The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment-related Cachexia

Abstract Background Poor sleep is common for children during cancer treatment, but there is limited understanding of the nature of children’s sleep throughout the treatment trajectory. The current exploratory study used an explanatory sequential mixed method approach to examine quantitative associations among sleep problems in children with cancer, parental behavior, and children’s sleep hygiene, with follow-up qualitative characterizations of children’s sleep across cancer treatment stages. Procedure Eighty parents of children with cancer (aged 2–10 years; in active treatment, maintenance treatment, or off treatment) completed an online survey querying the child’s sleep quality (Sleep Disturbance Scale for Children—Disorders of Initiating and Maintaining Sleep subscale) and behaviors (Child Sleep Hygiene Scale) and sleep-related parenting behaviors (Parental Sleep Strategies). A subsample (n = 17 parents) participated in qualitative interviews to better characterize the processes of children’s sleep and parents’ sleep-related behaviors. Results Children’s sleep quality, sleep hygiene, or parental sleep strategies were not significantly different by cancer treatment groups. Greater sleep disturbance in children was associated with their parents’ tendency to accommodate the child’s bedtime requests. Qualitatively, cancer treatment-related anxiety in both children and parents influence the onset of these disruptive sleep behaviors. Conclusion Parents’ sleep-related behaviors affect children’s sleep during cancer treatment. Parents’ accommodation may start during active treatment to alleviate cancer-related challenges, and these behaviors may continue into maintenance therapy and off treatment to reinforce sleep disturbance. Behavioral interventions targeting unhelpful parental behaviors may improve sleep in children with cancer during and after cancer treatment.

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An Eicosapentaenoic Acid Supplement Versus Megestrol Acetate Versus Both for Patients With Cancer-Associated Wasting: A North Central Cancer Treatment Group and National Cancer Institute of Canada Collaborative Effort

Journal of Clinical Oncology ◽

10.1200/jco.2004.06.024 ◽

2004 ◽

Vol 22 (12) ◽

pp. 2469-2476 ◽

Cited By ~ 191

Author(s):

Aminah Jatoi ◽

Kendrith Rowland ◽

Charles L. Loprinzi ◽

Jeff A. Sloan ◽

Shaker R. Dakhil ◽

...

Keyword(s):

Treatment Group ◽

Eicosapentaenoic Acid ◽

Cancer Treatment ◽

Megestrol Acetate ◽

Omega 3 ◽

North Central ◽

Patients With Cancer ◽

Global Quality ◽

Liquid Suspension ◽

Global Quality Of Life

Purpose Studies suggest eicosapentaenoic acid (EPA), an omega-3 fatty acid, augments weight, appetite, and survival in cancer-associated wasting. This study determined whether an EPA supplement—administered alone or with megestrol acetate (MA)—was more effective than MA. Patients and Methods Four hundred twenty-one assessable patients with cancer-associated wasting were randomly assigned to an EPA supplement 1.09 g administered bid plus placebo; MA liquid suspension 600 mg/d plus an isocaloric, isonitrogenous supplement administered twice a day; or both. Eligible patients reported a 5-lb, 2-month weight loss and/or intake of less than 20 calories/kg/d. Results A smaller percentage taking the EPA supplement gained ≥ 10% of baseline weight compared with those taking MA: 6% v 18%, respectively (P = .004). Combination therapy resulted in weight gain of ≥ 10% in 11% of patients (P = .17 across all arms). The percentage of patients with appetite improvement (North Central Cancer Treatment Group Questionnaire) was not statistically different: 63%, 69%, and 66%, in EPA-, MA-, and combination-treated arms, respectively (P = .69). In contrast, 4-week Functional Assessment of Anorexia/Cachexia Therapy scores suggested MA-containing arms experienced superior appetite stimulation compared with the EPA arm, with scores of 40, 55, and 55 in EPA-, MA-, and combination-treated arms, respectively (P = .004). Survival was not significantly different among arms. Global quality of life was not significantly different among groups. With the exception of increased impotence in MA-treated patients, toxicity was comparable. Conclusion This EPA supplement, either alone or in combination with MA, does not improve weight or appetite better than MA alone.

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3 Megestrol acetate (MA) in breast cancer treatment. A neglected drug?

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(87)91677-3 ◽

1987 ◽

Vol 28 ◽

pp. 213

Author(s):

Stener Kvinnsland ◽

Steinar Lundgren ◽

Edle Utaaker ◽

Stein Gundersen

Keyword(s):

Breast Cancer ◽

Cancer Treatment ◽

Breast Cancer Treatment ◽

Megestrol Acetate

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Multi-Dimensional Humanistic Care for the Kids with Hematological Malignancies in Guangzhou Women and Children's Medical Center (GWCMC)

Blood ◽

10.1182/blood-2018-99-116557 ◽

2018 ◽

Vol 132 (Supplement 1) ◽

pp. 3560-3560

Author(s):

Haiying Huang ◽

Zhimin Liang ◽

Yongxian Huang ◽

Hui Zhang

Keyword(s):

Cancer Treatment ◽

Nursing Care ◽

Hematological Malignancies ◽

Conflicts Of Interest ◽

Medical Center ◽

Clinical Care ◽

Treatment Compliance ◽

Children With Cancer ◽

Nursing Experience ◽

Pediatric Cancer Patients

Abstract Objective: To evaluate the effects of multi-dimensional humanistic care on kids with hematological malignancies and their parents and facilitate the effective nursing experience and professional nursing in such clinical care. Methods: A total of 567 children with cancer and their parents were enrolled in this study. From January to December in 2017, multi-dimensional humanistic care was systematically implemented to provide care for all these patients and their family members. A warm and comfortable in-patient atmosphere was created with regular playing-games, health education meetings, and personal palliative care support were provided to all newly-diagnosed pediatric cancer patients and their parents who admitted to our department. In the meanwhile, case management were implemented by nurses. Children and parents in demand were referred to game therapists and social workers for visits, psychological counseling and emotional support. Financial assistance was also provided to care for those well-off families to support their systemic cancer treatment. Follow-up visits to hospitals were also offered. Results: The implementation of multi-dimensional humanistic care measures significantly reduced the anxiety level of hospitalized children with cancer and their parents, which in turn improve their treatment compliance. Next, more easier caregiving ability and compliance were also recorded. The results of satisfaction survey showed that the satisfaction to nursing care rose from 85.6% in 2016 to 96.9% in 2017 after the implementation of multi-dimensional humanistic care in our hospital. The nurses' service attitude, medication guidance, hospitalization guidance, timely bedside services, and nurses' operating technology satisfaction also increased by 10.86%, 12.17%, 8.3%, 12.80%, and 12.15% respectively. Conclusion: The multi-dimensional humanistic care effectively reduces the anxiety of kids with hematological malignancies and their parents, improves the caregiver's caring ability and compliance, and their satisfaction to nursing care. All these results point out the significance of systemic care services in the childhood cancer therapy, it is noteworthy to pour more attention and capacity to the clinics which may facilitate the cancer treatment. Figure. Figure. Disclosures No relevant conflicts of interest to declare.

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Acute Malnutrition among Children at Time of Cancer Diagnosis at a Paediatric Oncology Centre in South West Uganda

10.22541/au.161495698.85656290/v1 ◽

2021 ◽

Author(s):

Ndayisenga jeanine ◽

Atwiine Barnabas ◽

Francis Oriokot ◽

Atwiine Daniel ◽

Stella Kyoyagara ◽

...

Keyword(s):

Regression Analysis ◽

Cancer Treatment ◽

Cancer Diagnosis ◽

Data Extraction ◽

Retrospective Chart Review ◽

Paediatric Oncology ◽

Acute Malnutrition ◽

Older Children ◽

Children With Cancer ◽

Diagnosis Of Cancer

Background: Acute malnutrition is a frequent comorbidity in children with cancer and is associated with poor cancer treatment outcomes.This study describes the prevalence of acute malnutrition and its predictors at time of cancer diagnosis at Mbarara Regional Referral Hospital (MRRH). Methods: This was a retrospective chart review of children <15 years of age at diagnosis of cancer seen at the Children’s Cancer Unit of MRRH between May 2017 and May 2019. Using a data extraction tool, information regarding demographics, anthropometry at admission and cancer diagnosis was extracted from the children’s medical records. Descriptive statistics and logistic regression analysis were used to determine the prevalence and patterns of acute malnutrition among children at diagnosis of cancer and the factors associated with acute malnutrition, respectively. The study was approved by the Mbarara University of Science and Technology Research and Ethics Committee. Results: One hundred and thirty-three children were included in the study with a mean age of 6.6 years (SD 3.9).54.9% of the children were male. Overall, 46 (34.6%) of subjects had acute malnutrition at time of cancer diagnosis. Of these, 25 (54.3%) had moderate acute malnutrition and 21/46 (45.7%) had severe acute malnutrition.The factors independently associated with acute malnutrition after multivariate logistical regression analysis were age >5 years (p<0.0001) and reduced appetite (p=0.002). Conclusion: Acute malnutrition is common among children with cancer at diagnosis, especially in older children and those reporting poor appetite. Nutrition assessment and care should be incorporated into routine childhood cancer care to improve cancer treatment outcomes.

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Endocrine and Metabolic Disorders in Children with Cancer Treatment

Zahedan Journal of Research in Medical Sciences ◽

10.17795/zjrms-6244 ◽

2016 ◽

Vol In Press (InPress) ◽

Author(s):

Maryam Nakhaei-Moghadam ◽

Aria Setoodeh ◽

Noormohammad Noori ◽

Parastoo Rostami ◽

Alireza Teimouri

Keyword(s):

Cancer Treatment ◽

Metabolic Disorders ◽

Children With Cancer

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Children with Cancer and their Designs: Evaluation of psychological development of children in cancer treatment

International Journal of English Literature and Social Sciences ◽

10.22161/ijels.61.12 ◽

2021 ◽

Vol 6 (1) ◽

pp. 095-108

Author(s):

Helena Rubia de Santana Botelho ◽

Francisca Morais da Silveira ◽

Marina da Silveira de Melo

Keyword(s):

Cancer Treatment ◽

Psychological Development ◽

Children With Cancer

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The Experiences of Chinese Children 5- to 7-year-old during cancer Treatment Reflected Through Interviews and Drawings

Journal of Pediatric Oncology Nursing ◽

10.1177/10434542211041919 ◽

2021 ◽

pp. 104345422110419

Author(s):

Lei Cheng ◽

Xinlei Zhao ◽

Youhong Ge ◽

Yingwen Wang ◽

Qiongfang Kang

Keyword(s):

Content Analysis ◽

Cancer Treatment ◽

Medical Center ◽

Chinese Children ◽

Dynamic Nature ◽

Multiple Cancer ◽

Disease Treatment ◽

Children With Cancer ◽

The Voice ◽

Inpatient Department

Background: For children with cancer, the experience during treatment can be challenging. There is a limited number of studies on self-reported treatment experiences of younger Chinese children with cancer using qualitative methods. Objectives: This study aimed at exploring the experience of Chinese children aged 5 to 7 years during cancer treatment reflected through interviews and drawings. Methods: This study used a descriptive qualitative design with the technique of “draw-and-tell.” Participants were enrolled from the pediatric oncology inpatient department of one national children's medical center in China. They were asked to draw a picture of “your feelings in the hospital.” An inductive content analysis approach was used. Results: Twelve participants were enrolled (8 male, mean age 5.7 years). Four themes were established: (1) suffering from adverse treatment effects; (2) perceiving changed relationships; (3) being thankful for others; and (4) trying out coping strategies. Conclusion: Chinese children aged 5 to 7 years expressed multiple cancer treatment impacts. They appreciated others’ support and had their own way to cope with treatment demands. The authors also extended the dynamic nature of using the “draw-and-tell” methodology. Study findings highlight the importance of inviting and hearing the voice of young children during their cancer treatment, with particular consideration of the influence of disease, treatment, child development, family dynamics, and culture.

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THE PROPER LEARNING ENGLISH METHOD FOR CHILDREN WITH CANCER IN INDONESIA CARE FOR CANCER KIDS FOUNDATION JOGJAKARTA (YKAKI JOGJA)

UAD TEFL International Conference ◽

10.12928/utic.v1.200.2017 ◽

2017 ◽

Vol 1 ◽

pp. 456

Author(s):

Rizka Dinta Murbaningtyas

Keyword(s):

Cancer Treatment ◽

Side Effect ◽

English Literature ◽

First Language ◽

Research Data ◽

Learning Method ◽

Children With Cancer ◽

Learning Methods ◽

English Class ◽

Learning English

Cancer is a chronic illness that could suffer every people included children. Because of cancer treatment for more than 2 years, some students should postpone their school. Through ‘sekolah-ku’ program, YKAKI Jogja freely gives facility for children getting cancer treatment to continue their study in the hospital and in the shelter home. Children living in YKAKI Jogja were often visited by foreign volunteers and got English literature book donation. They interested in learning English but they felt difficult to use English because English is not their first language. However, the children with cancer have limitation in Learning English caused by: 1) side effect of chemotherapy, 2) less self-confident, 3) less support from their family. The research aimed at finding out the proper learning method to teach English for children with cancer in YKAKI Jogja. The research methods used direct observation and interview in order to gain the research data. In the English class, the researcher used bilingual communication with students and created comfort situation in the ward. Some learning methods were applied during learning English such as playing games, watching English videos, and storytelling. The result of this research showed that the children was more motivated to study English when the researcher combined two of three learning methods in the English class than used one method in that class.

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Parents' Roles in Decision Making for Children With Cancer in the First Year of Cancer Treatment

Journal of Clinical Oncology ◽

10.1200/jco.2010.32.0507 ◽

2011 ◽

Vol 29 (15) ◽

pp. 2085-2090 ◽

Cited By ~ 37

Author(s):

Jennifer W. Mack ◽

Joanne Wolfe ◽

E. Francis Cook ◽

Holcombe E. Grier ◽

Paul D. Cleary ◽

...

Keyword(s):

Decision Making ◽

Cancer Treatment ◽

First Year ◽

Physician Communication ◽

Cross Sectional Survey ◽

High Quality ◽

Children With Cancer ◽

Cross Sectional ◽

Physician Perceptions ◽

Dana Farber Cancer Institute

Purpose To evaluate the extent to which parents of children with cancer are involved in decision making in the ways they prefer during the first year of treatment. Methods We conducted a cross-sectional survey of 194 parents of children with cancer (response rate, 70%) in their first year of cancer treatment at the Dana-Farber Cancer Institute and Children's Hospital (Boston, MA) and the children's physicians. We measured parents' preferred and actual roles in decision making and physician perceptions of parents' preferred roles. Results Most parents (127 of 192; 66%) wanted to share responsibility for decision making with their children's physician. Although most parents (122 of 192; 64%) reported that they had their preferred role in decision making, those who did not tended to have more passive roles than they wished (47 of 70; 67%; P < .001). Parents were no more likely to hold their ideal roles in decision making when the physician accurately identified the parents' preferred role (odds ratio [OR], 1.04; P = .92). Parents were less likely to hold more passive roles than they wished in decision making when they felt that physician communication (OR, 0.39; P = .04) and information received (OR, 0.45; P = .04) had been of high quality. Parents who held more passive roles than they wished in decision making were less likely to trust their physicians' judgments (OR, 0.46; P = .03). Conclusion Most parents of children in their first year of cancer treatment participate in decision making to the extent that they wish; although, nearly one fourth hold more passive roles than desired. High-quality physician communication is associated with attainment of one's preferred role.

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