Behavioral and Psychophysiological Investigations of Irritability

2019 ◽  
pp. 45-70
Author(s):  
Mariah DeSerisy ◽  
Christen M. Deveney
Keyword(s):  
Quality Of Life ◽  
Executive Functioning ◽  
Frustrative Nonreward ◽  
Reward Processing ◽  
Future Research ◽  
Improve Quality ◽  
Emotional Stimuli ◽  
Emotion Identification ◽  
Insight Into

A better understanding of neurocognitive mechanisms underlying irritability has the potential to inform treatments and improve quality of life for the children for whom this symptom is severe and persistent. This chapter examines the existing behavioral and psychophysiological investigations into irritability-related mechanisms in youth. Together, these measures provide insight into the cognitive and socioemotional abilities of youth with irritability. Existing research explores three domains: executive functioning, reward processing, and responses to emotional stimuli. Although deficits have been observed in each domain, the strongest evidence exists for atypical frustrative nonreward responses (i.e., when an expected reward is not received), face emotion identification deficits, and increased attention toward threatening faces. We discuss limitations to the existing literature and propose avenues for future research, including exploring cognitive-emotion interactions, using dimensional measures of irritability, and examining whether deficits are unique to irritability or related to co-occurring symptoms.

scholarly journals The REQUITE Project: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve quality of life in cancer survivors.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 85-85
Author(s):  
Riccardo Valdagni ◽  
Anusha Appanvel ◽  
Akke Botma ◽  
Adam Webb ◽  
David Azria ◽  
...  
Keyword(s):  
Quality Of Life ◽  
European Union ◽  
Side Effects ◽  
Cancer Survivors ◽  
Predictive Models ◽  
Future Research ◽  
Improve Quality ◽  
The European Union ◽  
Centralized Database

85 Background: To present the REQUITE project (Validating Predictive Models and Biomarkers of Radiotherapy (RT) toxicity to reduce side-effects and improve quality-of-life in cancer survivors) and first results on the enrollment and acute toxicity (tox) of prostate cancer (Pca) patients (pts). Methods: The European Union funded REQUITE project involves centers in Europe and the USA. The main objectives of the project are to: carry out a multicentre, cohort study collecting blood samples, standardized epidemiology and treatment data, longitudinal side-effect and quality of life data (before and after treatment, years 1 and 2); produce a centralized database and biobank of DNA for 5,300 patients; validate clinical/dosimetric predictors of RT tox and incorporate biomarker data. The project focuses on cancers of the breast, lung and prostate. For PCa the primary endpoint is rectal bleeding at 2 years. Results: A centralized database was established for data collection, including storage of complete dosimetric information in DICOM RT format. Enrollment started in April 2014 and will end in August 2018. In the first 16 months 909 PCa pts were enrolled: 10% low risk, 33% intermediate and 57% high risk. 63% pts received exclusive RT (neoadjuvant hormone therapy in 62%) and 37% post-prostatectomy; 97% external beam RT (prescription doses: 60-85Gy, 2Gy equivalent, alpha/beta=3Gy), while 3% received brachytherapy. Data on acute tox at RT end (measured by CTCAE 4.03) are available for 496 pts. 79 G2-G3 GI tox were reported, with proctitis and diarrhea having the higher prevalence (45 and 30 events respectively). 74 pts exhibited G2-G3 GU tox, with 34 pts reporting multiple symptoms and frequency and urgency having the higher prevalence (43 and 30 events respectively, 25 pts both). Conclusions: REQUITE is proving the feasibility of a prospective standardized collection of epidemiological/clinical/dosimetric/toxicity data coupled to centralized storing of biological material. Meanwhile a large database is being created, which will be of value also for future research in the field of radioinduced side effects. REQUITE is funded by a European Union FP7 grant (601826).

Chronic Pain, Goal Conflict and Goal Frustration

2018 ◽  
Author(s):  
Nathalie Claes ◽  
Winifred Gebhardt
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Real Life ◽  
Goal Conflict ◽  
Future Research ◽  
Improve Quality ◽  
Multiple Goals ◽  
Regulatory Perspective ◽  
Life Context

This chapter argues for extending models of chronic pain within an explicit goal and self-regulatory perspective. A self-regulatory perspective allows one to conceptualize pain as an experience that occurs within the real-life context comprising multiple goals. The chapter presents two fictitious cases, which will be used throughout the chapter to clarify goal concepts. Next, it outlines the possible interrelations between goals, after which it specifically focuses on goal conflict and its role in pain. The chapter then provides a definition and overview of the literature on goal frustration and offers insights into the link between goal conflict and goal frustration. It also presents an overview of interventions that focus on tackling goal conflict and goal frustration to improve quality of life. The chapter then discusses potential implications of the theoretical stance and the empirical findings for existing theories of chronic pain problems. Finally, it formulates suggestions for future research.

Self-Compassion and Quality of Life in Adults Who Stutter

2020 ◽  
Vol 29 (4) ◽  
pp. 2097-2108
Author(s):  
Robyn L. Croft ◽  
Courtney T. Byrd
Keyword(s):  
Quality Of Life ◽  
Social Connectedness ◽  
The Self ◽  
Future Research ◽  
Self Compassion ◽  
Adults Who Stutter ◽  
And Gender ◽  
Relationship Of ◽  
The Impact

Purpose The purpose of this study was to identify levels of self-compassion in adults who do and do not stutter and to determine whether self-compassion predicts the impact of stuttering on quality of life in adults who stutter. Method Participants included 140 adults who do and do not stutter matched for age and gender. All participants completed the Self-Compassion Scale. Adults who stutter also completed the Overall Assessment of the Speaker's Experience of Stuttering. Data were analyzed for self-compassion differences between and within adults who do and do not stutter and to predict self-compassion on quality of life in adults who stutter. Results Adults who do and do not stutter exhibited no significant differences in total self-compassion, regardless of participant gender. A simple linear regression of the total self-compassion score and total Overall Assessment of the Speaker's Experience of Stuttering score showed a significant, negative linear relationship of self-compassion predicting the impact of stuttering on quality of life. Conclusions Data suggest that higher levels of self-kindness, mindfulness, and social connectedness (i.e., self-compassion) are related to reduced negative reactions to stuttering, an increased participation in daily communication situations, and an improved overall quality of life. Future research should replicate current findings and identify moderators of the self-compassion–quality of life relationship.

Widening the horizons: Information space of the library for the blind as the resource to improve quality of life of visually impaired people

2020 ◽  
Author(s):  
Olga Novikova ◽  
Keyword(s):  
Quality Of Life ◽  
Continuing Education ◽  
Visually Impaired ◽  
Information Space ◽  
Advanced Training ◽  
Improve Quality ◽  
Visually Impaired People ◽  
Impaired People ◽  
Special Library

The special library acts as the cultural and educational center for visually impaired people, and as the center for continuing education. The multifunctional performance of the library is substantiated. The joint projects accomplished in cooperation with theatres and museums and aimed at integrating the visually impaired people into the society are described. Advanced training projects for the library professionals accomplished in 2018 are discussed.

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