scholarly journals 59Outbreak investigation of dengue fever in union council (UC) Bharakahu, Islamabad, Pakistan, 2019

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Sajjad Ahmad Khan Sajjad Khan
Keyword(s):  
Dengue Fever ◽  
Attack Rate ◽  
Health Workers ◽  
Nonstructural Protein ◽  
Health Department ◽  
Control Measures ◽  
Stagnant Water ◽  
Blood Samples ◽  
Breeding Sites ◽  
Nonstructural Protein 1

Abstract Background During third week of September 2019, lady health workers reported twelve suspected cases of dengue fever from UC Bharakahu, Islamabad (population 70,000) to health department. Outbreak investigation conducted with objectives to determine risk factors and recommend control measures. Methods Investigation conducted from 20th September to 04th November 2019. Case was defined as any resident of UC Bharakahu with fever and two or more of following signs/symptoms; headache, retro-orbital pain, arthralgia, myalgia, petechial rash with NS1 (Nonstructural Protein 1) positive during 12th August to 18th November 2019. Age and sex matched healthy controls recruited from same neighborhood. Blood samples from seven suspected cases sent for laboratory confirmation. Results Total 993 houses surveyed and 113 cases identified. Mean age was 34.2 years (range 13-90 years). Most affected age group was 35-44 years (Attack Rate 0.78%), Overall attack rate was 0.15%. Males were predominantly involved n = 70 (62%). Out of total cases, 34 (70%) had stagnant water inside and around houses (OR 2.0, CI 1.06-3.75, p < 0.005), 40 (35%) used repellent lotions (OR 0.55, CI 0.32-0.95, p < 0.05), 34 (30%) used insecticide spray (OR 0.35, CI 0.20-0.61, p < 0.05), 97 (86%) used full protective clothing (OR 0.22, CI 0.07-0.68, p < 0.05). All seven blood samples tested positive for NS-1 Ag. Conclusion Presence of stagnant rain water inside and around houses acted as breeding grounds for aedes aegypti mosquitoes and was most probable cause of outbreak. Following our recommendations, health department initiated mosquito breeding sites control activities through insecticide residual spray and advocacy on use of protective measures against mosquito bites. Key words Outbreak, dengue, stagnant water, Bhara Kahu, Islamabad, 2019

scholarly journals Investigation of Dengue Fever Outbreak in a Rural Area of Islamabad, Pakistan: A Case Control Study

2021 ◽  
Author(s):  
Fawad Khalid Khan ◽  
Khurram Shahzad Akram ◽  
Ambreen Chaudhry ◽  
Mir Muhammad Hassan Bullo ◽  
zakir Hussain ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Nonstructural Protein ◽  
Health Department ◽  
Control Measures ◽  
Outbreak Investigation ◽  
Blood Samples ◽  
Breeding Sites ◽  
Nonstructural Protein 1 ◽  
Breeding Grounds ◽  
Ns1 Antigen

Background: In the second week of October 2019, five suspected cases of dengue fever were reported from union council Sohan, Islamabad rural (population 45,747) to the health department, Islamabad Capital Territory (ICT).  Outbreak investigation was conducted with the objectives to identify risk factors and to recommend control measures. Methods: Outbreak investigation was conducted from 17 th October to 25 th November 2019. A case was defined as, “fever and two or more of the following signs/symptoms; headache, retro-orbital pain, joint/bone pain, myalgia and petechial rash with NS1 test (Nonstructural Protein 1) positive during 8 th October to 25 th November 2019 among residents of Sohan”. Age and sex-matched controls were recruited from the same neighborhood. All cases were positive for NS1 antigen. Blood samples from five suspected cases were collected and tested for laboratory confirmation. Results:   A total of 547 households were surveyed and 85 cases were identified. The mean age was 34.4 years + 16.05 (range 3-71 years). The attack rate was 0.19% whereas the most affected age group was the 45-54 years (AR 0.43%). Males were predominantly affected (n=48 56.5%). Among all cases, 32% (n=27)) had stagnant water inside or around their houses (aOR 2.65, CI 1.20-5.83, P= 0.005), 33% (n=28) were using mosquito repellent (aOR 0.35, CI 0.17-0.70, P <0.001), 31% (n=26) used indoor residual spray insecticide (aOR 0.48, CI 0.24-0.97, P =0.041), and 73% (n=62) used full protective clothing (aOR 0.17, CI 0.05-0.58, P <0.001). All five blood samples were tested positive for NS-1 antigen. Conclusion: The presence of accumulated rainwater in pools and empty receptacles around houses acted as breeding grounds for Aedes aegypti mosquitos and was the most probable cause of this outbreak. Following our recommendations, the health department-initiated mosquito breeding sites control activities through residual insecticide spray and advocacy on the use of protective measures against mosquito bites.

Risk factors associated with Dengue fever outbreak in Islamabad, Pakistan (Preprint)

2021 ◽  
Author(s):  
Chaudhry Amjad Mehmood ◽  
Fawad Khalid Khan ◽  
Zakir Hussain ◽  
Mumtaz Ali Laghari ◽  
Ambreen Chaudhry ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dengue Fever ◽  
Attack Rate ◽  
Disease Surveillance ◽  
Signs And Symptoms ◽  
Open Water ◽  
Bed Nets ◽  
Stagnant Water ◽  
Blood Samples ◽  
Active Case

BACKGROUND On 23rd Oct 2016, 79 dengue fever cases were reported from the Union Council (UC) Tarlai to Federal Disease Surveillance and Response Unit Islamabad. A team was deputed to investigate the suspected dengue outbreak. OBJECTIVE This study was aimed to determine the extent of the outbreak and identify the possible risk factors. METHODS Active case finding was conducted through a house-to-house survey. A case was defined as, acute onset of Fever ≥ 38 ℃ in a resident of Tarlai from Oct 2-Nov 11, 2016, with a positive NS-1 test, and any two of the following signs and symptoms; retro-orbital/ocular pain, headache, rash, myalgia, arthralgia, and hemorrhagic manifestations. A structured questionnaire was used to collect data. Age and sex-matched controls (1:1) were identified from the same area. Blood samples were taken and sent to the National Institute of Health for genotype identification. RESULTS During the active case search, 145 cases of dengue fever were identified by surveying 928 houses from 23rd Oct to 11th Nov 2016. Attack rate (AR) was 17.0/10,000 population. The mean age was 34.4±14.4 years. More than half of the cases were male (n=80, 55.2%). Among all cases, 29% belong to the 25-34 years age group while the highest attack rate was found in 35-44 years (AR 35.6/10,000) followed by 55-64 years (AR 35.5/10,000). All five blood samples tested positive for NS-1 (genotype DENV-2). The most frequent presenting sin/symptom was fever and headache (100%). Stagnant water around houses (OR = 4.86, CI: 2.94 -8.01, P<0.0001), presence of flower pots in-home (OR = 2.73, CI: 1.67-4.45, P<0.0001), and open water container (OR 2.24, CI: 1.36-3.60, P<0.0001) showed higher odds among cases. While. use of bed nets (OR 0.44, CI: 0.25-0.77, P 0.003), insecticidal spray (OR 0.33, CI: 0.22-0.55, P<0.0001), door screening (OR 0.27, CI: 0.15-0.46, P<0.0001), use of mosquito coil/mat (OR 0.26, CI: 0.16-0.44, P<0.0001) and cleanliness in house (OR 0.12, CI: 0.05-0.26, P<0.0001) showed a significant protective effect. CONCLUSIONS Stagnant water acting as breeding grounds for vector was the probable cause of the spread of the outbreak. The establishment of a surveillance and early reporting system and the use of protective measures against the vector is strongly recommended.

scholarly journals Rhabdomyolysis and Dengue Fever: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Tanya Sargeant ◽  
Tricia Harris ◽  
Rohan Wilks ◽  
Sydney Barned ◽  
Karen Galloway-Blake ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Dengue Fever ◽  
Private Hospital ◽  
Nonstructural Protein ◽  
Febrile Illness ◽  
University Hospital ◽  
Close Monitoring ◽  
Nonstructural Protein 1 ◽  
The University

The medical literature contains only a few reports of rhabdomyolysis occurring in patients with dengue fever. We report the case of a 25-year-old Jamaican man who was admitted to a private hospital four days after the onset of an acute febrile illness with fever, myalgia, and generalized weakness. Dengue fever was confirmed with a positive test for the dengue antigen, nonstructural protein 1. He remained well and was discharged on day 6 of his illness. On day 8, he started to pass red urine and was subsequently admitted to the University Hospital of the West Indies. On admission he was found to have myoglobinuria and an elevated creatine phosphokinase (CPK) of 325,600 U/L, leading to a diagnosis of rhabdomyolysis. Dengue IgM was positive. He was treated with aggressive hydration and had close monitoring of his urine output, creatinine, and CPK levels. His hospital course was uneventful without the development of acute renal failure and he was discharged after 14 days in hospital, with a CPK level of 2463 U/L. This case highlights that severe rhabdomyolysis may occur in patients with dengue fever and that early and aggressive treatment may prevent severe complications such as acute renal failure and death.

scholarly journals Contaminated Pond Water Favors Cholera Outbreak at Haibatpur Village, Purba Medinipur District, West Bengal, India

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Dilip Kumar Biswas ◽  
Rama Bhunia ◽  
Dipankar Maji ◽  
Palash Das
Keyword(s):  
Risk Factors ◽  
Attack Rate ◽  
Stool Specimen ◽  
West Bengal ◽  
Health Workers ◽  
Pond Water ◽  
Underground Water ◽  
Control Measures ◽  
Cholera Outbreak ◽  
Epidemic Curve

Health workers reported an increased number of diarrhea cases at Haibatpur village on June 17, 2012. This outbreak was investigated with the followingobjectives: to confirm the existence of diarrhea outbreak, to find out the risk factors, and propose control measures. Cases were listed; spot map and epidemic curve were drawn. Attack rate was calculated by age and sex and risk factors were found out by calculating odds ratio (OR) with 95% confidence interval (CI). Rectal swabs were taken and water specimens were collected for laboratory test. Forty-one cases of patients were identified with overall attack rate (AR) was 5% (41/780). AR among men was higher 6% (25/404) than women. There was no death.V. cholerae01 Eltor Ogawa was isolated from one (1/4) stool specimen. Spot map showed cases clustered around two ponds which were contaminated with coliform organisms. The underground water was a bit saline in nature. Using pond water for preparation of fermented rice (Panta Bhat) (OR 4.73, 95% CI 1.69–13.51), washing utensil in pond water (OR 7.31, 95% CI 1.77–42.29) were associated with cholera outbreak. Health education was done to villagers. Disinfection of two ponds with bleaching powder was done. We proposed supplying of safe drinking water and repairing defective deep tube well to village.

scholarly journals DENGUE FEVER OUTBREAK IN TWIN CITIES; A TERTIARY CARE CENTER EXPERIENCE

2021 ◽  
Vol 71 (5) ◽  
pp. 1524-28
Author(s):  
Taimoor Ashraf Khan ◽  
Shazia Nisar ◽  
Muhammad Mahad Qureshi ◽  
Muhammad Samiullah ◽  
Muhammad Israr
Keyword(s):  
Alkaline Phosphatase ◽  
Platelet Count ◽  
Dengue Fever ◽  
Alanine Aminotransferase ◽  
Nonstructural Protein ◽  
Care Center ◽  
Tertiary Care ◽  
Immunoglobulin M ◽  
Military Hospital ◽  
Nonstructural Protein 1

Objective: To characterize the clinical presentations and laboratory markers (as disease predictors and markers) and severity of disease in patients admitted with dengue fever. Study Design: Prospective observational study. Place and Duration of Study: Department of Infectious Diseases, Pak Emirates Military Hospital Rawalpindi, from May to Oct 2018 Methodology: In our study, we included the patients treated for dengue fever. Data were recorded on predesigned proforma and analyzed using Microsoft excel 365 and Social Package for Statistical Sciences version 23. Results: A total of 160 patients were included in this study, all were males. All cases were positive for Nonstructural Protein 1 Antigen. Symptoms seen in abundance were fever with rigors, chills, backache, retro-orbital pain, nausea and vomiting. Manual platelet count at admission ranged from 15-396 x 103 (mean 107.5 ± 6.8 x 103). Platelet count on discharge ranged from 102-577 x 103 (mean 207.9 ± 95.4 x 103). A total of 34 (21.25%) patients out of 160 confirmed and admitted dengue fever cases had Dengue Hemorrhagic Fever (Nonstructural Protein 1 Antigen positive, thrombocytopenia and leukopenia) and 2 patient went into dengue shock syndrome. The derangement in alanine aminotransferase and alkaline phosphatase levels were shown in 98 (61.2%) and 62 (31.2%) of patients. All these patients were immunoglobulin M and Nonstructural Protein 1Antigen positive. Conclusion: Raised serum alanine aminotransferase and alkaline phosphatase levels along with early positive Nonstructural Protein 1 Antigen is a marker of disease severity.

scholarly journals Post Flood Study on the Incidence of Leptospirosis in Alappuzha District of Kerala, India

2021 ◽  
Vol 53 (03) ◽  
pp. 127-134
Author(s):  
Rajendran R ◽  
Keyword(s):  
Infectious Diseases ◽  
Health Workers ◽  
Care Delivery ◽  
Health Department ◽  
Control Measures ◽  
Public Health Issue ◽  
Local Health ◽  
Laboratory Facilities ◽  
Significant Public Health ◽  
Flood Period

Alappuzha district was severely affected by floods due to the intense rainfall in August 2018. A three member team with the assistance of local health workers was entrusted to assess the post flood situation and to assist the local health department to extend expertise mainly to control infectious diseases and propose suggestions regarding hygiene and sanitary measures to be taken for health and wellbeing of the community. Among the infectious diseases, Leptospirosis poses a significant public health issue in the flood affected areas of Alappuzha district. Majority of households had taken chemoprophylaxis for Leptospirosis as per standard protocol as also temporary rehabilitation camps in the flood affected areas. There was no episode of Acute Diarrheal Diseases (ADD), found in clusters in any of the areas. The number of dengue fever cases reported in post flood period was less when compared to previous year. Risk assessment is essential in post-disaster situations mainly concerned with the rapid implementation of control measures through refurbishment and improvement of health care delivery. The findings presented relate to an assessment carried out in Alappuzha district in September 2018 that included epidemiological situation analysis, appraisal of laboratory facilities for microbiology investigations, evaluation of health facilities and infrastructure available at Local Self Governments (LSGs).

scholarly journals Risk Factors of Dengue Fever Outbreak in Karo District, North Sumatera, Indonesia

2019 ◽  
Vol 5 (1) ◽  
pp. 16-22
Author(s):  
Frans Yosep Sitepu
Keyword(s):  
Risk Factors ◽  
Dengue Fever ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Significant Risk ◽  
Public Health Problem ◽  
Signs And Symptoms ◽  
Control Measures ◽  
Breeding Sites ◽  
Mosquito Breeding

Dengue fever (DF) infection continues to present a seriuos public health problem in North Sumatera, Indonesia. A DF outbreak was reported in Merek Sub-district, Karo District which is one tourist destination in North Sumatera during April-May 2017. An epidemiological investigation was conducted to identify the risk factors and recommend control measures. An observational study with a matched case control design was conducted. A case was defined as any resident of Merek sub-district who had suffer major clinical symptoms of DF such as fever, severe headache, pain behind eyes, muscle and joint pains, and rash from April – May, 2017. A control was defined as neighbors of cases who did not have clinical signs and symptoms of DF and were matched for age and sex. We interviewed 37 cases and 37 controls. Age cases ranged from 2 year to 37 years (median= 12 years). The multivariate analyses showed that presence of mosquito breeding sites (OR=4.87, 95%CI=1.33-17.85) and habit of hanging worn clothes (OR=5.12, 95%CI=1.25-21.03) were significant risk factors. It is recommended to eliminate mosquito breeding sites routinely, avoid habit of hanging worn clothes, and conduct strict surveillance of DF continously.

scholarly journals Potential of Rainfall, Humidity and Temperature, Against the Increasing of larvae in Makassar City, Indonesia

2019 ◽  
Vol 9 (1) ◽  
pp. 1485-1487 ◽  
Keyword(s):  
Data Analysis ◽  
Dengue Fever ◽  
Rainy Season ◽  
Secondary Data ◽  
Hemorrhagic Fever ◽  
Health Department ◽  
Breeding Sites ◽  
Breeding Grounds ◽  
Mosquito Breeding ◽  
Observation Results

Cases of dengue hemorrhagic fever are associated with the potential for rainfall, temperature, and humidity. In a month mosquitoes can lay eggs approximately four times. In a month mosquitoes can lay eggs between 400 to 600 eggs. Mosquito eggs can survive, do not hatch, for six months because they do not touch the water. The existence of rainfall, humidity, and the appropriate temperature can accelerate the process of hatching mosquito eggs. Secondary data analysis research methods on BMKG data and Makassar City Health Department data in 2014, 2015, 2016, 2017 and 2018. The data analysis was carried out on 1–8 October 2019. The observation results revealed that high rainfall occurred in January, February, March, April, May and June. In July, August, September the rainfall is very low. Then entering November and December, the rainfall starts to high again. Air temperature does not occur significantly or not too extreme a difference every month. Humidity in the rainy season tends to be high. The incidence of dengue fever in the rainy season tends to increase. The number of mosquito larvae also tends to increase in the rainy season. It is recommended that before entering the rainy season, it should increase awareness of the incidence of dengue fever by reducing mosquito breeding sites through draining, closing, stockpiling. Drain and close the bathtub, and bury cans, plastic, and objects that can become mosquito breeding grounds.

scholarly journals Coinfection of chikungunya and dengue viruses: A serological study from North Western region of Punjab, India

2018 ◽  
Vol 10 (04) ◽  
pp. 443-447 ◽  
Author(s):  
Maninder Kaur ◽  
Kanwardeep Singh ◽  
Shailpreet K Sidhu ◽  
Pushpa Devi ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Nonstructural Protein ◽  
Dengue Infection ◽  
Signs And Symptoms ◽  
Control Measures ◽  
Health Concern ◽  
Serological Study ◽  
Serum Samples ◽  
Nonstructural Protein 1 ◽  
Antibody Capture ◽  
North Western

ABSTRACT INTRODUCTION: Dengue and chikungunya (CHIK) infections appear to be increasing in all parts of India. Aedes aegypti mosquitoes are common vectors for dengue virus (DENV) and CHIK virus (CHIKV). In areas where both viruses cocirculate, they can be transmitted together. There are very few studies discussing the dengue-chik coinfection from Punjab region of India. The present study was undertaken to study the clinical features of dengue–CHIK coinfection and compare with monoinfection. MATERIALS AND METHODS: IgM antibody capture (MAC) ELISA for dengue IgM and CHIK IgM and ELISA for nonstructural protein 1 antigen was performed on serum samples obtained from suspected patients. RESULTS: Out of total 3160 samples from suspected patients for dengue infection, 2178 (68.92%) samples were positive for DENV while CHIK IgM antibodies were positive in 127 patients out of the total suspected 373 cases (34.04%). In addition to this, 283 samples were tested for both viruses, out of which 27 sera were positive (9.54%) for coinfection of dengue and CHIK. The comparison of signs and symptoms showed that the coinfected patients had fever in all cases while rash was seen in only 30% cases. Arthralgia (79%) and thrombocytopenia (77%) was seen in significant number of coinfected cases thus revealing overlapping nature of dengue–CHIK coinfection. Conclusions: Increase in the number of Dengue and Chikungunya infections and their cocirculation is an important public health concern which warrants the implementation of strict control measures.

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