Plato’s Objects-Based Epistemology

2021 ◽  
pp. 50-85
Author(s):  
Jessica Moss
Keyword(s):  

When we read Plato’s epistemology—both the Republic’s powers argument and other texts—without in any way trying to avoid a Distinct Objects interpretation, we find ample evidence not only for that interpretation, but also for a stronger one. First, cognitive powers and their accomplishments are individuated by their objects. Second, cognitive powers and their accomplishments are defined by their objects: it is the objects that make them what they are (section 2). Finally, cognitive accomplishments—understood as occurrent cognitions—inherit their character from their objects: cognition works on the principle Aristotle calls “like-by-like.” Thus Plato’s epistemology is thoroughly objects-based. Epistêmê is, in essence, the kind of thing one can have only in relation to a special kind of object; doxa is, in its essence, the kind of thing one can have only in relation to a different special kind of object

Author(s):  
Petra Jahn ◽  
Johannes Engelkamp

There is ample evidence that memory for action phrases such as “open the bottle” is better in subject-performed tasks (SPTs), i.e., if the participants perform the actions, than in verbal tasks (VTs), if they only read the phrases or listen to them. It is less clear whether also the sole intention to perform the actions later, i.e., a prospective memory task (PT), improves memory compared with VTs. Inconsistent findings have been reported for within-subjects and between-subjects designs. The present study attempts to clarify the situation. In three experiments, better recall for SPTs than for PTs and for PTs than for VTs were observed if mixed lists were used. If pure lists were used, there was a PT effect but no SPT over PT advantage. The findings were discussed from the perspective of item-specific and relational information.


2006 ◽  
Vol 27 (3) ◽  
pp. 172-182 ◽  
Author(s):  
Y. Hamama-Raz ◽  
Z. Solomon

The study examines the contributions of hardiness, attachment style, and cognitive appraisal to the psychological adjustment of 300 survivors of malignant melanoma: The findings show that the survivors' adjustment is by far better predicted by their personal resources and cognitive appraisal than by their sociodemographic features (with the exception of marital status) and features of their illness. Of all the variables, their adjustment was best predicted by their attachment style, with secure attachment making for greater well-being and less distress. These findings add to the ample evidence that personal resources help persons to cope with stressful or traumatic events.


2019 ◽  
pp. 53-65
Author(s):  
Renata Domingos ◽  
Emeli Guarda ◽  
Elaise Gabriel ◽  
João Sanches

In the last decades, many studies have shown ample evidence that the existence of trees and vegetation around buildings can contribute to reduce the demand for energy by cooling and heating. The use of green areas in the urban environment as an effective strategy in reducing the cooling load of buildings has attracted much attention, though there is a lack of quantitative actions to apply the general idea to a specific building or location. Due to the large-scale construction of high buildings, large amounts of solar radiation are reflected and stored in the canyons of the streets. This causes higher air temperature and surface temperature in city areas compared to the rural environment and, consequently, deteriorates the urban heat island effect. The constant high temperatures lead to more air conditioning demand time, which results in a significant increase in building energy consumption. In general, the shade of the trees reduces the building energy demand for air conditioning, reducing solar radiation on the walls and roofs. The increase of urban green spaces has been extensively accepted as effective in mitigating the effects of heat island and reducing energy use in buildings. However, by influencing temperatures, especially extreme, it is likely that trees also affect human health, an important economic variable of interest. Since human behavior has a major influence on maintaining environmental quality, today's urban problems such as air and water pollution, floods, excessive noise, cause serious damage to the physical and mental health of the population. By minimizing these problems, vegetation (especially trees) is generally known to provide a range of ecosystem services such as rainwater reduction, air pollution mitigation, noise reduction, etc. This study focuses on the functions of temperature regulation, improvement of external thermal comfort and cooling energy reduction, so it aims to evaluate the influence of trees on the energy consumption of a house in the mid-western Brazil, located at latitude 15 ° S, in the center of South America. The methodology adopted was computer simulation, analyzing two scenarios that deal with issues such as the influence of vegetation and tree shade on the energy consumption of a building. In this way, the methodological procedures were divided into three stages: climatic contextualization of the study region; definition of a basic dwelling, of the thermophysical properties; computational simulation for quantification of energy consumption for the four facade orientations. The results show that the façades orientated to north, east and south, without the insertion of arboreal shading, obtained higher values of annual energy consumption. With the adoption of shading, the facades obtained a consumption reduction of around 7,4%. It is concluded that shading vegetation can bring significant climatic contribution to the interior of built environments and, consequently, reduction in energy consumption, promoting improvements in the thermal comfort conditions of users.


2010 ◽  
pp. 439-450
Author(s):  
Marta Janczewska

Research team of physicians and lab technicians under Izrael Milejkowski’s direction undertook the effort to carry out a series of clinical and biochemical experiments on patients dying of starvation in the Warsaw ghetto so as to receive the fullest possible picture of hunger disease. The research was carried out according to all the rigors of strict scientific discipline, and the authors during their work on academic articles, published it after the war entitled: „Starvation disease: hunger research carried out in the Warsaw ghetto in 1942,” according to their own words, they “supplemented the gap in accordance with the progress of knowledge.” The article is devoted to the reflections over ethical dilemmas of the research team, who were forced in their work to perform numerous medical treatments of experimental nature on extremely exhausted patients. The ill, according to Dr Fajgenblat’s words,“demonstrated negativism toward the research and treatment, which extremely hindered the work, and sometimes even frustrated it.” The article attempts to look at the monumental research work of the Warsaw ghetto doctors as a special kind of response of the medical profession to the feeling of helplessness to the dying patients. The article analyzes the situation of Warsaw ghetto doctors, who undertook the research without support of any outer authority, which could settle their possible ethical dilemmas (Polish deontological codes, European discussions on the conditions of the admissibility of medical research on patients, etc.).


2002 ◽  
Vol 4 (1) ◽  
pp. 31-43
Author(s):  
Sophie de Mijolla-Mellor

This paper deals with the evolution of the psychoanalytic practice with psychotic patients beginning with Freud's scepticism about the transference capacities of those patients to a new definition of a special kind of psychotic transference. The main hypothesis is that the actual case of psychotics within a psychoanalytic cure has modified the psychoanalytic method itself, even in the field of neuroses. Within the framework and, more specifically, in the case of schizophrenics, this paper develops some reflections on the evolution of the three following concepts: transference/countertransference, communication and interpretation, and reality.


Fachsprache ◽  
2019 ◽  
Vol 41 (S1) ◽  
pp. 87-100
Author(s):  
Wenke Mückel

Metaphorical elements are a highly productive language means in live reports about sport events on TV. They occur in different relations to what is simultaneously seen on screen and depend on the reporter as well as on the special kind of sport. But nevertheless, general structures and functions of metaphors in those medium-bound oral texts can be indicated; as one of the markers they contribute to what is often called language of sport or maybe rather communicative template of sport. Examples taken from TV reports of the European Football Championship and the Olympic Games (both took place in 2016) are used to illustrate this character of metaphorical expressions in sport reports on TV.


Author(s):  
Katie Demakopoulou ◽  
Nicoletta Divari-Valakou ◽  
Monica Nilsson ◽  
Ann-Louise Schallin

Excavations in Midea continued in 2007 as a Greek-Swedish programme under the direction of Dr Katie Demakopoulou in collaboration with Dr Ann-Louise Schallin. In the West Gate area excavation continued in the west part of the building complex that abuts the fortification wall. Room XIV was excavated with abundant remains of LH IIIB2 pottery. A sealstone with a unique, possibly ritual, scene was also found. On the lower west terrace of the acropolis excavation continued in Trench C, where a large section of the fortification wall was uncovered. Room I was excavated here, adjacent to the inner face of the fortification wall. Finds in this room date to the early phase of LH IIIC, under which there was ample evidence of the LH IIIB2 destruction, including human skeletons. Under this debris, a large opening leading to a gallery or syrinx through the thickness of the fortification wall was found. Excavation was resumed also in the East Gate area, where a new wall was revealed in the baulk between Trench 3 and Room 9. The wall is perpendicular to the citadel wall and borders Trench 3. Excavation was also resumed in Trenches 9 and 14. The latest Mycenaean material in this area dates to LH IIIB2, but there is evidence of post-Bronze Age activity, which is demonstrated mainly by pottery finds.


2018 ◽  
Vol 23 (46) ◽  
pp. 7027-7039 ◽  
Author(s):  
Georgia Vogiatzi ◽  
Evangelos Oikonomou ◽  
Gerasimos Siasos ◽  
Sotiris Tsalamandris ◽  
Alexandros Briasoulis ◽  
...  

Background: Chronic inflammation and immune system activation underlie a variety of seemingly unrelated cardiac conditions including not only atherosclerosis and the subsequent coronary artery disease but also peripheral artery disease, hypertension with target organ damage and heart failure. The beneficial effects of HMG-CoA reductase inhibitors or statins are mainly attributed to their ability to inhibit hepatic cholesterol biosynthesis. Beyond their lipid lowering activity, ample evidence exists in support of their potent anti-inflammatory properties which initiate from the inhibition of GTPase isoprenylation, activating a cataract of secondary pathways and extend to the inhibition and blocking of immune cell activation and interaction. </P><P> Objective: To summarize the anti-inflammatory mechanisms of statins in clinical and experimental settings in cardiovascular disease. </P><P> Methods: A systematic search of PubMed and the Cochrane Database was conducted in order to identify the majority of trials, studies, current guidelines and novel articles related to the subject. </P><P> Results: In vitro, statins have immuno-modulatory and anti-inflammatory effects, and they can exert antiatherosclerotic effects independently of their hypolipidemic actions. In addition, positive results have emerged from mechanistic and experimental studies on the active role of HMG-CoA reductase inhibitors in HF. By extrapolating those data in clinical setting, we further understand how HMG-CoA reductase inhibitors can beneficially affect not only systolic but also diastolic HF. </P><P> Conclusion: In this review article, we present the basic pathophysiologic data supporting the anti-inflammatory actions of statins in clinical and experimental settings and we link these mechanisms with confirmatory clinical data on the potent non lipid lowering effects of HMG-CoA reductase inhibitors.


2020 ◽  
Vol 23 (8) ◽  
pp. 814-826
Author(s):  
Pradeep Hanumanthappa ◽  
Arpitha Ashok ◽  
Inderjit Prakash ◽  
Carmel I. Priya ◽  
Julie Zinzala ◽  
...  

Background: Parkinson’s disease ranks second, after Alzheimer’s as the major neurodegenerative disorder, for which no cure or disease-modifying therapies exist. Ample evidence indicate that PD manifests as a result of impaired anti-oxidative machinery leading to neuronal death wherein Cullin-3 has ascended as a potential therapeutic target for diseases involving damaged anti-oxidative machinery. Objective: The design of target specific inhibitors for the Cullin-3 protein might be a promising strategy to increase the Nrf2 levels and to decrease the possibility of “off-target” toxic properties. Methods: In the present study, an integrated computational and wet lab approach was adopted to identify small molecule inhibitors for Cullin-3. The rational drug designing process comprised homology modeling and derivation of the pharmacophore for Cullin-3, virtual screening of Zinc natural compound database, molecular docking and Molecular dynamics based screening of ligand molecules. In vivo validations of an identified lead compound were conducted in the PD model of C. elegans. Results and Discussion: Our strategy yielded a potential inhibitor; (Glide score = -12.31), which was evaluated for its neuroprotective efficacy in the PD model of C. elegans. The inhibitor was able to efficiently defend against neuronal death in PD model of C. elegans and the neuroprotective effects were attributed to its anti-oxidant activities, supported by the increase in superoxide dismutase, catalase and the diminution of acetylcholinesterase and reactive oxygen species levels. In addition, the Cullin-3 inhibitor significantly restored the behavioral deficits in the transgenic C. elegans. Conclusion: Taken together, these findings highlight the potential utility of Cullin-3 inhibition to block the persistent neuronal death in PD. Further studies focusing on Cullin-3 and its mechanism of action would be interesting.


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