Bipolar illness

2013 ◽  
pp. 301-350
Keyword(s):  
Affective Disorder ◽  
Historical Perspective ◽  
Bipolar Affective Disorder ◽  
Manic Episode ◽  
Spectrum Disorder ◽  
Bipolar Illness ◽  
Clinical Notes ◽  
Bipolar Spectrum Disorder ◽  
Hypomanic Episode ◽  
Depressive Episodes

Introduction Historical perspective Mania/manic episode Hypomania/hypomanic episode Bipolar spectrum disorder Bipolar (affective) disorder 1: classification Bipolar (affective) disorder 2: clinical notes Bipolar (affective) disorder 3: aetiology Bipolar (affective) disorder 4: management principles Other issues affecting management decisions Treatment of acute manic episodes Treatment of depressive episodes...

Bipolar illness

2019 ◽  
pp. 315-360
Author(s):  
David Semple ◽  
Roger Smyth
Keyword(s):  
Bipolar Disorder ◽  
Manic Episode ◽  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Pharmacological Interventions ◽  
Bipolar Illness ◽  
Bipolar Spectrum Disorder ◽  
Clinical Presentations ◽  
Depressive Episodes

This chapter covers bipolar illness. Definitions of mania and a manic episode are defined, as well as hypomania and hypomanic episodes. Bipolar spectrum disorder and different forms of bipolar disorder are classified, clinical presentations and notes described, and management principles discussed. Treatment of acute manic episodes and depressive episodes are covered, including prophylaxis and psychotherapeutic and pharmacological interventions (lithium, valproate, carbamazepine, and lamotrigine).

Mania with Bupropion: A Dose-Related Phenomenon?

2000 ◽  
Vol 34 (5) ◽  
pp. 619-621 ◽  
Author(s):  
Jessica L Goren ◽  
Gary M Levin
Keyword(s):  
Affective Disorder ◽  
Bipolar Depression ◽  
Bipolar Affective Disorder ◽  
Antidepressant Drug ◽  
Manic Episode ◽  
Total Daily Dose ◽  
High Dose ◽  
Related Phenomenon ◽  
Increased Risk ◽  
Daily Dose

OBJECTIVE: To report a case in which bipolar depression was resistant to usual therapies, requiring dosages of bupropion >450 mg/d and to review the literature on mania associated with bupropion and propose a potential theory of a dose-related threshold associated with bupropion and mania. CASE SUMMARY: A 44-year-old white man with a 25-year history of bipolar affective disorder presented with depression resistant to usual therapies. Bupropion therapy was initiated and the dosage was titrated to 600 mg/d. After exceeding the maximum recommended daily dose (450 mg/d), he experienced a manic episode attrib uted to high-dose bupropion. DISCUSSION: Due to increased risk of seizures, current prescribing guidelines state that the total daily dose of bupropion is not to exceed 450 mg/d. Since bupropion is the agent least likely to cause a manic switch in bipolar disorder, this agent seemed a logical choice to treat the patient's depression. Due to a lack of response, the bupropion dosage was titrated to a maximum of 600 mg/d. Since the patient did not switch into mania until the dosage exceeded 450 mg/d, we speculate that this adverse reaction is a dose-related phenomenon. Scientific literature supports this theory. CONCLUSIONS: A switch into mania is a potential risk associated with antidepressant drug use in bipolar affective disorder. Bupropion is believed to be associated with a decreased risk compared with other antidepressant therapies. However, our case report as well as others support the theory that this decreased risk may be due to dosages not exceeding the recommended daily dose (450 mg/d). Doses of bupropion >450 mg/d should be used with caution in depressed patients with bipolar affective disorder.

Lithium use in a patient on haemodialysis with bipolar affective disorder and lithium-induced nephropathy

2021 ◽  
Vol 14 (7) ◽  
pp. e242841
Author(s):  
Sam Topp ◽  
Emma Salisbury
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Manic Episode ◽  
Dose Titration ◽  
Dialysis Session ◽  
Treatment Resistant ◽  
History Of ◽  
End Stage ◽  
Level Monitoring

Lithium is an effective mood stabiliser used to treat bipolar affective disorder (BPAD); however, it can also adversely affect the kidneys, causing acute toxic effects, nephrogenic diabetes insipidus, chronic renal dysfunction and end-stage kidney disease (ESKD) in a minority of patients. We describe the case of a man with a 34-year history of BPAD type-1 and a 2-year history of ESKD secondary to lithium-induced nephropathy who experienced a manic relapse. He previously responded well to lithium but, following a deterioration in kidney function, was switched to olanzapine and sodium valproate. This precipitated a period of instability, which culminated in a treatment-resistant manic episode requiring hospital admission. After a multidisciplinary team discussion, lithium therapy was restarted and provided remission. This was achieved safely through a reduced dosing schedule of three times a week post dialysis, slow dose titration and blood level monitoring prior to each dialysis session.

Verapamil in Bipolar Illness

1986 ◽  
Vol 31 (5) ◽  
pp. 442-444 ◽  
Author(s):  
Leigh Solomon ◽  
Peter Williamson
Keyword(s):  
Calcium Channel ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Blocking Agent ◽  
Bipolar Illness ◽  
The Past ◽  
First Case ◽  
Treatment Of Depression ◽  
Channel Blocking ◽  
Successful Control

The authors report two cases of Bipolar Affective Disorder which were responsive to Lithium therapy in the past, but could no longer be treated with Lithium due to hyperparathyroidism in the first case and noncompliance in the second. In both cases, successful control of hypomania was achieved with Verapamil, but treatment of depression required the addition of Trazodone. The rationale for employing a calcium channel blocking agent, such as Verapamil, in bipolar illness is reviewed.

scholarly journals Neurocysticercosis presenting as bipolar disorder: a case report

2021 ◽  
Vol 34 (6) ◽  
pp. e100663
Author(s):  
Surbhi Batra ◽  
Sumit Kumar ◽  
Lokesh Singh Shekhawat
Keyword(s):  
Bipolar Disorder ◽  
Case Report ◽  
Depressive Symptoms ◽  
Affective Disorder ◽  
Postpartum Period ◽  
Bipolar Affective Disorder ◽  
Taenia Solium ◽  
Manic Episode ◽  
Symptoms And Signs ◽  
Rule Out

Neurocysticercosis is the most common neuro-parasitosis caused by the larval stage of Taenia solium. The most common manifestations include seizures and hydrocephalus. Psychiatric abnormalities are relatively rare but depressive symptoms are frequent in patients with neurocysticercosis. However, mania as a presentation is relatively rare. Pregnancy and the postpartum period are relatively vulnerable times and they can lead to reactivation of existing neurocysterci lesions. We are discussing the case of a 23-year-old female patient with neurocysticercosis leading to the reactivation of lesions in the peripartum and postpartum period leading to bipolar affective disorder. Improvement in the patient was seen with a combination of antipsychotics, antihelmintics, antiepileptics and steroids, along with improved radiological signs of neurocysterci lesions. Although neurocysticercosis is a common illness, its prevalence presenting as a manic episode is merely 2.6% and, hence, missed easily. Therefore, it is important to rule out organic aetiology in patients even with a classic presentation of bipolar affective disorder and those having any other neurological symptoms and signs.

scholarly journals Kluver-Bucy Syndrome in a Patient with Bipolar Affective Disorder

2018 ◽  
Vol 6 (1) ◽  
pp. 36-40
Author(s):  
Madhur Basnet ◽  
Luna Paudel ◽  
Bikram Prasad Gajurel ◽  
Nidesh Sapkota ◽  
Raj Kumar Rauniyar
Keyword(s):  
Rhesus Monkeys ◽  
Dietary Habits ◽  
Bipolar Affective Disorder ◽  
Cerebral Atrophy ◽  
Manic Episode ◽  
Temporal Lobectomy ◽  
Bipolar Illness ◽  
Close Relatives ◽  
Increased Activity ◽  
Lobe Atrophy

Introduction: Kluver and Bucy described a behavioral syndrome in rhesus monkeys following bilateral temporal lobectomy which included psychic blindness, hyperorality, hypermetamorphosis, hypersexuality, and emotional unresponsiveness. Case report: A 44 years old right handed male of Indo-aryan origin, blacksmith by profession, had presented in manic phase of bipolar illness. He had hypersexuality, hypermetamorphosis, hyperorality, and altered dietary habits along with amnesia and fleeting misrecognition of even his close relatives. MRI of the patient showed mild cerebral atrophy with right temporal lobe atrophy. The patient was treated with lithium and olanzapine along with benzodiazepines. The symptoms resolved gradually with resolution of the manic phase. Patient had similar features in the previous manic episode as well that resolved with resolution of mania. Conclusion: The symptoms of Kluver-Bucy syndrome like increased libido, increased activity might be confused with that of mania. Other features of Kluver-Bucy syndrome and the overt hypersexuality could help identify it even during manic phase of bipolar illness.

scholarly journals Aggression Protects Against the Onset of Major Depressive Episodes in Individuals With Bipolar Spectrum Disorder

2017 ◽  
Vol 48 (3) ◽  
pp. 311-321 ◽  
Author(s):  
Tommy H. Ng ◽  
Rachel D. Freed ◽  
Madison K. Titone ◽  
Jonathan P. Stange ◽  
Rachel B. Weiss ◽  
...  
Keyword(s):  
Spectrum Disorder ◽  
Bipolar Spectrum ◽  
Major Depressive ◽  
Bipolar Spectrum Disorder ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Bipolar Affective Disorder in Old Age

1980 ◽  
Vol 136 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Kenneth Shulman ◽  
Felix Post
Keyword(s):  
Retrospective Study ◽  
Affective Disorder ◽  
Old Age ◽  
Bipolar Affective Disorder ◽  
Bipolar Disorders ◽  
Long Period ◽  
Bipolar Patients ◽  
Depressive Episodes ◽  
Recurrent Nature

SummaryIn a retrospective study of 67 elderly bipolar patients the first manic attack occurred at about age 60, often after a long period from the time of the first affective episode, after which further depressive episodes occurred. This calls into question Perris’ criteria for unipolar diagnosis. Among the men, a preponderance of cerebral-organic disorders was found. The evidence for sub-classification of bipolar disorders into secondary or symptomatic manias is discussed. The recurrent nature of the illness in old age stresses the need for further evaluation of lithium prophylaxis.

PERIPHERAL NON_ ENZYMATIC ANTIOXIDANTS LEVELS IN SCHIZOPHRENIA AND BIPOLAR ILLNESS A COMPARATIVE CROSS-SECTIONAL STUDY

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Rajendra Kumar Acharya ◽  
Rahul Gupta ◽  
Sanjay Gehlot
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Cross Sectional Study ◽  
Enzymatic Antioxidants ◽  
Sectional Study ◽  
Cross Sectional ◽  
Bipolar Illness ◽  
Nonenzymatic Antioxidants

Background: Nervous tissue is extremely sensitive to oxidative damage Recent studies show an elevated level of oxidative stress indicators in Schizophrenia. Current studies on oxidative stress in Schizophrenia mainly focus on enzymatic antioxidants, while limited studies have been carried out on non-enzymatic antioxidants Some studies discovered that plasma non-enzymatic antioxidants (uric acid, bilirubin, and albumin) in Schizophrenia are lower than those of healthy controls. Aim: To compare levels of nonenzymatic antioxidants in Schizophrenia and bipolar illness. Material and Methods: The present study is a hospital_ based cross-sectional study conducted among 100 patients with Schizophrenia and Bipolar Affective disorder included as per inclusion and exclusion criteria and undergone psychiatric assessment as per diagnostic criteria. Results: S. albumin, S.bilirubin, S.uric acid were found to be low in Schizophrenia but statistically, the significant difference was evaluated for S.uric acid. Conclusion: S. uric acid lower significant levels in Schizophrenia as compared to bipolar affective disorder shows the more impaired peripheral antioxidant scavenging system in Schizophrenia. However, pure peripheral antioxidant system dysfunction could not be ascertained in Schizophrenia through this study. Keywords: nonenzymatic antioxidants, Schizophrenia, bipolar illness.

Effects of season and climate on the first manic episode of bipolar affective disorder in Korea

2002 ◽  
Vol 113 (1-2) ◽  
pp. 151-159 ◽  
Author(s):  
Heon-Jeong Lee ◽  
Leen Kim ◽  
Sook-Haeng Joe ◽  
Kwang-Yoon Suh
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Manic Episode
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