HOUT-08. PATIENT AND PHYSICIAN PERSPECTIVES ON LUMBAR PUNCTURE

Abstract OBJECTIVE To investigate patients’ and physicians’ perceptions of lumbar puncture (LP) and tolerability. METHODS Adult patients were surveyed prior to and after the procedure regarding patient perceptions and actual experience of LP. Presence of symptoms pre- and post-LP were compared by McNemar test; symptom severity score was rated 0–10, compared by Wilcoxon test; and relative risks were compared by Fisher’s exact test. In addition to patient surveys, email requests to complete an eight-question survey regarding LP tolerability was sent to faculty physicians at two academic centers. RESULTS A total of 154 patients and 302 physicians completed the surveys during 1/2017-5/2019. Ninety-one patients (59%) reported anxiety prior to-LP compared to 52 (34%) who reported anxiety after the LP (p< 0.0001). Whereas 74% of patients predicted LP to be painful prior to LP, only 48% reported that LP was painful after the procedure (p< 0.0001). On an 11-point scale, patients anticipated significantly greater pain from LP than they reported after the procedure (mean 3.4 and 2.0 respectively, p< 0.0001). Patients who anticipated pain were more likely to experience pain (RR=1.65, 95% CI 1.07–2.73). There was no significant difference in symptoms such as headache, nausea, generalized pain, vision or gait disturbance before and after the procedure. After the LP, 117 patients (77%) answered they would repeat LP if recommended by their doctors. Out of 302 physicians (40% women), the majority (81%) felt that the LP induces anxiety or worry in patients, and 50% answered that the LP is painful for patients in general. CONCLUSION We observed that although anticipation of pain contributed to pre-procedure anxiety, LP was generally well-tolerated. The majority of patients experienced minimal pain. The results of this study suggest that measures to reduce pre-procedure anxiety may improve the tolerability of LP, an important diagnostic tool in neuro-oncology.

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THE EFFECTIVENESS OF TRIPLE-DOSE ALBENDAZOLE IN COMPARISON WITH MEBENDAZOLE FOR THE TREATMENT OF TRICHURIASIS IN CHILDREN

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019.v11s6.33559 ◽

2019 ◽

pp. 104-107

Author(s):

SALEHA SUNGKAR ◽

FANNY P. IRMAWATI ◽

ROSE A. HASWINZKY ◽

YASMINE A. DWINASTITI ◽

SRI WAHDINI ◽

...

Keyword(s):

Controlled Trial ◽

Reduction Rate ◽

Wilcoxon Test ◽

Cure Rate ◽

Exact Test ◽

Randomized Controlled ◽

Significant Difference ◽

Before And After ◽

Egg Reduction Rate ◽

Triple Dose

Objective: Trichuriasis is difficult to treat with single-dose anthelmintic. Although a higher cure rate (CR) can be achieved by treatment with triple-dose albendazole and mebendazole, the results of studies are inconsistent. This study aimed to evaluate the effectiveness of triple-dose albendazole and mebendazole in treating trichuriasis. Methods: A randomized controlled trial was conducted in a primary school in the Pandeglang District, Banten Province, Indonesia in July–August, 2018; 382 children were recruited. Stools were collected and examined microscopically using the Kato–Katz method to identify Trichuriasis eggs. Children positive for Trichuris trichiura were randomized and divided into two groups. One was given a triple dose of 400 mg albendazole and the other a triple dose of 500 mg mebendazole. On day 14 after treatment, stools were reexamined to calculate CR and the egg reduction rate (ERR). Data were analyzed using SPSS version 20. Results: The prevalence of soil-transmitted helminth infection was 42%, and that of trichuriasis and ascariasis was 25.1% and 29.8%. There was a significant difference (Wilcoxon test, P<0.01) in the intensity of infection before and after intervention. Both groups showed high values of CR (mebendazole: 95.2%, albendazole: 85.4%; Fisher’s exact test, P = 0.125) and ERR (mebendazole: 99%, albendazole: 96%; Mann–Whitney test, P = 0.110). There was no significant difference in CR and ERR between the two groups. Conclusion: Triple-dose albendazole was as effective as triple-dose mebendazole in treating trichuriasis.

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Comparison of Copper Level and Color Vision in Pulmonary Tuberculosis Patients Before and After Ethambutol Treatment in Category I and II

Sriwijaya Journal of Ophthalmology ◽

10.37275/sjo.v3i1.39 ◽

2020 ◽

Vol 3 (1) ◽

pp. 19-25

Author(s):

Febria Restissa ◽

Ahmad Rasyid ◽

Devi Azri Wahyuni

Keyword(s):

Color Vision ◽

Total Error ◽

T Test ◽

Wilcoxon Test ◽

Copper Level ◽

Tuberculosis Patients ◽

Vision Disorder ◽

Significant Difference ◽

Before And After ◽

Paired T Test

ABSTRACT Objective : to determine the correlation between duration of ethambutol and copper levels in serum with color vision disorder examined with Farnsworth Munsell 100 Hue (FM100) in patients with tuberculosis. Methods: This study was an explorative observation of 20 samples during November 2017 - January 2018 period. Comparative analysis using independent t-test, paired t-test, Wilcoxon test and Mann-Whitney test, while correlation analysis using Spearman's test and Pearson's test. Results: There was a significant difference of FM100 value before and after in category I (p=0.000) with increase of total error value 11.80+5.31 or category II (p=0.000) with increase of total error value 15.00+7.41. There was significant difference of Cu2+ level before and after in category I (p=0.005) with decrease of Cu2+ level 15.57+5.04 mg/dL or category II (p=0.005) with decrease of Cu2+ level 31.66+7.35 mg/dL. There was significant correlation between color vision and duration of ethambutol (p=0.000), but there was no significant correlation of Cu2+ with color vision (p>0.05). Conclusion: The duration of Ethambutol was related to changes in color vision examined with FM100.

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Malondialdehyde Levels in Preeclampsia before and after Delivery

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v6i3.777 ◽

1970 ◽

pp. 143

Author(s):

Harold Rumopa ◽

Freddy W. Wagey ◽

Eddy Suparman

Keyword(s):

Oxidative Stress ◽

Plasma Levels ◽

Cross Sectional Study ◽

Hplc Method ◽

Wilcoxon Test ◽

Sectional Study ◽

Cross Sectional ◽

Average Value ◽

Significant Difference ◽

Before And After

Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery. Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory. Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000). Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress. Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

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Peningkatan Status Perkembangan Anak Prasekolah dengan Stimulasi Perkembangan

JKEP ◽

10.32668/jkep.v5i2.363 ◽

2020 ◽

Vol 5 (2) ◽

pp. 150-160

Author(s):

Santun Setiawati ◽

Agus Citra Dermawan ◽

Raden Siti Maryam

Keyword(s):

Univariate Analysis ◽

Wilcoxon Test ◽

Good Growth ◽

Frequency Distributions ◽

Growth Status ◽

Development Status ◽

Significant Difference ◽

Before And After ◽

Quasi Experimental ◽

Children Development

The children are not small adults, but have unique characteristics that are always growing and evolving since their conception until the end of adolescence. Good growth and development of children requires appropriate stimulation and accordance with the age such as developmental stimulation. The aim of this study was to determine the influence development simulations towards pre-school children’s growth status. This research was using the quasi-experimental design without control. The numbers of respondents were 30 children (with aged 60-72 month). The children with dubious developmental status had performed the development stimulations for 2 weeks for 3-4 housr a day and evaluated the development status. Developmental Pre-Screening Questionnaire (KPSP) instrument used in this research. The data analysis was using univariate analysis (frequency distributions), bivariate (Wilcoxon test) and multivariate (ANCOVA test). There was a significant difference in the children’s development status before and after development stimulation interventions (p= 0.000), but there was no children and mothers’ characteristic factors that affect the children development status. Stimulation associated with the value of child development, where the high category of stimulation is not found in children whose development category is slow. So it takes stimulation of children from an early age. Growth stimulations can be done routinely as a part of efforts to improve the children development status.

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Effect of whitening dentifrices on the surface roughness of a nanohybrid composite resin

European Journal of Dentistry ◽

10.4103/1305-7456.178305 ◽

2016 ◽

Vol 10 (02) ◽

pp. 170-175 ◽

Cited By ~ 2

Author(s):

Gabriela Migliorin da Rosa ◽

Luciana Mendonça da Silva ◽

Márcio de Menezes ◽

Hugo Felipe do Vale ◽

Diego Ferreira Regalado ◽

...

Keyword(s):

Surface Roughness ◽

Composite Resin ◽

Wilcoxon Test ◽

Control Group ◽

Mean Values ◽

Short Period ◽

Significant Difference ◽

Before And After ◽

Nanohybrid Composite ◽

One Way Anova

ABSTRACT Objectives: The present study verified the influence of whitening dentifrices on the surface roughness of a nanohybrid composite resin. Materials and Methods: Thirty-two specimens were prepared with Filtek™ Z350 XT (3M/ESPE) and randomly divided into four groups (n = 08) that were subjected to brushing simulation equivalent to the period of 1 month. The groups assessed were a control group with distilled water (G1), Colgate Total 12 Professional Clean (G2), Sensodyne Extra Whitener Extra Fresh (G3), and Colgate Luminous White (G4). A sequence of 90 cycles was performed for all the samples. The initial roughness of each group was analyzed by the Surface Roughness Tester (TR 200-TIME Group Inc., CA, USA). After the brushing period, the final roughness was measured, and the results were statistically analyzed using nonparametric Kruskal–Wallis and Dunn tests for intergroup roughness comparison in the time factor. For intragroup and “Δ Final − Initial” comparisons, the Wilcoxon test and (one-way) ANOVA were, respectively, performed (α = 0.05). Results: The roughness mean values before and after brushing showed no statistically significant difference when the different dentifrices were used. None of the dentifrices analyzed increased significantly the nanohybrid composite resin surface roughness in a 1 month of tooth brushing simulation. Conclusions: These results suggest that no hazardous effect on the roughness of nanohybrid composite resin can be expected when whitening dentifrices are used for a short period. Similar studies should be conducted to analyze other esthetic composite materials.

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Evolution of clinical outcomes of metastatic pancreatic adenocarcinoma: A 10-year single-institution retrospective study.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e16760 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e16760-e16760

Author(s):

Moataz Ellithi ◽

Mohamed A. Abdallah ◽

Mahum Shahid ◽

Isaak Ailts ◽

Kate Waligoske ◽

...

Keyword(s):

Retrospective Study ◽

Clinical Outcomes ◽

Pancreatic Adenocarcinoma ◽

Cox Regression ◽

The United States ◽

Wilcoxon Test ◽

Cox Regression Analysis ◽

Metastatic Pancreatic Adenocarcinoma ◽

Significant Difference ◽

Before And After

e16760 Background: Pancreatic adenocarcinoma represents the fourth leading cause of cancer-related death in the United States. A majority of patients have locally advanced or metastatic disease at the time of diagnosis. For many years, gemcitabine monotherapy was the standard of care for advanced disease, until recent studies demonstrated survival benefits for FOLFIRINOX (5-FU, leucovorin, irinotecan, and oxaliplatin) and Gem/nab-P (gemcitabine/nab-paclitaxel). In this study, we evaluated the clinical outcomes in patients with metastatic pancreatic adenocarcinoma in a single health system before and after the incorporation of these newer treatments into practice. Methods: A retrospective study of metastatic pancreatic adenocarcinoma patients diagnosed between January 2009 to December 2018 with follow up until December 2019. Overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier survival analysis. Univariate and multivariable Cox regression analyses were used to explore predictors of survival. Results: 394 patients were diagnosed with metastatic pancreatic adenocarcinoma at Sanford Health hospitals during the study period. There was no statistically significant difference in OS between the cohort diagnosed between 2009-2013 compared to 2014-2018, with median OS of 4.7 and 3.6 months respectively; in those receiving at least one line of chemotherapy, the median OS was 6.7 and 7.3 months. While subgroup analysis of all study population based on the type of first-line chemotherapy showed improved survival with FOLFIRINOX and Gem/nabP as compared to gemcitabine monotherapy [10.7, 6.9, 4 months respectively] (Wilcoxon Test of Homogeneity of Survival Curves p = 0.0002). Univariate and multivariate Cox regression analysis of all study data revealed that at the time of the diagnosis, age (HR: 1.021, p = 0.0013), ECOG performance status > 1 (HR: 3.47, p = 0.0001), serum albumin (HR: 0.708, p = 0.0002), Neutrophil-to-Lymphocytes ratio (HR: 1.076, p≤0.0001) and platelets-to-lymphocyte ratio (HR: 0.998, p = 0.0031) were predictors of survival. Conclusions: Although newer treatments appear to offer improved survival for eligible patients, overall outcomes for metastatic pancreatic adenocarcinoma in this cohort were similar before and after the incorporation of newer treatment regimens. Further advances in the treatment and early detection of pancreatic cancer are needed to improve clinical outcomes.

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PENURUNAN NYERI KEPALA PADA LANSIA DENGAN HIPERTENSI MENGGUNAKAN RELAKSASI AUTOGENIK DI KELURAHAN MERSI PURWOKERTO

Media Ilmu Kesehatan ◽

10.30989/mik.v7i2.229 ◽

2019 ◽

Vol 7 (2) ◽

pp. 104-113

Author(s):

Dwi Novitasari ◽

Ikit Netra Wirakhmi

Keyword(s):

The Elderly ◽

Wilcoxon Test ◽

Relaxation Technique ◽

P Value ◽

Common Symptom ◽

Parasympathetic System ◽

Significant Difference ◽

Before And After ◽

Autogenic Relaxation ◽

The Mean

Background: Headache in the occipital region is the most common symptom of hypertension, caused by enhanchement intra-cranial pressure and vasoconstriction resulting in decreased perfusion of cerebral tissue. This causes insomnia, decreased concentration and decreased ability of daily living activity. Autogenic relaxation causes vasodilation and a calm emotional response that increases the response of the parasympathetic system. This modulation stimulus can decrease perception of headache. Objective: The aims of this study was to find out how the reduction of headache on hypertension before and after autogenic relaxation. Methods: The design of this research was pre experimental with one group pretest-postest design approach. The sample are 38 patients with hypertension who complained of headache in Mersi Purwokerto. Selection has been using purposive sampling. Measurement of head pain using visual analog scale. Data analysis using Wilcoxon test. Results: The mean headache before the autogenic relaxation technique was 5.24, and the mean headache after autogenic relaxation technique was 3.47, including the range of moderate pain. There was a significant difference between headache before and after the autogenic relaxation technique with p value: 0,000. Conclusion: Autogenic relaxation can be used by the elderly with hypertension to reduce headache. Keywords: Autogenic relaxation, headache, hypertension.

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CD4 LYMPHOCYTE IN HIV / AIDS BEFORE AND AFTER ANTIRETROVIRAL THERAPY

Berkala Kedokteran ◽

10.20527/jbk.v13i2.4074 ◽

2017 ◽

Vol 13 (2) ◽

pp. 183

Author(s):

Rangsang Bagus Prabowo ◽

Dewi Indah Noviana Pertiwi ◽

FX. Hendriyono

Keyword(s):

Antiretroviral Therapy ◽

Lymphocyte Count ◽

Wilcoxon Test ◽

P Value ◽

Cross Sectional ◽

Infected People ◽

Significant Difference ◽

Cd4 Lymphocyte Count ◽

Before And After ◽

Cd4 Lymphocyte

Abstract: Human Immunodefficiency Virus (HIV) is a virus that decreases the human immunity system, therefore the infected people become susceptible to any kind of infections. Examination of CD4 lymphocyte count periodically is one of the antiretroviral therapy success indicators. The purpose of this research was to determine the difference of CD4 lymphocyte count before and after antiretroviral therapy at Ulin General Hospital Banjarmasin on 2013-2015. The method of this research was observational analytic with cross-sectional approach. The study population was 55 patients which were selected by inclusion and exclusion criteria. Results portrayed an increase of the CD4 lymphocyte count in 51 patients after being given four kinds of antiretroviral for 6 months with the mean increase in CD4 lymphocyte count was 92,72 cell/µL. Data analysis result with Wilcoxon test portrayed a difference of the CD4 lymphocyte count before and after antiretroviral therapy with p value=0,000. In conclusion, there was a significant difference of the CD4 lymphocyte count before and after antiretroviral therapy. Keywords: Human Immunodeficiency Virus, CD4, lymphocyt, antiretroviral therapy

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Analisis Reaksi Investor di Bursa Efek Indonesia pada Pelantikan Joko Widodo

Jurnal Pendidikan Ekonomi Undiksha ◽

10.23887/jjpe.v12i1.21514 ◽

2020 ◽

Vol 12 (1) ◽

pp. 50

Author(s):

Komang Lia Karina ◽

I Nyoman Sujana ◽

M. Rudi Irwansyah

Keyword(s):

Trading Volume ◽

Stock Exchange ◽

Abnormal Returns ◽

Secondary Data ◽

Wilcoxon Test ◽

Stock Index ◽

Stock Trading ◽

Significance Level ◽

Significant Difference ◽

Before And After

This study aimed to analyze the reaction of investors on Indonesia Stock Exchange to the inauguration of the 8th President by observing whether there were any significant differences in abnormal returns and stock trading volume activities before and after the event. The observation period used in this study was 10 days, with details of each 5 days before and after the President's inauguration event that occurred on 20 October 2019. This research was quantitative research and used daily transaction data on the market capital as a secondary data source. The samples used were companies that were included in the LQ45 stock index for the period August 2019 - January 2020. A non-parametric test in the form of Wilcoxon test was used to test the hypothesis. The results of this study showed that there were no significant difference in abnormal return and stock trading volume activity in the period before and after the event. This was evidenced by the probability value above the significance level of 5%. Thus, the results of this study were stated that there was no reaction from the investor related to the event of the inauguration of the 8th President in Indonesia.

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Perbedaan pH Saliva Sebelum Dan Sesudah Mengunyah Permen Karet Xylitol Pada Pemakai Alat Orthodonti Cekat

Journal of Oral Health Care ◽

10.29238/ohc.v6i1.325 ◽

2018 ◽

Vol 6 (1) ◽

pp. 15-19

Author(s):

Gita Komala Dewi ◽

Susilarti Susilarti ◽

Almujadi Almujadi

Keyword(s):

Environmental Changes ◽

Salivary Flow ◽

Oral Bacteria ◽

Wilcoxon Test ◽

P Value ◽

Orthodontic Appliance ◽

Significant Difference ◽

Salivary Ph ◽

Before And After ◽

Fixed Orthodontic Appliance

Orthodontic treatment may lead to environmental changes in the oral cavity that may occur in a number of users of the orthodontic appliance, such as changes in bacterial concentration, salivary buffering capacity, salivary acidity (pH) and salivary flow rate. Xylitol stimulates salivary flow and helps restore saliva acid/base balance because it cannot be converted to acid by oral bacteria. To identify the difference in salivary pH before and after chewing xylitol gum in the users of fixed orthodontic appliance. This research is quasi-experimental with one group pretest-posttest design. Samples were students of SMA Kolombo Sleman who used a fixed orthodontic appliance. Data were analyzed using a Wilcoxon test. The salivary pH of the users of a fixed orthodontic appliance before chewing xylitol gum mostly belonged to acid criterion (43.8%), and the base criterion (34.3%). After chewing xylitol gum, the salivary pH of the users of fixed orthodontic appliance mostly belonged to a neutral criterion (78.1%). The results of the Wilcoxon test showed that the salivary pH before and after chewing gum xylitol in the users of fixed orthodontic appliance had a P value of 0.027 <α 0.05. There is a significant difference in salivary pH before and after chewing xylitol gum in users of fixed orthodontic appliance.

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