scholarly journals Prevalence and Transmission of Beta and Gamma Human Papillomavirus in Heterosexual Couples

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
Anna-Barbara Moscicki ◽  
Yifei Ma ◽  
Tarik Gheit ◽  
Sandrine McKay-Chopin ◽  
Sepideh Farhat ◽  
...  
Keyword(s):  
At Risk ◽  
Human Papillomavirus ◽  
Skin Cancer ◽  
Confidence Interval ◽  
Transmission Rate ◽  
Primary Objective ◽  
Nonmelanoma Skin Cancer ◽  
Heterosexual Couples ◽  
Sexually Transmitted ◽  
Hpv Types

Abstract Background Beta (β) and gamma (γ) human papillomavirus (HPV) are commonly found on the skin. Few of the β types are associated with nonmelanoma skin cancer. Little is known about transmission patterns of these HPV, specifically in the anogenital (AG) areas. The primary objective of this study was to examine the AG concordance and transmission of β and γHPV types between heterosexual couples. Methods Archival samples from a previously published study examining concordance of alpha HPV types between couples were tested for β and γHPV. Hand, mouth, and genital samples were obtained 5 times over a 6-week period. Results Of the 21 couples examined, β and γHPV were detected in AG sites in 67% and 30% of men, respectively, and 41% and 25% of women. Positive concordance for β and γHPV was 27% and 20%, respectively, which was greater than the observed concordance between noncouples (10% for βHPV and 4% for γHPV). Transmission rate of βHPV between AG areas was 15.9 (95% confidence interval [CI], 3.3–46.5) per 100 person months for men-to-women at risk and for γHPV was 6.6 (95% CI, .2–36.7). Risks for women-to-men were similar. Conclusions Beta and γHPV are common in the AG area, and data suggest that they can be sexually transmitted.

Human Papillomavirus and Overexpression of P16INK4a in Nonmelanoma Skin Cancer

2004 ◽  
Vol 30 (3) ◽  
pp. 409-414
Author(s):  
INGO NINDL ◽  
THOMAS MEYER ◽  
TOBIAS SCHMOOK ◽  
CLAAS ULRICH ◽  
RÜDIGER RIDDER ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Skin Cancer ◽  
Nonmelanoma Skin Cancer

scholarly journals Clinical and Analytical Performance of the Onclarity HPV Assay Using the VALGENT Framework

2015 ◽  
Vol 53 (10) ◽  
pp. 3272-3279 ◽  
Author(s):  
K. Cuschieri ◽  
D. T. Geraets ◽  
C. Moore ◽  
W. Quint ◽  
E. Duvall ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Confidence Interval ◽  
Cervical Screening ◽  
Intraepithelial Neoplasia ◽  
Relative Sensitivity ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Screening Population ◽  
Relative Specificity ◽  
Hpv Types

As the demand for human papillomavirus (HPV)-related cervical screening increases, emerging HPV tests must be evaluated robustly using well-annotated samples, such as those generated in the Validation of HPV Genotyping Tests (VALGENT) framework. Through VALGENT, we assessed the performance of the BD Onclarity HPV assay, which detects 14 high-risk (HR) types and resolves six individual types and three groups of types. Consecutive samples from a screening population (n= 1,000), enriched with cytologically abnormal samples (n= 300), that had been tested previously with the GP5+/6+ PCR enzyme immunoassay (EIA) and the GP5+/6+ PCR LMNX assay (Diassay) were tested with the Onclarity assay. Type-specific HPV prevalences were analyzed according to age and cytological result. The accuracy of the Onclarity assay for the detection of cervical intraepithelial neoplasia grade 2+ (CIN2+) and CIN3+ was assessed relative to the GP5+/6+ EIA results by using noninferiority criteria. Overall agreement and type-specific agreement between the Onclarity assay and the GP5+/6+ LMNX assay were assessed. The prevalence of HPV types 16, 18, 31, and 45 increased with the severity of cytological results (Pfor trend, <0.05). For the detection of CIN2+, the Onclarity assay had a relative sensitivity of 1.02 (95% confidence interval [CI], 0.99 to 1.05;P< 0.001 for noninferiority) and a relative specificity of 0.99 (95% CI, 0.97 to 1.00;P= 0.186 for noninferiority). The kappa for agreement between the Onclarity assay and the GP5+/6+ LMNX assay for HR-HPV was 0.92 (95% CI, 0.89 to 0.94), and values for the six individual types ranged from 0.78 (95% CI, 0.68 to 0.87) for HPV-52 to 0.96 (95% CI, 0.93 to 0.99) for HPV-16. These data suggest that the Onclarity assay offers applications for clinical workstreams while providing genotyping information that may be useful for risk stratification beyond types 16 and 18.

scholarly journals Prevalence of Human Papillomavirus (HPV) infection in women living in remote riverine communities in the Amazonas, Brazil

2019 ◽  
Author(s):  
Marco Antonio Zonta ◽  
Karina Bonilha Roque ◽  
Yara Juliano ◽  
Anne Liljander ◽  
Markus Cavalar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Hpv Infection ◽  
Public Health Services ◽  
Cervical Lesions ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Remote Areas ◽  
Hpv Types ◽  
Crucial Part

Abstract Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Since some HPV types are associated with the development of cervical cancer, routine screening for HPV plays a crucial part in cancer prevention programs at global level. In Brazil, the cervical cancer rate is among the highest in the world, in particular in indigenous women living in remote areas with limited access to public health services. The objective of this study was to determine the prevalence of HPV infections and their co-occurrence with cervical lesions in Brazilian women living in isolated riverine communities. Moreover, the association between social environment, sexual activity and prevalence of HPV infection was assessed.

scholarly journals Recurring infection with ecologically distinct human papillomavirus (HPV) types explains high prevalence and diversity

2017 ◽  
Author(s):  
Sylvia Ranjeva ◽  
Edward B. Baskerville ◽  
Vanja Dukic ◽  
Luisa Villa ◽  
Eduardo Lazcano-Ponce ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
Hpv Prevalence ◽  
Increased Risk ◽  
High Prevalence ◽  
Hpv Types ◽  
One Year ◽  
The One ◽  
The Impact

AbstractThe high prevalence of human papillomavirus (HPV), the most common sexually transmitted infection, arises from the coexistence of over 200 genetically distinct types. Accurately predicting the impact of vaccines that target multiple types requires understanding the factors that determine HPV diversity. The diversity of many pathogens is driven by type-specific or “homologous” immunity, which promotes the spread of variants to which hosts have little immunity. To test for homologous immunity and to identify mechanisms determining HPV transmission, we fitted nonlinear mechanistic models to longitudinal data on genital infections in unvaccinated men. Our results provide no evidence for homologous immunity, instead showing that infection with one HPV type strongly increases the risk of infection with that type for years afterwards. For HPV16, the type responsible for most HPV-related cancers, an initial infection increases the one-year probability of reinfection by 20-fold, and the probability of reinfection remains 14-fold higher two years later. This increased risk occurs in both sexually active and celibate men, suggesting that it arises from auto-inoculation, episodic reactivation of latent virus, or both. Overall our results show that high HPV prevalence and diversity can be explained by a combination of a lack of homologous immunity, frequent reinfections, weak competition between types, and variation in type fitness between host subpopulations. Due to the high risk of reinfection, vaccinating boys that have not yet been exposed may be crucial to reduce prevalence, but our results suggest that there may also be large benefits from vaccinating previously infected individuals.

scholarly journals Vaginal microbiota and human papillomavirus infection among young Swedish women

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Liqin Cheng ◽  
Johanna Norenhag ◽  
Yue O. O. Hu ◽  
Nele Brusselaers ◽  
Emma Fransson ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Alpha Diversity ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Vaginal Microbiota ◽  
Microbial Composition ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Hpv Types ◽  
Oncogenic Hpv

Abstract Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. To define the HPV-associated microbial community among a high vaccination coverage population, we carried out a cross-sectional study with 345 young Swedish women. The microbial composition and its association with HPV infection, including 27 HPV types, were analyzed. Microbial alpha-diversity was found significantly higher in the HPV-infected group (especially with oncogenic HPV types and multiple HPV types), compared with the HPV negative group. The vaginal microbiota among HPV-infected women was characterized by a larger number of bacterial vaginosis-associated bacteria (BVAB), Sneathia, Prevotella, and Megasphaera. In addition, the correlation analysis demonstrated that twice as many women with non-Lactobacillus-dominant vaginal microbiota were infected with oncogenic HPV types, compared with L. crispatus-dominated vaginal microbiota. The data suggest that HPV infection, especially oncogenic HPV types, is strongly associated with a non-Lactobacillus-dominant vaginal microbiota, regardless of age and vaccination status.

Prevalence, Concordance, and Transmission of Human Papillomavirus Infection Among Heterosexual Couples in Liuzhou, China: An Observational Perspective Study

2019 ◽  
Vol 220 (6) ◽  
pp. 980-989 ◽  
Author(s):  
Yingying Su ◽  
Feixue Wei ◽  
Xiumin Huang ◽  
Yafei Li ◽  
Lingxian Qiu ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Transmission Rate ◽  
Hpv Vaccination ◽  
Heterosexual Couples ◽  
Important Public Health ◽  
Vaccination Strategies ◽  
Papillomavirus Infection ◽  
Exfoliated Cells ◽  
Male To Female ◽  
Male Genital

Abstract Background Knowledge of human papillomavirus (HPV) transmission dynamics, which have important public health implications for designing HPV vaccination strategies, is scarce in undeveloped areas. Methods From May to July 2014, 390 couples were enrolled from the general population in Liuzhou, China. Exfoliated cells from male penis shaft/glans penis/coronary sulcus (PGC) and perianal/anal canal (PA) sites and from female vaginal, vulvar, and PA sites were collected biannually for 1 year. Results The HPV type-specific concordance rate between couples was 15.5% (95% confidence interval [CI], 8.5%–25.0%). For anogenital HPV transmission, the male-to-female transmission rate (11.5 [95% CI, 4.3–30.7] per 1000 person-months) was similar to the female-to-male transmission rate (11.3 [95% CI, 5.9–21.7] per 1000 person-months). The concordance rates between male PGC site and female vaginal, vulvar, and PA sites were 20.0%, 21.8%, and 14.9%, respectively, which were significantly higher than expected by chance. Infections transmitted from males to females seemed mainly originated from male genital sites, whereas for female-to-male transmission, the vaginal, vulvar, and PA sites might be all involved. Conclusions Among the heterosexual couples with relatively conservative sexual behavior, the anogenital HPV transmission rate for females to males is similar to that of males to females. In addition to the vagina and vulva, the female PA site is also an important reservoir for HPV transmission.

scholarly journals The role of herpes and human papillomavirus infection in prostate and bladder carcinogenesis

2022 ◽  
Vol 20 (4) ◽  
pp. 153-161
Author(s):  
L. M. Mikhaleva ◽  
A. A. Kamalov ◽  
G. G. Maryin ◽  
V. K. Karpov ◽  
E. P. Akopyan ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Malignant Tumors ◽  
Hpv Infection ◽  
Research Area ◽  
Scientific Data ◽  
Sexually Transmitted ◽  
Depth Study ◽  
Hpv Types ◽  
Oncogenic Hpv

Human papillomavirus (HPV) is a small epithelial, non-enveloped, double-stranded DNA virus that belongs to the Papillomaviridae family. HPV infection is one of the most common sexually transmitted infections, and certain types of HPV are known to be carcinogenic to humans. According to the scientific literature, there is reliable information about the role of highly oncogenic HPV types in the development of cervical, anal, vulvar, vaginal, penile, and oropharyngeal cancer.Currently, a relevant and promising research area is the study of the role of HPV infection in prostate cancer (PC) and bladder cancer (BC), but scientific data on the potential pathogenetic relationship between these phenomena remain contradictory. An in-depth study of the question how herpes and human papillomavirus affect the origin of malignant tumors of the prostate and bladder, as well as the course of these diseases, and the prognosis of their development can become a source of information for development of new approaches to their diagnosis, prevention, and monitoring of morbidity. This literature review analyzes the results of modern studies on the role of oncogenic HPV types in the carcinogenesis of PC and BC. 

scholarly journals Multiple-Type Human Papillomavirus (HPV) Infections: A Cross-Sectional Analysis of the Prevalence of Specific Types in 309,000 Women Referred for HPV Testing at the Time of Cervical Cytology

2013 ◽  
Vol 23 (7) ◽  
pp. 1295-1302 ◽  
Author(s):  
Elizabeth Louise Dickson ◽  
Rachel Isaksson Vogel ◽  
Robin L. Bliss ◽  
Levi S. Downs
Keyword(s):  
Human Papillomavirus ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Negative Relationship ◽  
Multivariate Logistic Regression Analysis ◽  
Multiple Infections ◽  
Hpv Testing ◽  
Entire Sample ◽  
Hpv Types ◽  
Multiple Type

ObjectivesTo determine the frequency of multiple-type cervical human papillomavirus (HPV) infections, and whether any types are involved in multiple-type infections more or less frequently than might be expected if these infections occur randomly.MethodsIn this retrospective analysis of type-specific HPV testing, results from women 18 to 65 years old with samples collected between July 2007 and May 2011 were considered.Multivariate logistic regression analysis was used to model the presence of each of the 24 most prevalent HPV types, adjusting for one other HPV type, age, laboratory region, and age-by-region interactions.ResultsHuman papillomavirus infection was present in 74,543 (24.1%) of 309,471 women and 65,492 (21.1%) were positive for one of the top 24 most prevalent HPV types. The most common HPV type was type 16, occurring in 4.1% of the entire sample. A total of 14,181 women were positive for 2 or more HPV types (4.6% of entire sample and 19.0% of HPV-positive sample). Two-way HPV type comparisons were analyzed. Types 52, 53, 81, and 83 were more likely to occur in multiple infections with other types; and types 16, 58, and 66 were less likely to occur in multiple infections with other types. Human papillomavirus types 72 and 81 have the strongest positive relationship (odds ratio, 5.2; 95% confidence interval, 3.6–7.4). Human papillomavirus types 33 and 66 have the strongest negative relationship (odds ratio, 0.4; 95% confidence interval, 0.2–0.6).ConclusionsIn this population, multiple-type HPV infections were present in 4.6% of all women. Our findings suggest that there may be both competitive and cooperative interactions between HPV types.

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