Clinical trials

This chapter explores the role of clinical trials within the cancer setting. It covers the history of clinical trials within medicine and describes the key stages of ethical approval and the legal framework within which clinical trials exist. Phases of clinical trials are also covered, as well as nurses' responsibilities within a trial setting. The final part of the chapter explores the vulnerable nature of many cancer patients and how to reduce risk for these patients.

Author(s):  
Dr. Manisha ◽  
Dr. Ruchi Jindal

Background: The term "ovarian cancer" includes several different types of cancer that  arise from cells of the ovary, most commonly, tumors arise from the epithelium or lining cells of the ovary.  Ovarian cancer risk is positively associated with higher consumption of dietary cholesterol and eggs, and inversely associated with a higher intake of vegetables. High consumption of fats may increase circulating estrogen levels, thus increasing the possibility of cell damage and proliferation that is responsible for cancerous growth. Material & Methods: The present study was conducted at Geetanjali Medical College and Hospital, Udaipur (Rajasthan). Total  100 cases (females) attending the obstetrics and gynecology department for some gynecological and other problem  were selected for this study between the age of 40-60 years, who were attending cancer centre at GEETANJALI MEDICAL COLLEGE AND  HOSPITAL, Udaipur (Rajasthan).                GROUP I: - It consisted of healthy females control subjects (n=50) .By routine examination and tests, we ensured that all the subjects were healthy and there were no signs and symptoms or history of ovarian tumor and diseases GROUP II: - It consisted of ovarian cancer females subjects (n=50) with a history of ovarian tumor. Results:   Higher level of cholesterol, LDL, VLDL and low level of HDL are found in ovarian cancer patients. Conclusion: The present study we highlights the importance and role of serum lipid profile in diagnosis, prognosis and recurrence of the disease. The study shows that serum level of cholesterol, LDL, VLDL was elevated in  patients of ovarian cancer while low level of HDL are found in ovarian cancer patients. Key words: lipid profile, ovarian cancer.


2020 ◽  
Author(s):  
А.Б. Бритаева

В представленной статье на материале произведений Музафера Дзасохова известного современного осетинского писателя, поэта, публициста, переводчика, рассматриваются художественные особенности лирической прозы, а именно, автобиографической повести в осетинской детской литературе. Повесть Весенние звезды (1973) и ее продолжение На берегу Уршдона Барагун (1981) стали началом эпопеи о жизни отдельно взятой семьи, а на их примере всей страны в тяжелые послевоенные годы. В качестве одной из важнейших констант художественного мира писателя рассматривается образ детства. В ходе анализа особое внимание уделяется преобладанию нравственного аспекта, актуализации проблемы регулятивно-воспитательной функции национального этикета, ценностно-нормативных ориентиров осетинской ментальности. С опорой на биографический и историко-генетический методы, основное внимание в исследовании акцентируется на темах послевоенного детства, роли семьи и общества в формировании нравственных ориентиров, в становлении личности, образе матери, теме памяти, а также на художественном осмыслении этих проблем и тем в автобиографических повестях писателя. Типологически воплощение детской темы в творчестве М. Дзасохова во многом опирается на традицию изображения детства в русской автобиографической прозе XX в. В заключительной части сформулированы выводы, отражающие особенности лирической прозы в творчестве М. Дзасохова, обозначено место автобиографических повестей автора в контексте осетинской детской литературы второй половины XX века.Актуальность и научная новизна работы обусловлены недостаточной исследованностью истории и проблем осетинской детской литературы. Результаты исследования могут быть использованы при написании истории осетинской детской литературы. The present article examines the artistic features of lyrical prose, namely, autobiographical story in the Ossetian childrens literature in the works of Muzafer Dzasokhov, a well-known modern Ossetian writer, poet, publicist, translator. The story Spring Stars (1973) and its continuation - On the Bank of Ursdon Baragun ... (1981) marked the beginning of an epic about the life of a family, and via their fates the author shows life of the whole country in the difficult post-war years. The theme of childhood is considered as one of the most important constants of the writers artistic world. In the course of the analysis, special attention is paid to the predominance of the moral aspect, the actualization of the problem of the regulatory and educational function of national etiquette, the value and normative guidelines of the Ossetian mentality. The focus of the study is based on biographical and historical-genetic methods and highlights the themes of post-war childhood, the role of the family and society in the formation of moral guidelines, in the formation of personality, the image of the mother, the theme of memory, as well as on the artistic understanding of these problems and topics in autobiographical novels of the writer. Typologically, the embodiment of the childrens theme in the works of M. Dzasokhov is largely based on the tradition of depicting childhood in Russian autobiographical prose of the XXth century. The formulated conclusions in the final part reflect the peculiarities of lyrical prose in the works of M. Dzasokhov, the place of the authors autobiographical stories is indicated in the context of Ossetian childrens literature of the second half of the XXth century. The relevance and scientific novelty of the work are due to insufficient research on the history and problems of Ossetian childrens literature. The results of the study can be used in writing the history of Ossetian childrens literature.


2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Ali Zalpour ◽  
Michael H. Kroll ◽  
Vahid Afshar-Kharghan ◽  
Syed Wamique Yusuf ◽  
Carmen Escalante

The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment has been anticoagulation therapy, unless contraindicated. This therapy consists of unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), factor Xa inhibitor, or vitamin K antagonist (VKA). Current guidelines recommend LMWH over VKA for the treatment of VTE in cancer patients. Factor-specific anticoagulants have been proven safe and effective, and recently factor Xa inhibitors have emerged as a treatment alternative to heparins and VKA. Currently, three factor Xa inhibitors have been identified: fondaparinux (the only one approved so far by the US Food and Drug Administration), idraparinux (in clinical trials), and idrabiotaparinux (in clinical trials). This paper will examine the role of these agents, focusing on fondaparinux, for the prevention and treatment of VTE in cancer patients.


2020 ◽  
Vol 13 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Laura Evangelista ◽  
Matteo Sepulcri ◽  
Giulia Pasello

Objective: In recent years, the introduction of immune checkpoint inhibitors has significantly changed the outcome of patients affected by lung cancer and cutaneous melanoma. Although the clinical advantages, the selection of patients and the evaluation of response to immunotherapy remain unclear, the immune-related Response Evaluation Criteria in Solid Tumor (irRECIST) was proposed as an update of the RECIST criteria for the assessment of response to immunotherapy. However, morphological images cannot predict early response to therapy that represents a challenge in clinical practice. 18F-FDG PET/CT before and after immunotherapy has an indeterminate role, demonstrating ambiguous results due to inflammatory effects secondary to activation of the immune system. The aim of the present review was to analyze the role of PET/CT as a guide for immunotherapy, by analyzing the current status and future perspectives. Methods: A literature search was conducted in order to select all papers that discussed the role of PET/CT with FDG or other tracers in the evaluation or prediction of response to immunotherapy in lung cancer patients. Results: Many papers are now available. Many clinical trials have demonstrated the efficacy of immunotherapy in lung cancer patients. FDG PET/CT can be used for the prediction of response to immunotherapy, while its utility for the evaluation of response is not still clearly reported. Moreover, the standardization of FDG PET/CT interpretation is missing and different criteria, such as information, have been investigated until now. Conclusions: The utility of FDG PET/CT for patients with lung cancer undergoing immunotherapies is still preliminary and not well addressed. New agents for PET are promising, but large clinical trials are mandatory.


2019 ◽  
Vol 18 (4) ◽  
pp. 865-882
Author(s):  
Vladimir I. Fokin ◽  
Elena E. Elts

Russia and China have both shown increasing interest in the promotion their cultural achievements and have utilized culture as essential soft-power resource. Moreover, the concept of ‘soft power’ has gained popularity in Russia’s and China’s academic and political discourse. Russian-Chinese cultural cooperation is gaining momentum due to this exchange, and the scale and the depth of the cultural projects have expanded. At the moment, museums are involved in development of diplomatic relations, including within the framework of friendship societies, and through the development of the Russian-Chinese tourism. ‘Red tourism’ (it means visiting the monuments of the revolutionary history of Russia) in particular has expanded through the implementation of cultural seasons, Cross-Years of Culture, and the promotion of cultural exchanges of contemporary art. As shown in the case of Hermitage, Moscow Kremlin Museums, National Museum of China, Palace Museum ‘Gugong’ in Beijing, famous world museums have been carrying out the ambitious development programmes, scaling up their resource capacities, and since the beginning of the 21st century have begun to promote their brand. The article considers the potential for museums to participate in the development of bilateral relations, and in improving the foreign-policy image of both countries. The authors’ research reveals the features of museum diplomacy, areas of museums’ international activities that enhanced the efficiency of Russia’s and China’s soft power and identifies the common avenues for disseminating the neoliberal messages in museum sphere. Moreover, particular attention is paid by the authors’ to ‘soft power’ rankings and to lists of the most visited museums. Furthermore, new modalities of international museum cooperation are discussed by the authors, with a focus on areas of joint collaboration within the framework of SCO, BRICS, and the “One belt, one road” initiative. The authors conclude that there is a need to improve the legal framework for Russian-Chinese museum cooperation in response to the deepening interaction and transformation of the role of museums in both international and bilateral relations.


2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Devakinandan Sharma ◽  
Gyanesh Kumar Tiwari ◽  
Gyanesh Kumar Tiwar

The study aimed to examine the impacts of spiritual beliefs of diagnosed cancer patients and normal healthy participants on their perceived health. The present research employed a correlational research design to collect and analyze data. The purposive sampling method was used to select the participants in the study. Sixty diagnosed male (M = 52.32, SD = 10.52) and female (M = 51.68, SD = 6.90) cancer patients and 60 normal healthy male (M = 44.00, SD = 10.45) and female (M = 47.15, SD = 11.32) participants constituted the samples for the study. The findings of the study evinced that spiritual beliefs had important role in shaping the nature and extent of the perceived health of the cancer patients and normal healthy participants. The gender has also been observed to play pivotal role in impacting the perceived health of the participants. It was also observed that spiritual beliefs had shown positive correlations with the scores of perceived health of the male, female and all the cancer patients and normal healthy participants. An important finding of the study denoted that spiritual beliefs contributed significantly and even higher in degree to the scores of the perceived health of the participants inflicted with cancer as compared to the participants with no known history of chronic diseases. In essence, the findings of the study corroborated the important role of spiritual beliefs in determining the perceived health of the participants suffering from fatal disease like cancer. The findings of the study have significant implications in understanding the spiritual beliefs and perceived health of the patients inflicted with fatal diseases and it will benefit equally health professional, care-givers and public at large. The limitations and future directions for future researchers have been discussed at the end.


2016 ◽  
Vol 61 (S24) ◽  
pp. 187-211 ◽  
Author(s):  
Fernando Mendiola

AbstractThis article contributes to the debate on the persistence of forced labour within capitalist development. It focuses on Spain, which has been deeply rooted in the global economy, firstly as a colonial metropolis, and later as part of the European Union. In the first place, I analyse the different modalities of unfree labour that are included in the taxonomy established by the Global Collaboratory on the History of Labour Relations, taking into account the different political regimes in which they are inserted. Therefore, the legal framework regarding unfree labour is analysed for four different political contexts: liberal revolution with colonial empire (1812–1874); liberal parliamentarism with colonial empire (1874–1936); civil war and fascist dictatorship, with decolonization (1936–1975); and parliamentary democracy within globalization (1975–2014). The article goes on to deal with the importance of the main economic reasons driving the demand for forced labour: relative labour shortage and the search for increasing profits. In the conclusion, and taking the Spanish case as a basis, I suggest a series of challenges for furthering the global debate on the role of forced labour under capitalism.


Author(s):  
Natália Da Silva Perez

In this introductory text to the special issue Regulating Access: Privacy and the Private in Early Modern Dutch Contexts, Natália da Silva Perez argues that privacy can be a productive analytical lens to examine the social history of the Dutch Republic. She starts by providing an overview of theoretical definitions of privacy and of the ‘private versus public’ dichotomy, highlighting their implications for the study of society. Next, she discusses the modern view of privacy as a legally protected right, explaining that we must adjust expectations when applying the concept to historical examination: in the early modern period, privacy was not yet fully incorporated within a legal framework, and yet, it was a widespread need across different echelons of society. She provides a historical overview of this widespread need for privacy through instances where people attempted to regulate access to their material and immaterial resources. Finally, she describes how the four articles in this special issue contribute to our understanding of the role of privacy in early modern Dutch life.


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