scholarly journals 158. Invasive Group B Streptococcal Diseases in Adults: A Retrospective Study in Thailand (2013–2017)

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S105-S105
Author(s):  
Nasikarn Angkasekwinai ◽  
Nantaporn Pirogard ◽  
Pakpoom Phoompoung ◽  
Amornrut Leelaporn
Keyword(s):  
Diabetes Mellitus ◽  
Susceptibility Testing ◽  
Group B Streptococcus ◽  
Positive Culture ◽  
Adult Patients ◽  
Invasive Group ◽  
Invasive Diseases ◽  
Siriraj Hospital ◽  
Group B ◽  
Overall Mortality

Abstract Background Group B Streptococcus (GBS) has been increasingly associated with invasive diseases in nonpregnant adults. This study aims to describe the epidemiology of invasive GBS (iGBS) diseases in adult patients. Methods A retrospective cohort study was conducted at Siriraj Hospital between January 1, 2013 and December 31, 2017. We included adult patients with a positive culture of GBS isolated from sterile sites. Results Among 224 patients recruited to the study, 170 patients (75.9%) had bacteremia. The median age of all patients was 63 years (IQR 53–73 years) and 52.7% were female. Approximately 80% of all patients had comorbid diseases. Diabetes mellitus (38.8%), cancer (18.8%) and heart disease (12.5%) were the three most common comorbidities. Skin and soft-tissue infection (30.8%), septic arthritis (21.4%), primary bacteremia (21%), and meningitis (7.1%) were the four most common presenting syndrome of iGBS diseases. Overall mortality within 30 days of infection was 12%. Non-survived patients were older, had chronic kidney disease, bacteremia, pneumonia and had at least one comorbidity than survived patients. However, only pneumonia was found independently associated with the 30-day overall mortality, with adjusted odd ratio (aOR) of 24.96 (95% confidence interval [CI]: 5.95–104.75). Antimicrobial susceptibility testing of 69 isolates demonstrated that 7 (10%) and 9 (13%) were resistant to erythromycin and clindamycin, respectively. All isolates remain susceptible to penicillin. Conclusion Invasive GBS is an emerging disease in non-pregnant adults particularly in elderly and diabetes mellitus patients. Two-thirds of iGBS patients have concomittant bacteremia. Even though the overall mortality was 12% but a significant morbidity was observed. Disclosures All authors: No reported disclosures.

scholarly journals Maternal Obesity and Rectovaginal Group B Streptococcus Colonization at Term

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Shelby M. Kleweis ◽  
Alison G. Cahill ◽  
Anthony O. Odibo ◽  
Methodius G. Tuuli
Keyword(s):  
Risk Factor ◽  
Maternal Obesity ◽  
Management Strategies ◽  
Group B Streptococcus ◽  
Significant Risk ◽  
Positive Culture ◽  
Significant Risk Factor ◽  
Entire Cohort ◽  
Group B ◽  
The Impact

Objective. To test the hypothesis that maternal obesity is an independent risk factor for rectovaginal group B streptococcus (GBS) colonization at term.Study Design. Retrospective cohort study of consecutive women with singleton term pregnancies admitted in labor at Barnes-Jewish Hospital (2004–2008). Maternal BMI ≥ 30 Kg/m2(obese) or <30 Kg/m2(nonobese) defined the two comparison groups. The outcome of interest was GBS colonization from a positive culture. Baseline characteristics were compared using Student’st-test and Chi-squared or Fisher’s exact test. The association between obesity and GBS colonization was assessed using univariable and multivariable analyses.Results. Of the 10,564 women eligible, 7,711 met inclusion criteria. The prevalence of GBS colonization in the entire cohort was relatively high (25.8%). Obese gravidas were significantly more likely to be colonized by GBS when compared with nonobese gravidas (28.4% versus 22.2%,P<0.001). Obese gravidas were still 35% more likely than nonobese women to test positive for GBS after adjusting for race, parity, smoking, and diabetes (adjusted OR 1.35 [95% CI 1.21–1.50]).Conclusion. Maternal obesity is a significant risk factor for GBS colonization at term. Further research is needed to evaluate the impact of this finding on risk-based management strategies.

scholarly journals Invasive group B Streptococcus among non-pregnant adults in Brussels-Capital Region, 2005–2019

2020 ◽  
Author(s):  
Elena Graux ◽  
Maya Hites ◽  
Delphine Martiny ◽  
Evelyne Maillart ◽  
Marc Delforge ◽  
...  
Keyword(s):  
Group B Streptococcus ◽  
Invasive Group ◽  
Capital Region ◽  
Group B

scholarly journals Group B Streptococcus Recto-Vaginal Colonization in Near-Term Pregnant Women, Southwest Ethiopia

2020 ◽  
Vol 30 (5) ◽  
Author(s):  
Woubishet Girma ◽  
Nadia Yimer ◽  
Tesfaye Kassa ◽  
Elias Yesuf
Keyword(s):  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
Susceptibility Testing ◽  
Group B Streptococcus ◽  
Susceptibility Pattern ◽  
Southwest Ethiopia ◽  
Vaginal Colonization ◽  
History Of ◽  
Near Term ◽  
Group B

BACKGROUND: Group B Streptococcus (GBS) is recognized as an important cause of maternal and neonatal morbidity and mortality. Maternal vaginal carriage of GBS (Streptococcus agalactiae) can lead to vertical transmission to the neonate at the time of delivery. However, little is known about its prevalence, predictors and antibiotic susceptibility pattern in Jimma, Ethiopia. This study assessed the prevalence, antimicrobial susceptibility pattern and determinants of GBS recto-vaginal colonization among near-term pregnant women.METHODS: A cross-sectional study was conducted from May to August 2015 at Jimma University Medical Centre in Southwest Ethiopia. Data through questionnaire and GBS isolates from vaginal and rectal swabs were collected. Antimicrobial susceptibility testing was performed.RESULTS: The overall prevalence of GBS colonization among near term pregnant women (35-37 weeks) was 16.3% (22/135). The majority of GBS isolates were sensitive to Ampicillin and Penicillin G with 95.5% and 90.1%, respectively. Erythromycin and clindamycin were resisted by 50% and 40.9% of the isolates, respectively, whereas gentamicin was resisted by all isolates. GBS colonization was significantly associated with a history of preterm delivery (PTD) (AOR: 6.3, 95% CI: 1.42, 28.3) and history of urinary tract infection (UTI) during current pregnancy (AOR: 6.4, 95% CI, 1.95, 21.1).CONCLUSION: Our study indicated that one among six near-term pregnant women had recto-vaginal GBS colonization. In places where universal screening is not feasible, selective screening for factors particularly history of PTD and UTI during current pregnancy may be a reasonable option. Antibiotic susceptibility testing should be performed while using Erythromycin, Clindamycin or Gentamicin. 

scholarly journals Molecular and phenotypic characterization of invasive group B streptococcus strains from infants in Norway 2006–2007

2009 ◽  
Vol 15 (12) ◽  
pp. 1182-1185 ◽  
Author(s):  
H. Bergseng ◽  
J.E. Afset ◽  
A. Radtke ◽  
K. Loeseth ◽  
R.V. Lyng ◽  
...  
Keyword(s):  
Group B Streptococcus ◽  
Phenotypic Characterization ◽  
Invasive Group ◽  
Group B

scholarly journals Temporal Changes in Invasive Group B Streptococcus Serotypes: Implications for Vaccine Development

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0169101 ◽  
Author(s):  
Ziyaad Dangor ◽  
Clare L. Cutland ◽  
Alane Izu ◽  
Gaurav Kwatra ◽  
Siobhan Trenor ◽  
...  
Keyword(s):  
Vaccine Development ◽  
Group B Streptococcus ◽  
Temporal Changes ◽  
Invasive Group ◽  
Group B

scholarly journals MLST Application in Analysis of Relationship between Group B Streptococcus Resistance Gene and Induction Resistance in Shanghai, China

2020 ◽  
Author(s):  
Jing Gao ◽  
Yisheng Chen ◽  
Yiqian Peng ◽  
Nanyan Jiang ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Resistance Genes ◽  
Susceptibility Testing ◽  
Group B Streptococcus ◽  
Public Health Problem ◽  
Resistance Ratio ◽  
Diffusion Method ◽  
Relative Distribution ◽  
Slow Development ◽  
Group B

Abstract Background With the gradual severe bacterial resistance and slow development of antibiotics, drug-resistant bacterial strains are widely distributed and have become a serious public health problem. Group B Streptococcus (GBS) which cause Group B strep-related disease is the major cause of severe infection in newborns. However, Clindamycin resistance of GBS induced by Erythromycin is emerging and become important clinical concerns today. Methods A retrospective study was conducted on the drug resistance analysis of GBS strains isolated from Obstetrics and Gynecology Hospital from Jan 2016 to Dec 2017. The clinical and microbiological data including patient demographics, antimicrobial susceptibility testing, relative distribution drug resistance-associated genes mefA & ermB to Erythromycin, and multilocus sequence typing (MLST typing) were collected and analyzed. The Kirby-Bauer and VITEK2-compact were used to perform the susceptibility testing. The double disk diffusion method (D-test) was used for the detection of inducible clindamycin resistance. MLST was employed to identify sequence types of these strains. Polymerase Chain Reaction (PCR) was conducted to detect the drug resistance genes mefA & ermB to Erythromycin. Results A total of 1021 strains were cultured and isolated from 31894 specimens. Erythromycin and clindamycin resistance was 53.6%（547/1021）and 50.1 % (512/1021), respectively, in which 74.4%（407/547）had harbored constitutive macrolide, lincosamide and streptogramin B resistance (cMLS B ), 45.0%（63/140）were inducible MLS B (iMLS B ). Additionally, MLST identified 12 different ST types including a new ST type ST1072 in 63 iMLS B GBS strains and the dominant STs were ST12 (30.1%) and ST19 (25.4%). The resistance ratio of ST19 to Levofloxacin (75.0%) was higher than that of other ST types. The relevance resistance ratio of mefA and ermB was respectively 27.0% and 41.3% among 63 GBS isolates. Conclusion Our study not only demonstrated a genetic diversity in iMLS B GBS in Shanghai through the analysis of MLST typing and resistance genes, but also found that there exist different distribution patterns of resistance and related resistance genes between different ST types. These findings would provide theoretical support for clinical prevention and treatment of resistant iMLS B GBS infection.

scholarly journals Prevalence of Group B Streptococcus Colonization in Pregnant Women in Jiangsu, East China

2019 ◽  
Author(s):  
Rui Wang ◽  
Hongmei Qiu ◽  
Ge Yanmei ◽  
Fei Pan ◽  
Shuhui Bian
Keyword(s):  
Pregnant Women ◽  
Antimicrobial Susceptibility ◽  
Neonatal Sepsis ◽  
Susceptibility Testing ◽  
Bacterial Culture ◽  
Group B Streptococcus ◽  
East China ◽  
Age Group ◽  
The Difference ◽  
Group B

Abstract Background : Group B streptococcus (GBS) is the leading cause of early-onset neonatal sepsis. This study assessed the prevalence of GBS colonization among pregnant women in Jiangsu, East China. Methods: A total of 16,184 pregnant women at 34 to 37 weeks , gestation aged 16–47 years were recruited from Nanjing Kingmed Diagnostics, including 9022 pregnant women who received GBS screening by PCR detection and 7162 by bacterial culture, antimicrobial susceptibility testing was performed on GBS positive samples. Results: The overall GBS prevalence was 8.7% for pregnant women studied by PCR and 3.5% by culture. The 25-29 age group had the highest rate of GBS colonization in the pregnant women. The prevalence of resistance to erythromycin, clindamycin and levofloxacin was 77.5%, 68.3% and 52.2%, respectively. Conclusions: This study revealed the prevalence characteristics of GBS in pregnant women and the difference of GBS colonization between culture and PCR in Jiangsu province.

scholarly journals Invasive Group B Streptococcal Infection with Toxic Shock-Like Syndrome in a Postsplenectomy Patient

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Pradeep Kumar Mada ◽  
Gabriel Castano ◽  
Andrew Stevenson Joel Chandranesan
Keyword(s):  
Diabetes Mellitus ◽  
Streptococcal Infection ◽  
Toxic Shock ◽  
Invasive Group ◽  
Streptococcal Disease ◽  
Control And Prevention ◽  
History Of ◽  
Group B Streptococcal Disease ◽  
Group B ◽  
Underlying Risk

The incidence of invasive group B streptococcal disease (GBS) in nonpregnant population is increasing. As per the Centers for Disease Control and Prevention (CDC), there are 10 cases in every 100,000 nonpregnant adults each year, and 1 in 20 nonpregnant adults with serious GBS infections die. GBS infection is almost always associated with underlying risk factors such as diabetes mellitus or malignancy. We present a 47-year-old female with a remote history of splenectomy presented with toxic shock-like syndrome secondary to invasive GBS infection.

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