A comparative Study Between Needling and Homologous Autoimplantation Techniques in Treatment of Multiple Plantar Warts

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Nermeen Samy Abdel Fattah ◽  
Rania Mahmoud Elhusseiny ◽  
Aml Magdy Darahem
Keyword(s):  
Treatment Response ◽  
De Novo ◽  
Response To Treatment ◽  
Clinical Appearance ◽  
Skin Contact ◽  
Common Warts ◽  
Significant Difference ◽  
Assess Treatment Response ◽  
Skin To Skin ◽  
Plantar Warts

Abstract Background Warts are a common dermatologic complaint resulting from infection with HPV which spread by direct skin-to-skin contact or by autoinoculation. The clinical appearance of warts is variable depends on the type of HPV involved and the site of infection. There are various types of viral warts including common warts, plantar warts, plane warts and genital warts, usually diagnosis of warts is made through clinical examination of the lesions and no laboratory investigations are required. Objective To compare between the therapeutic efficacy and safety of needling versus homologous autoimplantation techniques in treatment of multiple plantar warts and assess their recurrence rate. Patients and Methods Our study included 40 patients with multiple de novo planter warts(3 -10 warts) of (>1 and <3 years duration) divided into 2 groups, 20 patients per group, one group subjected to autoimplantation of wart tissue and the other subjected to needling procedure. Follow up of studied patients was assessed by physician after 2,8 and 12 weeks of procedure through clinical and dermoscopic examination to assess treatment response and after 16 weeks to assess recurrence Results Results of our study reported that there was high statistically significant difference between the 2 studied groups as regard response to treatment after 12 weeks being higher among autoimplantation group (p = 0.001). Moreover, there were no significant relations between treatment response of both patient groups and each of gender, age of patients, number of warts and duration of lesions. Conclusion Autoimplantation technique is more effective and less painful than needling procedure in treatment of multiple plantar warts (both manipulated and remote warts). No significant relations were found between treatment response of either techniques and demographic or clinical characteristics of studied patients.

scholarly journals Lupus Nephritis: Role of Serum Complement Levels as Prognostic Marker

2020 ◽  
Vol 6 (1) ◽  
pp. 01-05
Author(s):  
Richmond Gomes
Keyword(s):  
Lupus Nephritis ◽  
Treatment Response ◽  
Lupus Erythematosus ◽  
Serum Complement ◽  
Class Iii ◽  
Proliferative Lupus Nephritis ◽  
Significant Difference ◽  
Before And After ◽  
Assess Treatment Response ◽  
Serological Biomarkers

Background: Lupus Nephritis (LN) is one of the most common and serious manifestations in Systemic Lupus Erythematosus (SLE) patients that causes significant morbidity and mortality. Certain biomarkers for LN are sometimes able to assess treatment response of lupus nephritis. Objective: To compare serum complement levels (C3 & C4) as markers of treatment response of LN and their relation to the LN class in renal biopsy. Methods: This prospective observational study was conducted in the Department of Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2018 to August 2019. Twenty seven patients who were diagnosed with lupus nephritis after kidney biopsy were included in this study. Serum complement levels (C3 & C4), 24 hours urinary total protein (24-hr UTP) and anti-double-stranded DNA (anti-ds DNA) were measured in all patients at baseline, 3 months and 6 months after treatment. These biomarker values before and after treatment were compared between the treatment response and non response groups. Results: Serum C3 levels were significantly different in patients of proliferative lupus nephritis (Class III & Class IV) than non proliferative lupus nephritis (Class V) at baseline (0.47 ± 0.32 vs0.89 ± 0.43g/l, p = 0.009) and levels changed significantly 6 months after treatment (p <0.001) and likewise for Serum C4 levels (0.10 ± 0.06 vs0.24 ± 0.26g/l, p = 0.040). Serum C3 levels were also found to correlate significantly with SLEDAI and renal SLEDAI. No significant difference was observed for 24-hr UTP levels at baseline between remission and non-remission groups. Conclusion: Serum C3 & C4 levels may be utilized as serological biomarkers to predict and monitor the treatment response of lupus nephritis.

Ionic Anti-Viral Intralesional Therapy in Plantar Warts

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ghada Fathy Mohammed ◽  
Ahmed Abd-Elfattah Afify ◽  
Wessam Moustafa Abo Elmagd Abdel Latif
Keyword(s):  
Normal Skin ◽  
University Hospital ◽  
Response To Treatment ◽  
Alternative Form ◽  
Steady Increase ◽  
Intralesional Injection ◽  
Significant Difference ◽  
Group 2 ◽  
Plantar Warts ◽  
Group 1

Abstract Background Warts (verrucas) are an extremely common, benign, and usually self-limited skin disease. Their size ranges from a few millimetres to several centimetres. The normal skin lines are interrupted by skin coloured to brownish-grey proliferations, the diagnosis is established clinically; no supplementary histologic or virologic investigations are needed. Objective The aim of this two armed double blinded randomized clinical trial was to evaluate the clinical efficacy of intralesional combined digoxin and furosemide in the treatment of multiple planter warts. Methods This study included 40 patients with plantar warts, they were divided into 2 groups, 20 patients per group, the first group received intralesional normal saline, one injection session every week for maximum 5 injection sessions. The second group received intralesional combined digoxin and furosemide, one injection session every week for maximum 5 injection sessions. All the patients were recruited from the Dermatology outpatient clinic at Ain-Shams University Hospital and Shobra General Hospital during the period From July 2018 to July 2019. Results There was no statistically significant difference between the 2 studied groups as regard size of wart before treatment. While there was statistically significant difference between the 2 studied groups as regard size of wart after the 5th session. Also there was a steady increase in the response to treatment in group 2 showing an earlier response to treatment and most of patients with excellent and very good response to treatment after the 5th session. There was no statistically significant difference between the 2 studied groups as regard the number of warts before treatment. While there was statistically significant difference between the 2 studied groups as regard the number of warts after the 5th session. There was no statistically significant correlation between age, sex, disease duration and response to treatment (as regard reduction in number of warts) after the 5th session in group 2. While in group 1 there was no reduction in number of warts after the 5th session. There was a statistically significant difference between the number of warts before and after receiving the active treatment in group 1, in group 2 and for both groups together (all patients). Conclusion We concluded from this study that intralesional injection of combined digoxin and furosemide offers effective alternative form of treatment for plantar warts in adults. It is inexpensive and safe to treat plantar warts.

Diffuse Large B-Cell Lymphoma: Relevance of bcl-2 Expression at a National Hospital from Lima Peru 2000–2002.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4610-4610
Author(s):  
Cecilia M. Egoavil R. ◽  
Victor M. Delgado G. ◽  
Jesus La Serna
Keyword(s):  
B Cell ◽  
Clinical Characteristics ◽  
De Novo ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Response To Treatment ◽  
Clear Trend ◽  
Large B Cell Lymphoma ◽  
Significant Difference ◽  
Large B Cell

Abstract Diffuse large B-cell lymphoma (DLCL) exhibits heterogeneous clinical features and varies in response to treatment and prognosis. Establishment of parameters that can predict outcome could help to identify patients who may benefit from risk-adjusted therapies. Because apoptosis-related proteins may play an important role in predicting the prognosis of DLCL, the current study investigated the significance of bcl-2 expression in relation to clinical characteristics in this patients. We studied 125 patients (74/51 men/women; median age 64.17 years) consecutively diagnosed with de novo DLBCL in a single institution from Peru (HNGAI) during 3-year period (2000–2002).Morphology, and clinical characteristics were analyzed according to the primary site of the lymphoma and edge. Paraffin-embedded specimens from 88 were analyzed immunohistochemically for bcl-2 protein expression. Cases with a positive immunohistological stain in more than 20% of the tumor cells were considered positive expression. Results: Sites of the disease were: lymph node, 78 cases (62.4%); Waldeyer’s ring, 18 (14.4%); and extranodal sites, 45 (36%), including GI tract in 33 cases. 5-year overall survival (OS) was 19.7%. Log-rank analyses of survival showed significant differences between ≥60 years old and younger patients (P=0.003).bcl-2 expression was identified in 34 patients (38.6%), There was no significant difference in the OS (P=0.453) between the bcl-2+ (n=34) and bcl-2− (n=54) groups. In conclusion, bcl-2 expression appeared to be non predictive of a good OS in patients with DLCL, however, there was still a clear trend that the bcl-2+ patients died sooner than the patients with tumors that contained bcl-2− lymphoma cells. The current study show all patients as were staged or confined in a group with high or high intermediate IPI scores and could be candidates for alternative therapeutic approaches.

scholarly journals Computed tomographic perfusion imaging for the prediction of response and survival to transarterial chemoembolization of hepatocellular carcinoma

2017 ◽  
Vol 52 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Peter Popovic ◽  
Ana Leban ◽  
Klara Kregar ◽  
Manca Garbajs ◽  
Rok Dezman ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Response ◽  
Perfusion Imaging ◽  
Transarterial Chemoembolization ◽  
Intermediate Stage ◽  
Complete Response ◽  
Response To Treatment ◽  
Computed Tomographic ◽  
Significant Difference ◽  
Pre Treatment

Abstract Background The purpose of this retrospective cohort study was to evaluate the clinical value of computed tomographic perfusion imaging (CTPI) parameters in predicting the response to treatment and overall survival in patients with hepatocellular carcinoma (HCC) treated with drug-eluting beads transarterial chemoembolization (DEBTACE). Patients and methods Between December 2010 and January 2013 eighteen patients (17 men, 1 woman; mean age 69 ± 5.8 years) with intermediate stage HCC underwent CTPI of the liver prior to treatment with DEBTACE. Treatment response was evaluated on follow-up imaging according to modified Response Evaluation Criteria in Solid Tumors. Pre-treatment CTPI parameters were compared between patients with complete response and partial response with a Student t-test. We compared survival times with Kaplan-Meier method. Results CTPI parameters of patients with complete response and others did not show statistical significant difference. The mean survival time was 25.4 ± 3.2 months (95%; CI: 18.7-32.1). Survival was statistically significantly longer in patients with hepatic blood flow (BF) lower than 50.44 ml/100 ml/min (p = 0.033), hepatic blood volume (BV) lower than 13.32 ml/100 ml (p = 0.028) and time to peak (TTP) longer than 19.035 s (p = 0.015). Conclusions CTPI enables prediction of survival in patients with intermediate stage HCC, treated with DEBTACE based on the pre-treatment values of BF, BV and TTP perfusion parameters. CT perfusion imaging can’t be used to predict treatment response to DEBTACE.

scholarly journals Assess the Effectiveness of Planned Teaching on Knowledge Regarding Kangaroo Mother Care among Husbands of Primigravida Mother

2021 ◽  
pp. 532-539
Author(s):  
Suwarna Ghugare ◽  
Tessy Sebastian ◽  
Manjusha Gulabrao Mahakalkar ◽  
Darshana Durgadass Wankhede
Keyword(s):  
Standard Deviation ◽  
Education Programme ◽  
Demographic Variables ◽  
Kangaroo Mother Care ◽  
P Value ◽  
Early Care ◽  
Skin Contact ◽  
Significant Difference ◽  
Post Test ◽  
Skin To Skin

Kangaroo care is a practise that allows moms and fathers to have direct skin-to-skin contact with their infants. It has been demonstrated to promote the mother's mental health, strengthen mother-infant connection, and increase maternal lactation. Many studies feel that returning to the original paradigm of infant-mother early care, rather than our current incubator, bottle, and formula-feeding model, will result in happier and healthier newborns [1]. Objective: 1) To determine whether primigravida women' spouses have any awareness of kangaroo mother care. 2) To assess the efficiency of a planned education programme on kangaroo mother care among primigravida moms' husbands.3) To see if there's a link between post-test knowledge scores on kangaroo mother care among primigravida moms' spouses and certain demographic variables.  Methodology: A total of 60 people took part in the research. Husbands of primigravida women from various hospitals will be used as study subjects. Results: There is a significant difference between pre-test and post-test knowledge scores when measuring effective planned training on knowledge about kangaroo mother care among husbands. The pretest has a mean of 8.18, while the posttest has a mean of 16.30, and the pretest has a standard deviation of 2.855, while the posttest has a standard deviation of 1.710. The t-value is 18.57, and the p-value is 0.000. Conclusion: As a result, the planned education on knowledge about kangaroo mother care among primigravida moms' husband is statistically interpreted. The research hypothesis was accepted in this study, while the null hypothesis was denied.

The Effect of Skin Contact on Maternal-infant Attachment Behaviors in Emotional, Proximity-seeking, and Caretaking Dimensions in Planned and Unplanned Pregnancies in 2017, Iran: A Research

2020 ◽  
Vol 16 (3) ◽  
pp. 206-213
Author(s):  
Tahere Eslaminia ◽  
Maasumeh Kaviani ◽  
Marzieh Akbarzadeh
Keyword(s):  
Unplanned Pregnancy ◽  
Medical Sciences ◽  
Infant Attachment ◽  
Skin Contact ◽  
Significant Difference ◽  
Unplanned Pregnancies ◽  
Women's Lives ◽  
The Difference ◽  
Skin To Skin ◽  
Control Study

Background: Unplanned pregnancy is a potential danger for women’s lives in the reproduction ages. Objective: The present study aimed to compare planned and unplanned pregnancies regarding the maternal-infant attachment behaviors in emotional, proximity-seeking, and caretaking dimensions. Methods: The present analytical case-control study was conducted on 140 women who had given birth to their children in the hospitals affiliated to Shiraz University of Medical Sciences in 2017. The participants were divided into planned and unplanned pregnancy groups. Within the first hour and 24 hours after birth, the babies were put naked in skin-to-skin contact with their mothers for 15 minutes and the study questionnaire was completed. The data were collected using the Avant checklist. P<0.05 was considered to be statistically significant. Results: The mean score of attachment in the early hours was 84.22±12.59 in the planned pregnancy group and 74.28±15.81 in the unplanned pregnancy group, and the difference was statistically significant (p<0.001). However, no significant difference was observed between the two groups in this regard after 24 hours (p=0.122). Additionally, the results revealed a significant difference between the two groups concerning emotional (p<0.001) and caretaking (p=0.007) behaviors. However, no significant difference was found between the two groups regarding the three behaviors after 24 hours. Emotional (talking and smiling, p=0.001), proximity-seeking (circling one’s arms around the baby, p=0.001), and caretaking (paying attention to the baby, p=0.001) behaviors were significantly more observed in the two groups in the early hours and the first 24 hours. Conclusions: Mother’s skin-to-skin contact with her baby during lactation increased attachment in unplanned pregnancies after 24 hours.

scholarly journals Clinical response to interferon beta and glatiramer acetate in multiple sclerosis patients: a Brazilian cohort

2012 ◽  
Vol 70 (10) ◽  
pp. 774-779 ◽  
Author(s):  
Valéria Coelho Santa Rita Pereira ◽  
Fabíola Rachid Malfetano ◽  
Isabella D'Andrea Meira ◽  
Letícia Fêzer de Souza ◽  
Assuncion Martinez Liem ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Response ◽  
Treatment Response ◽  
Glatiramer Acetate ◽  
Interferon Beta ◽  
Response To Treatment ◽  
Clinical Criteria ◽  
Significant Difference ◽  
One Year ◽  
Multiple Sclerosis Patients

INTRODUCTION: Many patients with multiple sclerosis (MS) are currently receiving treatment with interferon beta (IFNb) and glatiramer acetate (GA). Identifying nonresponders patients is important to define therapy strategies. Several criteria for treatment response to IFNb and GA have been proposed. OBJECTIVE: It was to investigate the response to treatment with IFNb-1a, IFNb-1b and GA among relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: We analyzed treatment response to IFNb and GA in ninety-one RRMS patients followed for at least one year. Clinical response was established by clinical criteria based on relapses, disability progression or both. RESULTS: We observed a proportion of nonresponders, ranging from 3.3 to 42.9%, depending on the stringency of the criteria used. CONCLUSIONS: Our sample of Brazilian patients with MS has similarities when compared to other studies and there was no statistically significant difference regarding age, gender, ethnicity or disease duration between responders and nonresponders.

scholarly journals PENGARUH SKIN TO SKIN CONTACT (PMK) TERHADAP PENURUNAN SUHU TUBUH PADA BAYI DEMAM

2019 ◽  
Vol 3 (1) ◽  
pp. 79
Author(s):  
Heni Purwaningsih ◽  
Widuri Widuri
Keyword(s):  
Body Temperature ◽  
P Value ◽  
Temperature Decrease ◽  
Control Center ◽  
Purposive Sampling ◽  
Skin Contact ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental ◽  
Skin To Skin

Demam merupakan suatu keadaan suhu tubuh diatas normal sebagai akibat peningkatan pusat pengatur suhu di hipothalamus. Cara yang dapat menurunkan suhu tubuh adalah dengan menggunakan metode kontak kulit ibu dan kulit bayi (Skin to Skin Contact). Tujuan penelitian ini adalah untuk mengetahui pengaruh skin to skin contact (PMK) terhadap penurunan suhu tubuh pada bayi demam di Rumah Sakit Ken Saras Kabupaten Semarang. Jenis penelitian ini adalah Quasi Experimental dengan pre-post test dalam satu kelompok (One-Group Pre-test-posttest Design). Populasi adalah rata-rata jumlah bayi yang mengalami demam perbulan di Rumah Sakit Ken Saras selama tahun 2016 sebanyak 87 anak. Sampel 14 orang yang diambil secara purposive sampling. Alat pengumpulan data menggunakan termometer digital axila. Hasil penelitian menunjukkan terdapat perbedaan secara bermakna suhu tubuh pada bayi demam sesudah dilakukan skin to skin contact (PMK)  dengan p value 0,000 < α (0,05). Perawat dapat memberikan intervensi skin to skin contact (PMK) sebagai salah satu intervensi keperawatan nonfarmakologis dalam penatalaksanaan bayi demam. Kata kunci: Bayi demam, skin to skin contact, perawatan metode kanguru Abstract The Effects of Skin to Skin Contact (PMK) on Body Temperature Decrease in Infants with Fever. Fever is a body temperature above normal circumstances as a result of increased temperature control center in the hypothalamus. One of the ways that can reduce body temperature is using skin to skin method of mother and baby’s skin (Skin to Skin Contact). The purpose of this research is to analyze the effects of skin to skin contact (pmk) on body temperature decrease in infants with fever at Ken Saras Hospital of Semarang Regency. The type of this research was Quasi Experimental with pre-post test in one group (One-Group Pre-test-posttest Design). The population was all the average number of infants with fever per month at Ken Saras Hospital during 2017 as many as 38 patients. 14 samples were taken by purposive sampling. The collecting data tool used a axilla digital thermometer. The research results showed that  there is a significant difference of body temperature in infants with fever after skin to skin contact (PMK) with p value 0,000 <α (0,05). Nurses can provide skin to skin contact (PMK) interventions as one of the nonpharmacological nursing interventions in the management of infants with fever. Keywords : Infants with fever, skin to skin contact, kangaroo care method

scholarly journals MicroRNA-150 down Regulation in Acute Myeloid Leukaemia Patients and Its Prognostic Implication

2018 ◽  
Vol 6 (11) ◽  
pp. 1993-2000 ◽  
Author(s):  
Dalia Adel Abdelhalim ◽  
Basma M. Elgamal ◽  
Mona R. ElKafoury ◽  
Naglaa M. Hassan ◽  
Marwa M. Hussein ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Target Genes ◽  
De Novo ◽  
Response To Treatment ◽  
Variable Response ◽  
Significant Difference ◽  
The Impact ◽  
Acute Myeloid

BACKGROUND: MicroRNAs (miRNAs) are small, non-coding RNAs that are important for post-transcriptional gene regulation in both healthy and morbid conditions. Numerous miRNAs promote tumorigenesis, while others have a tumour suppressive effects. Acute myeloid leukaemia (AML) is a heterogeneous group of genetically diverse hematopoietic malignancies with variable response to treatment. AIM: Our study aimed to investigate the possible role of miR-150 in de novo adult AML and the impact of its level on survival, and we used in the silicon analysis to predict the main target genes involved in miR-150 mediated cancer pathway. MATERIAL AND METHODS: We evaluated miR-150 expression profiling assay using TaqMan primer probes RT-PCR in the plasma of 50 adult AML patients, before the start of treatment and at day 28 of treatment, along with 20 normal adult control samples. miR-16 was used as an endogenous reference for standardisation. Follow-up of patients during treatment at day 28 of induction chemotherapy and after one year was done. RESULTS: In this study, we found a significantly lower level of miR-150 in AML patients when compared to controls (p = 0.005) with 0.62 fold change than in healthy controls. Patients were divided into two groups: the low miR-150 group (miR-150 < 1) and the high miR-150 group (miR-150 > 1). A statistically significant difference was found between the two groups regarding initial total leukocytic count and initial PB blast count while for the TLC, HB and PLT count at follow up. No difference in the overall survival between the low and the high miR-150 groups could be demonstrated. CONCLUSION: Our results suggest that miR-150 functions as a tumour suppressor and gatekeeper in inhibiting cell transformation and that its downregulation is required for leukemogenesis.

Effect of skin-to-skin contact on the placental separation time, mother’s oxytocin and pain levels: randomized controlled trial

2019 ◽  
Vol 44 (5) ◽  
pp. 706-713
Author(s):  
Zekiye Turan ◽  
Ayten Şentürk Erenel
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Intervention Group ◽  
Routine Care ◽  
Control Group ◽  
Separation Time ◽  
Randomized Controlled ◽  
Skin Contact ◽  
Significant Difference ◽  
Skin To Skin

Abstract Objective This study determined the effect of skin-to-skin contact (SSC) between mother and infant during the third stage of labor on postpartum levels of oxytocin and pain and placental separation time. Methods This randomized controlled trial was composed of 64 parturients: 32 in the intervention group and 32 in the control group. SSC interventions between infants and their mothers occurred for 30 min after birth, whereas infants in the control group were provided routine care. Data were gathered using an introductory information form, Visual Analog Scale, determination of placental separation degree form, and time and records of oxytocin analyses. Results There was no significant difference regarding placental separation time and 1st and 30th min oxytocin levels of mothers (p>0.05), whereas postpartum 5th, 15th and 30th min pain levels of women in the intervention group were significantly lower than women in the control group (p<0.05). Conclusion SSC is a valuable practice for both mother and infant, which especially reduces a mother’s pain. The study should be reiterated by excluding other variables that are likely to affect oxytocin levels.

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