scholarly journals 1302Potential exposure-response relationships between vitamin D and cognitive performance in middle to older-aged adults

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Janis Harse ◽  
Kun Zhu ◽  
Romola Bucks ◽  
Michael Hunter ◽  
Ee Mun Lim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Performance ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Linear Pattern ◽  
Hydroxyvitamin D ◽  
Exposure Response ◽  
Non Linear ◽  
Global Cognition ◽  
And Performance

Abstract Background Low vitamin D status is consistently associated with poorer global cognition in older adults, particularly women, but findings in relation to higher status are unclear. A better understanding of the relationship across the range is required. Methods We investigated patterns of association between serum levels of 25-hydroxyvitamin D (25OHD), the standard measure of vitamin D status, and cognitive performance in 4872 middle to older-aged adults from the Busselton Healthy Ageing Study. Global cognition and performance in domains of attention, memory, and executive function were modelled using linear regression and restricted cubic splines, while controlling for demographic, lifestyle, and health factors. Results Mean (SD) serum 25OHD levels were 78 (24) nM/L for women and 87 (25) nM/L for men. Positive, linear patterns for global cognition in women (p = 0.023) and attention accuracy in men (p = 0.022) suggested cognitive performance improved throughout the range. A non-linear pattern for attention accuracy in women suggested performance improved up to 25OHD levels of approximately 80 nM/L and then plateaued (p = 0.035). In men, negative patterns for semantic verbal fluency (linear, p = 0.025) and global cognition (non-linear, p = 0.015) suggested performance declined as 25OHD levels increased. Conclusions Effects were small and patterns of association were inconsistent for men and women and across domains. However, the positive patterns identified for women, particularly in relation to attention accuracy, have biological plausibility as early, exposure-response relationships.

scholarly journals Investigating Potential Dose–Response Relationships between Vitamin D Status and Cognitive Performance: A Cross-Sectional Analysis in Middle- to Older-Aged Adults in the Busselton Healthy Ageing Study

2021 ◽  
Vol 19 (1) ◽  
pp. 450
Author(s):  
Janis D. Harse ◽  
Kun Zhu ◽  
Romola S. Bucks ◽  
Michael Hunter ◽  
Ee Mun Lim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Performance ◽  
Dose Response ◽  
Linear Trend ◽  
Healthy Ageing ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Serum 25Ohd ◽  
Ageing Study ◽  
Global Cognition

Low vitamin D status has been linked to adverse cognitive outcomes in older adults. However, relationships at higher levels remain uncertain. We aimed to clarify patterns of association between vitamin D status and cognitive performance, using flexible regression methods, in 4872 middle- to older-aged adults (2678 females) from the Busselton Healthy Ageing Study. Cross-sectional associations of serum levels of 25-hydroxyvitamin D (25OHD) and performance in cognitive domains were modelled using linear regression and restricted cubic splines, controlling for demographic, lifestyle, and health factors. Mean ± SD serum 25OHD levels were 78 ± 24 nM/L for women and 85 ± 25 nM/L for men. Increasing levels in women were associated with better global cognition (linear trend, p = 0.023) and attention accuracy (continuity of attention), with improvement in the latter plateauing around levels of 80 nM/L (nonlinear trend, p = 0.035). In men, increasing levels of serum 25OHD were associated with better attention accuracy (linear trend, p = 0.022), but poorer semantic verbal fluency (linear trend, p = 0.025) and global cognition (nonlinear trend, p = 0.015). We identified patterns of association between serum 25OHD levels and cognitive performance that may reflect early dose–response relationships, particularly in women. Longitudinal analyses extending through to older ages may help to clarify the nature, strength, and temporality of these relationships.

Vitamin D - From Essentiality to Functionality

2012 ◽  
Vol 82 (5) ◽  
pp. 321-326 ◽  
Author(s):  
Heike Bischoff-Ferrari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Vitamin D Intake ◽  
Severe Deficiency ◽  
Normal Vitamin ◽  
25 Hydroxyvitamin D ◽  
Muscle Health

Vitamin D is essential in bone and muscle health. Severe deficiency (25-hydroxyvitamin D serum levels < 25 nmol/l) can result in rickets and osteomalacia, fractures, myopathy and falls. All recent recommendations on vitamin D agree that children and adults should reach a target 25-hydroxyvitamin D range of at least 50 nmol/l (threshold for normal vitamin D status) and 50 % of the population may be below that threshold. A vitamin D intake of 600 to 800 IU per day as recommended today will prevent about 97 % of children and adults from vitamin D deficiency. Notably, a higher 25-hydroxyvitamin D threshold of more than 60 nmol/l is needed for optimal functionality, fall and fracture in adults age 65 and older.

scholarly journals Directly measured free and total 25-hydroxyvitamin D levels in relation to metabolic health in multi-ethnic postmenopausal females in Saudi Arabia

2021 ◽  
Author(s):  
Shatha Alharazy ◽  
M Denise Robertson ◽  
Susan Lanhman-New ◽  
Muhammad Imran Naseer ◽  
Adeel G. Chaudhary ◽  
...  
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Serum Levels ◽  
Metabolic Health ◽  
Vitamin D Status ◽  
Biochemical Tests ◽  
Hydroxyvitamin D ◽  
Metabolic Bone ◽  
Vitamin D Levels ◽  
Free Vitamin D

Background: Measurement of free 25-hydroyvitamin D (25(OH)D) status has been suggested as a more representative marker of vitamin D status than that of total 25(OH)D. Previously, free 25(OH)D could only be calculated indirectly; however, a newly developed direct assay for the measurement of free 25(OH)D is now available. The aim of this study therefore was to investigate directly measured total and free vitamin D levels association with metabolic health in postmenopausal healthy women living in Saudi Arabia. Methods: A sample of 302 postmenopausal women aged ≥ 50 years (n=302) living in Saudi Arabia were recruited in a cross-section study design. Blood samples were collected from subjects for measurement of serum levels of total 25(OH)D, directly measured free 25(OH)D, metabolic bone parameters, lipid profile, and other biochemical tests. Results: A positive correlation was found between directly measured free and total 25(OH)D (r=0.64, P<0.0001). Total, but not free 25(OH)D showed significant association with serum intact parathyroid hormone (P=0.004); whilst free 25(OH)D but not total 25(OH)D showed a significant association with total cholesterol and LDL-C (P=0.032 and P=0.045; respectively). Conclusions: Free 25(OH)D and total 25 (OH)D were found to be consistently correlated; but with different associations to metabolic health parameters. Further research is needed to determine which marker of vitamin D status would be the most appropriate in population studies.

scholarly journals Year-round vitamin D deficiency among Saudi female out-patients

2012 ◽  
Vol 16 (3) ◽  
pp. 544-548 ◽  
Author(s):  
Raed M Kanan ◽  
Yousef M Al Saleh ◽  
Hana M Fakhoury ◽  
Maysoon Adham ◽  
Saleh Aljaser ◽  
...  
Keyword(s):  
Vitamin D ◽  
Saudi Arabia ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Blood Samples ◽  
Hydroxyvitamin D ◽  
High Prevalence ◽  
25 Hydroxyvitamin D ◽  
Women Clinicians

AbstractObjectiveThe aim of the present study was to investigate vitamin D status among female out-patients in Saudi Arabia during the summer and winter seasons.DesignData were retrospectively collected using medical record abstraction.SettingA multidisciplinary hospital in Riyadh between January and December 2009.SubjectsSaudi females (age ≥19 years;n1556) attending out-patient clinics for various complaints comprised the studied population. The population was subdivided into two groups depending on the date of their visit where blood samples were collected: summer (n659) and winter groups (n897). The summer group was further subdivided into premenopausal (age 19–49 years;n425) and postmenopausal subgroups (age ≥50 years;n234). Similarly, the winter group was subdivided into premenopausal (n543) and postmenopausal subgroups (n354). Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured using HPLC.ResultsThe prevalence of vitamin D deficiency (25(OH)D <50 nmol/l) was high in both premenopausal and postmenopausal groups (80 % and 68 %, respectively) during the summer, as well as during the winter (85 % and 76 %, respectively).ConclusionsA high prevalence of vitamin D deficiency among Saudi female out-patients was observed throughout the year despite the routine supplementation with 10–20 μg vitamin D3for postmenopausal women. Clinicians should seriously consider determining the vitamin D status of Saudi females routinely and prescribing them proper supplementation.

Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants

1986 ◽  
Vol 110 (1) ◽  
pp. 43-50 ◽  
Author(s):  
L. Cancela ◽  
N. Le Boulch ◽  
L. Miravet
Keyword(s):  
Vitamin D ◽  
Post Partum ◽  
Serum Levels ◽  
Maternal Serum ◽  
Vitamin D Status ◽  
Maternal Milk ◽  
Hydroxyvitamin D ◽  
Dihydroxyvitamin D ◽  
Nursing Mothers ◽  
Breast Fed

ABSTRACT This work was designed to study the effect of the vitamin D content of human milk on the vitamin D status of exclusively breast-fed infants, and the relation between milk and maternal serum concentrations of vitamin D during the first month of lactation. Serum levels of calcium (Ca), phosphorus (P), magnesium (Mg) and 25-hydroxyvitamin D (25-OH-D) were determined in a racially heterogenous population of nursing women, between days 3 and 5 (L3), 15 and 18 (L15) and 30 and 45 (L30) post partum. The same parameters were determined in the serum of 1-month-old breast-fed infants. Maternal milk samples were obtained at L3, L15 and L30 and analysed for Ca, P, Mg, vitamin D and 25-OH-D content. Milk levels of Ca, P and Mg were found to be within the range previously described by other authors. No correlation was found between serum and milk levels of vitamin D and 25-OH-D in nursing mothers. The 25-OH-D concentration in milk was related to its vitamin D content and strongly correlated (P < 0·001) with the 25-OH-D levels in the serum of exclusively breast-fed infants. No significant changes were observed in maternal serum levels of 1,25-dihydroxyvitamin D (1,25-(OH)2D3) measured at L3 and L30, or between maternal and infant levels of 1,25-(OH)2D3 at L30. This study emphasizes the importance of the 25-OH-D content of maternal milk, in being primarily responsible for the vitamin D concentrations found in the serum of exclusively breast-fed infants. In contrast, serum levels of 1,25-(OH)2D3 measured in the breast-fed baby seemed mainly related to its calcaemia. J. Endocr. (1986) 110, 43–50

scholarly journals Metabolismo Óseo

2018 ◽  
Vol 5 (2) ◽  
pp. 77-82
Author(s):  
Asociación Colombiana de Endocrinología Diabetes y Metabolismo
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Observational Study ◽  
Study Design ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Vitamina D ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Baseline Characteristics

Listado Póster Niveles séricos de 25 hidroxivitamina D en una cohorte de gestantes con y sin preeclampsia de la ciudad de Bogotá.  Yessica Agudelo Zapata, Luis Miguel Maldonado Acosta, Héctor Fabio Sandoval Alzate, Natalia Elvira Poveda, María Fernanda Garcés, Jonathan Alexander Cortés Vásquez, Andrés Felipe Linares Vaca, Carlos Alejandro Mancera Rodríguez, Shahar Alexandra Perea Ariza, Karen Yuliana Ramírez Iriarte, Camilo Andrés Castro Saldarriaga, Juan Manuel Arteaga Díaz, Roberto Franco Vega, Edith Ángel Müller, Arturo José Parada Baños y Jorge E. Caminos. Póster Determinantes hormonales y biquímicos de la densidad mineral ósea en hombres no diabéticos.  Romero MC, Martínez LA, Pulido JC, Rincón JD, Roncancio JS, Alzate JP, Arteaga JM, Franco R, Maldonado LM, Caminos JE. Póster Utilidad del FRaX® de población colombiana dentro del algoritmo de diagnóstico y tratamiento de la osteoporosis en el II Consenso Colombiano de osteoporosis.  Medina, Rosero O, Rueda Plata P, Sánchez Escobar F, Chalem Choueka M, González MA,. Román A, Terront A, Páez A, Rueda C, Builes CA, Pérez C, Fernández Ávila DG Vásquez, D, González D, Pinilla E, Reina E, Vásquez EM, Vargas F, Linares F, Altamar G, Molina GA, Pineda GA, Arenas HM, Vélez JA, Molina JF, Jaller JJ, Londoño R, Clark P, Angulo O, Molina CF. Póster Vitamina D y dislipidemias en mujeres mayores de 50 años en los municipios de Baranoa y Sabanalarga, Atlántico. Becerra JE, Sarmiento Rubiano L, Rebolledo Cobos R, Suárez Dávila H, Sánchez L. Póster Estudio retrospectivo-prospectivo observacional en la vida real del tratamiento con denosumab en pacientes mexicanas (base de datos ROSEMARY).  Cons M. Fidencio Jasqui Salomón, Salinas Carlos, Macias Amador, Zarain Alfonso, Reza Albarrán AA, Peña Hugo, Morales Jorge, Balcázar José Luis, Elizondo Jaime, De la Peña Pilar. Póster Relevancia de la nacionalidad para la determinación del riesgo de fracturas según FRaX®. Jasqui Bucay A, Jasqui Bucay A, Jasqui Romano S. Póster Vitamin D status and effects of 25-Hydroxyvitamin D (25oHD) serum levels on the risk of fractures in the teriparatide versus risedronate vero clinical trial.  Minisola S, Marin F, Kendler DL, Geusens P, Zerbini C, Russo L, Greenspan SL, Casado E, Fahrleitner- Pammer A, Stepan JJ, Lespessailles E, Moericke R, Bagur A, Lakatos P, López-Romero P, Body JJ. Póster Study design and baseline characteristics of the population enrolled in a multinational, observational study of teriparatide (alafos).  Chen CH, Alsalmawy A, Ish-Shalom S, Lim SJ, Al- Ali N, Cunha Borges JL, Yang H, Casas N, Altan L, Moll T, Gurbuz S, Brnabic AJM, Marin F Póster Manejo subóptimo de fracturas por fragilidad en servicio de traumatología del Hospital Regional de antofagasta 2015-2016.  Zapata Pizarro A, Alvarado Villarroel J, Leppes Jenkis F. Póster Cultivos primarios, una aproximación experimental para el estudio del desarrollo osteogénico.  Soria AM, Pustovrh MC, Salazar L, Ortiz M, Valencia C. Póster Composición corporal, densidad mineral ósea y fuerza muscular en transgénero mujer y hombre previo al tratamiento cruzado (THC).  Abdala R; *Nagelberg A; Zanchetta MB; Silveira F. Póster Calcificación de arterias coronarias en una paciente con hiperparatiroidismo secundario y falla renal crónica.  Castellanos R, Vesga B, Isaza JR, Hoyos K.

scholarly journals Comparison of Vitamin D and 25-Hydroxyvitamin D Concentrations in Human Breast Milk between 1989 and 2016–2017

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 573
Author(s):  
Naoko Tsugawa ◽  
Mayu Nishino ◽  
Akiko Kuwabara ◽  
Honami Ogasawara ◽  
Maya Kamao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Breast Milk ◽  
Sun Exposure ◽  
Stepwise Multiple Regression ◽  
Human Breast Milk ◽  
Vitamin D Status ◽  
Human Breast ◽  
Hydroxyvitamin D ◽  
Lactating Mothers ◽  
25 Hydroxyvitamin D

Background: Breast milk is considered the optimal source of nutrition during infancy. Although the vitamin D concentration in human breast milk is generally considered poor for infants, vitamin D in breast milk is an important source for exclusively breastfed infants. Increases in vitamin D insufficiency and deficiency in lactating mothers may reduce vitamin D concentrations in breast milk. This study aimed to compare vitamin D and 25-hydroxyvitamin D (25OHD) concentrations in breast milk collected in 1989 and 2016–2017 and simultaneously analyze them with liquid chromatography-tandem mass spectrometry (LC-MS/MS); the association between the lifestyle of recent lactating mothers (2016–2017) and vitamin D status in human breast milk was also evaluated. Method: Lactating mothers were recruited from three regions of Japan in 1989 (n = 72) and 2016–2017 (n = 90), and milk from 3–4 months was collected in summer and winter. The samples were strictly sealed and stored at −80℃ until measurement. Breast milk vitamin D and 25OHD concentrations were analyzed by LC-MS/MS. Vitamin D intake, sun exposure, and sunscreen use of the lactating mothers in 2016–2017 were assessed. Results: Both vitamin D and 25OHD concentrations in breast milk were higher in the summer regardless of the survey year. Significantly lower vitamin D and 25OHD concentrations were observed in 2016–2017 compared with 1989 in summer, but no survey year difference was observed in winter. The stepwise multiple regression analyses identified season, daily outdoor activity, and suntan in the last 12 months as independent factors associated with vitamin D3 concentrations. Conclusion: The results suggest that low vitamin D status in recent lactating mothers may have decreased vitamin D and 25OHD concentrations in breast milk compared with the 1980s. These results are helpful for developing public health strategies to improve vitamin D status in lactating mothers and infants.

scholarly journals Implementation Strategies for Improving Vitamin D Status and Increasing Vitamin D Intake in the UK: Current Controversies and Future Perspectives. Proceedings of the 2nd Rank Prize Funds Forum on Vitamin D

2021 ◽  
pp. 1-60
Author(s):  
J.L. Buttriss ◽  
S.A. Lanham-New ◽  
S. Steenson ◽  
L. Levy ◽  
G.E. Swan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Implementation Strategies ◽  
Vitamin D Status ◽  
Cost Information ◽  
Hydroxyvitamin D ◽  
Minority Ethnic Groups ◽  
Modelling Studies ◽  
Clinical Consequences ◽  
The Uk

Abstract A multi-disciplinary expert group met to discuss vitamin D deficiency in the UK, and strategies for improving population intakes and status. Changes to UK Government advice since the 1st Rank Forum on Vitamin D (2009) were discussed, including rationale for setting a RNI (10µg/day;400IU/day) for adults and children (4+ years). Current UK data show inadequate intakes among all age groups, and high prevalence of low vitamin D status among specific groups (e.g. pregnant women and adolescent males/females). Evidence of widespread deficiency within some minority ethnic groups, resulting in nutritional rickets (particularly among Black and South Asian infants), raised particular concern. It is too early to establish whether population vitamin D status has altered since Government recommendations changed in 2016. Vitamin D food fortification was discussed as a potential strategy to increase population intakes. Data from dose-response and dietary modelling studies indicate dairy products, bread, hens’ eggs and some meats as potential fortification vehicles. Vitamin D3 appears more effective than vitamin D2 for raising serum 25-hydroxyvitamin D concentration, which has implications for choice of fortificant. Other considerations for successful fortification strategies include: i) need for ‘real-world’ cost information for use in modelling work; ii) supportive food legislation; iii) improved consumer and health professional understanding of vitamin D’s importance; iv) clinical consequences of inadequate vitamin D status; v) consistent communication of Government advice across health/social care professions, and via the food industry. These areas urgently require further research to enable universal improvement in vitamin D intakes and status in the UK population.

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