268 In-feed Antibiotics Elicit Intestinal Integrity Modifications Early in Post-weaning Life

Abstract The physiological mechanisms by which in-feed antibiotics improve pig growth performance are largely unknown. One proposed mode of action is improvements in intestinal integrity and function. Therefore, the objective of this study was to test the hypothesis that in-feed therapeutic and sub-therapeutic antibiotics would improve intestinal integrity and function in nursery pigs. Twenty-four weaned pigs (6.1±1.1 kg BW) were randomly allotted to individual pens and assigned one of three dietary treatments as follows (n = 8 pigs/trt): 1) control, no antibiotics (CON), 2) CON + sub-therapeutic chlortetracycline [40 ppm in feed (sCTC)], and 3) CON + chlortetracycline-tiamulin [400 ppm + 35 ppm, respectively (CTCDen)]. The study consisted of two consecutive 14 d phases. Chlortetracycline-tiamulin was only fed in phase 1, sCTC was fed in both phases. Phase 1 and 2 ADG, ADFI, and G:F were determined. After 28 d, ileal and colonic ex vivo intestinal integrity was assessed via transepithelial resistance (TER) and macromolecule flux (FD4) in modified Ussing chambers. All data were analyzed for the fixed effects of treatment and start BW as a covariate. In phase 1, compared with CON and sCTC, CTCDen tended to have greater ADG (0.28, 0.31, and 0.33 kg/d, respectively, P = 0.10) and ADFI (0.28, 0.30, and 0.35 kg/d, respectively, P = 0.09). No differences in phase 1 G:F were observed (P = 0.11). Phase 2 ADG, ADFI, and G:F did not differ (P > 0.10). Further, ileal TER and FD4 did not differ (P > 0.10). Colonic TER tended to be increased in sCTC compared with CON and CTCDen (78, 56, and 59 Ω/cm2, respectively, P = 0.07). Compared with CON, colonic FD4 flux was decreased in sCTC and CTCDen by 35–40% (P = 0.03). Altogether, these data indicate that in-feed antibiotics improve colon integrity early in production which may contribute to improved growth performance.

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135 The effects of functional feed additive proteins with or without antibiotics on the growth and health status of nursery pigs

Journal of Animal Science ◽

10.1093/jas/skz122.138 ◽

2019 ◽

Vol 97 (Supplement_2) ◽

pp. 75-75

Author(s):

Leigh A Ruckman ◽

John F Patience

Keyword(s):

Growth Performance ◽

Fixed Effects ◽

Phase 1 ◽

Antibiotic Use ◽

Feed Additive ◽

Experimental Unit ◽

Medical Treatments ◽

Nursery Pigs ◽

Des Moines ◽

Dietary Treatments

Abstract The objective of this experiment was to determine the effects of dietary functional proteins with or without antibiotics on the growth and health of nursery pigs. A total of 1,230 pigs weaned at 15–18 days (4.93 ± 0.02 kg BW; PIC 359 X 1050, Hendersonville, TN) were randomly assigned to 1 of 6 dietary treatments (10 pens/treatment) for a 42-d experiment. Treatments were arranged as a 2 X 3 factorial of in-feed antibiotics (no vs yes) and functional feed additive proteins [none (CON), spray-dried plasma proteins (SDPP; AP 920, APC Inc., Ankeny, IA), or dried egg protein with IgY (DEP; Globimax JS, EW Nutrition, Des Moines, IA)]. Diets were fed in 4 phases with phase 3–4 common across treatments. Proteins were fed in phases 1 (d 0–13; 3% SDPP or 0.2% DEP) and 2 (d 13–26; 2% SDPP or 0.1% DEP). Antibiotics were fed in phase 1–3 (662 mg chlortetracycline/kg, 28 mg carbadox/kg, 441 mg chlortetracycline/kg, respectively). Growth performance data were analyzed using PROC MIXED of SAS (9.4). Pen was the experimental unit; proteins and antibiotics and their interaction were considered fixed effects. In the absence of antibiotics, compared with CON, SDPP and DEP increased ADG (CON: 0.237 kg, SDPP: 0.254 kg, DEP: 0.257 kg/d; P = 0.036) and ADFI (CON: 0.360, SDPP: 0.378, DEP: 0.383 kg/d; P = 0.040). In the presence of antibiotics, SDPP increased ADG compared with DEP, but not CON, (CON: 0.258, SDPP: 0.268, DEP: 0.251 kg/d; P = 0.036) and ADFI (CON: 0.385, SDPP: 0.398, DEP: 0.381 kg/d; P = 0.040). Diet had no effect on feed efficiency (P > 0.10). SDPP and DEP decreased the number of medical treatments administered (P = 0.001). In conclusion, the functional proteins increased growth performance in the absence of antibiotics, but not when antibiotics were used. However, the functional proteins were effective in decreasing medical treatments regardless of antibiotic use.

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364 Impact of porcine reproductive and respiratory syndrome virus challenge and deoxynivalenol on intestinal integrity and nutrient transport

Journal of Animal Science ◽

10.1093/jas/skz122.263 ◽

2019 ◽

Vol 97 (Supplement_2) ◽

pp. 148-149

Author(s):

Samuel Gerrard ◽

Emma T Helm ◽

Blaire Todd ◽

Nicholas K Gabler

Keyword(s):

Glucose Transport ◽

Fixed Effects ◽

Ex Vivo ◽

Respiratory Syndrome Virus ◽

Ussing Chambers ◽

Prrs Virus ◽

Intestinal Integrity ◽

Glutamine Transport ◽

And Function ◽

The Impact

Abstract Porcine reproductive and respiratory syndrome (PRRS) virus infections and mycotoxin contaminated feedstuffs are two common issues facing the pork industry as both act, independently, to antagonize pig intestinal function, growth performance, and health. However, the combined impact of PRRS and mycotoxin exposure on pig intestinal health and function has not been investigated. Therefore, the objective of this experiment was to examine the impact of the mycotoxin deoxynivalenol (DON) on the intestinal integrity and function of PRRS infected pigs, employing an ex vivo model. Jejunum samples were collected from PRRS naïve (control; n = 6) and 21 day post inoculated PRRS virus infected (n = 8) gilts (10 weeks of age). In duplicate, explants were mounted into modified Ussing Chambers and incubated with or without 25 mM DON for 45 minutes prior to assessment of transepithelial resistance (TER), mucosal to serosal macromolecule (FD4) flux, and active glucose and glutamine transport. Data were analyzed using the mixed model procedure of SAS and a split plot design to examine the fixed effects of PRRS, DON, and their interaction. There were no PRRS by DON interactions for any ex vivo parameters assessed. Irrespective of DON, PRRS jejunum segments had decreased TERs (57%, P < 0.001), increased FD4 flux (P = 0.005), and tended to have increased active glucose transport (P = 0.093) compared with uninfected controls. Irrespective of PRRS status, DON increased FD4 flux (113%, P = 0.013), and tended to increase active glucose transport (P = 0.088) compared with jejunal explants not treated with DON. However, TERs and active glutamine transport did not differ due to DON treatment. Taken together, these data highlight the impacts that viral health challenge and mycotoxin contamination have on aspects of intestinal integrity and function. However, it does not appear that PRRS challenged pigs are more sensitive to the effects of DON than their healthy counterparts.

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PSVI-1 Dietary protease supplementation on growth performance and post-weaning diarrhea of nursery pigs

Journal of Animal Science ◽

10.1093/jas/skaa054.337 ◽

2020 ◽

Vol 98 (Supplement_3) ◽

pp. 191-192

Author(s):

Jorge Y Perez-Palencia ◽

David A Clizer ◽

Christian Ramirez-Camba ◽

Ryan S Samuel ◽

Crystal L Levesque

Keyword(s):

Growth Performance ◽

Phase 1 ◽

Dietary Treatment ◽

Experimental Period ◽

Phase 2 ◽

Deficient Diet ◽

Nursery Pigs ◽

Feeding Program ◽

Dietary Treatments ◽

Fecal Score

Abstract This experiment evaluated the effect of dietary protease supplementation on pig’s growth performance and post-weaning diarrhea in a 43-d trial. A total of 936 weaned pigs [21 d of age, initial BW 5.87 ± 0.31 kg] were used in a 2 × 2 factorial design (2 nutritional levels × 2 protease levels). The nutritional levels corresponded to a standard feeding program and a reduced feeding program (15% lower SID Lys) and without or with protease supplementation (0.0125% inclusion). Piglets were distributed in 36 pens with 26 pigs per pen and 9 replicates per dietary treatment. Pigs received a common Phase 1 diet and experimental diets in Phase 2, 3, and 4, (0.91, 3.4, 4.5, and 24.0 kg/pig, respectively). Phytase was included at 2,500 U in Phase 2 – 4, all diets met energy and AA:Lys requirements for nursery pigs. Feed intake and body weight were determined every 2 weeks. A pen fecal score assessment was performed at d7, 10, and 14. Performance data were analyzed using the PROC MIXED procedure and fecal score data using the PROC FREQ procedure (SAS Inst., Inc., Cary, NC). No significant interactions (P > 0.05) were observed between dietary treatments. From d15 to 43 and during overall experimental period, pigs fed standard diets had greater BW, ADG, and G:F (P < 0.05) than pigs fed deficient diets (Table 1). On d7, pigs fed deficient diet had more (X2 < 0.05) soft and watery feces, and consequently less normal feces compared to pigs fed standard diets (Figure 1). On d7, 10, and 14, pigs fed diets with protease supplementation had more (X2 < 0.05) normal feces compared to control pigs. Overall, effects of dietary protease supplementation on growth performance were not expressive under the conditions of this study but protease addition benefited intestinal health of nursery pigs.

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PSIV-19 Flavors and Sweeteners in Nursery Pig Diets Increased Intake and Reduced Soft Feces in the First Weeks After Weaning

Journal of Animal Science ◽

10.1093/jas/skab054.303 ◽

2021 ◽

Vol 99 (Supplement_1) ◽

pp. 179-180

Author(s):

Jorge Y Perez-Palencia ◽

Xixi Chen ◽

Jirong Lv ◽

Maíra Resende ◽

Rhuan F Chaves ◽

...

Keyword(s):

Growth Performance ◽

Feed Intake ◽

Block Design ◽

Phase 1 ◽

Poor Performance ◽

Stressful Events ◽

Gut Health ◽

Nursery Pigs ◽

Feeding Program ◽

Dietary Treatments

Abstract The stressful events associated with weaning predispose piglets to reduced feed intake, which in concert with immature digestive and immune systems, results in increased incidences of diarrhea and poor performance. Flavors and sweeteners can be used in diets for young pigs as a means of attracting them to dry feed and increase their feed intake and performance after weaning. The objective of this study was to evaluate the effects of dietary inclusion of flavors and sweeteners and their combination on growth performance and post-weaning gut health of nursery pigs. A total of 1,144 weaned pigs (initial BW 6.61 ± 0.2 kg) were used in a randomized complete block design and assigned to one of four dietary treatments, with 11 replicates (pens) of 26 piglets per pen. Dietary treatments were 1) Control: standard 4-phase nursery feeding program; 2) Sweetener: control plus sweetener (0.015%); 3) Flavor: control plus flavoring (0.05%); 4) Combination: control plus sweetener and flavoring. Experimental diets were provided at a budget of 0.9, 3.4, 4.5, and 24 kg/pig in Phase 1, 2, 3, and 4, respectively. A common phase 5 diet was provided ad libitum until d56 after weaning. Feed disappearance and body weight were measured every other week. A pen fecal score assessment was performed at d4, 7, 10, and 14 after weaning. Overall, there were no differences among dietary treatments for growth performance. However, during the first two weeks post-weaning pigs fed diets containing flavors and sweeteners had a greater (P = 0.097) ADFI than control pigs. On d14, pigs fed diets containing flavors and sweeteners had less incidence of soft and watery feces (χ2 < 0.05) compared to control pigs. This study provides evidence that dietary inclusion of flavors and sweeteners has important benefits to the overall health of nursery pigs likely related to feed intake in the period immediately after weaning.

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PSII-18 Effect of L-trp Source and Standard Ileal Digestible (SID) Tryptophan to Lysine Ratio on Growth Performance of Nursery Pigs

Journal of Animal Science ◽

10.1093/jas/skab054.283 ◽

2021 ◽

Vol 99 (Supplement_1) ◽

pp. 168-168

Author(s):

Tsung Cheng Cheng Tsai ◽

kristopher Bottom ◽

Kyle Coble ◽

Amanda J Gerhart ◽

Jeffrey Chewning ◽

...

Keyword(s):

Growth Performance ◽

Phase 1 ◽

Animal Health ◽

Linear Increase ◽

Nursery Pigs ◽

Impact Performance ◽

Ratio Data ◽

Quadratic Response ◽

Dietary Treatments ◽

Different Sources

Abstract To evaluate the different sources of L-Trp on growth performance, a total of 288 weaned pigs (PIC1050 x DNA600) were stratified by gender and BW, and assigned to 1 of 7 dietary treatments. Treatments were control (devoid of feed grade Trp to create SID Trp/Lys = 17), and L-Trp from (Ajinomoto CO., INC., TrpA vs Daesang CO., LTD., TrpD) was added to form SID Trp:Lys ratios of 19, 21, and 23. Chlortetracycline (Zoetis Inc. Parsippany-Troy Hills, NJ) was supplemented in phase 1 (6 d) &2 (9 d), and Mecadox (Philbro Animal Health Corp., Ridgefield Park, NJ) was added in phase 3 (10 d) while antibiotic free diets were fed in phase 4 (17 d). Individual pig BW and pen feed intake was measured at each phase to determine BW, ADG, ADFI and F:G ratio. Data were analyzed as Mixed procedure of SAS as RCBD. Orthogonal contrast was conducted to determine linear and quadratic response with SID Trp/Lys from 17 (control) to 23 for each source of L-Trp. Adding both sources of L-Trp had minimum impact on growth performance in phase 1–3. As in phase 4, a tendency and significant linear increase on ADG with increasing level of TrpA (P = 0.09) and TrpD (P = 0.04) was observed with the highest ADG in pigs fed TrpA19. Pigs fed increasing level of SID Trp/Lys from TrpA had a quadratic reduction on F:G ratio (P = 0.09). The results suggested that a Trp:Lys ratio over 17 may enhance growth performance and source of L-Trp may impact performance.

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285 Black soldier fly (Hermetia illucens) larvae oil improves growth performance of nursery pigs

Journal of Animal Science ◽

10.1093/jas/skz258.244 ◽

2019 ◽

Vol 97 (Supplement_3) ◽

pp. 118-118 ◽

Cited By ~ 1

Author(s):

Eric van Heugten ◽

Gabriela Martinez ◽

Alejandra McComb ◽

Elizabeth Koutsos

Keyword(s):

Growth Performance ◽

Blood Cells ◽

Corn Oil ◽

Phase 1 ◽

White Blood Cells ◽

High Energy ◽

Black Soldier Fly ◽

Nursery Pigs ◽

Dietary Treatments ◽

The Impact

Abstract Insect-derived protein and lipid sources are sustainable, alternative ingredients for the feed industry. The present study was conducted to determine the impact of increasing levels of supplemental black soldier fly larvae (BSFL) oil on growth performance and serological and hematological indices in nursery pigs. Newly weaned, 21-day old pigs (n = 192; BW=6.9±0.15 kg) were randomly assigned within sex and BW blocks to 1 of 4 dietary treatments, using 48 pens (4 pigs/pen; 12 replicates/treatment). Treatments consisted of 0, 2, 4, and 6% supplemental BSFL oil (mainly contained C12:0, C18:2, C16:0, C18:1, and C14:0 at 36.9, 17.3, 14.6, 13.1, and 9.8 g/100 g of lipid, respectively), replacing equal amounts of corn oil. Dietary treatments were fed in 3 dietary phases (14, 11, and 15 d for Phase 1 to 3, respectively). Supplementation of BSFL oil linearly increased BW (P ≤ 0.052) on d 14, 21, 25, 33, and 40 (final BW of 27.83, 27.62, 28.84, and 28.44 kg, respectively) and ADG during Phase 1 (P = 0.017), 2 (P = 0.055), and overall (P = 0.048; 523, 518, 548, and 539 g/d). Gain:feed was improved linearly during Phase 1 (P = 0.001) and 2 (P = 0.049), but ADFI was not affected (P > 0.36). Supplemental BSFL oil did not affect (P > 0.18) serum concentrations of total protein, albumin, globulin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, γ-glutamyltranspeptidase, urea N, creatinine, glucose, Ca, P, Mg, K, Na, Cl, triglycerides, amylase, lipase, or creatine phosphokinase, but linearly increased (P < 0.001) serum cholesterol. White blood cells, red blood cells, hemoglobin, hematocrit, neutrophils, lymphocytes, monocytes, eosinophils, and basophils were not affected (P > 0.17) by BSFL oil, but platelet count tended to linearly increase (P = 0.082). All serological and hematological analytical results were within normal expected ranges. In conclusion, BSFL oil is a promising, high energy feed ingredient that can be successfully fed to nursery pigs, while improving their growth performance.

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PSVI-21 Interactive effects of Zn sources, Cu sources and phytase on growth performance in nursery pigs

Journal of Animal Science ◽

10.1093/jas/skz122.373 ◽

2019 ◽

Vol 97 (Supplement_2) ◽

pp. 212-213

Author(s):

Ping Ren ◽

Joe Cushing ◽

Karen Wedekind ◽

Mercedes Vazquez-Anon

Keyword(s):

Body Weight ◽

Growth Performance ◽

Feed Efficiency ◽

Phase 1 ◽

Interactive Effects ◽

Phase 2 ◽

Initial Body Weight ◽

Phase 3 ◽

Nursery Pigs ◽

Dietary Treatments

Abstract This study investigated the interactive effects of Zn sources, Cu sources and phytase on growth performance in nursery pigs. A total of 288 weaning barrows (BW = 5.71 ± 0.81 kg), blocked by initial body weight, were randomly allotted to 1 of 8 dietary treatments, with 9 pens per treatment and 4 pigs per pen. The 8 dietary treatments were arranged in 2 × 2 × 2 factorial design, with 2 Zn sources [2000 ppm Zn from ZnO during phase 1 (d 1 to 14) and 2 (d 15 to 28), and 100 ppm Zn from ZnO during phase 3 (d 29 to 42); 100 ppm Zn from Zn methionine hydroxy analogue chelate (Zn-MHAC, MINTREX® Zn, Novus International Inc., St. Charles, MO) during phase 1 to 3], 2 Cu sources [150 ppm Cu from CuSO4 or Cu-MHAC (MINTREX® Cu) during phase 1, and 80 ppm Cu from CuSO4 or Cu-MHAC during phase 2 and 3], and 2 phytase inclusion levels (0, 500 FTU/kg). Results showed that there were no differences (P > 0.10) between ZnO and Zn-MHAC groups in terms of growth performance during the entire nursery period. Compared with CuSO4, Cu-MHAC tended to increase ADG (P = 0.07) and G:F (P = 0.08) during the entire nursery period. There tended to be an interaction (P = 0.09) between Cu sources and phytase on G:F during phase 2. Specifically, without phytase supplementation, there was no difference (P = 0.63) on G:F during phase 2 between Cu-MHAC and CuSO4, whereas with phytase supplementation, Cu-MHAC increased G:F during phase 2 (P = 0.05) compared with CuSO4. In conclusion, Zn-MHAC supplementation at 100 ppm could replace pharmacological level of ZnO without affecting growth performance. Cu-MHAC could improve growth performance compared with CuSO4. Cu-MHAC exerted synergistic effect with phytase on improving feed efficiency.

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PSIV-18 Effect of sub-therapeutic antibiotics and pharmacological zinc oxide on nursery pig performance and intestinal integrity and function

Journal of Animal Science ◽

10.1093/jas/skz122.335 ◽

2019 ◽

Vol 97 (Supplement_2) ◽

pp. 190-190

Author(s):

Carson De Mille ◽

Emma T Helm ◽

Crystal L Loving ◽

Eric R Burrough ◽

Nicholas K Gabler

Keyword(s):

Zinc Oxide ◽

T Cell ◽

Ex Vivo ◽

Ussing Chambers ◽

Cell Abundance ◽

Intestinal Integrity ◽

Nursery Pig ◽

Pig Performance ◽

And Function ◽

The Impact

Abstract The objective of this study was to evaluate the impact of sub-therapeutic chlortetracycline (CTC) and pharmacological zinc oxide on nursery pig performance and intestinal integrity and function. Twenty-four newly weaned pigs (4.51 ± 0.21 kg BW) were randomly assigned to one of three dietary treatments for 21 d (n = 8/treatment): 1) Control diet (NC), 2) NC + Zinc oxide at 3000 ppm for 7 d followed by 2000 ppm for 14 d (ZnO), and 3) NC + 40 ppm CTC for 21 d (sCTC). Pig ADG, ADFI, and G:F were determined for the overall 21 d test period. At d 21, all pigs were euthanized for tissue collection. Jejunum and ileum ex vivo transepithelial resistance (TER), macromolecule (FD4) flux, and active glucose and glutamine transport were assessed in modified Ussing Chambers. Additionally, jejunum brush border enzyme and Na+/K+ ATPase activities were determined. Morphology and T-cell abundance were determined in all ileum sections by H&E staining and immunohistochemistry, respectively. Compared to the NC, sCTC and ZnO increased ADG (0.14, 0.20 and 0.23 kg/d, respectively, P = 0.020). Overall ADFI was increased by 150% due to sCTC compared to the NC and ZnO pigs (P < 0.05). G:F was increased due to ZnO and sCTC compared to the NC (0.82, 0.63 and 0.47, respectively, P < 0.01). Jejunum and ileum ex vivo function and integrity did not differ. Ileal villus height was increased in the NC compared to sCTC treatment (P < 0.01), but not different from the ZnO treatment. In the ileum, total T-cell number per unit area was significantly lower in the ZnO segments compared to sCTC and NC (0.95, 2.29 and 2.59 count per μm2, respectively, P = 0.05). These data indicate that ZnO and sCTC improved pig performance but did not directly alter small intestinal integrity and function. However, mucosal T cell abundance was altered.

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Interactive effects of zinc and copper sources and phytase on growth performance, mineral digestibility, bone mineral concentrations, oxidative status, and gut morphology in nursery pigs

Translational Animal Science ◽

10.1093/tas/txaa083 ◽

2020 ◽

Vol 4 (2) ◽

pp. 783-798 ◽

Cited By ~ 1

Author(s):

Ping Ren ◽

Juxing Chen ◽

Karen Wedekind ◽

Deana Hancock ◽

Mercedes Vázquez-Añón

Keyword(s):

Growth Performance ◽

Feed Efficiency ◽

Significant Interaction ◽

Phase 1 ◽

Oxidative Status ◽

Interactive Effects ◽

Phase 2 ◽

Nursery Pigs ◽

Dietary Treatments ◽

Mineral Concentrations

Abstract This study investigated the interactive effects of zinc (Zn) and copper (Cu) sources and phytase on growth performance, oxidative status, mineral digestibility, tissue mineral concentrations, and gut morphology in nursery pigs. A total of 288 weaning barrows [body weight (BW) = 5.71 ± 0.81 kg], blocked by initial BW, were randomly allotted to one of eight dietary treatments, with nine pens per treatment and four pigs per pen. The eight dietary treatments were arranged in 2 × 2 × 2 factorial design, with two Zn sources [2,000, 2,000, and 100 mg/kg Zn from zinc oxide (ZnO) during phase 1 (days 1–14) and phase 2 (days 15–28), and phase 3 (days 29–42), respectively; 100 mg/kg Zn from zinc methionine hydroxy analogue chelate (Zn-MHAC) from phases 1 to 3], two Cu sources [150, 80, and 80 mg/kg Cu from copper sulfate (CuSO4) or copper methionine hydroxy analogue chelate (Cu-MHAC) during phases 1–3, respectively], and two phytase inclusion levels (0 or 500 FTU/kg). Results showed that ZnO supplementation at 2,000 mg/kg Zn significantly increased average daily feed intake (ADFI; P = 0.01) and average daily gain (ADG; P = 0.03) during phase 1 compared to Zn-MHAC group; however, Zn-MHAC supplementation tended (P = 0.06) to improve gain to feed ratio (G:F) during phase 2 compared to ZnO group. There were no differences (P > 0.10) between ZnO and Zn-MHAC groups in terms of ADG, ADFI, and G:F during the entire nursery period. Compared with CuSO4, Cu-MHAC tended to increase ADG (P = 0.07) and G:F (P = 0.08) during the entire nursery period. Phytase supplementation significantly increased ADG (P < 0.01), ADFI (P < 0.01), and G:F (P < 0.01) during the entire nursery period compared with no phytase supplementation. There was a significant interaction (P < 0.01) between Zn source and phytase on standardized total tract digestibility (STTD) of phosphorus (P), whereas there was no interaction (P = 0.21) between Cu sources and phytase on STTD of P. However, there was a significant interaction between Cu sources and phytase on calcium (Ca; P = 0.02) and P (P = 0.03) concentrations in metacarpal bones and G:F in phase 2 (P = 0.09). Furthermore, pigs fed diets containing Zn-MHAC tended to have lower ileum villus width (P = 0.07), compared with those fed diets containing ZnO, and pigs fed diets containing Cu-MHAC tended to have lower plasma malondialdehyde concentration (P = 0.10) compared with those fed diets containing CuSO4. In conclusion, under the conditions of the current study, ZnO supplementation at 2,000 mg/kg Zn was only effective in the first 2 wk postweaning, whereas Zn-MHAC supplementation at 100 mg/kg Zn could achieve better feed efficiency during phase 2 compared to pharmacological levels of ZnO, therefore, leading to no difference of growth performance in the entire nursery period. Low levels of Zn-MHAC may improve phytase efficacy on degrading phytate P compared to pharmacological levels of ZnO. Cu-MHAC may be more effective to promote growth compared to CuSO4, which may be partially driven by reduced oxidative stress. Results also indicated that Cu-MHAC might exert a synergistic effect with phytase on improving feed efficiency and bone mineralization.

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Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs

Toxins ◽

10.3390/toxins12090604 ◽

2020 ◽

Vol 12 (9) ◽

pp. 604

Author(s):

Zhong-Xing Rao ◽

Mike D. Tokach ◽

Jason C. Woodworth ◽

Joel M. DeRouchey ◽

Robert D. Goodband ◽

...

Keyword(s):

Growth Performance ◽

Linear Response ◽

Animal Feed ◽

Average Daily Gain ◽

Fumonisin B1 ◽

Nursery Pigs ◽

Feed Production ◽

Dietary Treatments ◽

Daily Gain ◽

Effect Of Feeding

Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance. This experiment was conducted to determine the effect of feeding fumonisin-contaminated corn on growth performance and sphinganine (SA) to sphingosine (SO) ratios of 9 to 28 kg pigs. A total of 350 pigs, were used with 5 pigs/pen and 14 pens/treatment. Dietary treatments contained fumonisin-contaminated corn (50 mg/kg of fumonisin B1 + B2) blended with low fumonisin corn (10 mg/kg of fumonisin B1 + B2) to provide dietary fumonisin concentrations of 7.2, 14.7, 21.9, 32.7, and 35.1 mg/kg. From day 0 to 28, increasing fumonisin concentration decreased (linear, p < 0.001) average daily gain, average daily feed intake (linear, p = 0.055), and gain:feed ratio (linear, p = 0.016). Although these response criteria tested linear, the greatest reduction in performance was in pigs fed with 32.7 and 35.1 mg/kg of fumonisin (B1 + B2). Increasing fumonisin concentration increased the serum SA:SO ratio (linear, p < 0.001) on day 14 and 28. In summary, for 9 to 28 kg nursery pigs, increasing fumonisin linearly decreased average daily gain and gain:feed ratio. However, despite the linear response, diets containing up to 21.9 mg/kg of fumonisin did not have as dramatic a decrease in growth performance as those fed more than 32.7 mg/kg. Further research is warranted to determine the effect of fumonisin concentrations between 21.9 and 32.7 mg/kg.

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