activity levels failed to predict rate of decline in most cognitive abilities. Changes in social activity were not consistently associated with cognitive functioning. Our findings do not provide consistent evidence that changes in social activity correspond to immediate benefits in cognitive functioning, except perhaps for verbal fluency.

scholarly journals Migraine and cognitive decline in the population-based EVA study

Cephalalgia ◽  
2011 ◽  
Vol 31 (12) ◽  
pp. 1291-1300 ◽  
Author(s):  
Pamela M Rist ◽  
Carole Dufouil ◽  
M Maria Glymour ◽  
Christophe Tzourio ◽  
Tobias Kurth
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Cognitive Functioning ◽  
Migraine Headache ◽  
Severe Headache ◽  
P Value ◽  
Adult Intelligence Scale ◽  
Time Interaction ◽  
The Relationship ◽  
Over Time

Background: Previous studies on migraine and cognition have shown mixed results. However, many could not assess the relationship between migraine and change in cognitive function or only used a limited number of cognitive tests. Methods: Prospective cohort study among 1170 participants of the Epidemiology of Vascular Ageing Study who provided information about migraine status and completed cognitive testing. Participants were classified as having no severe headache, non-migraine headache and migraine. Cognitive functioning was measured at up to four time points using nine different cognitive functioning tests. Linear mixed effects models were used to evaluate the relationship between migraine status and change in cognitive function. Results: Of the 1170 participants, 938 had no severe headache, 167 had migraine, and 65 had non-migraine headache. After adjusting for age, gender, education and smoking status, people with migraine or non-migraine headache did not experience a greater rate of cognitive decline than those without headache or migraine in any domain (for the Mini Mental State Examination (MMSE), p-values were 0.68 for the non-migraine headache and time interaction and 0.85 for the migraine and time interaction) during 4–5 years of follow-up. For the Wechsler Adult Intelligence Scale-Revised, those with migraine declined less over time (p-value = 0.02). Conclusion: Migraine was not associated with faster cognitive decline over time.

Cerebral Microbleeds are Associated with Impairments in Executive Function and Processing Speed

2021 ◽  
pp. 1-8
Author(s):  
Xuanting Li ◽  
Junliang Yuan ◽  
Wei Qin ◽  
Lei Yang ◽  
Shuna Yang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Function ◽  
Processing Speed ◽  
Population Aging ◽  
Brain Magnetic Resonance Imaging ◽  
Executive Dysfunction ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Global Cognitive Function

Background: Cerebral microbleed (CMB) is an increasingly important risk factor for cognitive impairment due to population aging. Controversies, however, remain regarding the exact association between CMB and cognitive dysfunction. Objective: We aimed to determine the relationship between CMB burden and cognitive impairment, and also explore the characteristics of cognitive decline in CMB patients for middle-aged and elderly people. Methods: The present cross-sectional study included 174 participants (87 CMB patients and 87 controls) who underwent brain magnetic resonance imaging and a battery of neuropsychological test. Global cognitive function was measured using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Compound z-scores were calculated for three cognitive subdomains: memory, executive function and processing speed. Results: CMB patients had lower scores of MMSE (p <  0.001) and MoCA (p <  0.001). Patients at each category of CMB count had worse performance in global cognitive function and all three cognitive subdomains (p <  0.001). In multiple linear regression models, CMB patients had significantly greater declines in executive function (p <  0.001), processing speed (p <  0.001), and MoCA (p = 0.003) with increasing number of CMB. We found no relationship between CMB location and cognition (p <  0.05). Conclusion: CMB is associated with impairment in global cognition as well as for all tested subdomains. Strongest effect sizes were seen for tests which rely on executive functioning, where performance deficits increased in proportion to degree of CMB burden. Prospective studies are needed to evaluate whether the association between CMB and executive dysfunction is causal.

scholarly journals Perceived Everyday Discrimination and C- Reactive Protein Influence on Cognition of Older Black Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 1049-1049
Author(s):  
Sydney Kirven ◽  
Amy Thierry ◽  
Heather Farmer
Keyword(s):  
Older Adults ◽  
Cognitive Functioning ◽  
Perceived Discrimination ◽  
Linear Regression Models ◽  
C Reactive Protein ◽  
Black Adults ◽  
Reactive Protein ◽  
Nationally Representative ◽  
Poor Cognition ◽  
Everyday Discrimination

Abstract Black adults and women are more likely to experience serious cognitive decline in older age than their white and male counterparts. Evidence suggests perceived discrimination is associated with poor cognition in older adults, though the mechanisms remain unclear. Perceived discrimination has been linked to elevated inflammatory markers, such as C-reactive protein (CRP), which increases risk for worse cognitive functioning. Yet, little research has investigated whether CRP is implicated in the association between discrimination and cognition among Black older adults or if this relationship differs by gender. Using 2006-2016 data from Black adults ≥65 years old(N=1343) in the nationally representative Health and Retirement Study, random effects linear regression models (1) tested the association between discrimination and cognitive functioning; (2) explored whether this relationship differed for women and men; and (3) assessed whether elevated CRP mediated the association between discrimination and cognitive functioning. More frequent discrimination was associated with worse cognitive functioning (b= -0.24, SE=0.11, p&lt;0.05), though gender did not moderate this relationship. Elevated CRP was significantly associated with worse cognitive functioning (b= 0.40, SE=0.18, p&lt;0.05). Discrimination remained statistically significant in this model, indicating no mediation by CRP. Of note, inclusion of depressive symptoms and cardiometabolic conditions accounted for the association between both discrimination and CRP with cognitive functioning. These findings demonstrate the need for more within-group research on older Black adults documenting the complex relationship between discrimination, inflammation, and cognitive health. This approach will provide greater understanding of the biopsychosocial mechanisms underlying disparities in cognitive functioning in Black adults.

scholarly journals THE BIDIRECTIONAL RELATIONSHIP BETWEEN AGING IN PLACE AND COGNITIVE FUNCTIONING OVER TIME

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S414-S414
Author(s):  
Jonathan Platt ◽  
Yvonne Michael ◽  
Gina Lovasi ◽  
Andrea Rosso
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Functioning ◽  
Aging In Place ◽  
Cardiovascular Health Study ◽  
Residential Stability ◽  
Bidirectional Relationship ◽  
Time Varying Covariates ◽  
Over Time

Abstract Residential stability (aging in place) in older adults may be either supportive or detrimental to cognitive aging, and may be dynamic over time. Using residential histories of 3608 older adults in the Cardiovascular Health Study, this study seeks to estimate the potentially bidirectional relationship between residential change and cognitive functioning. Residential data were recorded and georeferenced annually, and the Modified Mini-Mental State Examination assessed global cognitive functioning. Marginal structural models will be used to assess the effect of residential and cognitive exposures over time, in the presence of time-varying covariates that may act as confounders and mediators at different time points. We hypothesize that residential stability will have a bidirectional relationship with cognitive functioning over time. Aging in place will be associated with higher cognitive function during follow-up, and predict longer dementia-free survival. In turn, time to residential relocation during follow-up will be shorter among those with lower cognitive function.

scholarly journals Effects of Acupuncture on Vascular Cognitive Impairment with No Dementia: A Randomized Controlled Trial

2021 ◽  
pp. 1-11
Author(s):  
Li Huang ◽  
Xuan Yin ◽  
Wei Li ◽  
Yan Cao ◽  
Yueqi Chen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Statistical Tests ◽  
Controlled Trial ◽  
Depression Scale ◽  
Vascular Cognitive Impairment ◽  
Serious Adverse Events ◽  
Randomized Controlled ◽  
Over Time

Background: Acupuncture has been used for treating vascular cognitive impairment, but evidence for its effectiveness remains limited. Objective: This single-center, patient-accessor blinded, randomized controlled trial was designed to assess whether acupuncture could improve the cognitive function of patients with vascular cognitive impairment with no dementia (VCIND). Methods: 120 VCIND patients were randomly assigned to the electro-acupuncture (EA) or sham acupuncture (SA) group at a 1 : 1 ratio, with treatment conducted thrice weekly for 8 weeks. The primary outcome was the changes of cognitive function measured by the Montreal Cognitive Assessment (MoCA) from baseline to week 8. The secondary outcomes included the scores of the Mini-Mental State Examination (MMSE), the Modified Barthel Index (MBI) and the Self-rating Depression Scale (SDS). Follow-up assessments were performed with MoCA and MMSE at week 16 and 32. Linear mixed-effects models were used for analysis and all statistical tests were two-sided. Results: The results showed that patients in the EA group had a significantly greater improvement in MoCA score (23.85±4.18) than those in the SA group (21.48±4.44) at week 8 (95% CI = 0.81, 3.93, p = 0.04), as well as higher MoCA scores over time (p <  0.001 for interaction). Patients who received EA showed a greater increase in MMSE scores (26.42±3.47) than those who received SA (24.40±3.85) along 8 weeks (95% CI = 0.69, 3.34, p = 0.0036). However, results diminished over time. No serious adverse events occurred during the trial. Conclusion: EA is a safe and effective technique to improve cognition over the short term of 8 weeks in VCIND patients.

scholarly journals Alcohol Consumption and Cognitive Function in an Older Population in China

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 154-154
Author(s):  
Anying Bai ◽  
Bo Hou ◽  
Junsong Chen ◽  
Boming Fu
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Episodic Memory ◽  
Cognitive Functioning ◽  
Chinese Population ◽  
Memory Function ◽  
Moderate Drinking ◽  
Significant Difference ◽  
Lagged Dependent Variable ◽  
Nationally Representative

Abstract The relationship between alcohol consumption and cognitive function has only been studied to a limited extent in China. This paper examines this relationship using the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative dataset of the Chinese population aged over 45. Alcohol consumption was measured by drinking status (never, former, moderate, excessive drinkers) based on number of standard drinks per week. Mental status and episodic memory function were used as measures of cognitive function. Lagged dependent variable models were used to examine independent associations between alcohol consumption and cognitive function. Our models controlled for demographic factors, socioeconomic factors, baseline cognitive functioning and an indicator for lifestyle. We also tested for an inverted J shaped relationship between alcohol consumption and cognitive functioning. A total of 10404 nondrinkers (60.09%), 2450 former drinkers (14.15%), 1599 moderate drinkers (9.24%) and 1525 excessive drinkers (8.81%) were included. Compared to never drinkers, there were no statistically significant difference between this group and moderate drinking group. While, excessive drinkers were consistently associated with on average 0.13-point decrease in episodic memory scores (p =0.031). For mental intactness, there were no statistically significant differences between never drinkers and other groups. Furthermore, we did not find evidence to support an inverted J-shaped association between standard drinks per week and measures of cognitive functioning. Excessively drinking was associated with greater decline in episodic memory function, but not in mental intactness in elder Chinese population. There is no significant association between moderate drinking and cognitive functioning measures.

scholarly journals Deterioration in Sleep Quality Affects Cognitive Depression in Prostate Cancer Patients

2021 ◽  
Vol 15 (2) ◽  
pp. 155798832110012
Author(s):  
Christopher F. Sharpley ◽  
David R. H. Christie ◽  
Vicki Bitsika
Keyword(s):  
Prostate Cancer ◽  
Sleep Quality ◽  
Treatment Options ◽  
Depression Scale ◽  
Severity Index ◽  
Sleep Difficulty ◽  
Specific Symptom ◽  
Falling Asleep ◽  
Index Comparison ◽  
Sleep Difficulties

Men who suffer from prostate cancer (PCa) need to make important decisions regarding their treatment options. There is some evidence that these men may suffer from sleep difficulties due to their cancer or its diagnosis and treatment. Although sleep difficulties have been associated with cognitive depression in other samples of men, they have not been examined in PCa patients, despite the importance of decision-making for these men. This study was designed to investigate the association between sleep difficulties and cognitive depression in PCa patients. A sample of 96 PCa patients completed a background questionnaire, the Zung Self-Rating Depression Scale, and the Insomnia Severity Index. Comparison was made between sleep difficulty scores from before the patients received their diagnosis of PCa to the time of survey, allowing use of a “retrospective pretest” methodology. Just over 61% of the sample reported a deterioration in sleep quality, and this was significantly associated with cognitive depression ( r = .346, p = .007). At the specific symptom level, having a clear mind significantly contributed to the variance in difficulty falling asleep (R2 change = .140, F for change = 9.298, p = .003). Sleeping difficulties, particularly falling asleep, are common and associated with depression-related to ability to think clearly in PCa patients. This has potentially adverse effects upon the ability of men with PCa to understand their treatment options and make decisions about them.

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