092 Effect of the dual orexin receptor antagonist (DORA) daridorexant on behaviour upon awakening in rats and dogs

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A38-A39
Author(s):  
Giorgio Bergamini ◽  
Catherine Roch ◽  
Sean Durkin ◽  
Michel Steiner
Keyword(s):  
Grip Strength ◽  
Motor Skills ◽  
Muscle Weakness ◽  
Motor Behavior ◽  
Motor Impairment ◽  
Phase Behaviour ◽  
Fine Motor ◽  
Dependent Manner ◽  
The Impact ◽  
Time Point

Abstract Introduction The ability to be fast alert and to interact with the environment without motor impairment upon waking up, is a critical feature of natural sleep. DORAs represent a new class of insomnia medications that specifically inhibit the wake-promoting effects of orexin neuropeptides. Daridorexant is a potent and selective DORA under late stage development for the treatment of insomnia. Here, we assessed the impact of sleep-promoting doses of daridorexant on rats’ and dogs’ behaviour upon forced awakening. Zolpidem (a positive GABAA receptor modulator) was used as active comparator in rats because of its known negative impact on motor functions. Methods Rats were woken up at different time points after oral administration of daridorexant (10, 30, 100 mg/kg) or zolpidem (30, 100 mg/kg) during their inactive phase, and repeatedly subjected to two motor tasks: 1) the rotating rod test (lasting 120 sec, at each time point) assessing gross motor skills and coordination, and 2) the forepaw grip strength test assessing fine motor skills and muscle strength. Dogs were presented with food as an external, salient stimulus, three hours after administration of daridorexant in gelatin capsules (10, 30 or 90 mg/dog) during their active phase. Behaviour and signs of muscle weakness, after having woken up, were assessed by manual inspection of video recordings and concomitant electroencephalogram/electromyogram recordings. Results In both the rotarod and grip tests, daridorexant treatment had no effect on motor behavior at any dose or time point tested, while zolpidem significantly reduced the time spent on the rotarod and the grip strength in a dose and time-dependent manner (N=12/group; p<0.001;) (e.g. at 30 min post-dose, time spent on the rotarod was 84, 79–89 and 10–19 sec for vehicle, daridorexant and zolpidem, respectively). Dogs treated with daridorexant were able to wake up easily upon food presentation. They behaved and ate normally and did not show any signs of muscle weakness. Conclusion The type of sleep promoted by daridorexant is surmountable in rats and dogs and similar to physiological sleep. It allows animals to easily wake up, to behave normally without motor impairment and to respond efficiently to the environmental conditions. Support (if any) Funded by Idorsia Pharmaceuticals Ltd

scholarly journals Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Patrícia A Correia ◽  
Eran Lottem ◽  
Dhruba Banerjee ◽  
Ana S Machado ◽  
Megan R Carey ◽  
...  
Keyword(s):  
Motor Behavior ◽  
Motor Impairment ◽  
Long Term Effects ◽  
Strong Suppression ◽  
Serotonin Neurons ◽  
Short And Long Term ◽  
Rapid Kinetics ◽  
Long Term Facilitation ◽  
The Impact

Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions.

Assessment of Hand Grip Strength & Fine Motor Skills in Skilled & Non Skilled Persons

2019 ◽  
Vol 7 (3) ◽  
pp. 12
Author(s):  
B.V. Uma ◽  
M. Vishnu Priya ◽  
P. Harshitha ◽  
K.N. Maruthy
Keyword(s):  
Grip Strength ◽  
Motor Skills ◽  
Hand Grip Strength ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Hand Grip

Motor Problems among Children of Very Low Birthweight

1989 ◽  
Vol 52 (3) ◽  
pp. 97-99 ◽  
Author(s):  
B L Roberts ◽  
N Marlow ◽  
R W I Cooke
Keyword(s):  
Motor Skills ◽  
Low Birthweight ◽  
Motor Impairment ◽  
Occupational Therapists ◽  
Demographic Variables ◽  
Fine Motor ◽  
Early Assessment ◽  
Very Low Birthweight ◽  
Motor Outcome ◽  
Motor Problems

The motor outcome for 53 six-year-old children with birthweights of 1251g or less who were receiving mainstream education is reported. Compared with age and sex matched classmates, these children had significantly poorer motor skills, as assessed by the Test of Motor Impairment. Despite lower scores in tests of fine motor, ball and balancing skills, these children were perceived by their teachers to be performing satisfactorily at school. The impairment observed was independent of IQ and social and demographic variables. Because of the risk of later schooling difficulties, very low birthweight children should be considered for early assessment by occupational therapists and physiotherapists in view of the frequent motor problems encountered.

scholarly journals ASSESSING MOTOR SKILLS TO INFORM A FETAL ALCOHOL SPECTRUM DISORDER DIAGNOSIS FOCUSING ON PERSONS OLDER THAN 12 YEARS: A SYSTEMATIC REVIEW OF THE LITERATURE

2018 ◽  
Vol 25 (1) ◽  
pp. e25-e38 ◽  
Author(s):  
Bernadette Safe ◽  
Annette Joosten ◽  
Roslyn Giglia
Keyword(s):  
Systematic Review ◽  
Motor Skills ◽  
Fetal Alcohol Spectrum Disorder ◽  
Motor Impairment ◽  
Spectrum Disorder ◽  
Current Evidence ◽  
Fine Motor ◽  
Prenatally Exposed ◽  
Fetal Alcohol ◽  
Fetal Alcohol Spectrum

Background Motor impairments are one of the difficulties present in people prenatally exposed to alcohol, and are included in the diagnostic criteria for Fetal Alcohol Spectrum Disorder. Objectives The aim of this review was to examine the extent and common types of motor impairment present in persons aged over 12 years prenatally exposed to alcohol as evidence for determining the skills that should be assessed and addressed in intervention. Methods A systematic review of current evidence using various electronic databases was conducted. Studies were appraised using a recognised clinical appraisal tool. Results Seven studies published between 1998 and 2014 met the inclusion criteria. There is some evidence that difficulties with fine motor skills, visual motor integration, and balance skills persist in people who have been prenatally exposed to alcohol. Most studies did not focus on adolescent or adult participants in isolation, making it difficult to generalise results. Varied methodological designs made it difficult to compare studies as few used common standardised assessments Conclusion A review of functional difficulties in each individual would be required to determine if a motor assessment is warranted. Further research is required using assessments recommended in diagnostic guidelines to determine the common motor difficulties seen in adolescents and adults.

scholarly journals Disorders of fine motor skills after a stroke: the processes of neuroplasticity and sensorimotor integration

2019 ◽  
Vol 10 (1) ◽  
pp. 16-22
Author(s):  
Eugeniia V. Ekusheva ◽  
A. A. Komazov
Keyword(s):  
Ischemic Stroke ◽  
Motor Skills ◽  
Motor Impairment ◽  
Fine Motor ◽  
Voluntary Movements ◽  
Moderate Degree ◽  
Fine Motor Skills ◽  
Social Maladjustment ◽  
The Right

Background. Impairment of fine motor skills in the hand is one of the most frequent causes of the persistent loss of professional skills, social maladjustment, and the impossibility of self-care in patients after a stroke, which ultimately leads to a significant reduction in the quality of their life. The article discusses the features of the fine motor skills’ impairment in the hand in patients after a stroke, in the context of a lateralized hemispheric lesion. Methods. We have studied 26 patients after a primary ischemic stroke in the pool of middle cerebral artery of the right (n=12) or left (n=14) brain hemisphere. The average age of patients was 55.7±7.3 years. Patients with a right-sided ischemic stroke were comparable to those with a left-sided stroke in their age, disease duration, size of the lesion and the gender ratio. Results. All the patients after an ischemic stroke had motor impairment in the form of a hemiparesis of a mild or moderate degree. Discussion. We suggest the existence of differentiated mechanisms for the development of fine and highly coordinated voluntary movements in the hand of patients after an ischemic stroke, depending on the lateralization of the supratentorial lesion: diffuse deficit of the afferent support in a right-sided ischemic stroke vs. bilateral efferent deficit for a left hemisphere lesion. Conclusion. The obtained data on the differentiated mechanisms for the development of fine and highly coordinated voluntary movements in the hand of patients after an ischemic stroke warrant the necessity of a further, more targeted research on those disorders in the post-stroke period, on order to optimize the existing rehabilitation approaches and improve the functional potential and quality of life of such patients.

Impacts and Burden of Niemann Pick Type-C: A Patient and Caregiver Perspective

2021 ◽  
Author(s):  
Eugen Mengel ◽  
Marc C Patterson ◽  
Michael Chladek ◽  
Christina Guldberg ◽  
Christine íDali ◽  
...  
Keyword(s):  
Lived Experience ◽  
Motor Skills ◽  
Age Of Onset ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Increased Risk ◽  
Wide Range ◽  
Type C ◽  
Niemann Pick ◽  
The Impact

Abstract Background Niemann-Pick disease type C (NPC) is a debilitating condition that impacts patients’ and caregivers’ quality of life (QOL) and reduces the patient’s life expectancy. Since there is little qualitative research from the perspective of patients and family caregivers, this study explored the impact of NPC on patients’ and caregivers’ daily lives to understand the burden of disease.Results A survey of caregivers for patients with NPC and adult patients with NPC (n = 49; patient age: 13 months – 65 years) assessed NPC severity, importance of NPC symptoms, and how symptoms impacted patients’ and caregivers’ activities of daily living (ADLs) and health-related QOL (HRQOL). Follow-up interviews with a subset of survey participants (n = 28) explored the ranking of NPC symptom importance and impact on ADLs and HRQOL.Findings indicated that the most important manifestations of NPC were ambulation, swallowing, speech, fine motor skills, and cognition, which were those that had the most significant impact on ADLs and HRQOL. A wide range of ADLs were affected by NPC, mainly eating/drinking and ability to perform daily tasks, including self-care, communicating, participating in school or work, and moving indoors as well as outside the home. Along with these impacts, there was an increased risk of experiencing dangerous or life-threatening situations leading to loss of patient independence and additional caregiver burden, often requiring changes in lifestyle such as giving up work. All aspects of patients’ and caregivers’ HRQOL were affected. Participants reported feelings of social isolation, loss of enjoyment in activities (patients), and feelings of sadness or worry (caregivers).ConclusionsAmbulation, swallowing, speech, fine motor skills, and cognition are important manifestations of NPC. ADLs and HRQOL were impaired in the majority of patients as well as their caregivers. The findings were independent of current age, age of onset of symptoms, and level of NPC disease-related disability; however, the impact increased at higher levels of disease disability. Knowing the impact of NPC on patients and caregivers is important for understanding the lived experience of NPC and for identifying potential areas of support.Trial registrationNCT02612129. Registered 23 November 2015, https://clinicaltrials.gov/ct2/show/NCT02612129

scholarly journals Racial Disparities in Stroke Recovery Persistence in the Post-Acute Stroke Recovery Phase: Evidence from the Health and Retirement Study

2020 ◽  
Vol 30 (2) ◽  
pp. 339-348
Author(s):  
Joy N. J. Buie ◽  
Yujing Zhao ◽  
Suzanne Burns ◽  
Gayenell Magwood ◽  
Robert Adams ◽  
...  
Keyword(s):  
Racial Differences ◽  
Motor Skills ◽  
Stroke Recovery ◽  
Fine Motor ◽  
Stroke Survivors ◽  
Factors Associated ◽  
Post Stroke ◽  
Stroke Disability ◽  
The Impact

Background and Purpose: Blacks have a higher burden of post-stroke disability. Factors associated with racial differences in long-term post-stroke disability are not well-understood. Our aim was to assess the long-term racial differences in risk factors associated with stroke recovery.Methods: We examined Health and Retire­ment Study (HRS) longitudinal interview data collected from adults living with stroke who were aged >50 years during 2000- 2014. Analysis of 1,002 first-time, non- Hispanic, Black (210) or White (792) stroke survivors with data on activities of daily liv­ing (ADL), fine motor skills (FMS) and gross motor skills (GMS) was conducted. Ordinal regression analysis was used to assess the impact of sex, race, household residents, household income, comorbidities, and the time since having a stroke on functional outcomes.Results: Black stroke survivors were young­er compared with Whites (69 ± 10.4 vs 75 ± 11.9). The majority (~65%) of Black stroke survivors were female compared with about 54% White female stroke survivors (P=.007). Black stroke survivors had more household residents (P<.001) and comor­bidities (P<.001). Aging, being female, being Black and a longer time since stroke were associated with a higher odds of hav­ing increased difficulty in ADL, FMS and/or GMS. Comorbidities were associated with increased difficulty with GMS. Black race increased the impact of comorbidities on ADL and FMS in comparison with Whites.Conclusion: Our data suggest that the effects of aging, sex and unique factors associated with race should be taken into consideration for future studies of post-stroke recovery and therapy.Ethn Dis. 2020;30(2):339-348; doi:10.18865/ ed.30.2.339

scholarly journals THE IMPACT OF PHYSICAL AND SPORTS REHABILITATION OF PEOPLE WITH CEREBRAL PALSY ON THE PROPRIOCEPTIVE SYSTEM IMPROVEMENT

2019 ◽  
pp. 36-45
Author(s):  
Olha Herus ◽  
Tereza Klymus ◽  
Marta Kozak
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Palsy ◽  
Motor Skills ◽  
Physical Therapists ◽  
Sensory System ◽  
Fine Motor ◽  
Slow Development ◽  
The Central Nervous System ◽  
The Impact

Introduction: Cerebral palsy occurs as a result of affecting those parts of the central nervous system that control the muscles and are responsible for the balance and movements arbitrariness. It has a number of forms with varying degrees of damage to the central nervous system and impaired physiological functions. And this certainly affects the perception. Due to perception distortion, sensory interpretation is slowed down and incorrectly analyzed in the cerebral cortex. The improvement of the motor sphere implies the development of general and small motor skills, and the improvement of movements coordination. The correction of motor sphere disorders should be done in a comprehensive, systematic manner, with the involvement of specialists (neurologists, physical therapists, rehabilitologists, sensory therapists). This will help to determine the content of motor sphere correction exercises and define the step-by-step measures for physical condition improvement. Aim: to investigate the impact of physical and sports rehabilitation measures of people with cerebral palsy disabilities on improving the proprioceptive system basing on an analysis of the practical application of the bocce game program. Methodology: SIPT (Sensory Integration and Praxis Tests) breach detection study. Bocce game lessons were tested (as a method of physical and sport rehabilitation) in order to improve the sensory system. Object of the study – 10 people aged 28–35 with a clinical diagnosis of "Cerebral palsy" with impaired mobility, who are using a trolley and are undergoing rehabilitation at the rehabilitation center in Lviv. Results: It was found that 9 out of 10 participants had dysarthric disorders. General somatic attenuation and slow development of locomotor functions are accompanied by a lag in the motor sphere development of the people with cerebral palsy. Conclusion: The study found that engaging in sports and exercise leads to increased physical health and improved gross fine motor skills related to the sensorimotor system

scholarly journals The effects of using virtual reality in the rehabilitation of stroke patients: Systematic review

2021 ◽  
Vol 20 (1) ◽  
pp. 73-83
Author(s):  
Letícia De S. Vidal ◽  
Lilian Maria M. C. De Oliveira ◽  
Tassiane Maria A. Pereira ◽  
Janaína De M. Silva
Keyword(s):  
Systematic Review ◽  
Virtual Reality ◽  
Literature Review ◽  
Motor Skills ◽  
Motor Behavior ◽  
Treatment Seeking ◽  
Fine Motor ◽  
Upper Limbs ◽  
Stroke Patients ◽  
Functional Rehabilitation

Introdution: Stroke causes several alterations, the morefrequent are motor, physical and psychological. Since rehabilitationtakes time and can become monotonous, the useof virtual reality can act as a stimulating way to involve thepatient in the treatment, seeking to develop its functionality.Objective: The objective of this study was to verify in theavailable literature the effects of using virtual reality in thetreatment of the sequelae of the Stroke, to gain functionalityin the upper limbs. Methods: This literature review was basedon the PICO strategy, carried out in the databases Lílacs,Pubmed, Scielo and PEDro, using the keywords “physiotherapyAND virtual reality OR exergame OR exergaming ANDstroke AND upper limbs”. Complete articles were published inEnglish, Portuguese and Spanish, available and dated between2015 and 2020, excluding those that were review articles,incomplete and that did not address the topic. Results: As aresult, the search found 1,035 articles, of which only 14 metthe imposed criteria. Most studies have shown that the useof virtual reality through games has proved to be an efficientresource in the functional rehabilitation of patients withstroke. Presenting itself as a competent complementary tophysiotherapeutic treatment in improving fine motor skills,motor behavior of the limbs and cognitive performance,these gains directly influenced the gain in functionality ofthe samples. Conclusion: The use of virtual reality is useful toassist in the treatment and reduction of sequelae in the upperlimbs of patients with stroke, as it promotes greater functionalgain, range of motion and improves the dexterity of both themost and the least compromised hand.

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