scholarly journals Alcohol Consumption and Cognitive Function in an Older Population in China

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 154-154
Author(s):  
Anying Bai ◽  
Bo Hou ◽  
Junsong Chen ◽  
Boming Fu
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Episodic Memory ◽  
Cognitive Functioning ◽  
Chinese Population ◽  
Memory Function ◽  
Moderate Drinking ◽  
Significant Difference ◽  
Lagged Dependent Variable ◽  
Nationally Representative

Abstract The relationship between alcohol consumption and cognitive function has only been studied to a limited extent in China. This paper examines this relationship using the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative dataset of the Chinese population aged over 45. Alcohol consumption was measured by drinking status (never, former, moderate, excessive drinkers) based on number of standard drinks per week. Mental status and episodic memory function were used as measures of cognitive function. Lagged dependent variable models were used to examine independent associations between alcohol consumption and cognitive function. Our models controlled for demographic factors, socioeconomic factors, baseline cognitive functioning and an indicator for lifestyle. We also tested for an inverted J shaped relationship between alcohol consumption and cognitive functioning. A total of 10404 nondrinkers (60.09%), 2450 former drinkers (14.15%), 1599 moderate drinkers (9.24%) and 1525 excessive drinkers (8.81%) were included. Compared to never drinkers, there were no statistically significant difference between this group and moderate drinking group. While, excessive drinkers were consistently associated with on average 0.13-point decrease in episodic memory scores (p =0.031). For mental intactness, there were no statistically significant differences between never drinkers and other groups. Furthermore, we did not find evidence to support an inverted J-shaped association between standard drinks per week and measures of cognitive functioning. Excessively drinking was associated with greater decline in episodic memory function, but not in mental intactness in elder Chinese population. There is no significant association between moderate drinking and cognitive functioning measures.

scholarly journals Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anying Bai ◽  
Liyuan Tao ◽  
Jia Huang ◽  
Jing Tao ◽  
Jue Liu
Keyword(s):  
Physical Activity ◽  
Executive Function ◽  
Longitudinal Study ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Age Groups ◽  
Screening Tools ◽  
Diabetic Patients ◽  
Patients With Diabetes ◽  
Lagged Dependent Variable

Abstract Background We aimed to examine the effect of physical activity on different cognitive domains among patients with diabetes. Methods We used two waves of data from the Chinese Health and Retirement Longitudinal Study (CHARLS, 2013–2015), a nationally representative dataset of Chinese population aged over 45. Total physical activity scores were calculated based on the International Physical Activity Questionnaire (IPAQ). Executive function and episodic memory were used as measures of cognitive function. We conducted lagged dependent variable models to explore the association between physical activity and cognitive function in full sample as well as two different age groups (45–65, ≥65). Results: 862 diabetic patients were included. We found that diabetic participants who had greater level of physical activity at baseline were associated with better episodic memory function in 2 years (p < 0.05). Moreover, physical activity was significantly associated with less decline in episodic memory in fully adjusted models, and the associations were stronger among patients aged 45–65 years (p < 0.05). No statistically significant association was found between physical activity and executive function in all age groups. Conclusions Physical activity may prevent some of the potential decline in episodic memory in diabetic patients. Clinicians and public health departments should strengthen the promotion of physical activity and develop early screening tools among diabetic participants to prevent the progression of cognitive impairment.

Abstract P351: Longitudinal Association Between Low-to-moderate Alcohol Drinking and Cognition Trajectory in US Adults

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Ruiyuan Zhang ◽  
Luqi Shen ◽  
Toni Miles ◽  
Ye Shen ◽  
Jose Cordero ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Racial Differences ◽  
Mental Status ◽  
Alcohol Drinking ◽  
Odds Ratio ◽  
Word Recall ◽  
Function Word ◽  
Moderate Drinking ◽  
Age Related ◽  
Nationally Representative

Background: Findings on the effect of alcohol drinking on cognitive function are mixed. The present study aimed to investigate the longitudinal associations of low-to-moderate alcohol drinking with cognition trajectories and changing rates among a nationally representative sample of middle-aged and older Americans. Method: A total of 19,887 participants in the Health and Retirement Study were included in the analyses. Performance of cognitive function was assessed every two years in 3 domains: mental status (MS), word recall (WR), and vocabulary (VOC). Trajectories of the total cognitive function (TCF) and individual domains were constructed using the SAS proc traj procedure. Age at cognition measurement was used as a time scale. Age related annual changing rates of cognition measures were estimated by regressing cognition scores over age for all individuals. Due to very few people, heavy drinkers were excluded. Multivariate logistic regression and linear regression were used to estimate the effect of low to moderate drinking on the cognition trajectories and annual changing rates after adjusting for baseline age, gender, race, years of education, marital status, smoking and body mass index. Result: Participants were clustered into a consistently low trajectory and a consistently high trajectory for each cognition measure. Low-to-moderate drinking was associated with a better trajectory and lower declining rate. Compared to never drinkers, current low-to-moderate drinkers were 0.67 (95% confidence interval [CI]: 0.59-0.75, P <0.0001), 0.69 (95% CI: 0.61-0.79, P <0.0001), 0.75 (95% CI: 0.69-0.81, P <0.0001), and 0.63 (95% CI: 0.54-0.72, P <0.0001) less likely to have a consistently low trajectory for TCF, MS, WR, and VOC, respectively. Meanwhile, current low-to-moderate drinking was associated with 0.05 (95% CI: 0.03-0.08, P <0.0001), 0.02 (95% CI: 0.01-0.03, P =0.0001), 0.005 (95% CI: -0.003-0.01, P =0.23), 0.01 (95% CI: 0-0.02, P =0.04) units lower annual changing rates for those cognition measures. Racial differences were observed for trajectories of MS ( P =0.01), in which, low-to-moderate drinking was associated with the consistently low trajectory among whites (odds ratio=0.67, 95% CI: 0.58-0.76) but not among blacks (odds ratio =1.07, 95% CI: 0.79-1.45). There was no gender difference was observed. Conclusion: Current low-to-moderate alcohol drinkers associated with total cognitive function, word recall, mental status, and vocabulary in both men and women.

scholarly journals Impact of secondhand smoke exposure on cognitive function among middle-aged and older women in China: findings from three waves of the China Health and Retirement Longitudinal Study

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e039824
Author(s):  
Anying Bai ◽  
Yinzi Jin ◽  
Yangmu Huang
Keyword(s):  
Longitudinal Study ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Secondhand Smoke ◽  
Chinese Women ◽  
Memory Function ◽  
Pooled Analysis ◽  
Visuospatial Ability ◽  
Global Cognitive Function ◽  
Normal Cognitive Function

ObjectivesTo examine the association between secondhand smoke (SSH) and women’s global cognitive function and cognitive subdomains.DesignCohort study.ParticipantsData for this study were obtained from the China Health and Retirement Longitudinal Study (2011-2013-2015), and pooled analysis was applied to wave 1 and wave 2 (2011–2013), wave 2 and wave 3 (2013–2015) and wave 1 and wave 3 (2011–2015). Data from a total of 6875 Chinese women with normal cognitive function at baseline were selected for analysis, including 2981 who were interviewed in 2011, 2471 in 2013, and 1894 in 2015.Main outcome measures and methodsSHS was classified based on the number of exposed years (<25 years, ≥25 years to <30 years, ≥30 years to <40 years, ≥40 years). Global cognitive function, visuospatial ability, orientation and attention, and episodic memory function were used as measures of cognitive function. Three waves of data were pooled using a dummy variable to differentiate between 2-year and 4-year groups. LDV models were used to examine independent associations between SHS and cognitive function. Demographic factors, socioeconomic factors, baseline cognitive functioning and health conditions were controlled for in our models.ResultsSSH was found to be inversely and significantly associated with cognitive function. Compared with those who had not been exposed to household SSH, women who had lived with a smoking husband had a significantly faster cognition decline, especially in global cognitive function (β=−0.33, 95% CI=−0.66 to −0.01, p<0.01), visuospatial ability (β=−0.04, 95% CI=−0.08 to −0.01, p<0.05) and episodic memory function (β=−0.16, 95% CI=−0.31 to −0.01, p=0.031).ConclusionsHousehold SSH exposure for more than 40 years was associated with a more significant decline in global cognitive function, visuospatial ability and episodic memory function, but not in orientation and attention function among older Chinese women.

scholarly journals COGNITIVE IMPAIRMENT AND SLEEP DIFFICULTIES OVER 10 YEARS IN A NATIONAL SAMPLE OF OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S453-S453
Author(s):  
Rebecca Robbins ◽  
Amanda Sonnega ◽  
Robert W Turner II ◽  
Girardin Jean-Louis ◽  
Kenneth Langa
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Functioning ◽  
Summary Score ◽  
Linear Regression Models ◽  
Sleep Difficulty ◽  
Falling Asleep ◽  
Nationally Representative ◽  
Sleep Difficulties ◽  
Over Time

Abstract Prior studies suggest that sleep difficulties (e.g., trouble falling asleep) may be associated with cognitive impairment. We used a large, nationally representative longitudinal survey of adults over the age of 50 in the US to examine the relationship between sleep difficulties and cognitive functioning. Generalized estimation equation (GEE) linear regression models were used to analyze data from the 2004-2014 waves of the Health and Retirement Study. We examined sleep difficulties and cognitive functioning within participants and across time (n=17,642). Sleep difficulty was measured as trouble falling asleep, nocturnal awakenings, and waking too early scored as 1= rarely/never, 2=sometimes, and 3=most of the time. A summary score indicated cognitive functioning (range 0-27). Models controlled for age, gender, race/ethnicity, marital status, education, chronic medical conditions, depressive symptoms, and body mass index (BMI). Compared to those with no sleep difficulties, those who reported difficulty falling asleep [“sometimes” OR=0.83,95%CI:0.71-0.96 and “most of the time” OR=0.79,95%CI: 0.64-0.98] and waking too early [“most of the time” OR=0.79,95%CI: 0.63-0.98] had worse cognitive functioning. Compared to those with no sleep difficulties, those who reported nocturnal awakenings [“most of the time” OR=1.29,95%CI:1.08-1.54] had higher cognitive functioning. Over time, lower cognitive function was more likely among those reporting difficulty falling asleep (OR=0.73,95%CI:0.54-0.97), nocturnal awakenings (OR=0.77,95%CI:0.61-0.97) and waking too early (OR=0.65,95%CI: 0.47-0.88). In this nationally representative, longitudinal sample of older US adults, we found that over time lower cognitive function was more likely among those who reported difficulty falling asleep, nocturnal awakenings, and waking too early.

scholarly journals Are Genetic and Environmental Contributions to Verbal Fluency and Episodic Memory Solely Moderated by Sleep?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 1001-1001
Author(s):  
Tina Vo ◽  
Shandell Pahlen ◽  
William Kremen ◽  
Matthew Mc Gue ◽  
Marianne Nygaard ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Cognitive Functioning ◽  
Sleep Duration ◽  
Verbal Fluency ◽  
Environmental Influences ◽  
Short Sleep ◽  
Genes And Environment ◽  
Long Sleep

Abstract Decreases in sleep duration and cognitive functioning often occur and co-occur in aging although these patterns are not universal. Underlying etiologies, i.e., genetic and environmental factors, contribute to why people differ on cognitive functioning at shorter versus longer sleep durations. The current study tested whether sleep duration alters the genetic and environmental contributions to why middle-aged and older adults vary on cognitive functioning. Using 4 twin studies from the Interplay of Genes and Environment Across Multiple Studies (IGEMS) consortium (Mage=56.5, range=35.0-91.2, N=5,210, 1,083 complete MZ pairs, 1,522 complete DZ pairs) we tested quantitative genetic twin models considering sleep, depressive symptoms, and age as moderators of verbal fluency (i.e., Animal Naming) and episodic memory (i.e., Word List). For verbal fluency, sleep duration and depressive symptoms were significant when dropped together from the model (χ2(6)=15.22, p=0.02) but not individually (χ2sleep(3)=7.17, p=0.07; χ2dep(3)=5.81, p=0.12), indicating that both moderators may affect differences in verbal fluency performance. For episodic memory, sleep duration moderation was only significant via the shared environmental factor (χ2(1)=5.26, p=0.02), indicating that sleep may affect differences in episodic memory performance via environmental influences that make siblings more similar to one another. Overall, results illustrate patterns of higher genetic influences on cognitive function at short sleep (4 hours) and higher shared environmental influences on cognitive function at long sleep (10 hours). These findings may align with associations of upregulation of neuroinflammatory processes at short sleep and common reporting of mental fatigue at long sleep, both of which are associated with poorer cognitive functioning.

scholarly journals The Effects of Light-to-Moderate Alcohol Consumption on the Cognitive Function of Community Nondemented Male Elderly: A Cohort Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Zhang Yan ◽  
Zhang Yingjie ◽  
An Na ◽  
Qiu Qi ◽  
Li Wei ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Heavy Drinking ◽  
The Elderly ◽  
Moderate Alcohol Consumption ◽  
Elderly Men ◽  
Moderate Drinking ◽  
Brain Functions ◽  
One Year

Aim. To investigate the effects of light-to-moderate drinking on the cognitive function of the elderly in a large elderly community cohort. Although heavy drinking is linked with impaired brain functions, the effects of light-to-moderate drinking on the cognitive function of the elderly are still controversial. Methods. A total of 1469 nondemented elderly men from 15 research centers in 8 cities and provinces were included and divided into two groups: drinking (531 subjects) and nondrinking (938 subjects). Cognitive functions were assessed by the Beijing version of the Montreal Cognitive Assessment (MoCA) at baseline and one-year follow-up. Results. There was no difference in total cognitive scores between the light-to-moderate drinking and nondrinking groups at baseline and follow-up. Nonalcohol users performed better naming and abstraction function at baseline and better naming function at follow-up. There was no difference in cognitive performance decline and new-onset dementia rates at follow-up. Conclusions. Light-to-moderate alcohol consumption had no significant impact on the overall cognitive function and the risk of dementia in elderly men.

scholarly journals Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men

2020 ◽  
pp. 1-13
Author(s):  
Riki E. Slayday ◽  
Daniel E. Gustavson ◽  
Jeremy A. Elman ◽  
Asad Beck ◽  
Linda K. McEvoy ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Alcohol Consumption ◽  
Episodic Memory ◽  
Apoe Genotype ◽  
Middle Aged ◽  
Heavy Alcohol ◽  
Heavy Alcohol Consumption ◽  
Ε4 Allele ◽  
Middle Aged Adults ◽  
The Relationship

Abstract Objective: Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) ε4 allele, a risk factor for Alzheimer’s disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would show better cognitive performance than heavy drinkers or non-drinkers. Additionally, we hypothesized that the association between alcohol use and cognitive function would differ by ApoE genotype (ε4+ vs. ε4−). Method: Participants were 1266 men from the Vietnam Era Twin Study of Aging (VETSA; M age = 56; range 51–60) who completed a neuropsychological battery assessing seven cognitive abilities: general cognitive ability (GCA), episodic memory, processing speed, executive function, abstract reasoning, verbal fluency, and visuospatial ability. Alcohol consumption was categorized into five groups: never, former, light, moderate, and heavy. Results: In fully adjusted models, there was no significant main effect of alcohol consumption on cognitive functions. However, there was a significant interaction between alcohol consumption and ApoE ε4 status for GCA and episodic memory, such that the relationship of alcohol consumption and cognition was stronger in ε4 carriers. The ε4+ heavy drinking subgroup had the poorest GCA and episodic memory. Conclusions: Presence of the ε4 allele may increase vulnerability to the deleterious effects of heavy alcohol consumption. Beneficial effects of light or moderate alcohol consumption were not observed.

Physical Predictors of Cognitive Function in Individuals With Hypertension: Evidence from the CHARLS Basline Survey

2018 ◽  
Vol 41 (4) ◽  
pp. 592-614 ◽  
Author(s):  
Manhua Zuo ◽  
Changping Gan ◽  
Tingting Liu ◽  
Jun Tang ◽  
Jianping Dai ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Episodic Memory ◽  
Grip Strength ◽  
Physical Performance ◽  
Walking Speed ◽  
Secondary Data ◽  
Performance Measure ◽  
Balance Test ◽  
Physical Performance Measure ◽  
Nationally Representative

The purpose of the study was to examine the independent associations of each individual physical performance measure (i.e., grip strength, walking speed, repeated chair stands, and balance test) with subdomains of cognitive function and to determine predictors for each subdomain of cognitive function. A secondary data analysis was performed using a nationally representative middle-aged and older sample of hypertensive population. The findings showed that after adding all four physical performance measures, stronger grip strength was significantly associated with better visuospatial abilities, episodic memory, orientation/attention, and overall cognitive function. In addition, faster walking speed and faster repeated chair stands were strongly associated with better episodic memory and overall cognitive function, respectively. Because grip strength was significantly associated with several subdomains of cognitive functioning, it seems conceivable that increasing physical activity would improve both grip strength and cognitive function in patients with hypertension.

scholarly journals The Promise of Intergenerational Choir for Improving Psychosocial and Cognitive Health for those with Dementia: The Voices in Motion Project

2019 ◽  
Vol 10 (1) ◽  
pp. 66-82
Author(s):  
Nicholas Tamburri ◽  
Michaella Trites ◽  
Debra Sheets ◽  
Andre Smith ◽  
Stuart MacDonald
Keyword(s):  
High School Students ◽  
Depressive Symptoms ◽  
Cognitive Function ◽  
Episodic Memory ◽  
Repeated Measures ◽  
Memory Function ◽  
Medical Science ◽  
Word Recall ◽  
Repeated Measures Design

Rates of dementia continue to increase along with life expectancy. As neither dementia’s causenor its cure is well understood from the perspective of medical science, further investigations ofcomplementary lifestyle and non-pharmaceutical interventions are imperative. Although arts-basedtherapies have been explored selectively, the significance of these interventions for persons withdementia (PwD) remains undervalued in both the general population and scientific literature. Thisstudy aims to examine one promising lifestyle intervention, the effect of intergenerational choirparticipation, on psychosocial and cognitive function for PwD. Participants (n = 32), in partnershipwith their family caregivers and local high school students, participated in an intergenerational choirfor as many as three choir seasons spanning up to 18 months of follow-up. Participants underwent anexpansive assessment of psychosocial, physiological, and cognitive function every four to six weeksas part of an intensive repeated measures design. Here, the potential benefits of choir for PwD wereexplored in relation to change for select cognitive (Mini-Mental State Examination: MMSE; TrailMaking Task A: TMT-A; Word Recall) and psychosocial (Patient Health Questionnaire: PHQ-9)indicators. Multilevel modelling was used to index initial levels (at baseline) and change (spanningup to eight follow-up assessments) in function for measures of global cognition, executive functioning,episodic memory, and depressive symptoms. Notably, no significant declines were observed for MMSEor TMT-A tasks. As expected, episodic memory function continued to decline, with a significantlessening of depressive symptoms and signs observed for the PHQ-9. These results suggest thatdespite the progressive nature of underlying neuropathology for dementia subtypes like Alzheimer’sDisease, preservation of select cognitive functions as well as mitigation of psychosocial comorbidities(depressive symptoms) is possible through participation in an intergenerational choir.

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