Genetic Principles

1993 ◽  
Keyword(s):  
Family Relationships ◽  
Raw Materials ◽  
Critical Role ◽  
Cell Formation ◽  
Building Blocks ◽  
Marrow Transplant ◽  
Basic Unit ◽  
Mixed Cell ◽  
The Law ◽  
Simple Carbohydrates

Genetics is the study of heredity. Each individual’s makeup, or phenotype, is determined by nature and modified by environmental factors. DNA identity analysis is based strictly on heredity, and only in the rare case where a human had a bone marrow transplant would the white blood cell genotype differ from that inherited. Difficulties can arise with specimens because of DNA degradation or contamination by extraneous materials, and mixed cell populations could be present in tumorous tissue. The analyst must always be cognizant of these complicating factors. The concept of the gene was advanced by the Moravian monk Gregor Mendel in 1865 based on observations he made after crossing different varieties of garden peas; these experiments are considered the beginning of the discipline of genetics. (The term gene was actually coined by the Danish plant scientist W. Johannsen in the early 1900s.) Mendel formulated two laws. The law of segregation or separation states that two members of each gene pair (alleles) in a diploid organism separate to different gametes during sex cell formation. The law of independent assortment states that members of different pairs of alleles, if located on separate chromosomes or far apart on the same homologous chromosome pair, assort independently into gametes. These laws are basic to the understanding of biological family relationships and play a critical role in such contemporary issues as paternity testing and immigration disputes. The basic unit of life is the cell. Cells are microfactories in which raw materials (amino acids, simple carbohydrates, lipids, and trace elements) are received, new substances (proteins, complex lipids, carbohydrates, and nucleic acids) are produced, and wastes are removed. The thousands of different enzymes required for the myriad ongoing chemical reactions are key to the efficient functioning of cells. Each cell has the ability to self-replicate using the deoxyribonucleic acid (DNA) code as the blueprint, raw materials as building blocks, and enzymes as catalysts. It has been estimated that the average human being is composed of approximately 100 trillion cells—a considerable amount of DNA.

Nutritional Value Research of Spelt Pasta with Vegetable Additives

Food Industry ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 61-70
Author(s):  
Oliya Fazullina ◽  
Stanislav Smirnov
Keyword(s):  
Dietary Fiber ◽  
Nutritional Value ◽  
Raw Materials ◽  
Health Indicators ◽  
Dietary Treatment ◽  
Raw Material ◽  
Whole Wheat ◽  
Healthy Nutrition ◽  
Physiologically Active Substances ◽  
Simple Carbohydrates

Health indicators of the population depend significantly on the food quality and nutritional value. Simple carbohydrates excess of and lack of protein, dietary fiber, vitamins, minerals, antioxidants and other physiologically active substances increase the risk of socially significant disease progress. The development and production of mass-consumed products with high nutritional and biological value, including affordable non-traditional raw materials use, are promising areas of the food industry development aimed at improving the nutritional status of the population. The article presents the research results on the developed Noodle products recipes from non-traditional raw materials that meet modern healthy nutrition requirements, intended for dietary treatment and dietary prevention of people with overweight / obesity. The research aimed at expanding the range of macaroni products with these characteristics. As the main raw material, a man selected whole-wheat flour – new spelt flour, and as additional raw materials – buckwheat flour, broccoli and celery powders. The researchers found that the introduction of macaroni products from buckwheat spelt, broccoli and celery powders into the recipe had a multidirectional effect, reducing or increasing various indicators of its nutritional value. The changes range did not affect the overall characteristics. The satisfaction degree of the average daily need for food substances and energy when consuming a portion of 100 g for each sample of developed Noodle products allows them to be classified as functional products that are protein and dietary fiber sources, according to the requirements of the TR CU 022/2011.

scholarly journals Wine By-Products as Raw Materials for the Production of Biopolymers and of Natural Reinforcing Fillers: A Critical Review

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 381
Author(s):  
Alessandro Nanni ◽  
Mariafederica Parisi ◽  
Martino Colonna
Keyword(s):  
Critical Review ◽  
Raw Materials ◽  
Green Revolution ◽  
Building Blocks ◽  
Poly Lactic Acid ◽  
Butylene Succinate ◽  
Reinforcing Fillers ◽  
Plastic Industry ◽  
Review Reports ◽  
By Products

The plastic industry is today facing a green revolution; however, biopolymers, produced in low amounts, expensive, and food competitive do not represent an efficient solution. The use of wine waste as second-generation feedstock for the synthesis of polymer building blocks or as reinforcing fillers could represent a solution to reduce biopolymer costs and to boost the biopolymer presence in the market. The present critical review reports the state of the art of the scientific studies concerning the use of wine by-products as substrate for the synthesis of polymer building blocks and as reinforcing fillers for polymers. The review has been mainly focused on the most used bio-based and biodegradable polymers present in the market (i.e., poly(lactic acid), poly(butylene succinate), and poly(hydroxyalkanoates)). The results present in the literature have been reviewed and elaborated in order to suggest new possibilities of development based on the chemical and physical characteristics of wine by-products.

scholarly journals Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections

2012 ◽  
Vol 11 (6) ◽  
pp. 820-826 ◽  
Author(s):  
Laura H. Okagaki ◽  
Kirsten Nielsen
Keyword(s):  
Cryptococcus Neoformans ◽  
Critical Role ◽  
Cell Formation ◽  
Pulmonary Cryptococcosis ◽  
Content Type ◽  
Cell Production ◽  
Human Fungal Pathogen ◽  
Large Size ◽  
Large Particles ◽  
The Relationship

ABSTRACTThe human fungal pathogenCryptococcus neoformansproduces an enlarged “titan” cell morphology when exposed to the host pulmonary environment. Titan cells exhibit traits that promote survival in the host. Previous studies showed that titan cells are not phagocytosed and that increased titan cell production in the lungs results in reduced phagocytosis of cryptococcal cells by host immune cells. Here, the effect of titan cell production on host-pathogen interactions during early stages of pulmonary cryptococcosis was explored. The relationship between titan cell production and phagocytosis was found to be nonlinear; moderate increases in titan cell production resulted in profound decreases in phagocytosis, with significant differences occurring within the first 24 h of the infection. Not only were titan cells themselves protected from phagocytosis, but titan cell formation also conferred protection from phagocytosis to normal-size cryptococcal cells. Large particles introduced into the lungs were not phagocytosed, suggesting the large size of titan cells protects against phagocytosis. The presence of large particles was unable to protect smaller particles from phagocytosis, revealing that titan cell size alone is not sufficient to provide the observed cross-protection of normal-size cryptococcal cells. These data suggest that titan cells play a critical role in establishment of the pulmonary infection by promoting the survival of the entire population of cryptococcal cells.

scholarly journals Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

Blood ◽  
2006 ◽  
Vol 107 (6) ◽  
pp. 2453-2460 ◽  
Author(s):  
Önder Alpdogan ◽  
Vanessa M. Hubbard ◽  
Odette M. Smith ◽  
Neel Patel ◽  
Sydney Lu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Critical Role ◽  
T Cell Development ◽  
Marrow Transplant ◽  
Cell Development ◽  
Allogeneic Bone ◽  
Thymic Regeneration

AbstractKeratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with KGF-/- mice and demonstrated that thymic cellularity and the distribution of thymocyte subsets among KGF-/-, wildtype (WT), and KGF+/- mice were similar. However, KGF-/- mice are more vulnerable to sublethal irradiation (450 cGy), and a significant decrease was found in thymic cellularity after irradiation. Defective thymopoiesis and peripheral T-cell reconstitution were found in KGF-/- recipients of syngeneic or allogeneic bone marrow transplant, but using KGF-/- mice as a donor did not affect T-cell development after transplantation. Despite causing an early developmental block in the thymus, administration of KGF to young and old mice enhanced thymopoiesis. Exogenous KGF also accelerated thymic recovery after irradiation, cyclophosphamide, and dexamethasone treatment. Finally, we found that administering KGF before bone marrow transplantation (BMT) resulted in enhanced thymopoiesis and peripheral T-cell numbers in middle-aged recipients of an allogeneic BM transplant. We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions. (Blood. 2006;107:2453-2460)

scholarly journals Konsep Talak Menurut Ibnu Qayyim Al-Jauziyyah (Analisis Waktu Dan Jumlah Penjatuhan Talak)

2020 ◽  
Vol 20 (1) ◽  
pp. 95
Author(s):  
Jamhuri Jamhuri ◽  
Zuhra Zuhra
Keyword(s):  
Family Relationships ◽  
Islamic Law ◽  
Descriptive Analysis ◽  
Foster Family ◽  
History Of ◽  
The Law ◽  
The Right

Talak merupakan hukum yang disyariatkan bagi satu pasangan yang tidak mungkin lagi membina hubungan keluarga dengan baik. Peluang talak ini dapat dipilih oleh suami dengan memperhatikan tata cara dan prosedur yang sesuai dengan hukum Islam. Terdapat beberapa hukum yang ulama tidak padu dan berbeda pendapat, khususnya mengenai konsep talak dilihat dari sisi waktu dan jumlah penjatuhannya. Penelitian ini henda mengkaji pendapat Ibn Qayyim. Masalah yang didalami adalah bagaimana pandangan Ibnu Qayyim al-Jauziyyah terhadap konsep dan pengaruh hukum talak syar’i dilihat dari segi waktu dan jumlah penjatuhan talak, dan bagaimana metode istinbaṭ yang ia gunakan. Penelitian ini termasuk penelitian pustaka, data yang terkumpul dianalisis dengan cara analisis-deskriptif. Hasil penelitian menunjukkan bahwa menurut Ibn Qayyim al-Jauziyyah, konsep talak secara umum ada dua bentuk, yaitu talak dari segi waktu dan dari segi jumlah. Dari segi waktu, talak dilakukan saat isteri suci dan tidak digauli saat suci tersebut. Pengaruh suami yang menceraikan isteri saat haid dan telah digauli, itu diharamkan dan talak tidak jatuh. Dari segi jumlah, hak talak suami hanya ada tiga. Tiga jumlah hak talak tersebut digunakan secara bertahap, tidak bisa digunakan sekaligus. Pengaruh suami yang menceraikan isteri dengan talak dua atau tiga sekaligus, talak yang jatuh hanya dipandang satu kali. Adapun dalil yang digunakan Ibn Qayyim yaitu QS. al-Ṭalāq ayat 1, QS. al-Baqarah ayat 229, QS. al-Baqarah ayat 230, dan QS. al-Nūr ayat 6. Adapun riwayat hadis di antaranya hadis dari Nafi’ riwayat Abī Dāwud, dari Sa’di bin Ibrahim riwayat Muslim, dari Abdullah bin Ali bin Sa’ib riwayat Abī Dāwud, dan dari Ibn Wahab riwayat HR. Nasā’i. Metode yang digunakan Ibn Qayyim yaitu bayanī dan metode istiṣlāḥī. Talak is a law prescribed to one spouse that is no longer likely to foster family relationships well. The chance of this Talak can be chosen by the husband taking into account the ordinances and procedures according to Islamic law. There are some laws that scholars do not mix and differ, especially regarding the concept of Talak seen from the time and number of the allotment. This study has studied Ibn Qayyim's opinion. The issue in the matter is how Ibn Qayyim al-Jauziyyah's view of the concept and influence of the law is seen in terms of time and the number of a bailout, and how the Istinbaṭ method he used. This research includes the research of libraries, the collected data is analyzed in a descriptive-analysis way. The results showed that according to Ibn Qayyim al-Jauziyyah, the concept of Talak, in general, there are two forms, namely Talak in terms of time and in terms of number. In terms of time, the Talak was performed during the Holy Wife and not in the holy moment. The influence of the husband who divorced the wife during menstruation and has been held, it is haraam and the Talak does not fall. In terms of numbers, the right to the husband is only three. The three total rights of the Board are used gradually, not to be used at once. The influence of the husband who divorced the wife with a two or three talak at once, a talak that fell only considered one time. The evidence that Ibn Qayyim used is QS.  al-Ṭalāq verse 1,  Qs. Al-Baqarah verses 229,  Qs. Al-Baqarah verses 230, and  Qs. Al-Nūr verse 6. The history of Hadith includes hadith from  Nafi ' History of Abī Dāwud,  from Sa'di bin Ibrahim  Muslim history, from Abdullah bin Ali bin Sa'ib  abī dāwud history, and Ibn Wahab narrated by the history of the Christian. The method used Ibn Qayyim was bayanī and the method Istiṣlāḥī. 

Development of New Geopolymer-Based System for Challenging Well Conditions

2021 ◽  
Author(s):  
Siti Humairah Abd Rahman ◽  
Anatoly Medvedev ◽  
Andrey Yakovlev ◽  
Yon Azwa Sazali ◽  
Bipin Jain ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Fly Ash ◽  
Construction Industry ◽  
Raw Materials ◽  
Critical Role ◽  
Acid Resistance ◽  
Oil Industry ◽  
Rapid Screening ◽  
Fluid Loss ◽  
Screening Methods

Abstract With the development of new oil formations and with the advent of new directions in the global energy sector, new requirements for materials for well construction appear. With the close attention to environmental footprint and unique properties, one of the promising materials for well cementing is geopolymers. Being a relatively new material, they are characterized by low carbon footprint, high acid resistance and attractive mechanical properties. This article is aimed at developing new geopolymer slurries for the oil industry, their characterization and field implementation analysis. With the ultimate goal of developing a methodology for the analysis of raw materials and designing the geopolymer slurries, studies were carried out on various raw materials, including different types of fly ash. Based on the data obtained and rapid screening methods, an approach was developed to formulate a geopolymer composition recipe. Since not all cement additives directly work in geopolymers, special attention was paid to control the thickening time and fluid loss. The methods of XRD, XRF, ICP-MS, density, particle size distribution measurements as well as API methods of cement testing were used to understand the composition and structure of the materials obtained, their properties and design limitations. A special approach was applied to study the acid resistance of the materials obtained and to compare with conventional cements and slags. Using one of the most common sources of aluminosilicate, fly ash, formulations with a density of 13.5 – 16.5 lbm/galUS were tested. A sensitivity analysis showed that the type of activator and its composition play a critical role both in the mechanical properties of the final product and in the solidification time and rheological properties of the product. The use of several samples of fly ash, significantly different in composition, made it possible to formulate the basic rules for the design of geopolymers for the oil industry. An analysis was also carried out on 10 different agents for filtration and 7 moderators to find a working formulation for the temperature range up to 100°C. The samples were systematically examined for changes in composition, strength, and acid resistance was previously measured. Despite the emergence of examples of the use of geopolymers in the construction industry and examples of laboratory testing of geopolymers for the oil industry, to the best of our knowledge, there has been no evidence of pumping geopolymers into a well. Our work is an attempt to develop an adaptation of the construction industry knowledge to the unique high pressure, high temperature conditions of the oil and gas industry. The ambitions of this work go far beyond the laboratory tests and involve yard test experiments.

Introduction

2019 ◽  
pp. 1-10
Author(s):  
Carlton F.W. Larson
Keyword(s):  
Eighteenth Century ◽  
Detailed Analysis ◽  
American Revolution ◽  
Critical Role ◽  
Central Issue ◽  
Declaration Of Independence ◽  
The Law

The Introduction opens with a vignette of James Wilson, prominent attorney and signer of the Declaration of Independence, fighting for his life against members of the Philadelphia militia in the “Fort Wilson” incident of 1779. It then turns to the primary themes of the book: treason and juries. Treason was a central issue of the American Revolution, shaping the early debates over the legality of British actions, the treatment of British adherents, and eventually the suppression of internal rebellions. Juries played a critical role in this process, and this book provides the most detailed analysis of eighteenth-century American jurors yet written. The book focuses on Pennsylvania, as this was the most critical jurisdiction for the law of treason.

Commerce, Labor, and Taxation

2019 ◽  
pp. 513-550
Author(s):  
Lawrence M. Friedman
Keyword(s):  
Nineteenth Century ◽  
Building Blocks ◽  
Contract Law ◽  
Legal Study ◽  
Tax Laws ◽  
American Law ◽  
Federal Taxation ◽  
The Law ◽  
State And Local ◽  
Death Taxes

This chapter discusses the development of commerce, labor, and tax laws in the second half of the nineteenth century. It covers contracts, negotiable instruments, the law of sales, usury laws, insurance, bankruptcy, admiralty, labor and law, federal taxation, state and local tax, and death taxes. The law of contract occupies a special place in American law in the nineteenth century. The dominance of contract was one of the sovereign notions of the nineteenth century. By constitutional mandate, no state could “impair” the obligation of contracts. Contract law was also one of the basic building blocks of legal study.

scholarly journals Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes

2011 ◽  
Vol 83 (12) ◽  
pp. 2153-2169 ◽  
Author(s):  
Bozhi Tian ◽  
Charles M. Lieber
Keyword(s):  
Critical Role ◽  
Physical Property ◽  
Building Blocks ◽  
Materials Synthesis ◽  
Design Synthesis ◽  
Unique System ◽  
Challenges And Opportunities ◽  
Iterative Control ◽  
Novel Applications

Semiconductor nanowires (NWs) represent a unique system for exploring phenomena at the nanoscale and are expected to play a critical role in future electronic, optoelectronic, and miniaturized biomedical devices. Modulation of the composition and geometry of nanostructures during growth could encode information or function, and realize novel applications beyond the conventional lithographical limits. This review focuses on the fundamental science aspects of the bottom-up paradigm, which are synthesis and physical property characterization of semiconductor NWs and NW heterostructures, as well as proof-of-concept device concept demonstrations, including solar energy conversion and intracellular probes. A new NW materials synthesis is discussed and, in particular, a new “nano-tectonic” approach is introduced that provides iterative control over the NW nucleation and growth for constructing 2D kinked NW superstructures. The use of radial and axial p-type/intrinsic/n-type (p-i-n) silicon NW (Si-NW) building blocks for solar cells and nanoscale power source applications is then discussed. The critical benefits of such structures and recent results are described and critically analyzed, together with some of the diverse challenges and opportunities in the near future. Finally, results are presented on several new directions, which have recently been exploited in interfacing biological systems with NW devices.

scholarly journals Synthesis of Bifunctional Molecules for the Production of Polymers Based on Unsaturated Fatty Acids as Bioderived Raw Materials

2020 ◽  
Vol 1 (3) ◽  
pp. 275-289
Author(s):  
Alessa Hinzmann ◽  
Selina Sophie Druhmann ◽  
Harald Gröger
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Carboxylic Acids ◽  
Unsaturated Fatty Acids ◽  
Raw Materials ◽  
Building Blocks ◽  
Product Formation ◽  
Bifunctional Molecules ◽  
Biorenewable Resources ◽  
Aldoxime Dehydratase

Currently, investigations of polymer-building blocks made from biorenewable feedstocks such as, for example, fatty acids, are of high interest for the chemical industry. An alternative synthesis of nitrile-substituted aliphatic carboxylic acids as precursors for ω-amino acids, which are useful to produce polymers, was investigated starting from biorenewable fatty acids. By hydroformylation of unsaturated fatty acids or unsaturated acids being accessible from unsaturated fatty acids by cross-metathesis reactions, aldehydes are formed. In this work, the hydroformylation of such unsaturated acids led to the formation of the corresponding aldehydes, which were afterwards converted with hydroxylamine to aldoximes. Subsequent dehydration by an aldoxime dehydratase as a biocatalyst or by CuII acetate led to the desired nitriles. Within this work, C7-, C9- and C11-carboxylic acids with a terminal nitrile functionality as well as a branched nitrile-functionalized stearate derivative were synthesized by means of this approach. As these nitriles serve as precursors for amino acids being suitable for polymerization, this work represents an alternative synthetic access to polyamide precursors, which starts directly from unsaturated fatty acids as biorenewable resources and avoids harsh reaction conditions as well as and by-product formation.

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